serine has been researched along with Cell Transformation, Neoplastic in 131 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1." | 7.74 | Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis. ( Fan, ST; Kwong, YL; Lee, TK; Pang, R; Poon, RT; Tse, E; Wong, KB, 2007) |
| " Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1." | 3.74 | Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis. ( Fan, ST; Kwong, YL; Lee, TK; Pang, R; Poon, RT; Tse, E; Wong, KB, 2007) |
| "The presence of AnxA2 in cancer cell-derived exosomes, as well as the potential regulation of exosomal AnxA2 by phosphorylation or other PTMs, are topics of great interest." | 2.55 | Protein phosphorylation and its role in the regulation of Annexin A2 function. ( Grindheim, AK; Saraste, J; Vedeler, A, 2017) |
| "Reduced growth of tumors composed of cells expressing the nonphosphorylatable KRAS S181A mutant was correlated with increased apoptosis." | 1.40 | Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth. ( Agell, N; Alvarez-Moya, B; Barceló, C; Bota-Rabassedas, N; Capella, G; Jaumot, M; Morell, M; Paco, N; Vilardell, F, 2014) |
| "TICs from primary NSCLC tumors express high levels of the oncogenic stem cell factor LIN28B and GLDC, which are both required for TIC growth and tumorigenesis." | 1.38 | Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. ( Ahmed, DA; Ang, HS; Bhakoo, KK; Jayapal, SR; Kaldis, P; Lim, B; Lim, EH; Ma, S; Mitchell, W; Nga, ME; Nichane, M; Noghabi, MS; Pang, YH; Rai, A; Robson, P; Shyh-Chang, N; Sing, WP; Soh, BS; Soo, RA; Sun, LL; Swarup, S; Tai, BC; Tam, J; Tan, C; Thirugananam, A; Umashankar, S; Yang, H; Yu, Q; Zhang, WC, 2012) |
| "Pituitary tumors are common intracranial neoplasms, yet few germline abnormalities have been implicated in their pathogenesis." | 1.37 | The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis. ( Asa, SL; Ezzat, S; Mayr, T; Tateno, T; Ullrich, A; Zheng, L, 2011) |
| "Here, we report that MEN2A-RET activates Signal Transducer and Activator of Transcription 3 (STAT3) via two YxxV/Q STAT3 docking sites, Tyr752 and Tyr928." | 1.31 | MEN2A-RET-induced cellular transformation by activation of STAT3. ( Buys, CH; Hagens, W; Hofstra, R; Kruijer, W; Schuringa, JJ; Vellenga, E; Wojtachnio, K, 2001) |
