serine has been researched along with Colorectal Neoplasms in 43 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effects of the proteasome inhibitor bortezomib on tumor growth in patients with advanced colorectal cancer, and to explore the relationship between correlative studies and clinical outcome." | 9.11 | A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. ( Birle, D; Degendorfer, P; Hedley, D; Mackay, H; Mackenzie, M; Major, P; Moore, M; Nicklee, T; Oza, A; Siu, L; Townsley, C; Tsao, MS; Vincent, M; Wright, J, 2005) |
| "In the current study, the underlying anti-metastatic mechanism of melatonin contained in some edible plants was explored in association with transmembrane protease serine 4 (TMPRSS4) mediated metastasis and epithelial-mesenchymal transition (EMT) signaling in human HCT15 and SW620 colorectal cancer cells." | 8.02 | Inhibition of TMPRSS4 mediated epithelial-mesenchymal transition is critically involved in antimetastatic effect of melatonin in colorectal cancers. ( Im, E; Kim, DH; Kim, SH; Koo, J; Lee, HJ; Oh, BS; Pak, JN; Park, JE; Park, WY; Park, Y; Shim, BS; Sim, DY, 2021) |
| "Moreover, the metastatic colorectal cancer cells, SW620, had more O-GlcNAc-PKM2 and showed lower PKM2-specific activity compared to the non-metastatic colorectal cancer SW480 cells." | 5.42 | Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells. ( Chaiyawat, P; Champattanachai, V; Chokchaichamnankit, D; Lirdprapamongkol, K; Srisomsap, C; Svasti, J, 2015) |
| "To evaluate the effects of the proteasome inhibitor bortezomib on tumor growth in patients with advanced colorectal cancer, and to explore the relationship between correlative studies and clinical outcome." | 5.11 | A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. ( Birle, D; Degendorfer, P; Hedley, D; Mackay, H; Mackenzie, M; Major, P; Moore, M; Nicklee, T; Oza, A; Siu, L; Townsley, C; Tsao, MS; Vincent, M; Wright, J, 2005) |
| "5-Fluorouracil (5-FU) is a key component of chemotherapy for colorectal cancer (CRC)." | 4.12 | SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis. ( Arcangeli, A; Caselli, A; Chiarugi, P; Cirri, P; Colantuoni, V; Leo, A; Lottini, T; Maddocks, ODK; Muccillo, L; Nesi, I; Paoli, P; Pardella, E; Parri, M; Pranzini, E; Raugei, G; Sabatino, L; Santi, A; Taddei, ML; Uribe, AH; Zhang, T, 2022) |
| "This experiment aimed to analysis of the intervention effects of modulating miR-7 on rats with colorectal cancer complicated with HP infection and the effects on (serine/threonine kinase) Akt / (glycogen synthase kinase 3 β） GSK-3 β/ （ β- β - Catenin) β- Influence of the catenin pathway." | 4.12 | Regulation effect of miR-7 on intervening colorectal cancer rats with HP infection through Akt/GSK-3β/β-catenin pathway. ( Chen, J; Ma, S; Ning, H; Su, X; Wang, W, 2022) |
