serine has been researched along with Cirrhosis in 15 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We hypothesized that Chikusetsusaponin IVa (CS), a major component of Saponins from Panaxjaponicus, may improve isoprenaline induced myocardial fibrosis via AMPK/mTOR/ULK1 mediated autophagy METHODS: Continuous subcutaneous injection of isoproterenol for 21 days was used to induce myocardial fibrosis in mice and high and low doses (15 mg/kg and 5 mg/kg) of CS was administered by oral gavage to observe the efficacy." | 7.91 | Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling. ( He, Y; Liu, C; Liu, X; Wang, J; Wang, L; Wang, T; Wu, X; Yuan, D; Zhang, C; Zheng, J; Zhou, Z, 2019) |
| "We hypothesized that Chikusetsusaponin IVa (CS), a major component of Saponins from Panaxjaponicus, may improve isoprenaline induced myocardial fibrosis via AMPK/mTOR/ULK1 mediated autophagy METHODS: Continuous subcutaneous injection of isoproterenol for 21 days was used to induce myocardial fibrosis in mice and high and low doses (15 mg/kg and 5 mg/kg) of CS was administered by oral gavage to observe the efficacy." | 3.91 | Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling. ( He, Y; Liu, C; Liu, X; Wang, J; Wang, L; Wang, T; Wu, X; Yuan, D; Zhang, C; Zheng, J; Zhou, Z, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 7 (46.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mendoza, FA | 1 |
| Jimenez, SA | 1 |
| Nyamsuren, G | 1 |
| Rapp, G | 1 |
| Dihazi, H | 1 |
| Zeisberg, EM | 1 |
| Tampe, D | 1 |
| Tampe, B | 1 |
| Zeisberg, M | 1 |
| Zhou, Z | 2 |
| Wang, H | 1 |
| Zhang, X | 1 |
| Song, M | 1 |
| Yao, S | 1 |
| Jiang, P | 1 |
| Liu, D | 1 |
| Wang, Z | 1 |
| Lv, H | 1 |
| Li, R | 1 |
| Hong, Y | 1 |
| Dai, J | 1 |
| Hu, Y | 1 |
| Zhao, G | 1 |
| Creeden, JF | 1 |
| Kipp, ZA | 1 |
| Xu, M | 1 |
| Flight, RM | 1 |
| Moseley, HNB | 1 |
| Martinez, GJ | 1 |
| Lee, WH | 1 |
| Alganem, K | 1 |
| Imami, AS | 1 |
| McMullen, MR | 1 |
| Roychowdhury, S | 1 |
| Nawabi, AM | 1 |
| Hipp, JA | 1 |
| Softic, S | 1 |
| Weinman, SA | 1 |
| McCullumsmith, R | 1 |
| Nagy, LE | 1 |
| Hinds, TD | 1 |
| Cai, J | 1 |
| Wang, T | 2 |
| Zhou, Y | 1 |
| Tang, C | 1 |
| Liu, Y | 1 |
| Dong, Z | 1 |
| Oliveira-Santos, A | 1 |
| Dagda, M | 1 |
| Wittmann, J | 1 |
| Smalley, R | 1 |
| Burkin, DJ | 1 |
| Chen, JX | 1 |
| Fang, QJ | 1 |
| Wan, YG | 1 |
| Liu, YL | 1 |
| Wang, Y | 1 |
| Wu, W | 1 |
| Tu, Y | 1 |
| Wang, MZ | 1 |
| Wang, DG | 1 |
| Ge, HT | 1 |
| Sai, C | 1 |
| Yunhan, J | 1 |
| Zhao, J | 1 |
| Yu, Z | 1 |
| Yun, Z | 1 |
| Zhezhe, C | 1 |
| Fuqin, T | 1 |
| Yingbin, X | 1 |
| Ruiyan, M | 1 |
| Wang, L | 1 |
| Yuan, D | 1 |
| Zheng, J | 1 |
| Wu, X | 1 |
| Wang, J | 1 |
| Liu, X | 1 |
| He, Y | 1 |
| Zhang, C | 1 |
| Liu, C | 1 |
| Gupta, MK | 1 |
| Gulick, J | 1 |
| James, J | 1 |
| Osinska, H | 1 |
| Lorenz, JN | 1 |
| Robbins, J | 1 |
| Chen, LH | 1 |
| Advani, SL | 1 |
| Thai, K | 1 |
| Kabir, MG | 1 |
| Sood, MM | 1 |
| Gibson, IW | 1 |
| Yuen, DA | 1 |
| Connelly, KA | 1 |
| Marsden, PA | 1 |
| Kelly, DJ | 1 |
| Gilbert, RE | 1 |
| Advani, A | 1 |
| Zhang, H | 1 |
| Makarewich, CA | 1 |
| Kubo, H | 1 |
| Wang, W | 1 |
| Duran, JM | 1 |
| Li, Y | 1 |
| Berretta, RM | 1 |
| Koch, WJ | 1 |
| Chen, X | 1 |
