serine has been researched along with Cerebral Ischemia in 36 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Excerpt | Relevance | Reference |
---|---|---|
"To investigate the neuroprotective effect of L-serine and its underlying mechanisms, focal cerebral ischemia was induced in rats by occlusion of middle cerebral artery (MCAO) with a suture, and reperfusion was given by filament withdrawal 2 hr later." | 7.76 | Neuroprotective effect of L-serine against temporary cerebral ischemia in rats. ( Chen, ZQ; Jiang, ZL; Li, X; Peng, LL; Wang, GH, 2010) |
"To observe the therapeutic time window of L-serine against focal cerebral ischemia/reperfusion injury in rats, and related mechanisms." | 7.76 | [Experimental study of therapeutic time window of L-serine against focal cerebral ischemia/reperfusion injury in rats]. ( Fan, XJ; Jiang, ZL; Shen, LH; Wang, GH; Zhang, XG, 2010) |
"Recent studies have indicated that cerebral ischemia induces rapid serine phosphorylation of synaptic RAS-GTPase activating protein (SynGAP) by calcium/Camodulin-dependent protein kinase II (CaMKII) in rat hippocampus." | 7.72 | PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus. ( Song, B; Yan, XB; Zhang, GY, 2004) |
"To investigate whether brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase (nNOS) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and the interaction between CaMKII? and nNOS in rat hippocampus." | 7.72 | Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus. ( Meng, FJ; Song, B; Yan, XB; Zhang, GY, 2004) |
"Infarct volume following middle cerebral artery occlusion is dramatically diminished in several regions of the brains of SR mutant mice despite evidence of increased NMDA receptor number and sensitivity." | 5.36 | Serine racemase deletion protects against cerebral ischemia and excitotoxicity. ( Ahmad, AS; Barrow, RK; Coyle, JT; Doré, S; Ehmsen, JT; Gazi, SK; Mustafa, AK; Sikka, G; Snyder, SH; Zeynalov, E, 2010) |
"Brain ischemia was induced by the four-vessel occlusion method on Sprague-Dawley rats." | 5.32 | Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. ( Guo, J; Meng, F; Song, B; Yan, X; Zhang, G, 2003) |
"To investigate the neuroprotective effect of L-serine and its underlying mechanisms, focal cerebral ischemia was induced in rats by occlusion of middle cerebral artery (MCAO) with a suture, and reperfusion was given by filament withdrawal 2 hr later." | 3.76 | Neuroprotective effect of L-serine against temporary cerebral ischemia in rats. ( Chen, ZQ; Jiang, ZL; Li, X; Peng, LL; Wang, GH, 2010) |
"To observe the therapeutic time window of L-serine against focal cerebral ischemia/reperfusion injury in rats, and related mechanisms." | 3.76 | [Experimental study of therapeutic time window of L-serine against focal cerebral ischemia/reperfusion injury in rats]. ( Fan, XJ; Jiang, ZL; Shen, LH; Wang, GH; Zhang, XG, 2010) |
" We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo." | 3.74 | The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. ( Atochin, DN; Ayata, C; Critchlow, JD; Dantas, AP; Huang, PL; Liu, VW; Looft-Wilson, R; Michel, T; Moskowitz, MA; Murata, T; Salomone, S; Sessa, WC; Shin, HK; Wang, A, 2007) |
" This study compared the neuroprotective efficacies of muscimol, a GABA A receptor agonist, and a GABA B receptor agonist baclofen in rat brain ischemia." | 3.74 | Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade. ( Li, C; Xu, J; Yin, XH; Zhang, GY, 2008) |
