serine has been researched along with Cortical Lewy Body Disease in 12 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased in Lewy body disease, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)." | 4.12 | α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity. ( Abdi, IY; Ardah, MT; Attems, J; Carloni, P; Dorn, A; El-Agnaf, OMA; Erskine, D; Fayyad, M; Ghanem, SS; Jensen, NM; Jensen, PH; Majbour, NK; McKeith, I; Melachroinou, K; Outeiro, TF; Poggiolini, I; Santos, P; Sudhakaran, IP; Vaikath, NN; Vasili, E; Vekrellis, K, 2022) |
| "Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of alpha-synuclein (alpha-syn) in Parkinson disease." | 3.76 | Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. ( Aebischer, P; Chegini, F; Chiappe, D; Eliezer, D; Fernandez, CO; Gai, WP; Kim, HY; Lamberto, GR; Lashuel, HA; Masliah, E; Moniatte, M; Oueslati, A; Paleologou, KE; Rospigliosi, CC; Schmid, A; Schneider, BL; Shakked, G; Zweckstetter, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sano, K | 1 |
| Iwasaki, Y | 1 |
| Yamashita, Y | 1 |
| Irie, K | 1 |
| Hosokawa, M | 1 |
| Satoh, K | 1 |
| Mishima, K | 1 |
| Ghanem, SS | 2 |
| Majbour, NK | 2 |
| Vaikath, NN | 2 |
| Ardah, MT | 1 |
| Erskine, D | 2 |
| Jensen, NM | 1 |
| Fayyad, M | 2 |
| Sudhakaran, IP | 2 |
| Vasili, E | 1 |
| Melachroinou, K | 1 |
| Abdi, IY | 1 |
| Poggiolini, I | 1 |
| Santos, P | 1 |
| Dorn, A | 1 |
| Carloni, P | 1 |
| Vekrellis, K | 2 |
| Attems, J | 2 |
| McKeith, I | 1 |
| Outeiro, TF | 1 |
| Jensen, PH | 1 |
| El-Agnaf, OMA | 2 |
| Abdesselem, H | 1 |
| Lamprokostopoulou, A | 1 |
| Morris, CM | 1 |
| Miners, JS | 1 |
| Renfrew, R | 1 |
| Swirski, M | 1 |
| Love, S | 1 |
| Schell, H | 1 |
| Hasegawa, T | 1 |
| Neumann, M | 1 |
| Kahle, PJ | 1 |
| Paleologou, KE | 1 |
| Oueslati, A | 1 |
| Shakked, G | 1 |
| Rospigliosi, CC | 1 |
| Kim, HY | 1 |
| Lamberto, GR | 1 |
| Fernandez, CO | 1 |
| Schmid, A | 1 |
| Chegini, F | 1 |
| Gai, WP | 2 |
| Chiappe, D | 1 |
| Moniatte, M | 1 |
| Schneider, BL | 1 |
| Aebischer, P | 1 |
| Eliezer, D | 1 |
| Zweckstetter, M | 1 |
| Masliah, E | 1 |
| Lashuel, HA | 1 |
| Lim, Y | 1 |
| Kehm, VM | 1 |
| Lee, EB | 1 |
| Soper, JH | 1 |
| Li, C | 1 |
| Trojanowski, JQ | 1 |
| Lee, VM | 1 |
| Muntané, G | 1 |
| Ferrer, I | 1 |
| Martinez-Vicente, M | 1 |
| Walker, DG | 1 |
| Lue, LF | 1 |
| Adler, CH | 1 |
| Shill, HA | 1 |
| Caviness, JN | 1 |
| Sabbagh, MN | 1 |
| Akiyama, H | 2 |
| Serrano, GE | 1 |
| Sue, LI | 1 |
| Beach, TG | 1 |
| Anderson, JP | 1 |
| Walker, DE | 1 |
| Goldstein, JM | 1 |
| de Laat, R | 1 |
| Banducci, K | 1 |
| Caccavello, RJ | 1 |
| Barbour, R | 1 |
| Huang, J | 1 |
| Kling, K | 1 |
| Lee, M | 1 |
| Diep, L | 1 |
| Keim, PS | 1 |
| Shen, X | 1 |
| Chataway, T | 1 |
| Schlossmacher, MG | 1 |
| Seubert, P | 1 |
| Schenk, D | 1 |
| Sinha, S | 1 |
| Chilcote, TJ | 1 |
| Obi, K | 1 |
| Kondo, H | 1 |
| Shimomura, Y | 1 |
| Hasegawa, M | 1 |
| Iwatsubo, T | 1 |
| Mizuno, Y | 1 |
| Mochizuki, H | 1 |
| Mata, IF | 1 |
| Samii, A | 1 |
| Schneer, SH | 1 |
| Roberts, JW | 1 |
| Griffith, A | 1 |
| Leis, BC | 1 |
| Schellenberg, GD | 1 |
| Sidransky, E | 1 |
| Bird, TD | 1 |
| Leverenz, JB | 1 |
| Tsuang, D | 1 |
| Zabetian, CP | 1 |
12 other studies available for serine and Cortical Lewy Body Disease
| Article | Year |
|---|---|
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Amino Acid Substitution; Autopsy; Brain; Casein Kinase II; | 2021 |
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Topics: alpha-Synuclein; Amyloid; Humans; Lewy Body Disease; Parkinson Disease; Phosphorylation; Protein Agg | 2022 |
Investigating the presence of doubly phosphorylated α-synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Animals; Female; Humans; Lewy Body Disease; Male; Mice; Ph | 2020 |
Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.
Topics: alpha-Synuclein; Alzheimer Disease; Brain; Calpain; Case-Control Studies; Cell Line, Tumor; Child; C | 2014 |
Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.
Topics: Aging; alpha-Synuclein; Amygdala; Animals; Brain; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Co | 2009 |
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cell Membrane; Creatine Kin | 2010 |
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.
Topics: Acoustic Stimulation; Age Factors; alpha-Synuclein; Analysis of Variance; Animals; Animals, Newborn; | 2011 |
α-synuclein phosphorylation and truncation are normal events in the adult human brain.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Animals; Brain; Cell Line, Tumor; Female; Humans; L | 2012 |
Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Female; Gyrus Cinguli; Humans; Lewy Body Disease; Male; Pa | 2013 |
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.
Topics: alpha-Synuclein; Amino Acid Sequence; Female; Humans; Lewy Body Disease; Middle Aged; Molecular Sequ | 2006 |
Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Amyloid beta-Peptides; Analysis of Variance; Cerebral Cort | 2008 |
Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders.
Topics: Aged; Asparagine; Case-Control Studies; DNA Mutational Analysis; Female; Gene Frequency; Genetic Pre | 2008 |