| "SW480 colon cancer cells that express a truncated APC, at position 1338, contain high levels of pbeta-catenin, whereas HT29 cells, expressing APC truncated at position 1555, accumulate non-phosphorylated beta-catenin, suggesting that the 1338-1555 amino acid region of APC is involved in the differential regulation of the dephosphorylation and degradation of pbeta-catenin." | 1.31 | Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells. ( Ben-Ze'ev, A; Conacci-Sorrell, M; Geiger, B; Kam, Z; Lando, Z; Sadot, E; Shnizer, D; Zharhary, D; Zhurinsky, J, 2002) |
| "The diamide effect was reversible with excess of DTT, whereas DTT could not restore the DNA binding of AML1 treated with N-ethylmaleimide." | 1.29 | A conserved cysteine residue in the runt homology domain of AML1 is required for the DNA binding ability and the transforming activity on fibroblasts. ( Hirai, H; Hirano, N; Kurokawa, M; Mitani, K; Ogawa, S; Tanaka, K; Tanaka, T; Yazaki, Y, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (9.92) | 18.7374 |
| 1990's | 27 (20.61) | 18.2507 |
| 2000's | 46 (35.11) | 29.6817 |
| 2010's | 36 (27.48) | 24.3611 |
| 2020's | 9 (6.87) | 2.80 |
| Authors | Studies |
|---|---|
| Simonsson, O | 1 |
| Bazin, O | 1 |
| Fisher, SD | 1 |
| Goldberg, SB | 1 |
| Clark, RA | 1 |
| Qiao, J | 1 |
| Jacobson, JC | 1 |
| Chung, DH | 1 |
| Li, H | 1 |
| Xing, J | 1 |
| Tang, X | 1 |
| Sheng, X | 1 |
| Chi, H | 1 |
| Zhan, W | 1 |
| Szarkowska, J | 1 |
| Cwiek, P | 1 |
| Szymanski, M | 1 |
| Rusetska, N | 1 |
| Jancewicz, I | 1 |
| Stachowiak, M | 1 |
| Swiatek, M | 1 |
| Luba, M | 1 |
| Konopinski, R | 1 |
| Kubala, S | 1 |
| Zub, R | 1 |
| Kucharz, J | 1 |
| Wiechno, P | 1 |
| Siedlecki, JA | 1 |
| Markowicz, S | 1 |
| Sarnowska, E | 1 |
| Sarnowski, TJ | 1 |
| Sun, H | 1 |
| Zheng, J | 1 |
| Xiao, J | 1 |
| Yue, J | 1 |
| Shi, Z | 2 |
| Xuan, Z | 1 |
| Chen, C | 2 |
| Zhao, Y | 1 |
| Tang, W | 1 |
| Ye, S | 1 |
| Li, J | 2 |
| Deng, Q | 1 |
| Zhang, L | 2 |
| Zhu, F | 5 |
| Shao, C | 1 |
| Duggan, WP | 1 |
| O'Connell, E | 1 |
| Prehn, JHM | 1 |
| Burke, JP | 1 |
| Huo, FC | 1 |
| Xie, M | 1 |
| Zhu, ZM | 1 |
| Zheng, JN | 1 |
| Pei, DS | 1 |
| Gonzalez Quesada, Y | 1 |
| Bonnet-Magnaval, F | 1 |
| DesGroseillers, L | 1 |
| Baksh, SC | 1 |
| Todorova, PK | 1 |
| Gur-Cohen, S | 1 |
| Hurwitz, B | 1 |
| Ge, Y | 1 |
| Novak, JSS | 1 |
| Tierney, MT | 1 |
| Dela Cruz-Racelis, J | 1 |
| Fuchs, E | 1 |
| Finley, LWS | 1 |
| Haensel, D | 1 |
