serine has been researched along with Colonic Neoplasms in 50 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, how PYCR2 promotes colon carcinogenesis remains ill understood." | 5.91 | Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling. ( Ahmad, A; Ahmad, R; Bastola, DK; Becker, DF; Dhawan, P; Kumar, B; Kumar, V; Lama Tamang, R; Patel, SM; Singh, AB; Thapa, I, 2023) |
| "alpha-Methylacyl-CoA racemase (AMACR), an enzyme involved in oxidation of branched chain fatty acids and cholesterol metabolites, as well as ibuprofen metabolism, is overexpressed in colorectal adenomas and cancer." | 5.12 | Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. ( Chatterjee, N; Daugherty, SE; Fallin, MD; Hayes, RB; Huang, WY; Isaacs, WB; Platz, EA; Shugart, YY; Welch, R, 2007) |
| "In samples of colonic adenocarcinomas, the mean activities of thymidine kinase, glucose-6-phosphate dehydrogenase, phosphoserine phosphatase and pyrroline-5-carboxylate reductase were several fold higher than those of nonneoplastic colon." | 3.66 | Human colon tumors: enzymic and histological characteristics. ( Greengard, O; Herzfeld, A; Legg, MA, 1978) |
| "However, how PYCR2 promotes colon carcinogenesis remains ill understood." | 1.91 | Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling. ( Ahmad, A; Ahmad, R; Bastola, DK; Becker, DF; Dhawan, P; Kumar, B; Kumar, V; Lama Tamang, R; Patel, SM; Singh, AB; Thapa, I, 2023) |
| "The study was performed on ovarian cancer cell line (OvBH-1), colon adenocarcinoma metastasis to ovary (SW626) and on cells isolated from ascitic fluids from patients with ovarian cancer: with (p53+) or without (p53-) p53 nuclear protein accumulation." | 1.48 | The association between p53 protein phosphorylation at serine 15, serine 20 and sensitivity of cells isolated from patients with ovarian cancer and cell lines to chemotherapy in in vitro study. ( Bar, JK; Kamińska, I, 2018) |
| "Colon cancer is the third most common malignancy worldwide." | 1.43 | Ghrelin induces colon cancer cell proliferation through the GHS-R, Ras, PI3K, Akt, and mTOR signaling pathways. ( Chen, BC; Lien, GS; Lin, CH; Wu, MS; Yang, YL, 2016) |
| "HCT-116 colon cancer xenografts lacking mitochondrial 1C pathway activity generate the 1C units required for growth by cytosolic serine catabolism." | 1.43 | Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. ( Chen, L; Ducker, GS; Esposito, M; Ghergurovich, JM; Kang, Y; Morscher, RJ; Rabinowitz, JD; Teng, X, 2016) |
| "Irinotecan has also displayed efficacy in clinical trials of NSCLC." | 1.42 | Topoisomerase-I PS506 as a Dual Function Cancer Biomarker. ( Gjerset, RA; Zhao, M, 2015) |
| "We studied Akt-FAK interaction in colon cancer cells under 15 mmHg increased extracellular pressure." | 1.37 | Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis. ( Basson, MD; Wang, S, 2011) |
