serine has been researched along with Cytomegalovirus in 16 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The 86-kDa major immediate-early protein (IE2/IEP86) of human cytomegalovirus (HCMV) contains a serine-rich region (amino acids 258 to 275) with several consensus casein kinase II (CKII) sites." | 7.73 | The phosphorylation status of the serine-rich region of the human cytomegalovirus 86-kilodalton major immediate-early protein IE2/IEP86 affects temporal viral gene expression. ( Alwine, JC; Barrasa, MI; Harel, NY, 2005) |
| "The virion basic phosphoprotein (BPP), UL32, of the human cytomegalovirus (HCMV) is a 149-kDa tegument protein that represents about 15% of the virion protein mass and is modified by O-linked N-acetylglucosamine (O-GlcNAc)." | 7.69 | Site-specific glycosylation of the human cytomegalovirus tegument basic phosphoprotein (UL32) at serine 921 and serine 952. ( Gibson, W; Greis, KD; Hart, GW, 1994) |
| "The product of the human cytomegalovirus (CMV) UL97 gene, which controls ganciclovir phosphorylation in virus-infected cells, is homologous to known protein kinases but diverges from them at a number of positions that are functionally important." | 7.69 | The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines. ( Biron, KK; Chu, L; Coen, DM; He, YS; He, Z; Kim, Y; Ohmstede, C, 1997) |
| "The virion basic phosphoprotein (BPP), UL32, of the human cytomegalovirus (HCMV) is a 149-kDa tegument protein that represents about 15% of the virion protein mass and is modified by O-linked N-acetylglucosamine (O-GlcNAc)." | 3.69 | Site-specific glycosylation of the human cytomegalovirus tegument basic phosphoprotein (UL32) at serine 921 and serine 952. ( Gibson, W; Greis, KD; Hart, GW, 1994) |
| "The product of the human cytomegalovirus (CMV) UL97 gene, which controls ganciclovir phosphorylation in virus-infected cells, is homologous to known protein kinases but diverges from them at a number of positions that are functionally important." | 3.69 | The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines. ( Biron, KK; Chu, L; Coen, DM; He, YS; He, Z; Kim, Y; Ohmstede, C, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, Y | 1 |
| Guo, X | 1 |
| Zhang, J | 1 |
| Li, J | 1 |
| Xu, M | 1 |
| Wang, Q | 1 |
| Liu, Z | 1 |
| Ma, Y | 1 |
| Qi, Y | 1 |
| Ruan, Q | 1 |
| Iwahori, S | 1 |
| Umaña, AC | 1 |
| Kalejta, RF | 1 |
| Murata, T | 1 |
| Peterson, LW | 1 |
| Kim, JS | 1 |
| Kijek, P | 1 |
| Mitchell, S | 1 |
| Hilfinger, J | 1 |
| Breitenbach, J | 1 |
| Borysko, K | 1 |
| Drach, JC | 1 |
| Kashemirov, BA | 1 |
| McKenna, CE | 1 |
| de Oliveira, CA | 1 |
| Guimarães, CR | 1 |
| Barreiro, G | 1 |
| de Alencastro, RB | 1 |
| Jarvis, MA | 1 |
| Jones, TR | 1 |
| Drummond, DD | 1 |
| Smith, PP | 1 |
| Britt, WJ | 1 |
| Nelson, JA | 2 |
| Baldick, CJ | 1 |
| Barrasa, MI | 1 |
| Harel, NY | 1 |
| Alwine, JC | 1 |
| Keller, MJ | 1 |
| Wu, AW | 1 |
| Andrews, JI | 1 |
| McGonagill, PW | 1 |
| Tibesar, EE | 1 |
| Meier, JL | 1 |
| Greis, KD | 1 |
| Gibson, W | 3 |
| Hart, GW | 1 |
| Welch, AR | 1 |
| McNally, LM | 1 |
| Hall, MR | 1 |
| Tong, L | 2 |
| Qian, C | 1 |
| Massariol, MJ | 2 |
| Bonneau, PR | 1 |
| Cordingley, MG | 1 |
| Lagacé, L | 2 |
| He, Z | 1 |
| He, YS | 1 |
| Kim, Y | 1 |
| Chu, L | 1 |
| Ohmstede, C | 1 |
| Biron, KK | 2 |
| Coen, DM | 1 |
| Duncan, PI | 1 |
| Stojdl, DF | 1 |
| Marius, RM | 1 |
| Bell, JC | 1 |
| Baldanti, F | 1 |
| Simoncini, L | 1 |
| Talarico, CL | 1 |
| Sarasini, A | 1 |
| Gerna, G | 1 |
| Fish, KN | 1 |
| Soderberg-Naucler, C | 1 |
| Plafker, SM | 1 |
| Woods, AS | 1 |
| Khayat, R | 1 |
| Batra, R | 1 |
16 other studies available for serine and Cytomegalovirus
| Article | Year |
|---|---|
Human cytomegalovirus RNA2.7 inhibits RNA polymerase II (Pol II) Serine-2 phosphorylation by reducing the interaction between Pol II and phosphorylated cyclin-dependent kinase 9 (pCDK9).