| Oro, AE | 1 |
| Seton-Rogers, S | 1 |
| Broadfield, LA | 1 |
| Duarte, JAG | 1 |
| Schmieder, R | 1 |
| Broekaert, D | 1 |
| Veys, K | 1 |
| Planque, M | 1 |
| Vriens, K | 1 |
| Karasawa, Y | 1 |
| Napolitano, F | 1 |
| Fujita, S | 1 |
| Fujii, M | 1 |
| Eto, M | 1 |
| Holvoet, B | 1 |
| Vangoitsenhoven, R | 1 |
| Fernandez-Garcia, J | 1 |
| Van Elsen, J | 1 |
| Dehairs, J | 1 |
| Zeng, J | 1 |
| Dooley, J | 1 |
| Rubio, RA | 1 |
| van Pelt, J | 1 |
| Grünewald, TGP | 1 |
| Liston, A | 1 |
| Mathieu, C | 1 |
| Deroose, CM | 1 |
| Swinnen, JV | 1 |
| Lambrechts, D | 1 |
| di Bernardo, D | 1 |
| Kuroda, S | 1 |
| De Bock, K | 1 |
| Fendt, SM | 1 |
| Grindheim, AK | 1 |
| Saraste, J | 1 |
| Vedeler, A | 1 |
| Peng, C | 3 |
| Zhu, Y | 1 |
| Zhang, W | 1 |
| Liao, Q | 1 |
| Chen, Y | 1 |
| Zhao, X | 1 |
| Guo, Q | 1 |
| Shen, P | 1 |
| Zhen, B | 1 |
| Qian, X | 1 |
| Yang, D | 1 |
| Zhang, JS | 1 |
| Xiao, D | 1 |
| Qin, W | 1 |
| Pei, H | 1 |
| Jusu, S | 1 |
| Presley, JF | 1 |
| Williams, C | 1 |
| Das, SK | 1 |
| Jean-Claude, B | 1 |
| Kremer, R | 2 |
| Jensen, HH | 1 |
| Holst, MR | 1 |
| Login, FH | 1 |
| Morgen, JJ | 1 |
| Nejsum, LN | 1 |
| Zhong, Q | 1 |
| Shi, G | 1 |
| Zhang, Q | 2 |
| Zhang, Y | 3 |
| Levy, D | 1 |
| Zhong, S | 2 |
| Slee, EA | 1 |
| Lu, X | 2 |
| Sun, J | 1 |
| Mohlin, S | 1 |
| Lundby, A | 1 |
| Kazi, JU | 1 |
| Hellman, U | 1 |
| Påhlman, S | 1 |
| Olsen, JV | 1 |
| Rönnstrand, L | 1 |
| Barceló, C | 1 |
| Paco, N | 1 |
| Morell, M | 1 |
| Alvarez-Moya, B | 1 |
| Bota-Rabassedas, N | 1 |
| Jaumot, M | 1 |
| Vilardell, F | 1 |
| Capella, G | 1 |
| Agell, N | 1 |
| Mandal, T | 1 |
| Bhowmik, A | 1 |
| Chatterjee, A | 2 |
| Chatterjee, U | 1 |
| Chatterjee, S | 1 |
| Ghosh, MK | 1 |
| Iyengar, AS | 1 |
| Miller, PJ | 1 |
| Loupe, JM | 1 |
| Hollenbach, AD | 1 |
| Li, Z | 2 |
| Park, HR | 1 |
| Pham, CD | 1 |
| Du, Y | 1 |
| Khuri, FR | 1 |
| Han, Q | 1 |
| Fu, H | 1 |
| Tecleab, A | 1 |
| Zhang, X | 1 |
| Sebti, SM | 1 |
| Zhu, J | 2 |
| Zhang, J | 2 |
| Huang, H | 2 |
| Yu, Y | 1 |
| Jin, H | 1 |
| Li, Y | 2 |
| Deng, X | 1 |
| Gao, J | 1 |
| Zhao, Q | 1 |
| Huang, C | 1 |
| Serasinghe, MN | 1 |
| Wieder, SY | 1 |
| Renault, TT | 1 |
| Elkholi, R | 1 |
| Asciolla, JJ | 1 |
| Yao, JL | 1 |
| Jabado, O | 1 |
| Hoehn, K | 1 |
| Kageyama, Y | 1 |
| Sesaki, H | 1 |
| Chipuk, JE | 1 |
| Wang, G | 1 |
| Song, Y | 1 |
