serine has been researched along with Colitis, Granulomatous in 3 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Binding to the Crohn's disease susceptibility protein, NOD2, is required for TRAF4 phosphorylation and subsequent inhibition of NOD2 signaling." | 1.38 | IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling. ( Abbott, DW; Cantley, LC; Cobb, BA; Homer, CR; Hutti, JE; Marinis, JM; McDonald, C, 2012) |
| "However, clinical trials with IL-10 in Crohn's disease were disappointing, although some patients showed healing of intestinal mucosa." | 1.32 | Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production. ( Foxwell, BM; Gangl, A; Gasche, C; Grundtner, P; Reinisch, W; Sarma, U; Shaw, SH; Williams, LM; Zdanov, A; Zwirn, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marinis, JM | 1 |
| Hutti, JE | 1 |
| Homer, CR | 1 |
| Cobb, BA | 1 |
| Cantley, LC | 1 |
| McDonald, C | 1 |
| Abbott, DW | 1 |
| Gasche, C | 1 |
| Grundtner, P | 1 |
| Zwirn, P | 1 |
| Reinisch, W | 1 |
| Shaw, SH | 1 |
| Zdanov, A | 1 |
| Sarma, U | 1 |
| Williams, LM | 1 |
| Foxwell, BM | 1 |
| Gangl, A | 1 |
| Mitoma, H | 1 |
| Horiuchi, T | 1 |
| Hatta, N | 1 |
| Tsukamoto, H | 1 |
| Harashima, S | 1 |
| Kikuchi, Y | 1 |
| Otsuka, J | 1 |
| Okamura, S | 1 |
| Fujita, S | 1 |
| Harada, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Anti-TNF Antibodies on the T-lymphocyte and Macrophage Cooperation in the Crohn Disease[NCT00561548] | 20 participants (Anticipated) | Interventional | 2007-05-31 | Terminated | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for serine and Colitis, Granulomatous
| Article | Year |
|---|---|
IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Crohn Disease; DNA Primers; D | 2012 |
Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production.
Topics: Amino Acid Substitution; Arginine; Crohn Disease; DNA, Complementary; Gene Frequency; Genetic Variat | 2003 |
Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-alpha.
Topics: Amino Acid Substitution; Anti-Inflammatory Agents; Antibodies, Monoclonal; Apoptosis; Base Sequence; | 2005 |