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serine and Deficiency of GP 2b 3a Complex

serine has been researched along with Deficiency of GP 2b 3a Complex in 4 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Platelets from Glanzmann thrombasthenia patient BL express approximately 30% of the normal alphaIIbbeta3 content and support fibrin-mediated clot retraction, but fail to bind fibrinogen or aggregate following cellular activation."1.30A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia. ( Jackson, DE; Jennings, LK; Newman, PJ; White, MM, 1998)
"We have studied a variant of Glanzmann thrombasthenia, a congenital bleeding disorder characterized by absence of platelet aggregation and fibrinogen binding."1.28Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. ( Caen, JP; Chen, YP; Cieutat, AM; Djaffar, I; Pidard, D; Rosa, JP; Steiner, B, 1992)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kieffer, N1
Melchior, C1
Guinet, JM1
Michels, S1
Gouon, V1
Bron, N1
Gruel, Y1
Pacouret, G1
Bellucci, S1
Caen, J1
Jackson, DE1
White, MM1
Jennings, LK1
Newman, PJ1
Chen, YP1
Djaffar, I1
Pidard, D1
Steiner, B1
Cieutat, AM1
Caen, JP1
Rosa, JP1

Other Studies

4 other studies available for serine and Deficiency of GP 2b 3a Complex

ArticleYear
Serine 752 in the cytoplasmic domain of the beta 3 integrin subunit is not required for alpha v beta 3 postreceptor signaling events.
    Cell adhesion and communication, 1996, Volume: 4, Issue:1

    Topics: Alanine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, CD; Cell Adhesion; CHO Cell

1996
Severe proximal deep vein thrombosis in a Glanzmann thrombasthenia variant successfully treated with a low molecular weight heparin.
    Blood, 1997, Jul-15, Volume: 90, Issue:2

    Topics: Aged; Anticoagulants; Femoral Vein; Genetic Variation; Heparin, Low-Molecular-Weight; Humans; Male;

1997
A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia.
    Thrombosis and haemostasis, 1998, Volume: 80, Issue:1

    Topics: Amino Acid Sequence; Amino Acid Substitution; Antigens, CD; Child; Humans; Integrin beta3; Integrins

1998
Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Nov-01, Volume: 89, Issue:21

    Topics: Amino Acid Sequence; Antibodies, Monoclonal; Base Sequence; Chromatography, Affinity; Female; Fibrin

1992