serine has been researched along with Deficiency of GP 2b 3a Complex in 4 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Excerpt | Relevance | Reference |
---|---|---|
"Platelets from Glanzmann thrombasthenia patient BL express approximately 30% of the normal alphaIIbbeta3 content and support fibrin-mediated clot retraction, but fail to bind fibrinogen or aggregate following cellular activation." | 1.30 | A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia. ( Jackson, DE; Jennings, LK; Newman, PJ; White, MM, 1998) |
"We have studied a variant of Glanzmann thrombasthenia, a congenital bleeding disorder characterized by absence of platelet aggregation and fibrinogen binding." | 1.28 | Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. ( Caen, JP; Chen, YP; Cieutat, AM; Djaffar, I; Pidard, D; Rosa, JP; Steiner, B, 1992) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 4 (100.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kieffer, N | 1 |
Melchior, C | 1 |
Guinet, JM | 1 |
Michels, S | 1 |
Gouon, V | 1 |
Bron, N | 1 |
Gruel, Y | 1 |
Pacouret, G | 1 |
Bellucci, S | 1 |
Caen, J | 1 |
Jackson, DE | 1 |
White, MM | 1 |
Jennings, LK | 1 |
Newman, PJ | 1 |
Chen, YP | 1 |
Djaffar, I | 1 |
Pidard, D | 1 |
Steiner, B | 1 |
Cieutat, AM | 1 |
Caen, JP | 1 |
Rosa, JP | 1 |
4 other studies available for serine and Deficiency of GP 2b 3a Complex
Article | Year |
---|---|
Serine 752 in the cytoplasmic domain of the beta 3 integrin subunit is not required for alpha v beta 3 postreceptor signaling events.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, CD; Cell Adhesion; CHO Cell | 1996 |
Severe proximal deep vein thrombosis in a Glanzmann thrombasthenia variant successfully treated with a low molecular weight heparin.
Topics: Aged; Anticoagulants; Femoral Vein; Genetic Variation; Heparin, Low-Molecular-Weight; Humans; Male; | 1997 |
A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antigens, CD; Child; Humans; Integrin beta3; Integrins | 1998 |
Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Base Sequence; Chromatography, Affinity; Female; Fibrin | 1992 |