| Gao, E | 1 |
| Valdivia, HH | 1 |
| Houser, SR | 1 |
| Zouein, FA | 1 |
| Zgheib, C | 1 |
| Hamza, S | 1 |
| Fuseler, JW | 1 |
| Hall, JE | 1 |
| Soljancic, A | 1 |
| Lopez-Ruiz, A | 1 |
| Kurdi, M | 1 |
| Booz, GW | 1 |
| Zhang, L | 1 |
| Keane, MP | 1 |
| Zhu, LX | 1 |
| Sharma, S | 1 |
| Rozengurt, E | 1 |
| Strieter, RM | 1 |
| Dubinett, SM | 1 |
| Huang, M | 1 |
| Soto, A | 1 |
| DelRaso, NJ | 1 |
| Schlager, JJ | 1 |
| Chan, VT | 1 |
1 review available for serine and Cirrhosis
| Article | Year |
|---|---|
Serine/threonine kinase inhibition as antifibrotic therapy: transforming growth factor-β and Rho kinase inhibitors.
Topics: Fibrosis; Humans; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rho- | 2022 |
14 other studies available for serine and Cirrhosis
| Article | Year |
|---|---|
PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Biomarkers; Disease Mo | 2021 |
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.
Topics: Actins; Adenosine; AMP-Activated Protein Kinases; Animals; Autophagy; Cadherins; Cathepsin D; Chloro | 2022 |
Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents.
Topics: Animals; Collagen; Discoidin Domain Receptors; Fibrosis; Humans; Liver; Liver Cirrhosis; Liver Disea | 2022 |
Phosphorylation by GSK-3β increases the stability of SIRT6 to alleviate TGF-β-induced fibrotic response in renal tubular cells.
Topics: Animals; beta Catenin; Fibrosis; Glycogen Synthase Kinase 3 beta; Kidney; Mice; Phosphorylation; Ser | 2022 |
Vemurafenib improves muscle histopathology in a mouse model of LAMA2-related congenital muscular dystrophy.
Topics: Animals; Fibrosis; Laminin; Mice; Muscle, Skeletal; Muscular Dystrophies; Protein Serine-Threonine K | 2023 |
[Effects and mechanisms of total flavones of Abelmoschus manihot in inhibiting podocyte necroptosis and renal fibrosis in diabetic kidney disease].
Topics: Abelmoschus; Animals; Collagen; Diabetes Mellitus; Diabetic Nephropathies; Fibrosis; Flavones; Human | 2023 |
Cyclin Dependent Kinase 1 (CDK1) Activates Cardiac Fibroblasts via Directly Phosphorylating Paxillin at Ser244.
Topics: Atrial Fibrillation; Atrial Remodeling; Becaplermin; CDC2 Protein Kinase; Cell Adhesion; Cell Aggreg | 2019 |
Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Cardiomyopat | 2019 |
Functional dissection of myosin binding protein C phosphorylation.
Topics: Amino Acid Sequence; Animals; Cardiomyopathy, Dilated; Carrier Proteins; Codon; Echocardiography; El | 2013 |
SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzylamines; Biopsy; Capillaries; Cell Li | 2014 |
Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Calcium Channels, L-Type; Cyclic AMP-Dependent Protein Kinas | 2012 |
Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Collagen; Cytokines; Electrocardiography; Fib | 2013 |
Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis.
Topics: Blotting, Northern; Blotting, Western; Cell Line, Tumor; Collagen; Collagen Type I; Collagen Type I, | 2004 |
D-Serine exposure resulted in gene expression changes indicative of activation of fibrogenic pathways and down-regulation of energy metabolism and oxidative stress response.
Topics: Animals; Cluster Analysis; Dose-Response Relationship, Drug; Down-Regulation; Energy Metabolism; Fib | 2008 |