serine has been researched along with Chronic Disease in 21 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent evidence indicates that enhancing N-methyl-D-aspartate (NMDA) neurotransmission with the treatment of NMDA/glycine site agonists, such as D-serine, or a glycine transporter-1 (GlyT-1) antagonist, N-methylglycine (sarcosine), can improve symptoms of schizophrenia." | 9.14 | A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia. ( Chang, YC; Huang, YJ; Lane, HY; Liao, CH; Lin, CH; Tsai, GE, 2010) |
| "We propose possible therapeutic approaches for some CNS diseases and chronic pain, targeting the D-serine levels by manipulating its uptake, biosynthesis and metabolism." | 6.45 | D-serine regulation: a possible therapeutic approach for central nervous diseases and chronic pain. ( Lee, TL; Sethuraman, R; Tachibana, S, 2009) |
| "Recent evidence indicates that enhancing N-methyl-D-aspartate (NMDA) neurotransmission with the treatment of NMDA/glycine site agonists, such as D-serine, or a glycine transporter-1 (GlyT-1) antagonist, N-methylglycine (sarcosine), can improve symptoms of schizophrenia." | 5.14 | A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia. ( Chang, YC; Huang, YJ; Lane, HY; Liao, CH; Lin, CH; Tsai, GE, 2010) |
| "We propose possible therapeutic approaches for some CNS diseases and chronic pain, targeting the D-serine levels by manipulating its uptake, biosynthesis and metabolism." | 2.45 | D-serine regulation: a possible therapeutic approach for central nervous diseases and chronic pain. ( Lee, TL; Sethuraman, R; Tachibana, S, 2009) |
| "Nimodipine treatment attenuated CCH induced tau phosphorylation by up-regulating expression of miR-132." | 1.48 | Nimodipine attenuates tau phosphorylation at Ser396 via miR-132/GSK-3β pathway in chronic cerebral hypoperfusion rats. ( Chen, Y; Liu, X; Tan, Z; Xie, W; Zhu, Y, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (28.57) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, T | 1 |
| Wang, R | 1 |
| Zhang, H | 1 |
| Zhao, F | 1 |
| Tan, Z | 1 |
| Chen, Y | 1 |
| Xie, W | 1 |
| Liu, X | 1 |
| Zhu, Y | 2 |
| da Costa, MZ | 1 |
| Pires, JG | 1 |
| Nasser, PD | 1 |
| Ferreira, Cda S | 1 |
| Teixeira, AC | 1 |
| Paranaguá-Vezozzo, DC | 1 |
| Guarita, DR | 1 |
| Carrilho, FJ | 1 |
| Ono, SK | 1 |
| Rizos, EN | 1 |
| Siafakas, N | 1 |
| Katsantoni, E | 1 |
| Lazou, V | 1 |
| Sakellaropoulos, K | 1 |
| Kastania, A | 1 |
| Kossida, S | 1 |
| Chatzigeorgiou, KS | 1 |
| Arsenis, G | 1 |
| Zerva, L | 1 |
| Katsafouros, K | 1 |
| Lykouras, L | 1 |
| Miyamoto, N | 1 |
| Tanaka, R | 1 |
| Zhang, N | 1 |
| Shimura, H | 1 |
| Onodera, M | 1 |
| Mochizuki, H | 1 |
| Hattori, N | 1 |
| Urabe, T | 1 |
| Potvin, S | 1 |
| Larouche, A | 1 |
| Normand, E | 1 |
| de Souza, JB | 1 |
| Gaumond, I | 1 |
| Grignon, S | 1 |
| Marchand, S | 1 |
| Sethuraman, R | 1 |
| Lee, TL | 1 |
| Tachibana, S | 1 |
| Lane, HY | 1 |
| Lin, CH | 1 |
| Huang, YJ | 1 |
| Liao, CH | 1 |
| Chang, YC | 1 |
| Tsai, GE | 1 |
| Wojciak-Stothard, B | 1 |
| Zhao, L | 1 |
| Oliver, E | 1 |
| Dubois, O | 1 |
| Wu, Y | 1 |
| Kardassis, D | 1 |
| Vasilaki, E | 1 |
| Huang, M | 1 |
| Mitchell, JA | 1 |