| Liu, T | 1 |
| Wang, C | 1 |
| Liu, F | 1 |
| Cai, X | 1 |
| Miao, Z | 1 |
| Xu, H | 2 |
| Cao, L | 2 |
| Li, F | 1 |
| Huang, L | 1 |
| Counter, CM | 2 |
| Kourtidis, A | 1 |
| Yanagisawa, M | 1 |
| Huveldt, D | 1 |
| Copland, JA | 1 |
| Anastasiadis, PZ | 1 |
| García-Bermúdez, J | 1 |
| Cuezva, JM | 1 |
| Velásquez, C | 1 |
| Cheng, E | 1 |
| Shuda, M | 1 |
| Lee-Oesterreich, PJ | 1 |
| Pogge von Strandmann, L | 1 |
| Gritsenko, MA | 1 |
| Jacobs, JM | 1 |
| Moore, PS | 1 |
| Chang, Y | 1 |
| Kottakis, F | 1 |
| Nicolay, BN | 1 |
| Roumane, A | 1 |
| Karnik, R | 1 |
| Gu, H | 1 |
| Nagle, JM | 1 |
| Boukhali, M | 1 |
| Hayward, MC | 1 |
| Li, YY | 1 |
| Chen, T | 1 |
| Liesa, M | 1 |
| Hammerman, PS | 1 |
| Wong, KK | 1 |
| Hayes, DN | 1 |
| Shirihai, OS | 1 |
| Dyson, NJ | 1 |
| Haas, W | 1 |
| Meissner, A | 1 |
| Bardeesy, N | 1 |
| Barbash, O | 1 |
| Zamfirova, P | 1 |
| Lin, DI | 1 |
| Chen, X | 1 |
| Yang, K | 1 |
| Nakagawa, H | 1 |
| Lu, F | 1 |
| Rustgi, AK | 1 |
| Diehl, JA | 1 |
| Qin, HR | 1 |
| Kim, HJ | 1 |
| Kim, JY | 1 |
| Hurt, EM | 1 |
| Klarmann, GJ | 1 |
| Kawasaki, BT | 1 |
| Duhagon Serrat, MA | 1 |
| Farrar, WL | 2 |
| van Gorp, AG | 1 |
| van der Vos, KE | 1 |
| Brenkman, AB | 1 |
| Bremer, A | 1 |
| van den Broek, N | 1 |
| Zwartkruis, F | 1 |
| Hershey, JW | 2 |
| Burgering, BM | 1 |
| Calkhoven, CF | 1 |
| Coffer, PJ | 1 |
| Nasr, R | 1 |
| Guillemin, MC | 1 |
| Ferhi, O | 1 |
| Soilihi, H | 1 |
| Peres, L | 1 |
| Berthier, C | 1 |
| Rousselot, P | 1 |
| Robledo-Sarmiento, M | 1 |
| Lallemand-Breitenbach, V | 1 |
| Gourmel, B | 1 |
| Vitoux, D | 1 |
| Pandolfi, PP | 1 |
| Rochette-Egly, C | 1 |
| de Thé, H | 1 |
| Cho, YY | 7 |
| Tang, F | 1 |
| Yao, K | 4 |
| Lu, C | 1 |
| Zheng, D | 4 |
| Pugliese, A | 1 |
| Bode, AM | 7 |
| Dong, Z | 8 |
| Yeh, HH | 1 |
| Giri, R | 1 |
| Chang, TY | 1 |
| Chou, CY | 1 |
| Su, WC | 1 |
| Liu, HS | 1 |
| Hutti, JE | 1 |
| Shen, RR | 1 |
| Abbott, DW | 1 |
| Zhou, AY | 1 |
| Sprott, KM | 1 |
| Asara, JM | 1 |
| Hahn, WC | 2 |
| Cantley, LC | 2 |
| Tange, S | 1 |
| Ito, S | 1 |
| Senga, T | 1 |
| Hamaguchi, M | 1 |
| Reich, NC | 1 |
| Hydbring, P | 1 |
| Bahram, F | 1 |
| Su, Y | 1 |
| Tronnersjö, S | 1 |
| Högstrand, K | 1 |
| von der Lehr, N | 1 |
| Sharifi, HR | 1 |
| Lilischkis, R | 1 |
| Hein, N | 1 |
| Wu, S | 1 |
| Vervoorts, J | 1 |
| Henriksson, M | 1 |
