serine has been researched along with Compensatory Hyperinsulinemia in 7 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inhibitory serine phosphorylation is a potential molecular mechanism for insulin resistance." | 7.72 | Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. ( Hansen, L; Lee, J; Shoelson, SE; Werner, ED; Yuan, M, 2004) |
| " Exposure of L6 myotubes to 25 mmol/L glucose and 100 nmol/L insulin for 24 h, to mimic hyperglycemia and hyperinsulinemia, abolished the acute insulin-stimulated glucose uptake, increased the serine phosphorylation of IRS-1 and the phosphorylation/activation of mTOR and p70S6K." | 4.02 | Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance. ( MacPherson, REK; Shamshoum, H; Tsiani, E; Vlavcheski, F, 2021) |
| "Inhibitory serine phosphorylation is a potential molecular mechanism for insulin resistance." | 3.72 | Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. ( Hansen, L; Lee, J; Shoelson, SE; Werner, ED; Yuan, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 1 |
| Zheng, A | 1 |
| Arias, EB | 1 |
| Kwak, SE | 1 |
| Pan, X | 1 |
| Duan, D | 1 |
| Cartee, GD | 1 |
| Shamshoum, H | 1 |
| Vlavcheski, F | 1 |
| MacPherson, REK | 1 |
| Tsiani, E | 1 |
| Kobayashi, T | 1 |
| Taguchi, K | 1 |
| Nemoto, S | 1 |
| Nogami, T | 1 |
| Matsumoto, T | 1 |
| Kamata, K | 1 |
| Werner, ED | 1 |
| Lee, J | 1 |
| Hansen, L | 1 |
| Yuan, M | 1 |
| Shoelson, SE | 1 |
| Pandolfi, A | 1 |
| Solini, A | 1 |
| Pellegrini, G | 1 |
| Mincione, G | 1 |
| Di Silvestre, S | 1 |
| Chiozzi, P | 1 |
| Giardinelli, A | 1 |
| Di Marcantonio, MC | 1 |
| Piccirelli, A | 1 |
| Capani, F | 1 |
| Consoli, A | 1 |
| Morino, K | 1 |
| Petersen, KF | 1 |
| Dufour, S | 1 |
| Befroy, D | 1 |
| Frattini, J | 1 |
| Shatzkes, N | 1 |
| Neschen, S | 1 |
| White, MF | 1 |
| Bilz, S | 1 |
| Sono, S | 1 |
| Pypaert, M | 1 |
| Shulman, GI | 1 |
| Treadway, JL | 1 |
| Whittaker, J | 1 |
| Pessin, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in Pulmonary Arterial Hypertension[NCT03979482] | 30 participants (Actual) | Observational | 2019-06-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for serine and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
AS160 expression, but not AS160 Serine-588, Threonine-642, and Serine-704 phosphorylation, is essential for elevated insulin-stimulated glucose uptake by skeletal muscle from female rats after acute exercise.
Topics: Animals; Female; Glucose; Glucose Transporter Type 4; GTPase-Activating Proteins; Hyperinsulinism; I | 2023 |
Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cells, Cultured; Deoxyglucose; Disease Models | 2021 |
Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Acetylcholine; Animals; Aorta; Blood Glucose; Blood Pr | 2009 |
Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.
Topics: Animals; Hyperinsulinism; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mice, Obese | 2004 |
Selective insulin resistance affecting nitric oxide release but not plasminogen activator inhibitor-1 synthesis in fibroblasts from insulin-resistant individuals.
Topics: Adult; Atherosclerosis; Cells, Cultured; Culture Media; Female; Fibroblasts; Glucose; Glycogen; Huma | 2005 |
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
Topics: Biopsy; Blood Glucose; Blotting, Western; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; D | 2005 |
Regulation of the insulin receptor kinase by hyperinsulinism.
Topics: Animals; Blotting, Western; Cell Line; Humans; Hyperinsulinism; Mice; Molecular Weight; Phosphorylat | 1989 |