| Harrington, LS | 1 |
| Louise, H | 1 |
| Prendergast, GC | 1 |
| Wilkins, MR | 1 |
| Eussen, SJ | 1 |
| Nilsen, RM | 1 |
| Midttun, Ø | 1 |
| Hustad, S | 1 |
| IJssennagger, N | 1 |
| Meyer, K | 1 |
| Fredriksen, Å | 1 |
| Ulvik, A | 1 |
| Ueland, PM | 1 |
| Brennan, P | 1 |
| Johansson, M | 1 |
| Bueno-de-Mesquita, B | 1 |
| Vineis, P | 1 |
| Chuang, SC | 1 |
| Boutron-Ruault, MC | 1 |
| Dossus, L | 1 |
| Perquier, F | 1 |
| Overvad, K | 1 |
| Teucher, B | 1 |
| Grote, VA | 1 |
| Trichopoulou, A | 1 |
| Adarakis, G | 1 |
| Plada, M | 1 |
| Sieri, S | 1 |
| Tumino, R | 1 |
| de Magistris, MS | 1 |
| Ros, MM | 1 |
| Peeters, PH | 1 |
| Redondo, ML | 1 |
| Zamora-Ros, R | 1 |
| Chirlaque, MD | 1 |
| Ardanaz, E | 1 |
| Sonestedt, E | 1 |
| Ericson, U | 1 |
| Schneede, J | 1 |
| van Guelpen, B | 1 |
| Wark, PA | 1 |
| Gallo, V | 1 |
| Norat, T | 1 |
| Riboli, E | 1 |
| Vollset, SE | 1 |
| Shi, Y | 1 |
| Baker, JE | 1 |
| Zhang, C | 1 |
| Tweddell, JS | 1 |
| Su, J | 1 |
| Pritchard, KA | 1 |
| Sun, H | 1 |
| Wang, HL | 1 |
| Wang, S | 1 |
| El-Mlili, N | 1 |
| Rodrigo, R | 1 |
| Naghizadeh, B | 1 |
| Cauli, O | 1 |
| Felipo, V | 1 |
| Kurumaji, A | 1 |
| Watanabe, A | 1 |
| Kumashiro, S | 1 |
| Semba, J | 1 |
| Toru, M | 1 |
| Hou, Y | 1 |
| McInnes, B | 1 |
| Hinek, A | 1 |
| Karpati, G | 1 |
| Mahuran, D | 1 |
| Mel'k, MV | 1 |
| Shcheglova, SA | 1 |
| Volkova, ZA | 1 |
| Gundalakh, AI | 1 |
| Hellings, JA | 1 |
| van der Veen-du Prie, J | 1 |
| Snelting-van Densen, R | 1 |
| Stute, R | 1 |
| Wolfson, M | 1 |
| Kopple, JD | 1 |
| Porembskiĭ, OB | 1 |
| Slobozhankin, AD | 1 |
| Orlova, TO | 1 |
| Smagin, VG | 1 |
| Asafov, GB | 1 |
| Ekisenina, NI | 1 |
| Ivanova, LM | 1 |
| Lumel'skiĭ, VIa | 1 |
| Mestyán, J | 1 |
| Fekete, M | 1 |
| Soltész, G | 1 |
| Járai, I | 1 |
| Gáti, I | 1 |
| Preisz, J | 1 |
| Doszpod, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NMDA Enhancers in the Treatment of Schizophrenia: Sarcosine vs. D-Serine[NCT00491569] | Phase 2 | 60 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| A Trial of the Effects of Glycine Loading on Clinical Symptoms and Logical Memory in Patients With Schizophrenia[NCT00575848] | Phase 1 | 16 participants (Anticipated) | Interventional | 2007-12-31 | Terminated (stopped due to Slow enrollment and due to personnel change there was no viable way to quantify glycine levels through imaging) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for serine and Chronic Disease
| Article | Year |
|---|---|
D-serine regulation: a possible therapeutic approach for central nervous diseases and chronic pain.
Topics: Animals; Central Nervous System Diseases; Chronic Disease; Humans; Pain; Serine; Stereoisomerism | 2009 |
1 trial available for serine and Chronic Disease
| Article | Year |
|---|---|
A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia.
Topics: Activities of Daily Living; Adult; Antipsychotic Agents; Chronic Disease; Double-Blind Method; Drug | 2010 |
19 other studies available for serine and Chronic Disease
| Article | Year |
|---|---|
Network pharmacology combined with metabolomics reveals the mechanism of Fuzi decoction against chronic heart failure in rats.