| Grandien, A | 1 |
| Lüscher, B | 1 |
| Larsson, LG | 1 |
| Sluss, HK | 1 |
| Gannon, H | 1 |
| Coles, AH | 1 |
| Shen, Q | 1 |
| Eischen, CM | 1 |
| Jones, SN | 1 |
| Xu, YM | 2 |
| Carper, A | 1 |
| Lau, AT | 3 |
| Zykova, TA | 2 |
| Kim, HG | 2 |
| Friedbichler, K | 2 |
| Kerenyi, MA | 1 |
| Kovacic, B | 1 |
| Li, G | 2 |
| Hoelbl, A | 2 |
| Yahiaoui, S | 1 |
| Sexl, V | 2 |
| Müllner, EW | 1 |
| Fajmann, S | 1 |
| Cerny-Reiterer, S | 1 |
| Valent, P | 1 |
| Beug, H | 1 |
| Gouilleux, F | 2 |
| Bunting, KD | 2 |
| Moriggl, R | 2 |
| Ma, WY | 2 |
| Lee, TH | 2 |
| Chen, CH | 1 |
| Suizu, F | 1 |
| Huang, P | 1 |
| Schiene-Fischer, C | 1 |
| Daum, S | 1 |
| Zhang, YJ | 1 |
| Goate, A | 1 |
| Chen, RH | 1 |
| Zhou, XZ | 1 |
| Lu, KP | 2 |
| Lee, SY | 1 |
| Li, SQ | 1 |
| Zhang, Z | 1 |
| Locasale, JW | 1 |
| Pringle, LM | 1 |
| Young, R | 1 |
| Quick, L | 1 |
| Riquelme, DN | 1 |
| Oliveira, AM | 1 |
| May, MJ | 1 |
| Chou, MM | 1 |
| Tateno, T | 1 |
| Asa, SL | 1 |
| Zheng, L | 1 |
| Mayr, T | 1 |
| Ullrich, A | 1 |
| Ezzat, S | 1 |
| Zhang, WC | 1 |
| Shyh-Chang, N | 1 |
| Yang, H | 1 |
| Rai, A | 1 |
| Umashankar, S | 1 |
| Ma, S | 1 |
| Soh, BS | 1 |
| Sun, LL | 1 |
| Tai, BC | 1 |
| Nga, ME | 1 |
| Bhakoo, KK | 1 |
| Jayapal, SR | 1 |
| Nichane, M | 1 |
| Yu, Q | 1 |
| Ahmed, DA | 1 |
| Tan, C | 1 |
| Sing, WP | 1 |
| Tam, J | 1 |
| Thirugananam, A | 1 |
| Noghabi, MS | 1 |
| Pang, YH | 1 |
| Ang, HS | 1 |
| Mitchell, W | 1 |
| Robson, P | 1 |
| Kaldis, P | 2 |
| Soo, RA | 1 |
| Swarup, S | 1 |
| Lim, EH | 1 |
| Lim, B | 1 |
| Rangasamy, V | 1 |
| Mishra, R | 1 |
| Sondarva, G | 1 |
| Das, S | 1 |
| Bakowska, JC | 1 |
| Tzivion, G | 1 |
| Malter, JS | 1 |
| Rana, B | 1 |
| Kanthasamy, A | 1 |
| Rana, A | 1 |
| Miyakoshi, M | 1 |
| Yamamoto, M | 1 |
| Tanaka, H | 1 |
| Ogawa, K | 1 |
| Yang, W | 2 |
| Xia, Y | 1 |
| Cao, Y | 1 |
| Zheng, Y | 1 |
| Bu, W | 1 |
| You, MJ | 1 |
| Koh, MY | 1 |
| Cote, G | 1 |
| Aldape, K | 1 |
| Verma, IM | 1 |
| Chiao, PJ | 1 |
| Lu, Z | 1 |
| Ma, L | 1 |
| Tao, Y | 1 |
| Duran, A | 1 |
| Llado, V | 1 |
| Galvez, A | 1 |
| Barger, JF | 1 |
| Castilla, EA | 1 |
| Chen, J | 2 |
| Yajima, T | 1 |
| Porollo, A | 1 |
| Medvedovic, M | 1 |
| Brill, LM | 1 |
| Plas, DR | 1 |
| Riedl, SJ | 1 |
| Leitges, M | 1 |
| Diaz-Meco, MT | 1 |
| Richardson, AD | 1 |
| Moscat, J | 1 |
| Simone, F | 1 |