| " As TACC3 localization to mitotic spindles depends on Aurora A-mediated phosphorylation, quantifying TACC3 mislocalization represents a novel pharmacodynamic approach for measuring Aurora A activity in cancer patients treated with inhibitors of Aurora A kinase." | 1.34 | Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity. ( Bowman, D; Burke, KE; Ecsedy, JA; Galvin, K; Hoar, KM; Hunter, JJ; LeRoy, PJ; Ruan, J; Shinde, V, 2007) |
| "In HT-29 colon cancer xenografts, p-Akt staining was present in fresh sample but not in tissue that had been allowed to stand for 30 minutes at room temperature." | 1.33 | Stability of phosphoprotein as a biological marker of tumor signaling. ( Baker, AF; Dragovich, T; Fenoglio-Preiser, C; Ihle, NT; Powis, G; Williams, R, 2005) |
| " This combination effect was found over wide dosage ranges of AC-7700 (20-80 mg/kg) and CDDP (2." | 1.32 | Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo. ( Ehara, S; Harada, K; Morinaga, Y; Nihei, Y; Suga, Y; Suzuki, M, 2003) |
| "SW480 colon cancer cells that express a truncated APC, at position 1338, contain high levels of pbeta-catenin, whereas HT29 cells, expressing APC truncated at position 1555, accumulate non-phosphorylated beta-catenin, suggesting that the 1338-1555 amino acid region of APC is involved in the differential regulation of the dephosphorylation and degradation of pbeta-catenin." | 1.31 | Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells. ( Ben-Ze'ev, A; Conacci-Sorrell, M; Geiger, B; Kam, Z; Lando, Z; Sadot, E; Shnizer, D; Zharhary, D; Zhurinsky, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.00) | 18.7374 |
| 1990's | 3 (6.00) | 18.2507 |
| 2000's | 17 (34.00) | 29.6817 |
| 2010's | 24 (48.00) | 24.3611 |
| 2020's | 3 (6.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lama Tamang, R | 1 |
| Kumar, B | 1 |
| Patel, SM | 1 |
| Thapa, I | 1 |
| Ahmad, A | 1 |
| Kumar, V | 1 |
| Ahmad, R | 1 |
| Becker, DF | 1 |
| Bastola, DK | 1 |
| Dhawan, P | 1 |
| Singh, AB | 1 |
| Ali, M | 2 |
| Zuzga, DS | 1 |
| Pitari, GM | 2 |
| Montrose, DC | 1 |
| Saha, S | 1 |
| Foronda, M | 1 |
| McNally, EM | 1 |
| Chen, J | 2 |
| Zhou, XK | 1 |
| Ha, T | 1 |
| Krumsiek, J | 1 |
| Buyukozkan, M | 1 |
| Verma, A | 1 |
| Elemento, O | 1 |
| Yantiss, RK | 1 |
| Chen, Q | 1 |
| Gross, SS | 1 |
| Galluzzi, L | 1 |
| Dow, LE | 1 |
| Dannenberg, AJ | 1 |
| Owczarek, K | 1 |
| Hrabec, E | 1 |
| Fichna, J | 1 |
| Sosnowska, D | 1 |
| Koziołkiewicz, M | 1 |
| Szymański, J | 1 |
| Lewandowska, U | 1 |
| Yao, K | 2 |
| Peng, C | 2 |
| Zhang, Y | 2 |
| Zykova, TA | 2 |
| Lee, MH | 1 |
| Lee, SY | 1 |
| Rao, E | 1 |
| Chen, H | 1 |
| Ryu, J | 1 |
| Wang, L | 1 |
| Gao, G | 1 |
| He, W | 1 |
| Ma, WY | 1 |
| Liu, K | 1 |
| Bode, AM | 2 |
| Dong, Z | 3 |
| Li, B | 1 |
| Yang, X | 1 |
| Wang, Z | 2 |
| Li, X | 2 |
| Liu, B | 1 |