| "In the current study, the underlying anti-metastatic mechanism of melatonin contained in some edible plants was explored in association with transmembrane protease serine 4 (TMPRSS4) mediated metastasis and epithelial-mesenchymal transition (EMT) signaling in human HCT15 and SW620 colorectal cancer cells." | 4.02 | Inhibition of TMPRSS4 mediated epithelial-mesenchymal transition is critically involved in antimetastatic effect of melatonin in colorectal cancers. ( Im, E; Kim, DH; Kim, SH; Koo, J; Lee, HJ; Oh, BS; Pak, JN; Park, JE; Park, WY; Park, Y; Shim, BS; Sim, DY, 2021) |
| "Changes in cancer cell metabolism can directly impact epigenetic regulation and promote transformation." | 1.43 | Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells. ( Adams, PD; Labuschagne, CF; Maddocks, OD; Vousden, KH, 2016) |
| "Moreover, the metastatic colorectal cancer cells, SW620, had more O-GlcNAc-PKM2 and showed lower PKM2-specific activity compared to the non-metastatic colorectal cancer SW480 cells." | 1.42 | Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells. ( Chaiyawat, P; Champattanachai, V; Chokchaichamnankit, D; Lirdprapamongkol, K; Srisomsap, C; Svasti, J, 2015) |
| "It is aberrantly down-regulated in colorectal cancers and colon cancer-derived cell lines by promoter hypermethylation." | 1.39 | Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells. ( Chang, WY; Hyun, JW; Kang, KA; Kim, GY; Kim, HS; Kim, KC; Na, SY; Zhang, R, 2013) |
| "One hundred ten colorectal cancer patients and 116 cancer-free individuals constituted the test and control groups, respectively." | 1.36 | Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma. ( Engin, A; Engin, AB; Karahalil, B; Karakaya, AE, 2010) |
| "Overexpression of Pak1 increased colorectal cancer cell motility and invasion, whereas down-regulation of Pak1 expression or activity reduced colorectal cancer cell migration and invasion." | 1.36 | P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910. ( Chen, XH; Feng, B; Li, LH; Liu, BY; Lu, AG; Luo, Q; Su, LP; Wang, ML; Ye, Q; Zheng, MH, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (4.65) | 18.2507 |
| 2000's | 11 (25.58) | 29.6817 |
| 2010's | 18 (41.86) | 24.3611 |
| 2020's | 12 (27.91) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, X | 2 |
| Liu, Y | 2 |
| Liu, Z | 1 |
| Lin, C | 1 |
| Meng, F | 1 |
| Xu, L | 1 |
| Zhang, X | 1 |
| Zhang, C | 1 |
| Zhang, P | 3 |
| Gong, S | 1 |
| Wu, N | 1 |
| Ren, Z | 1 |
| Song, J | 1 |
| Zhang, Y | 1 |
| Fan, L | 1 |
| Lu, C | 1 |
| Fan, Y | 1 |
