serine has been researched along with Deficiency, Pyridoxine in 25 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pathogenesis of vitamin B6 deficiency is largely unknown." | 1.46 | Vitamin B6 is essential for serine de novo biosynthesis. ( Burgering, B; Gerrits, J; Jans, JJ; Pras-Raves, ML; Prinsen, H; Ramos, RJ; van der Ham, M; Verhoeven-Duif, NM; Willemsen, M, 2017) |
| "Glycine is a precursor of purines, protein, glutathione, and 1-carbon units as 5,10-methylenetetrahydrofolate." | 1.35 | Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women. ( Fredriksen, A; Gilbert, LR; Gregory, JF; Keeling, C; Lamers, Y; Meyer, K; Newgard, CB; Quinlivan, EP; Ralat, M; Stacpoole, PW; Stevens, RD; Ueland, PM; Williamson, J, 2009) |
| "2." | 1.24 | EFFECT OF PYRIDOXINE DEFICIENCY ON NUCLEIC ACID METABOLISM IN THE RAT. ( AXELROD, AE; TRAKATELLIS, AC, 1965) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (72.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 3 (12.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ramos, RJ | 1 |
| Pras-Raves, ML | 1 |
| Gerrits, J | 1 |
| van der Ham, M | 1 |
| Willemsen, M | 1 |
| Prinsen, H | 1 |
| Burgering, B | 1 |
| Jans, JJ | 1 |
| Verhoeven-Duif, NM | 1 |
| da Silva, VR | 1 |
| Rios-Avila, L | 2 |
| Lamers, Y | 2 |
| Ralat, MA | 1 |
| Midttun, Ø | 2 |
| Quinlivan, EP | 2 |
| Garrett, TJ | 1 |
| Coats, B | 2 |
| Shankar, MN | 1 |
| Percival, SS | 1 |
| Chi, YY | 2 |
| Muller, KE | 1 |
| Ueland, PM | 3 |
| Stacpoole, PW | 4 |
| Gregory, JF | 6 |
| Ralat, M | 2 |
| Williamson, J | 3 |
| Gilbert, LR | 1 |
| Keeling, C | 1 |
| Stevens, RD | 1 |
| Newgard, CB | 1 |
| Meyer, K | 1 |
| Fredriksen, A | 1 |
| Nijhout, HF | 1 |
| Fitzpatrick, C | 1 |
| Cho, E | 1 |
| Lamers, KY | 1 |
| Ulrich, CM | 1 |
| Reed, MC | 1 |
| GERSHOFF, SN | 3 |
| FARAGALLA, FF | 1 |
| GANTI, Y | 1 |
| SHANMUGASUNDARAM, ER | 1 |
| Swendseid, ME | 1 |
| Villalobos, J | 1 |
| Friedrich, B | 1 |
| RUNYAN, TJ | 1 |
| TRAKATELLIS, AC | 1 |
| AXELROD, AE | 1 |
| Tews, JK | 2 |
| Lovell, RA | 1 |
| Aboaysha, AM | 1 |
| Kratzer, FH | 1 |
| Martinez, M | 1 |
| Cuskelly, GJ | 2 |
| Toth, JP | 1 |
| Baumgartner, TG | 1 |
| Wolfson, M | 1 |
| Kopple, JD | 1 |
| Wohllebe, W | 1 |
| Paul, I | 1 |
| Liao, LL | 1 |
| Richardson, KE | 1 |
| Pandit, VI | 1 |
| Chakrabarti, CH | 1 |
| Sifri, M | 1 |
| Daghir, NJ | 1 |
| Asmar, JA | 1 |
| Park, YK | 1 |
| Linkswiler, H | 1 |
| Brown, FC | 1 |
| Gordon, PH | 1 |
| Gill, TJ | 1 |
| Simonian, SJ | 1 |
| Steinberg, AI | 1 |
| Huovinen, JA | 1 |
| Thmas, JH | 1 |
| Fowler, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Vitamin B6 Effects on One-Carbon Metabolism[NCT01128244] | Phase 2/Phase 3 | 13 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Vitamin B6 Dependence of One-Carbon Metabolism[NCT00877812] | 45 participants (Actual) | Interventional | 2008-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
For all subjects, the concentration of plasma cystathionine in fasting blood samples taken before and after the supplementation period will provide a functional measure of vitamin B6 nutritional status. (NCT01128244)
Timeframe: Fasting blood samples will be taken at baseline and after 28 days of vitamin B6 supplementation.