Topics: Animals; beta-Alanine; Chronic Disease; Coenzyme A; Diterpenes; Drugs, Chinese Herbal; Glycine; Glyo | 2022 |
Nimodipine attenuates tau phosphorylation at Ser396 via miR-132/GSK-3β pathway in chronic cerebral hypoperfusion rats.
Topics: Animals; Apoptosis; Brain Ischemia; Cerebral Cortex; Chronic Disease; Gene Expression Regulation, En | 2018 |
Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls.
Topics: Chronic Disease; Chymotrypsin; Genetic Predisposition to Disease; Humans; Mutation; Pancreatitis; Se | 2016 |
Association of the dopamine D3 receptor Ser9Gly and of the serotonin 2C receptor gene polymorphisms with tardive dyskinesia in Greeks with chronic schizophrenic disorder.
Topics: Amino Acid Substitution; Chronic Disease; Dyskinesias; Female; Genetic Predisposition to Disease; Gl | 2009 |
Crucial role for Ser133-phosphorylated form of cyclic AMP-responsive element binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion.
Topics: Animals; Apoptosis; Brain Ischemia; Carotid Stenosis; Cerebral Ventricles; Cerebrovascular Circulati | 2009 |
DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls.
Topics: Adult; Amino Acid Sequence; Chronic Disease; DNA Mutational Analysis; Dopamine; Female; Fibromyalgia | 2009 |
Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia.
Topics: Actomyosin; Animals; Capillary Permeability; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, | 2012 |
North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
Topics: Adult; Aged; Alcohol Drinking; Chronic Disease; Ethnicity; Europe; Female; Folic Acid; Glycine; Heal | 2013 |
Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation.
Topics: Animals; Animals, Newborn; Benzoquinones; Blotting, Western; Chronic Disease; Enzyme Activation; Enz | 2002 |
D-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro.
Topics: Animals; Chronic Disease; Environmental Exposure; Excitatory Amino Acid Antagonists; Excitatory Post | 2007 |
Chronic hyperammonemia reduces the activity of neuronal nitric oxide synthase in cerebellum by altering its localization and increasing its phosphorylation by calcium-calmodulin kinase II.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebellum; Chronic Disease; Enzyme Act | 2008 |
A postmortem study of glycine and its potential precursors in chronic schizophrenics.
Topics: Adult; Aged; Brain Chemistry; Chromatography, High Pressure Liquid; Chronic Disease; Female; Glycine | 1996 |
A Pro504 --> Ser substitution in the beta-subunit of beta-hexosaminidase A inhibits alpha-subunit hydrolysis of GM2 ganglioside, resulting in chronic Sandhoff disease.
Topics: Amino Acid Substitution; Animals; Base Sequence; beta-N-Acetylhexosaminidases; CHO Cells; Chronic Di | 1998 |
[Some indices of nitrogen metabolism in patients with viral hepatitis].
Topics: Adolescent; Adult; Alanine; Ammonia; Asparagine; Chronic Disease; Cysteine; Cystinuria; Glutamates; | 1975 |
Preliminary results of transmission experiments of non-A, non-B hepatitis by mononuclear leucocytes from a chronic patient.
Topics: Adult; Animals; Chronic Disease; gamma-Glutamyltransferase; Glyoxylates; Hepatitis C; Hepatitis, Vir | 1985 |
The effects of vitamin B-6 deficiency in chronically azotemic and sham-operated rats.
Topics: Alanine; Animals; Asparagine; Aspartate Aminotransferases; Chronic Disease; Creatinine; Erythrocytes | 1987 |
[Conservative treatment of chronic, relapsing pancreatitis].
Topics: Anesthesia, Conduction; Ascorbic Acid; Blood Protein Disorders; Chronic Disease; Humans; Hydrocortis | 1968 |
[Amino acid levels in the blood serum of patients with chronic colitis].
Topics: Adult; Alanine; Amino Acids; Ammonia; Arginine; Aspartic Acid; Betaine; Chronic Disease; Citrulline; | 1974 |
The postnatal changes in the circulating free amino acid pool in the newborn infant. 3. The plasma amino acid ratio in infants born after pregnancies complicated by toxaemia, placental infarction, impaired umbilical circulation and chronic maternal diseas
Topics: Amino Acids; Chronic Disease; Female; Glutamine; Glycine; Heart Defects, Congenital; Heart Failure; | 1971 |