"Recent studies have indicated that cerebral ischemia induces rapid serine phosphorylation of synaptic RAS-GTPase activating protein (SynGAP) by calcium/Camodulin-dependent protein kinase II (CaMKII) in rat hippocampus." | 3.72 | PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus. ( Song, B; Yan, XB; Zhang, GY, 2004) |
"To investigate whether brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase (nNOS) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and the interaction between CaMKII? and nNOS in rat hippocampus." | 3.72 | Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus. ( Meng, FJ; Song, B; Yan, XB; Zhang, GY, 2004) |
"Nimodipine treatment attenuated CCH induced tau phosphorylation by up-regulating expression of miR-132." | 1.48 | Nimodipine attenuates tau phosphorylation at Ser396 via miR-132/GSK-3β pathway in chronic cerebral hypoperfusion rats. ( Chen, Y; Liu, X; Tan, Z; Xie, W; Zhu, Y, 2018) |
"Infarct volume following middle cerebral artery occlusion is dramatically diminished in several regions of the brains of SR mutant mice despite evidence of increased NMDA receptor number and sensitivity." | 1.36 | Serine racemase deletion protects against cerebral ischemia and excitotoxicity. ( Ahmad, AS; Barrow, RK; Coyle, JT; Doré, S; Ehmsen, JT; Gazi, SK; Mustafa, AK; Sikka, G; Snyder, SH; Zeynalov, E, 2010) |
"Brain ischemia was induced by the four-vessel occlusion method on Sprague-Dawley rats." | 1.32 | Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. ( Guo, J; Meng, F; Song, B; Yan, X; Zhang, G, 2003) |
"Pentobarbital pretreatment may be used to predict biochemical events involved in ischemic brain damage following bilateral carotid artery ligations in the gerbil, since it reduces the subsequent edema and mortality." | 1.28 | Arachidonic acid metabolism in gerbil cerebra: effects of ischemia and pentobarbital. ( Dorman, RV; Hamm, TF, 1990) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (5.56) | 18.2507 |
2000's | 19 (52.78) | 29.6817 |
2010's | 14 (38.89) | 24.3611 |
2020's | 1 (2.78) | 2.80 |
Authors | Studies |
---|---|
Cramer, T | 1 |
Gill, R | 1 |
Thirouin, ZS | 1 |
Vaas, M | 1 |
Sampath, S | 1 |
Martineau, F | 1 |
Noya, SB | 1 |
Panzanelli, P | 1 |
Sudharshan, TJJ | 1 |
Colameo, D | 1 |
Chang, PK | 1 |
Wu, PY | 1 |
Shi, R | 1 |
Barker, PA | 1 |
Brown, SA | 1 |
Paolicelli, RC | 1 |
Klohs, J | 1 |
McKinney, RA | 1 |
Tyagarajan, SK | 1 |
McQueen, J | 1 |
Ryan, TJ | 1 |
McKay, S | 1 |
Marwick, K | 1 |
Baxter, P | 1 |
Carpanini, SM | 1 |
Wishart, TM | 1 |
Gillingwater, TH | 1 |
Manson, JC | 1 |
Wyllie, DJA | 1 |
Grant, SGN | 1 |
McColl, BW | 1 |
Komiyama, NH | 1 |
Hardingham, GE | 1 |
Tan, Z | 1 |
Chen, Y | 1 |
Xie, W | 1 |
Liu, X | 1 |
Zhu, Y | 2 |
Lie, ME | 1 |
Gowing, EK | 1 |
Johansen, NB | 1 |
Dalby, NO | 1 |
Thiesen, L | 1 |
Wellendorph, P | 1 |
Clarkson, AN | 1 |
Zhan, L | 1 |
Lu, Z | 1 |
Zhu, X | 1 |
Xu, W | 1 |
Li, L | 1 |
Li, X | 2 |
Chen, S | 1 |
Sun, W | 1 |
Xu, E | 1 |
Kozoriz, MG | 1 |
Lai, S | 1 |
Vega, JL | 1 |
Sáez, JC | 1 |
Sin, WC | 1 |
Bechberger, JF | 1 |
Naus, CC | 1 |
Osuka, K | 1 |
Watanabe, Y | 1 |
Usuda, N | 1 |
Atsuzawa, K | 1 |
Takayasu, M | 1 |
Dhami, KS | 1 |
Churchward, MA | 1 |
Baker, GB | 1 |
Todd, KG | 1 |
Abe, T | 1 |
Suzuki, M | 1 |
Sasabe, J | 1 |
Takahashi, S | 1 |
Unekawa, M | 1 |
Mashima, K | 1 |
Iizumi, T | 1 |
Hamase, K | 1 |
Konno, R | 1 |
Aiso, S | 1 |