Topics: Cyclin-Dependent Kinase 9; Cytomegalovirus; DNA Replication; DNA, Viral; Phosphorylation; RNA Polyme | 2022 |
Serine 13 of the human cytomegalovirus viral cyclin-dependent kinase UL97 is required for regulatory protein 14-3-3 binding and UL97 stability.
Topics: 14-3-3 Proteins; Cyclin-Dependent Kinases; Cytomegalovirus; Humans; Phosphotransferases (Alcohol Gro | 2022 |
Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir.
Topics: Administration, Oral; Alanine; Animals; Antiviral Agents; Cells, Cultured; Cidofovir; Cytomegaloviru | 2011 |
Investigation of the induced-fit mechanism and catalytic activity of the human cytomegalovirus protease homodimer via molecular dynamics simulations.
Topics: Arginine; Binding Sites; Catalysis; Computer Simulation; Cytomegalovirus; Dimerization; Histidine; H | 2003 |
Phosphorylation of human cytomegalovirus glycoprotein B (gB) at the acidic cluster casein kinase 2 site (Ser900) is required for localization of gB to the trans-Golgi network and efficient virus replication.
Topics: Amino Acid Substitution; Casein Kinase II; Cells, Cultured; Cytomegalovirus; Fibroblasts; Humans; Op | 2004 |
The phosphorylation status of the serine-rich region of the human cytomegalovirus 86-kilodalton major immediate-early protein IE2/IEP86 affects temporal viral gene expression.
Topics: Base Sequence; Cell Line; Cytomegalovirus; Gene Expression Regulation, Viral; Humans; Immediate-Earl | 2005 |
Reversal of human cytomegalovirus major immediate-early enhancer/promoter silencing in quiescently infected cells via the cyclic AMP signaling pathway.
Topics: Cell Line; Cyclic AMP; Cytomegalovirus; DNA, Viral; Enhancer Elements, Genetic; Gene Silencing; Gene | 2007 |
Site-specific glycosylation of the human cytomegalovirus tegument basic phosphoprotein (UL32) at serine 921 and serine 952.
Topics: Acetylglucosamine; Amino Acid Sequence; Animals; Cell Line; Cells, Cultured; Chromatography, High Pr | 1994 |
Herpesvirus proteinase: site-directed mutagenesis used to study maturational, release, and inactivation cleavage sites of precursor and to identify a possible catalytic site serine and histidine.
Topics: Amino Acid Sequence; Binding Sites; Cells, Cultured; Cytomegalovirus; DNA Mutational Analysis; Endop | 1993 |
A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease.
Topics: Crystallography, X-Ray; Cytomegalovirus; Endopeptidases; Escherichia coli; Humans; Models, Molecular | 1996 |
The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines.
Topics: Animals; Cell Line; Cytomegalovirus; Ganciclovir; Glutathione Transferase; Humans; Phosphorylation; | 1997 |
In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase.
Topics: Adenovirus E1A Proteins; Alternative Splicing; Animals; Arginine; COS Cells; Cytomegalovirus; Exons; | 1997 |
Emergence of a ganciclovir-resistant human cytomegalovirus strain with a new UL97 mutation in an AIDS patient.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Retinitis; | 1998 |
Steady-state plasma membrane expression of human cytomegalovirus gB is determined by the phosphorylation state of Ser900.
Topics: Alanine; Animals; Antibodies, Monoclonal; Antifungal Agents; Aspartic Acid; Biological Transport; Ce | 1998 |
Phosphorylation of simian cytomegalovirus assembly protein precursor (pAPNG.5) and proteinase precursor (pAPNG1): multiple attachment sites identified, including two adjacent serines in a casein kinase II consensus sequence.
Topics: Amino Acid Sequence; Animals; Capsid; Casein Kinase II; Cell Line; Consensus Sequence; Cytomegalovir | 1999 |
Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Topics: Alanine; Binding Sites; Catalytic Domain; Conserved Sequence; Crystallization; Crystallography, X-Ra | 2001 |