| Intervention | micromol/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Plasma Cystathionine Concentration | 0.14 | 0.13 |
For all subjects, the concentration of plasma pyridoxal phosphate in fasting blood samples taken before and after the supplementation period will provide a direct measure of vitamin B6 nutritional status. (NCT01128244)
Timeframe: Fasting blood samples will be taken at baseline and after 28 days of vitamin B6 supplementation.
| Intervention | nmol/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Plasma Pyridoxal Phosphate Concentration | 25.8 | 143 |
Data from analysis of serine, methionine and leucine in the timed blood samples of all subjects will provide a measurement of the metabolic rate of homocysteine remethylation from serine-derived carbon before and after vitamin B6 supplementation. These flux values may be slightly higher than flux of total homocysteine remethylation in Outcome Measure 1 because of the small contribution of methionine salvage to the flux measured in Outcome Measure 2. (NCT01128244)
Timeframe: Blood samples will be taken prior to infusion and at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7.5, and 9h. Infusions will be conducted at baseline and after 28 days
| Intervention | micromol/(kg x hr) (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Homocysteine Remethylation Flux From Serine | 6.60 | 6.92 |
For all subjects, analysis of blood samples before and after vitamin B6 supplementation will allow evaluation of discriminating biomarkers using targeted metabolite profile analysis of one-carbon metabolism and tryptophan catabolism constituents. Also, we will conduct exploratory evaluation and potential identification of new biomarkers using metabolomics analysis on subjects before and after vitamin B6 supplementation. (NCT01128244)
Timeframe: April, 2010 - June, 2014
| Intervention | microl/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Secondary Analysis: Plasma 3-hydroxykynurenine Concentration | 25.9 | 27.3 |
Data from analysis of serine, methionine and leucine in the timed blood samples of all subjects will provide a measurement of the metabolic rate of total remethylation of homocysteine before and after vitamin B6 supplementation. (NCT01128244)
Timeframe: Blood samples will be taken prior to infusion and at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7.5, and 9h. Infusions will be conducted at baseline and after 28 days
| Intervention | micromol/(kg x hr) (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Total Homocysteine Remethylation Flux | 6.07 | 5.63 |
1 trial available for serine and Deficiency, Pyridoxine
| Article | Year |
|---|---|
Deficiencies of folate and vitamin B(6) exert distinct effects on homocysteine, serine, and methionine kinetics.
Topics: Adult; Amino Acids; Diet; Folic Acid Deficiency; Homocysteine; Humans; Leucine; Male; Methionine; Me | 2001 |
24 other studies available for serine and Deficiency, Pyridoxine
| Article | Year |
|---|---|
Vitamin B6 is essential for serine de novo biosynthesis.
Topics: Brain; Cells, Cultured; Glycine; Humans; Pyridoxal Phosphate; Pyridoxine; Serine; Vitamin B 6; Vitam | 2017 |
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine | 2013 |
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
Topics: 3-Hydroxyanthranilic Acid; Adult; Biomarkers; Carbon; Contraceptives, Oral; Cystathionine; Dietary S | 2015 |
Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women.
Topics: Adult; Cystathionine; Diet; Female; Glycine; Humans; Male; Serine; Tetrahydrofolates; Vitamin B 6; V | 2009 |
A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism.
Topics: Biomarkers; Carbon; Glutathione; Glycine; Glycine Hydroxymethyltransferase; Models, Biological; Oxid | 2009 |
Endogenous oxalate synthesis and glycine, serine, deoxypyridoxine interrelationships in vitamin B6-deficient rats.
Topics: Animals; Glycine; Oxalates; Rats; Serine; Vitamin B 6; Vitamin B 6 Deficiency | 1959 |
VARIATION OF FREE AMINO ACIDS IN CORCYRA CEPHALONICA ST. (RICE MOTH LARVAE) DURING SOME B VITAMIN DEFICIENCIES.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Chromatography; Glutamates; Glycine; Insecta; Larva; L | 1963 |
FREE AMINO ACIDS IN PLASMA AND TISSUES OF RATS FED A VITAMIN B6-DEFICIENT DIET.