Suzuki, N | 1 |
Sung, JH | 1 |
Koh, PO | 1 |
Oja, SS | 1 |
Saransaari, P | 1 |
Miyamoto, N | 1 |
Tanaka, R | 1 |
Zhang, N | 1 |
Shimura, H | 1 |
Onodera, M | 1 |
Mochizuki, H | 1 |
Hattori, N | 1 |
Urabe, T | 1 |
Stanton, PK | 1 |
Potter, PE | 1 |
Aguilar, J | 1 |
Decandia, M | 1 |
Moskal, JR | 1 |
Yao, LY | 1 |
Lin, Q | 1 |
Niu, YY | 1 |
Deng, KM | 1 |
Zhang, JH | 1 |
Lu, Y | 2 |
Mustafa, AK | 1 |
Ahmad, AS | 1 |
Zeynalov, E | 1 |
Gazi, SK | 1 |
Sikka, G | 1 |
Ehmsen, JT | 1 |
Barrow, RK | 1 |
Coyle, JT | 1 |
Snyder, SH | 1 |
Doré, S | 1 |
Wang, GH | 2 |
Jiang, ZL | 2 |
Chen, ZQ | 1 |
Peng, LL | 1 |
Wang, WW | 1 |
Hu, SQ | 1 |
Li, C | 2 |
Zhou, C | 1 |
Qi, SH | 1 |
Zhang, GY | 5 |
Zhang, XG | 1 |
Shen, LH | 1 |
Fan, XJ | 1 |
Stetler, RA | 1 |
Gao, Y | 1 |
Zhang, L | 1 |
Weng, Z | 1 |
Zhang, F | 1 |
Hu, X | 1 |
Wang, S | 1 |
Vosler, P | 1 |
Cao, G | 1 |
Sun, D | 1 |
Graham, SH | 1 |
Chen, J | 1 |
Song, B | 4 |
Meng, F | 1 |
Yan, X | 1 |
Guo, J | 1 |
Zhang, G | 1 |
Wang, J | 1 |
Liu, S | 1 |
Fu, Y | 1 |
Wang, JH | 1 |
Uchihara, T | 1 |
Nakamura, A | 1 |
Arai, T | 1 |
Ikeda, K | 1 |
Tsuchiya, K | 1 |
Yan, XB | 3 |
Buratta, S | 1 |
Mambrini, R | 1 |
Miniaci, MC | 1 |
Tempia, F | 1 |
Mozzi, R | 1 |
Meng, FJ | 1 |
Morioka, M | 2 |
Kawano, T | 2 |
Yano, S | 2 |
Kai, Y | 2 |
Tsuiki, H | 1 |
Yoshinaga, Y | 1 |
Matsumoto, J | 1 |
Maeda, T | 1 |
Hamada, J | 1 |
Yamamoto, H | 1 |
Fukunaga, K | 4 |
Kuratsu, J | 1 |
Sasaki, T | 1 |
Han, F | 2 |
Shioda, N | 2 |
Moriguchi, S | 2 |
Kasahara, J | 1 |
Ishiguro, K | 1 |
Atochin, DN | 1 |
Wang, A | 1 |
Liu, VW | 1 |
Critchlow, JD | 1 |
Dantas, AP | 1 |
Looft-Wilson, R | 1 |
Murata, T | 1 |
Salomone, S | 1 |
Shin, HK | 1 |
Ayata, C | 1 |
Moskowitz, MA | 2 |
Michel, T | 1 |
Sessa, WC | 1 |
Huang, PL | 2 |
Xu, J | 1 |
Yin, XH | 1 |
Shimizu-Sasamata, M | 1 |
Bosque-Hamilton, P | 1 |
Lo, EH | 1 |
Li, PA | 1 |
Shuaib, A | 1 |
Miyashita, H | 1 |
He, QP | 1 |
Siesjö, BK | 1 |
Warner, DS | 1 |
Hara, T | 1 |
Hamada , J | 1 |
Miyamoto, E | 1 |
Ushio, Y | 1 |
Friguls, B | 1 |
Justicia, C | 1 |
Pallàs, M | 1 |
Planas, AM | 1 |
Hamm, TF | 1 |
Dorman, RV | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
FLOW Trial: Fluoxetine to Open the Critical Period Time Window to Improve Motor Recovery After Stroke[NCT03448159] | Phase 2 | 52 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
36 other studies available for serine and Cerebral Ischemia
Article | Year |
---|---|
Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Infarction; Mice; Microglia; Receptor, t | 2022 |
Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.
Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Cerebral Cortex; Death-Associated Protein Kina | 2017 |
Nimodipine attenuates tau phosphorylation at Ser396 via miR-132/GSK-3β pathway in chronic cerebral hypoperfusion rats.
Topics: Animals; Apoptosis; Brain Ischemia; Cerebral Cortex; Chronic Disease; Gene Expression Regulation, En | 2018 |
GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; | 2019 |
Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats.
Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Ki | 2019 |
Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia.
Topics: Animals; Astrocytes; Brain Infarction; Brain Ischemia; Cell Death; Cells, Cultured; Connexin 43; Cra | 2013 |
Phosphorylation of neuronal nitric oxide synthase at Ser1412 in the dentate gyrus of rat brain after transient forebrain ischemia.