| Liu, M | 1 |
| Liu, L | 1 |
| Chen, S | 1 |
| Ren, M | 1 |
| Wang, Y | 3 |
| Yu, M | 1 |
| Wang, B | 3 |
| Zou, J | 1 |
| Zhu, WG | 1 |
| Yin, Y | 1 |
| Gu, W | 1 |
| Luo, J | 1 |
| Kamińska, I | 1 |
| Bar, JK | 1 |
| Zuazua-Villar, P | 1 |
| Rodriguez, R | 1 |
| Gagou, ME | 1 |
| Eyers, PA | 1 |
| Meuth, M | 1 |
| Rogers, LK | 1 |
| Zhao, M | 1 |
| Gjerset, RA | 1 |
| Prabhu, L | 2 |
| Mundade, R | 1 |
| Wei, H | 2 |
| Hartley, AV | 2 |
| Martin, M | 2 |
| McElyea, K | 1 |
| Temm, CJ | 1 |
| Sandusky, G | 1 |
| Liu, Y | 2 |
| Lu, T | 2 |
| Bu, Y | 2 |
| He, Y | 1 |
| Huang, C | 2 |
| Shen, Y | 2 |
| Cao, Y | 2 |
| Huang, D | 2 |
| Cai, C | 2 |
| Liao, DF | 2 |
| Cao, D | 2 |
| Yoon, S | 1 |
| Kim, JG | 1 |
| Seo, AN | 1 |
| Park, SY | 1 |
| Kim, HJ | 1 |
| Park, JS | 1 |
| Choi, GS | 1 |
| Jeong, JY | 1 |
| Jun, do Y | 1 |
| Yoon, GS | 1 |
| Kang, BW | 1 |
| Lien, GS | 1 |
| Lin, CH | 1 |
| Yang, YL | 1 |
| Wu, MS | 1 |
| Chen, BC | 1 |
| Ducker, GS | 1 |
| Chen, L | 1 |
| Morscher, RJ | 1 |
| Ghergurovich, JM | 1 |
| Esposito, M | 1 |
| Teng, X | 1 |
| Kang, Y | 1 |
| Rabinowitz, JD | 1 |
| Riscal, R | 1 |
| Schrepfer, E | 1 |
| Arena, G | 1 |
| Cissé, MY | 1 |
| Bellvert, F | 1 |
| Heuillet, M | 1 |
| Rambow, F | 1 |
| Bonneil, E | 1 |
| Sabourdy, F | 1 |
| Vincent, C | 1 |
| Ait-Arsa, I | 1 |
| Levade, T | 1 |
| Thibaut, P | 1 |
| Marine, JC | 1 |
| Portais, JC | 1 |
| Sarry, JE | 1 |
| Le Cam, L | 1 |
| Linares, LK | 1 |
| Graboń, W | 1 |
| Otto-Ślusarczyk, D | 1 |
| Chrzanowska, A | 1 |
| Mielczarek-Puta, M | 1 |
| Joniec-Maciejak, I | 1 |
| Słabik, K | 1 |
| Barańczyk-Kuźma, A | 1 |
| Cai, G | 1 |
| Zeng, X | 1 |
| Hua, L | 1 |
| Jiang, G | 1 |
| Pai, R | 1 |
| Dunlap, D | 1 |
| Qing, J | 1 |
| Mohtashemi, I | 1 |
| Hotzel, K | 1 |
| French, DM | 1 |
| Kang, HJ | 1 |
| Lee, H | 2 |
| Choi, HJ | 1 |
| Youn, JH | 1 |
| Shin, JS | 2 |
| Ahn, YH | 1 |
| Yoo, JS | 1 |
| Paik, YK | 1 |
| Kim, H | 2 |
| Adachi, S | 2 |
| Shimizu, M | 2 |
| Shirakami, Y | 1 |
| Yamauchi, J | 1 |
| Natsume, H | 1 |
| Matsushima-Nishiwaki, R | 1 |
| To, S | 1 |
| Weinstein, IB | 1 |
| Moriwaki, H | 2 |
| Kozawa, O | 2 |
| Xu, YM | 1 |
| Zhu, F | 1 |
| Cho, YY | 1 |
| Carper, A | 1 |
| Zheng, D | 1 |
| Lau, AT | 1 |
| Kim, HG | 1 |
| Wang, S | 1 |
| Basson, MD | 1 |
| Doller, A | 1 |
| Winkler, C | 1 |
| Azrilian, I | 1 |
| Schulz, S | 1 |
| Hartmann, S | 1 |
| Pfeilschifter, J | 1 |
| Eberhardt, W | 1 |
| Yasuda, I | 1 |
| Nakashima, M | 1 |
| Yamauchi, T | 1 |
| Kawaguchi, J | 1 |
| Itani, M | 1 |
| Nakamura, M | 1 |
| Nishii, Y | 1 |
| Yoshioka, T | 1 |
| Hirose, Y | 1 |
| Okano, Y | 1 |
| Hvid, H | 1 |
| Fendt, SM | 1 |
| Blouin, MJ | 1 |
| Birman, E | 1 |
| Voisin, G | 1 |
| Svendsen, AM | 1 |
| Frank, R | 1 |
| Vander Heiden, MG | 1 |
| Stephanopoulos, G | 1 |
| Hansen, BF | 1 |
| Pollak, M | 1 |
| Park, M | 1 |