| Tian, X | 1 |
| Lu, S | 1 |
| Li, Z | 1 |
| Xue, M | 1 |
| Tao, W | 1 |
| Peng, F | 1 |
| Chen, R | 1 |
| Tang, J | 1 |
| Zhao, M | 1 |
| Li, S | 1 |
| Yang, H | 1 |
| Li, W | 1 |
| Liu, JY | 1 |
| Ren, LW | 1 |
| Yang, YH | 1 |
| Ge, BB | 1 |
| Zhang, YZ | 1 |
| Fu, WQ | 1 |
| Zheng, XJ | 1 |
| Du, GH | 1 |
| Wang, JH | 1 |
| Pranzini, E | 1 |
| Pardella, E | 1 |
| Muccillo, L | 1 |
| Leo, A | 1 |
| Nesi, I | 1 |
| Santi, A | 1 |
| Parri, M | 1 |
| Zhang, T | 1 |
| Uribe, AH | 1 |
| Lottini, T | 1 |
| Sabatino, L | 1 |
| Caselli, A | 1 |
| Arcangeli, A | 1 |
| Raugei, G | 1 |
| Colantuoni, V | 1 |
| Cirri, P | 1 |
| Chiarugi, P | 1 |
| Maddocks, ODK | 1 |
| Paoli, P | 1 |
| Taddei, ML | 1 |
| Su, X | 1 |
| Wang, W | 1 |
| Ma, S | 1 |
| Ning, H | 1 |
| Chen, J | 1 |
| Pan, YJ | 3 |
| Huo, FC | 3 |
| Kang, MJ | 3 |
| Liu, BW | 3 |
| Wu, MD | 3 |
| Pei, DS | 3 |
| Pan, Q | 1 |
| Yu, F | 1 |
| Jin, H | 1 |
| Huang, X | 1 |
| Peng, J | 1 |
| Xie, X | 1 |
| Li, X | 1 |
| Ma, N | 1 |
| Wei, Y | 1 |
| Wen, W | 1 |
| Zhang, J | 1 |
| Zhang, B | 1 |
| Yu, H | 1 |
| Xiao, Y | 1 |
| Liu, RY | 1 |
| Liu, Q | 1 |
| Meng, X | 1 |
| Lee, MH | 2 |
| Cao, B | 1 |
| Zhang, K | 1 |
| Pan, C | 1 |
| Dong, Y | 1 |
| Lu, F | 1 |
| Li, K | 1 |
| Wu, JL | 1 |
| Qin, B | 1 |
| Fan, Z | 2 |
| Tang, Q | 1 |
| Lu, W | 1 |
| Zhang, H | 2 |
| Xing, F | 1 |
| Meng, M | 1 |
| Zou, S | 1 |
| Wei, W | 1 |
| Chen, H | 1 |
| Cai, J | 2 |
| Wang, H | 1 |
| Fang, L | 2 |
| Bian, X | 1 |
| Chen, C | 1 |
| Lan, P | 1 |
| Ghesquière, B | 1 |
| Hartley, AV | 1 |
| Wang, B | 1 |
| Jiang, G | 1 |
| Wei, H | 1 |
| Sun, M | 1 |
| Prabhu, L | 1 |
| Martin, M | 1 |
| Safa, A | 1 |
| Sun, S | 1 |
| Lu, T | 1 |
| Ohshima, K | 1 |
| Nojima, S | 1 |
| Tahara, S | 1 |
| Kurashige, M | 1 |
| Kawasaki, K | 1 |
| Hori, Y | 1 |
| Taniguchi, M | 1 |
| Umakoshi, Y | 1 |
| Okuzaki, D | 1 |
| Wada, N | 1 |
| Ikeda, JI | 1 |
| Fukusaki, E | 1 |
| Morii, E | 1 |
| Oh, BS | 1 |
| Im, E | 1 |
| Lee, HJ | 2 |
| Sim, DY | 1 |
| Park, JE | 1 |
| Park, WY | 1 |
| Park, Y | 1 |
| Koo, J | 1 |
| Pak, JN | 1 |
| Kim, DH | 1 |
| Shim, BS | 1 |
| Kim, SH | 1 |
| Chen, T | 1 |
| Li, J | 1 |
| Xu, M | 1 |
| Zhao, Q | 1 |
| Hou, Y | 1 |
| Yao, L | 1 |
| Zhong, Y | 1 |
| Chou, PC | 1 |
| Zhang, W | 1 |
| Zhou, P | 1 |
| Jiang, Y | 1 |
| Zhang, R | 1 |
| Kang, KA | 1 |
| Kim, KC | 1 |
| Na, SY | 1 |
| Chang, WY | 1 |
| Kim, GY | 1 |
| Kim, HS | 1 |
| Hyun, JW | 1 |
| Lin, PL | 1 |
| Wu, DW | 1 |
| Huang, CC | 1 |
| He, TY | 1 |
| Chou, MC | 1 |
| Sheu, GT | 1 |
| Lee, H | 1 |
| Lemieux, E | 1 |
| Cagnol, S | 1 |
| Beaudry, K | 1 |
| Carrier, J | 1 |
| Rivard, N | 1 |
| Suzuki, R | 1 |
| Fukui, T | 1 |