Topics: Animals; Blotting, Western; Brain Ischemia; Cyclic AMP-Dependent Protein Kinases; Dentate Gyrus; Nit | 2013 |
Fluoxetine and citalopram decrease microglial release of glutamate and D-serine to promote cortical neuronal viability following ischemic insult.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Citalopram; | 2013 |
Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Ischemia; Disease Models, Animal; Female; Humans; Infar | 2014 |
Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.
Topics: Animals; Apoptosis Regulatory Proteins; Brain Ischemia; Diabetes Mellitus, Experimental; Diabetic Ne | 2017 |
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid; | 2009 |
Crucial role for Ser133-phosphorylated form of cyclic AMP-responsive element binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion.
Topics: Animals; Apoptosis; Brain Ischemia; Carotid Stenosis; Cerebral Ventricles; Cerebrovascular Circulati | 2009 |
Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13.
Topics: Animals; Brain Ischemia; Carotid Artery Diseases; Cell Death; Cell Hypoxia; Female; Gerbillinae; Glu | 2009 |
Synthesis of Lipoamino acids and their activity against cerebral ischemic injury.
Topics: Anaerobiosis; Animals; Brain; Brain Ischemia; Hydrogen Peroxide; Neuroprotective Agents; Rats; Serin | 2009 |
Serine racemase deletion protects against cerebral ischemia and excitotoxicity.
Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Cells, Cultured; Cytoprotection; Disease Models, A | 2010 |
Neuroprotective effect of L-serine against temporary cerebral ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, Drug; Glu | 2010 |
Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia.
Topics: Amino Acid Sequence; Animals; Brain Ischemia; Catalytic Domain; Cytoprotection; Disks Large Homolog | 2010 |
[Experimental study of therapeutic time window of L-serine against focal cerebral ischemia/reperfusion injury in rats].
Topics: Animals; Brain Ischemia; Interleukin-6; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats, | 2010 |
Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cognition Disorders; Disease Models, Anim | 2012 |
Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent | 2003 |
Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors.
Topics: Amino Acid Sequence; Animals; Brain Ischemia; Cell Death; Cyclin-Dependent Kinase 5; Cyclin-Dependen | 2003 |
Microglial tau undergoes phosphorylation-independent modification after ischemia.
Topics: Aged; Aged, 80 and over; Antibodies; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Epitopes; | 2004 |
Postsynaptic density protein 95 mediates Ca2+/calmodulin-dependent protein kinase II-activated serine phosphorylation of neuronal nitric oxide synthase during brain ischemia in rat hippocampus.
Topics: Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Depe | 2004 |
PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus.
Topics: Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Depe | 2004 |
Group I metabotropic glutamate receptors mediate the inhibition of phosphatidylserine synthesis in rat cerebellar slices: a possible role in physiology and pathology.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Cerebellum; Electric Stimulation; Excitatory Amino Acid Agoni | 2004 |
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent | 2004 |
Hyperphosphorylation at serine 199/202 of tau factor in the gerbil hippocampus after transient forebrain ischemia.
Topics: Animals; Apoptosis; Binding Sites; Brain Ischemia; Gerbillinae; Hippocampus; Male; Phosphorylation; | 2006 |
Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
Topics: Animals; Antimanic Agents; Brain Infarction; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Ki | 2006 |
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo.
Topics: Alanine; Animals; Aspartic Acid; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; Gene Exp | 2007 |
Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia.
Topics: Analysis of Variance; Animals; Brain Ischemia; Calcineurin; Cell Death; Electrophoretic Mobility Shi | 2007 |
Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade.
Topics: Analysis of Variance; Animals; Baclofen; Brain Ischemia; Disease Models, Animal; Dose-Response Relat | 2008 |
Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene.
Topics: Alanine; Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cortical | 1998 |
Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Glutamic Acid; Glutamine; Glycine; Hyperglycemia; Male; Prosenceph | 2000 |
Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus.
Topics: Androstadienes; Animals; Apoptosis; Brain Ischemia; Enzyme Activation; Enzyme Inhibitors; Gerbillina | 2001 |
Focal cerebral ischemia causes two temporal waves of Akt activation.
Topics: Amino Acid Sequence; Animals; Apoptosis; bcl-Associated Death Protein; Brain Ischemia; Carrier Prote | 2001 |
Arachidonic acid metabolism in gerbil cerebra: effects of ischemia and pentobarbital.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Ischemia; Cerebral Cortex; Choline; Ethanolamine | 1990 |