| Shin, N | 1 |
| Kim, G | 1 |
| Kim, YG | 1 |
| Kawabata, A | 1 |
| Matsuzuka, T | 1 |
| Doi, C | 1 |
| Seiler, G | 1 |
| Reischman, J | 1 |
| Pickel, L | 1 |
| Ayuzawa, R | 1 |
| Nguyen, TA | 1 |
| Tamura, M | 1 |
| Ma, L | 1 |
| Tao, Y | 1 |
| Duran, A | 1 |
| Llado, V | 1 |
| Galvez, A | 1 |
| Barger, JF | 1 |
| Castilla, EA | 1 |
| Yajima, T | 1 |
| Porollo, A | 1 |
| Medvedovic, M | 1 |
| Brill, LM | 1 |
| Plas, DR | 1 |
| Riedl, SJ | 1 |
| Leitges, M | 1 |
| Diaz-Meco, MT | 1 |
| Richardson, AD | 1 |
| Moscat, J | 1 |
| Morinaga, Y | 1 |
| Suga, Y | 1 |
| Ehara, S | 1 |
| Harada, K | 1 |
| Nihei, Y | 1 |
| Suzuki, M | 1 |
| Kaeser, MD | 1 |
| Pebernard, S | 1 |
| Iggo, RD | 1 |
| Al-Fageeh, M | 1 |
| Li, Q | 1 |
| Dashwood, WM | 1 |
| Myzak, MC | 1 |
| Dashwood, RH | 1 |
| Sawhney, RS | 1 |
| Cookson, MM | 1 |
| Sharma, B | 1 |
| Hauser, J | 1 |
| Brattain, MG | 1 |
| Baker, AF | 1 |
| Dragovich, T | 1 |
| Ihle, NT | 1 |
| Williams, R | 1 |
| Fenoglio-Preiser, C | 1 |
| Powis, G | 1 |
| Gross, I | 1 |
| Lhermitte, B | 1 |
| Domon-Dell, C | 1 |
| Duluc, I | 1 |
| Martin, E | 1 |
| Gaiddon, C | 1 |
| Kedinger, M | 1 |
| Freund, JN | 1 |
| Tao, GZ | 1 |
| Nakamichi, I | 1 |
| Ku, NO | 1 |
| Wang, J | 1 |
| Frolkis, M | 1 |
| Gong, X | 1 |
| Zhu, W | 1 |
| Pytela, R | 1 |
| Omary, MB | 1 |
| Arakawa, Y | 1 |
| Suzuki, H | 1 |
| Saito, S | 1 |
| Yamada, H | 1 |
| Alessandro, R | 1 |
| Seidita, G | 1 |
| Flugy, AM | 1 |
| Damiani, F | 1 |
| Russo, A | 1 |
| Corrado, C | 1 |
| Colomba, P | 1 |
| Gullotti, L | 1 |
| Buettner, R | 1 |
| Bruno, L | 1 |
| De Leo, G | 1 |
| LeRoy, PJ | 1 |
| Hunter, JJ | 1 |
| Hoar, KM | 1 |
| Burke, KE | 1 |
| Shinde, V | 1 |
| Ruan, J | 1 |
| Bowman, D | 1 |
| Galvin, K | 1 |
| Ecsedy, JA | 1 |
| Daugherty, SE | 1 |
| Platz, EA | 1 |
| Shugart, YY | 1 |
| Fallin, MD | 1 |
| Isaacs, WB | 1 |
| Chatterjee, N | 1 |
| Welch, R | 1 |
| Huang, WY | 1 |
| Hayes, RB | 1 |
| Barnard, GF | 1 |
| Staniunas, RJ | 1 |
| Puder, M | 1 |
| Steele, GD | 1 |
| Chen, LB | 1 |
| Ji, H | 1 |
| Baldwin, GS | 1 |
| Burgess, AW | 1 |
| Moritz, RL | 1 |
| Ward, LD | 1 |
| Simpson, RJ | 1 |
| Ogier-Denis, E | 1 |
| Pattingre, S | 1 |
| El Benna, J | 1 |
| Codogno, P | 1 |
| Fournès, B | 1 |
| Sadekova, S | 1 |
| Turbide, C | 1 |
| Létourneau, S | 1 |
| Beauchemin, N | 1 |
| Sadot, E | 1 |
| Conacci-Sorrell, M | 1 |
| Zhurinsky, J | 1 |
| Shnizer, D | 1 |
| Lando, Z | 1 |
| Zharhary, D | 1 |
| Kam, Z | 1 |
| Ben-Ze'ev, A | 1 |
| Geiger, B | 1 |
| Herzfeld, A | 1 |
| Legg, MA | 1 |
| Greengard, O | 1 |
| Perán, S | 1 |
| Muñoz, M | 1 |
| Saiz, MT | 1 |
| Snell, K | 1 |
| Natsumeda, Y | 1 |
| Eble, JN | 1 |
| Glover, JL | 1 |
| Weber, G | 1 |
| Wolberg, WH | 1 |
1 trial available for serine and Colonic Neoplasms
| Article | Year |
|---|---|
Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma.
