serine has been researched along with Crohn Disease in 3 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Binding to the Crohn's disease susceptibility protein, NOD2, is required for TRAF4 phosphorylation and subsequent inhibition of NOD2 signaling." | 1.38 | IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling. ( Abbott, DW; Cantley, LC; Cobb, BA; Homer, CR; Hutti, JE; Marinis, JM; McDonald, C, 2012) |
| "However, clinical trials with IL-10 in Crohn's disease were disappointing, although some patients showed healing of intestinal mucosa." | 1.32 | Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production. ( Foxwell, BM; Gangl, A; Gasche, C; Grundtner, P; Reinisch, W; Sarma, U; Shaw, SH; Williams, LM; Zdanov, A; Zwirn, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marinis, JM | 1 |
| Hutti, JE | 1 |
| Homer, CR | 1 |
| Cobb, BA | 1 |
| Cantley, LC | 1 |
| McDonald, C | 1 |
| Abbott, DW | 1 |
| Gasche, C | 1 |
| Grundtner, P | 1 |
| Zwirn, P | 1 |
| Reinisch, W | 1 |
| Shaw, SH | 1 |
| Zdanov, A | 1 |
| Sarma, U | 1 |
| Williams, LM | 1 |
| Foxwell, BM | 1 |
| Gangl, A | 1 |
| Mitoma, H | 1 |
| Horiuchi, T | 1 |
| Hatta, N | 1 |
| Tsukamoto, H | 1 |
| Harashima, S | 1 |
| Kikuchi, Y | 1 |
| Otsuka, J | 1 |
| Okamura, S | 1 |
| Fujita, S | 1 |
| Harada, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Anti-TNF Antibodies on the T-lymphocyte and Macrophage Cooperation in the Crohn Disease[NCT00561548] | 20 participants (Anticipated) | Interventional | 2007-05-31 | Terminated | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for serine and Crohn Disease
| Article | Year |
|---|---|
IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Crohn Disease; DNA Primers; D | 2012 |
Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production.
Topics: Amino Acid Substitution; Arginine; Crohn Disease; DNA, Complementary; Gene Frequency; Genetic Variat | 2003 |
Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-alpha.
Topics: Amino Acid Substitution; Anti-Inflammatory Agents; Antibodies, Monoclonal; Apoptosis; Base Sequence; | 2005 |