| Kishimoto, M | 1 |
| Miyamoto, S | 1 |
| Takahashi, Y | 1 |
| Takeo, M | 1 |
| Mitsuyama, T | 1 |
| Sakaguchi, Y | 1 |
| Uchida, K | 1 |
| Nishio, A | 1 |
| Okazaki, K | 1 |
| Chaiyawat, P | 1 |
| Chokchaichamnankit, D | 1 |
| Lirdprapamongkol, K | 1 |
| Srisomsap, C | 1 |
| Svasti, J | 1 |
| Champattanachai, V | 1 |
| Thuringer, D | 1 |
| Berthenet, K | 1 |
| Cronier, L | 1 |
| Solary, E | 1 |
| Garrido, C | 1 |
| Xu, D | 1 |
| Song, R | 1 |
| Wang, G | 1 |
| Jeyabal, PV | 1 |
| Weiskoff, AM | 1 |
| Ding, K | 1 |
| Shi, ZZ | 1 |
| Yan, X | 1 |
| Shi, Y | 1 |
| Kou, B | 1 |
| Zhu, Z | 1 |
| Chai, J | 1 |
| Chen, D | 1 |
| Guo, H | 1 |
| Maddocks, OD | 1 |
| Labuschagne, CF | 1 |
| Adams, PD | 1 |
| Vousden, KH | 1 |
| Lee, SB | 1 |
| Kang, K | 1 |
| Yun, JH | 1 |
| Jho, EH | 1 |
| Kim, CY | 1 |
| Nho, CW | 1 |
| Engin, AB | 1 |
| Karahalil, B | 1 |
| Engin, A | 1 |
| Karakaya, AE | 1 |
| Li, LH | 1 |
| Zheng, MH | 1 |
| Luo, Q | 1 |
| Ye, Q | 1 |
| Feng, B | 1 |
| Lu, AG | 1 |
| Wang, ML | 1 |
| Chen, XH | 1 |
| Su, LP | 1 |
| Liu, BY | 1 |
| Knock, E | 1 |
| Deng, L | 1 |
| Krupenko, N | 1 |
| Mohan, RD | 1 |
| Wu, Q | 1 |
| Leclerc, D | 1 |
| Gupta, S | 1 |
| Elmore, CL | 1 |
| Kruger, W | 1 |
| Tini, M | 1 |
| Rozen, R | 1 |
| Sui, H | 1 |
| Zhou, S | 1 |
| Wang, Y | 1 |
| Zhou, L | 1 |
| Yin, P | 1 |
| Li, Q | 1 |
| Sakai, A | 1 |
| Otani, M | 1 |
| Miyamoto, A | 1 |
| Yoshida, H | 1 |
| Furuya, E | 1 |
| Tanigawa, N | 1 |
| Park, MH | 1 |
| Kim, DJ | 1 |
| You, ST | 1 |
| Lee, CS | 1 |
| Kim, HK | 1 |
| Park, SM | 1 |
| Shin, EY | 1 |
| Kim, EG | 1 |
| Mei, Q | 1 |
| Zhou, D | 1 |
| Han, J | 1 |
| Lu, H | 1 |
| Tang, B | 1 |
| Parker, AR | 1 |
| O'Meally, RN | 1 |
| Sahin, F | 1 |
| Su, GH | 1 |
| Racke, FK | 1 |
| Nelson, WG | 1 |
| DeWeese, TL | 1 |
| Eshleman, JR | 1 |
| Khor, TO | 1 |
| Gul, YA | 1 |
| Ithnin, H | 1 |
| Seow, HF | 1 |
| Fuszek, P | 1 |
| Lakatos, P | 1 |
| Tabák, A | 1 |
| Papp, J | 1 |
| Nagy, Z | 1 |
| Lakatos, PL | 1 |
| Speer, G | 1 |
| Mackay, H | 1 |
| Hedley, D | 1 |
| Major, P | 1 |
| Townsley, C | 1 |
| Mackenzie, M | 1 |
| Vincent, M | 1 |
| Degendorfer, P | 1 |
| Tsao, MS | 1 |
| Nicklee, T | 1 |
| Birle, D | 1 |
| Wright, J | 1 |
| Siu, L | 1 |
| Moore, M | 1 |
| Oza, A | 1 |
| Kondo, E | 1 |
| Miyake, T | 1 |
| Shibata, M | 1 |
| Kimura, T | 1 |
| Iwagaki, H | 1 |
| Nakamura, S | 1 |
| Tanaka, T | 2 |
| Ohara, N | 1 |
| Ichimura, K | 1 |
| Oka, T | 1 |
| Yanai, H | 1 |
| Shibasaki, F | 1 |
| Yoshino, T | 1 |
| Turecková, J | 1 |
| Kucerová, D | 1 |
| Vojtechová, M | 1 |
| Sloncová, E | 1 |
| Tuhácková, Z | 1 |
| Matsuzaki, K | 1 |
| Chang, AJ | 1 |
| Song, DH | 1 |
| Wolfe, MM | 1 |