Topics: Adenoma; Aged; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Case-Control Studies | 2007 |
49 other studies available for serine and Colonic Neoplasms
| Article | Year |
|---|---|
Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling.
Topics: beta Catenin; Carcinogenesis; Chromatography, Liquid; Colonic Neoplasms; Humans; Microtubule-Associa | 2023 |
Differential Ser phosphorylation of vasodilator-stimulated phosphoprotein regulates colon tumor formation and growth.
Topics: Animals; Biomarkers, Tumor; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Colonic Neop | 2021 |
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil.
Topics: Aged; Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Diet; DNA Damage; Drug Resistance | 2021 |
Flavanols from Japanese quince (Chaenomeles japonica) fruit suppress expression of cyclooxygenase-2, metalloproteinase-9, and nuclear factor-kappaB in human colon cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cyclooxygenas | 2017 |
RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth.
Topics: Animals; Bone Marrow Transplantation; Colonic Neoplasms; Female; Gene Expression Regulation, Neoplas | 2017 |
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Colonic Neoplasms; CRISPR-Cas Systems; Ge | 2018 |
The association between p53 protein phosphorylation at serine 15, serine 20 and sensitivity of cells isolated from patients with ovarian cancer and cell lines to chemotherapy in in vitro study.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell | 2018 |
DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.
Topics: Apoptosis; Aurora Kinase A; Aurora Kinase B; Checkpoint Kinase 1; Checkpoint Kinase 2; Chromatin Ass | 2014 |
Serine phosphorylation of vasodilator-stimulated phosphoprotein (VASP) regulates colon cancer cell survival and apoptosis.
Topics: Acridine Orange; Actins; Apoptosis; Blotting, Western; Caspase 3; Cell Adhesion Molecules; Cell Line | 2015 |
Topoisomerase-I PS506 as a Dual Function Cancer Biomarker.
Topics: Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Carcinoma, | 2015 |
Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer.
Topics: Cell Proliferation; Colonic Neoplasms; HEK293 Cells; HT29 Cells; Humans; I-kappa B Proteins; Mutatio | 2015 |
A phosphomimetic mutant of RelA/p65 at Ser536 induces apoptosis and senescence: An implication for tumor-suppressive role of Ser536 phosphorylation.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cellular Senescence; Colonic Neoplasms; Humans; Mice; Mutation | 2016 |
Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biom | 2015 |
Ghrelin induces colon cancer cell proliferation through the GHS-R, Ras, PI3K, Akt, and mTOR signaling pathways.
Topics: Cell Proliferation; Colonic Neoplasms; Ghrelin; HT29 Cells; Humans; Mutation; Phosphatidylinositol 3 | 2016 |
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.
Topics: Aminoimidazole Carboxamide; Carbon; Cell Compartmentation; Cell Proliferation; Colonic Neoplasms; CR | 2016 |
Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.
Topics: Activating Transcription Factor 4; Animals; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell P | 2016 |
Lactate Formation in Primary and Metastatic Colon Cancer Cells at Hypoxia and Normoxia.
Topics: Aspartate Aminotransferases; Aspartic Acid; Cell Count; Cell Hypoxia; Cell Line, Tumor; Colonic Neop | 2016 |
Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Colonic Neoplasms; Dose-Response Relati | 2016 |
Novel Serine 176 Phosphorylation of YBX1 Activates NF-κB in Colon Cancer.
Topics: Amino Acid Sequence; Cell Proliferation; Colon; Colonic Neoplasms; Cytokines; Gene Expression Regula | 2017 |
Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling.
Topics: Animals; Antibodies; beta Catenin; Catalytic Domain; Cell Proliferation; Colonic Neoplasms; Female; | 2008 |
Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers.
Topics: Adenocarcinoma; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Nucleus; Colonic Neoplasms; | 2009 |
(-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046/1047 by p38 MAPK in colon cancer cells.