Topics: Alanine; Amino Acids; Aspartic Acid; Blood; Diet; Glycine; Liver; Muscles; Proteins; Rats; Research; | 1964 |
THE EFFECT OF VITAMIN B6 DEFICIENCY IN RATS ON THE METABOLISM OF OXALIC ACID PRECURSORS.
Topics: Acetates; Amino Alcohols; Carbon Dioxide; Glucose; Glycine; Glycolates; Glycols; Hippurates; Kidney; | 1965 |
EFFECT OF PYRIDOXINE DEFICIENCY ON NUCLEIC ACID METABOLISM IN THE RAT.
Topics: Adenine; DNA; Formates; Liver; Metabolism; Methionine; Nucleic Acids; Nucleosides; Pyridoxal Phospha | 1965 |
The effect of a nutritional pyridoxine deficiency on free amino acids and related substances in mouse brain.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Brain Chemistry; Chromatography, Ion Exchange; Diet; | 1967 |
Serine utilization in the chick as influenced by dietary pyridoxine.
Topics: Animals; Aspartate Aminotransferases; Chickens; Glycine; Growth; In Vitro Techniques; Pyridoxine; Se | 1980 |
Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration.
Topics: Animals; Chromatography, High Pressure Liquid; Cystathionine beta-Synthase; Diet; Glycine Hydroxymet | 2000 |
The effects of vitamin B-6 deficiency in chronically azotemic and sham-operated rats.
Topics: Alanine; Animals; Asparagine; Aspartate Aminotransferases; Chronic Disease; Creatinine; Erythrocytes | 1987 |
[Report on a vitamin B 6 deficiency anemia].
Topics: Adult; Anemia, Sideroblastic; Folic Acid; Glycine; Humans; Male; Pyridoxine; Serine; Vitamin B 6 Def | 1966 |
The metabolism of oxalate precursors in isolated perfused rat livers.
Topics: Alanine; Animals; Carbon Isotopes; Ethanolamines; Female; Glycine; Glycolates; Glycols; Glyoxylates; | 1972 |
Studies on certain hepatic enzymes and protein biosynthesis in pyridoxine deficient rats.
Topics: Alanine Transaminase; Animals; Carbon Isotopes; Glutathione; Hydrogen-Ion Concentration; Liver; Male | 1972 |
Serum aminotransferase activities and plasma free amino acid concentration as criteria for pyridoxine nutritional status of chicks.
Topics: Alanine Transaminase; Amino Acids; Aminobutyrates; Ammonia; Animal Nutritional Physiological Phenome | 1972 |
Pyridoxine deficiency and brain amino acids.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Animals; Brain; Brain Chemistry; Diet; Glutamates; G | 1969 |
Effect of vitamin B6 depletion in adult man on the plasma concentration and the urinary excretion of free amino acids.
Topics: Adult; Alanine; Amino Acids; Fasting; Glycine; Humans; Isoleucine; Leucine; Male; Pyridoxine; Serine | 1971 |
A study of L-(14C)cystathionine metabolism in the brain, kidney, and liver of pyridoxine-deficient rats.
Topics: Amino Acids; Ammonia; Animals; Biological Transport; Brain; Carbon Isotopes; Chromatography, Ion Exc | 1971 |
Some effects of amino acid deficiencies on antibody formation in the rat.
Topics: Amino Acids; Animals; Antibody Formation; Antigens; Antimetabolites; Body Weight; Deficiency Disease | 1968 |
Effect of chronic pyridoxine deficiency and a pyridoxal antagonist on the assimilation of sulphide by the cysteine synthase reaction in the rat.
Topics: Amino Acid Oxidoreductases; Animals; Cysteine; Hydro-Lyases; In Vitro Techniques; Kidney; Liver; Mal | 1968 |
A rat liver system that catalyses a pyridoxal phosphate-independent alpha beta-eliminto.
Topics: Alanine Transaminase; Animals; Enzymes; Isoniazid; Liver; Protein Binding; Pyridoxal Phosphate; Rats | 1969 |