| Fernández-Majada, V | 1 |
| Pujadas, J | 1 |
| Vilardell, F | 1 |
| Capella, G | 1 |
| Mayo, MW | 1 |
| Bigas, A | 1 |
| Espinosa, L | 1 |
| Welman, A | 1 |
| Griffiths, JR | 1 |
| Whetton, AD | 1 |
| Dive, C | 1 |
| Michael, NP | 1 |
| Chester, KA | 1 |
| Melton, RG | 1 |
| Robson, L | 1 |
| Nicholas, W | 1 |
| Boden, JA | 1 |
| Pedley, RB | 1 |
| Begent, RH | 1 |
| Sherwood, RF | 1 |
| Minton, NP | 1 |
| Rubinfeld, B | 1 |
| Albert, I | 1 |
| Porfiri, E | 1 |
| Munemitsu, S | 1 |
| Polakis, P | 1 |
| Oda, K | 1 |
| Arakawa, H | 1 |
| Matsuda, K | 1 |
| Tanikawa, C | 1 |
| Mori, T | 1 |
| Nishimori, H | 1 |
| Tamai, K | 1 |
| Tokino, T | 1 |
| Nakamura, Y | 1 |
| Taya, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Expression of Klotho and LRP-6 Proteins in Gastric Adenocarcinoma, is it an Important Issue??[NCT05293535] | 45 participants (Anticipated) | Observational | 2023-04-01 | Not yet recruiting | |||
| Double-blind, Phase II Study to Assess the Effectiveness of Lycopene vs Placebo to Reduce Skin Toxicity in Patients With Colorectal Carcinoma Treated With Panitumumab[NCT03167268] | Phase 2 | 28 participants (Actual) | Interventional | 2016-08-03 | Active, not recruiting | ||
| A Phase II Study Of PS-341 In Patients With Metastatic Colorectal Cancer[NCT00052507] | Phase 2 | 0 participants | Interventional | 2003-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for serine and Colorectal Neoplasms
| Article | Year |
|---|---|
CYP1B1 Asn453Ser polymorphism and colorectal cancer risk: a meta-analysis.
Topics: Aryl Hydrocarbon Hydroxylases; Asparagine; Case-Control Studies; Colorectal Neoplasms; Confounding F | 2012 |
Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Colorec | 2006 |
1 trial available for serine and Colorectal Neoplasms
| Article | Year |
|---|---|
A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer.
Topics: Aged; Aged, 80 and over; Antigens, Neoplasm; Antineoplastic Agents; Biopsy; Boronic Acids; Bortezomi | 2005 |
40 other studies available for serine and Colorectal Neoplasms
| Article | Year |
|---|---|
CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.
Topics: 3' Untranslated Regions; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Animals; Biomarker | 2021 |
High-fat diet promotes colorectal carcinogenesis through SERCA2 mediated serine phosphorylation of Annexin A2.
Topics: Animals; Annexin A2; Carcinogenesis; Colorectal Neoplasms; Diet, High-Fat; Humans; Mice; Mice, Inbre | 2022 |
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
Topics: Alcohol Dehydrogenase; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neop | 2022 |
SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis.