Topics: Anticarcinogenic Agents; Catechin; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; ErbB Recept | 2009 |
Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; D | 2010 |
Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis.
Topics: Adenocarcinoma; Amino Acid Sequence; Caco-2 Cells; Catalytic Domain; Colonic Neoplasms; Focal Adhesi | 2011 |
High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells.
Topics: Antigens, Surface; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Colon; Colon | 2011 |
Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor.
Topics: Base Sequence; Cell Cycle; Cell Membrane; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Down-Reg | 2011 |
Stimulation of MC38 tumor growth by insulin analog X10 involves the serine synthesis pathway.
Topics: Animals; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colon; Colonic Neoplasms; Gene Expression | 2012 |
High mobility group box-1 is phosphorylated by protein kinase C zeta and secreted in colon cancer cells.
Topics: Active Transport, Cell Nucleus; Colonic Neoplasms; HCT116 Cells; HMGB1 Protein; Humans; Nuclear Loca | 2012 |
C1B domain peptide of protein kinase Cγ significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferat | 2012 |
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.
Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Biosynthetic Pathways; Cell Tr | 2013 |
Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Col | 2003 |
Regulation of p53 stability and function in HCT116 colon cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Colonic Neoplasms; DNA Damage; Doxorubicin; Drug Stabilit | 2004 |
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; beta Catenin; Binding Sites; Colonic Neoplasms; Cyt | 2004 |
Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells.
Topics: Autocrine Communication; Binding Sites; Biotinylation; Blotting, Western; Cell Adhesion; Cell Cultur | 2004 |
Stability of phosphoprotein as a biological marker of tumor signaling.
Topics: Animals; Biomarkers, Tumor; Blotting, Western; Colonic Neoplasms; HT29 Cells; Humans; Immunohistoche | 2005 |
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.
Topics: Adenocarcinoma; Alanine; Alkaline Phosphatase; Amino Acid Sequence; Amino Acid Substitution; Animals | 2005 |
Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies.
Topics: Animals; Antibodies, Bispecific; Antibodies, Monoclonal; Brain; Brain Chemistry; Cell Line; Colonic | 2006 |
Novel missense mutation of the DNA topoisomerase I gene in SN-38-resistant DLD-1 cells.
Topics: Amino Acid Substitution; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Colonic | 2006 |
Role of S128R polymorphism of E-selectin in colon metastasis formation.
Topics: Arginine; Cell Adhesion; Cell Movement; Colonic Neoplasms; E-Selectin; Female; Humans; Male; Middle | 2007 |
Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
Topics: Amino Acid Sequence; Animals; Aurora Kinase A; Aurora Kinases; Benzazepines; Centrosome; Colonic Neo | 2007 |
Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Colon; Colonic Neoplasms; DNA Primers; DNA, | 1994 |
Epidermal growth factor induces serine phosphorylation of stathmin in a human colon carcinoma cell line (LIM 1215).
Topics: Amino Acid Sequence; Base Sequence; Chromatography, High Pressure Liquid; Colonic Neoplasms; Electro | 1993 |
Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.
Topics: Alanine; Casein Kinase II; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; GTP Phosphohydrolases; | 2000 |
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, | 2001 |
Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells.
Topics: Adenomatous Polyposis Coli Protein; Amino Acid Sequence; Animals; beta Catenin; beta-Transducin Repe | 2002 |
Human colon tumors: enzymic and histological characteristics.
Topics: Adenocarcinoma; Cell Differentiation; Colonic Neoplasms; Glucosephosphate Dehydrogenase; Humans; Org | 1978 |
Rapid and steady-state amino acid transport in perfused human fibroblasts and colon adenocarcinoma cells: effects of methotrexate.
Topics: Adenocarcinoma; Amino Acids; Biological Transport; Colonic Neoplasms; Fibroblasts; Humans; Methotrex | 1990 |
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Topics: Aged; Animals; Carbohydrate Dehydrogenases; Colonic Neoplasms; Glycine Hydroxymethyltransferase; Hum | 1988 |
Response of DNA thymine synthesis in human tumor and normal tissue to 5-fluorouracil.
Topics: Breast Neoplasms; Carbon Isotopes; Chromatography, Paper; Colon; Colonic Neoplasms; Depression, Chem | 1972 |