Topics: Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Humans; Mitochondri | 2022 |
Regulation effect of miR-7 on intervening colorectal cancer rats with HP infection through Akt/GSK-3β/β-catenin pathway.
Topics: Animals; beta Catenin; Colorectal Neoplasms; Female; Glycogen Synthase Kinase 3; Glycogen Synthase K | 2022 |
Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
Topics: Alternative Splicing; Arginine; Colorectal Neoplasms; HSP70 Heat-Shock Proteins; Humans; RNA; Serine | 2022 |
Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
Topics: Alternative Splicing; Arginine; Colorectal Neoplasms; HSP70 Heat-Shock Proteins; Humans; RNA; Serine | 2022 |
Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
Topics: Alternative Splicing; Arginine; Colorectal Neoplasms; HSP70 Heat-Shock Proteins; Humans; RNA; Serine | 2022 |
Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
Topics: Alternative Splicing; Arginine; Colorectal Neoplasms; HSP70 Heat-Shock Proteins; Humans; RNA; Serine | 2022 |
Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
Topics: Alternative Splicing; Arginine; Colorectal Neoplasms; HSP70 Heat-Shock Proteins; Humans; RNA; Serine | 2022 |
Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
Topics: Alternative Splicing; Arginine; Colorectal Neoplasms; HSP70 Heat-Shock Proteins; Humans; RNA; Serine | 2022 |
Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
Topics: Alternative Splicing; Arginine; Colorectal Neoplasms; HSP70 Heat-Shock Proteins; Humans; RNA; Serine | 2022 |
Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
Topics: Alternative Splicing; Arginine; Colorectal Neoplasms; HSP70 Heat-Shock Proteins; Humans; RNA; Serine | 2022 |
Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
Topics: Alternative Splicing; Arginine; Colorectal Neoplasms; HSP70 Heat-Shock Proteins; Humans; RNA; Serine | 2022 |
eIF3f Mediates SGOC Pathway Reprogramming by Enhancing Deubiquitinating Activity in Colorectal Cancer.
Topics: Colorectal Neoplasms; Epidermal Growth Factor; Humans; Serine; Signal Transduction | 2023 |
NEK8 regulates colorectal cancer progression via phosphorylating MYC.
Topics: Colorectal Neoplasms; Humans; NIMA-Related Kinases; Protein Processing, Post-Translational; Proto-On | 2023 |
ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Epidermal Gr | 2020 |
Regulation of a PRMT5/NF-κB Axis by Phosphorylation of PRMT5 at Serine 15 in Colorectal Cancer.
Topics: Amino Acid Substitution; Cell Proliferation; Colorectal Neoplasms; HCT116 Cells; HEK293 Cells; HT29 | 2020 |
Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Heterografts; Humans; Mice; Mic | 2020 |
Inhibition of TMPRSS4 mediated epithelial-mesenchymal transition is critically involved in antimetastatic effect of melatonin in colorectal cancers.
Topics: Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Gene Expre | 2021 |
PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation.
Topics: Acetylation; Animals; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Colorectal Neoplasms; Epider | 2017 |
Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells.
Topics: Azacitidine; Colorectal Neoplasms; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine- | 2013 |
MicroRNA-21 promotes tumour malignancy via increased nuclear translocation of β-catenin and predicts poor outcome in APC-mutated but not in APC-wild-type colorectal cancer.
Topics: Adenomatous Polyposis Coli Protein; Aged; beta Catenin; Colorectal Neoplasms; Disease-Free Survival; | 2014 |
Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Cell Line, Tumor; Colorec | 2015 |
Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Cell Line, Tumor; Colorec | 2015 |
Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Cell Line, Tumor; Colorec | 2015 |
Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Cell Line, Tumor; Colorec | 2015 |
Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.
Topics: Animals; Azoxymethane; beta Catenin; Biomarkers, Tumor; Carcinogenesis; Colitis; Colorectal Neoplasm | 2015 |
Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells.
Topics: Acylation; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; N-Acety | 2015 |
Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells.
Topics: 14-3-3 Proteins; Adenosine Triphosphate; Capillaries; Cell Line, Tumor; Cell Movement; Coculture Tec | 2015 |
Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β-inhibitor 2-PP1 positive feedback loop.
Topics: Adenosine Triphosphatases; Animals; Blotting, Western; Colorectal Neoplasms; Feedback, Physiological | 2016 |
[Keratin 18 phosphorylation increases autophagy of colorectal cancer HCT116 cells and enhanced its sensitivity to oxaliplatin].
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Colorectal Neoplasms; Flow | 2016 |
Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Cell Line, Tumor; Colorectal Neoplasms; DNA Methyla | 2016 |
The chemopreventive effects of Carpesium abrotanoides are mediated by induction of phase II detoxification enzymes and apoptosis in human colorectal cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Asteraceae; Cell Cycle; Cell Line, Tumor | 2010 |
Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma.
Topics: Adult; Aged; Amino Acid Substitution; Colorectal Neoplasms; Cysteine; DNA Glycosylases; DNA-Binding | 2010 |
P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Enzyme Activation; Female | 2010 |
Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair.
Topics: Aminohydrolases; Animals; Colorectal Neoplasms; Diet; DNA Methylation; DNA Polymerase beta; DNA Repa | 2011 |
COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport | 2011 |
Identification of phosphorylated serine-15 and -82 residues of HSPB1 in 5-fluorouracil-resistant colorectal cancer cells by proteomics.
Topics: Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Gene Knockdown Techniq | 2012 |
Phosphorylation of β-catenin at serine 663 regulates its transcriptional activity.
Topics: beta Catenin; Colorectal Neoplasms; HCT116 Cells; HEK293 Cells; Humans; p21-Activated Kinases; Phosp | 2012 |
Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles.
Topics: Adenine; Adjuvants, Immunologic; Alleles; Amino Acid Sequence; Base Pair Mismatch; Carcinogens; Case | 2003 |
Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 473 but not threonine 308 in colorectal carcinoma.
Topics: Age Factors; Aged; Apoptosis; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; | 2004 |
[Significance of serum calcium levels in colorectal cancer].
Topics: Aged; Alanine; Biomarkers, Tumor; CA-19-9 Antigen; Calcium; Colorectal Neoplasms; Female; Genotype; | 2004 |
Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms.
Topics: Adenocarcinoma; Adenoma; Antibody Specificity; Apoptosis; Cell Cycle; Cell Line, Tumor; Colorectal N | 2005 |
Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells.
Topics: Adenocarcinoma; Alkaline Phosphatase; Androstadienes; beta Catenin; Butyrates; Cell Line, Tumor; Col | 2006 |
Attenuation of peroxisome proliferator-activated receptor gamma (PPARgamma) mediates gastrin-stimulated colorectal cancer cell proliferation.
Topics: Animals; Cell Proliferation; Colorectal Neoplasms; Gastrins; Humans; Mice; Mitogen-Activated Protein | 2006 |
Aberrant cytoplasmic localization of N-CoR in colorectal tumors.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Cell Line, Tumor; Colon; Colorectal Neoplasms; Cytoplasm; DNA- | 2007 |
Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells.
Topics: Amino Acid Sequence; Catalytic Domain; Colorectal Neoplasms; Doxycycline; Humans; Mass Spectrometry; | 2007 |
In vitro and in vivo characterisation of a recombinant carboxypeptidase G2::anti-CEA scFv fusion protein.
Topics: Animals; Artificial Gene Fusion; Blotting, Western; Carcinoembryonic Antigen; Chromatography, Affini | 1996 |
Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene.
Topics: Adenomatous Polyposis Coli Protein; Amino Acid Sequence; Amino Acid Substitution; beta Catenin; Cadh | 1997 |
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.
Topics: Adenocarcinoma; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoma, Non- | 2000 |