| Luo, RT | 1 |
| Polak, PE | 1 |
| Kaberlein, JJ | 1 |
| Thirman, MJ | 1 |
| Lai, R | 1 |
| Rassidakis, GZ | 1 |
| Medeiros, LJ | 1 |
| Leventaki, V | 1 |
| Keating, M | 1 |
| McDonnell, TJ | 1 |
| Leis, H | 1 |
| Segrelles, C | 1 |
| Ruiz, S | 1 |
| Santos, M | 1 |
| Paramio, JM | 1 |
| Nishizawa, M | 1 |
| Kataoka, K | 1 |
| Vogt, PK | 1 |
| Yeh, E | 1 |
| Cunningham, M | 1 |
| Arnold, H | 1 |
| Chasse, D | 1 |
| Monteith, T | 1 |
| Ivaldi, G | 1 |
| Stukenberg, PT | 1 |
| Shenolikar, S | 1 |
| Uchida, T | 1 |
| Nevins, JR | 1 |
| Means, AR | 1 |
| Sears, R | 1 |
| Vadlamudi, RK | 1 |
| Bagheri-Yarmand, R | 1 |
| Yang, Z | 1 |
| Balasenthil, S | 1 |
| Nguyen, D | 1 |
| Sahin, AA | 2 |
| den Hollander, P | 1 |
| Kumar, R | 1 |
| Yap, DB | 1 |
| Hsieh, JK | 1 |
| Heath, V | 1 |
| Gusterson, B | 1 |
| Crook, T | 1 |
| Qu, Z | 1 |
| Qing, G | 1 |
| Rabson, A | 1 |
| Xiao, G | 1 |
| Shuman, JD | 1 |
| Sebastian, T | 1 |
| Copeland, TD | 1 |
| Zhu, S | 1 |
| Smart, RC | 1 |
| Johnson, PF | 1 |
| Nasertorabi, F | 2 |
| Garcia-Guzman, M | 1 |
| Briknarová, K | 2 |
| Larsen, E | 1 |
| Havert, ML | 2 |
| Vuori, K | 2 |
| Ely, KR | 2 |
| Kim, SS | 1 |
| Li, C | 2 |
| Xu, X | 1 |
| Huber, LJ | 1 |
| Chodosh, LA | 1 |
| Deng, CX | 1 |
| Dunn, KL | 1 |
| Davie, JR | 2 |
| Eggleston, E | 1 |
| Hoyt, DW | 1 |
| Olson, AJ | 1 |
| Choi, HS | 1 |
| Choi, BY | 2 |
| Mizuno, H | 2 |
| Kang, BS | 1 |
| DeAngelis, T | 1 |
| Wu, A | 1 |
| Prisco, M | 1 |
| Baserga, R | 1 |
| Cha, TL | 1 |
| Zhou, BP | 1 |
| Xia, W | 2 |
| Wu, Y | 1 |
| Yang, CC | 1 |
| Chen, CT | 1 |
| Ping, B | 1 |
| Otte, AP | 1 |
| Hung, MC | 2 |
| Kumar, RN | 1 |
| Shore, SK | 1 |
| Dhanasekaran, N | 1 |
| Lin, YW | 1 |
| Yang, JL | 1 |
| Matsuzaki, K | 1 |
| Gu, J | 1 |
| Wu, X | 1 |
| Dong, Q | 1 |
| Romeo, MJ | 1 |
| Lin, X | 1 |
| Gutkind, JS | 1 |
| Berman, DM | 1 |
| Tatsumi, Y | 1 |
| He, Z | 1 |
| Seok Choi, H | 1 |
| Plaza-Menacho, I | 1 |
| van der Sluis, T | 1 |
| Hollema, H | 1 |
| Gimm, O | 1 |
| Buys, CH | 2 |
| Magee, AI | 1 |
| Isacke, CM | 1 |
| Hofstra, RM | 1 |
| Eggen, BJ | 1 |
| Pang, R | 1 |
| Lee, TK | 1 |
| Poon, RT | 1 |
| Fan, ST | 1 |
| Wong, KB | 1 |
| Kwong, YL | 1 |
| Tse, E | 1 |
| Zippo, A | 1 |
| De Robertis, A | 1 |
| Serafini, R | 1 |
| Oliviero, S | 1 |
| Bergen, HR | 1 |
| Madden, BJ | 1 |
| Yang, JY | 1 |
| Zong, CS | 1 |
| Yamaguchi, H | 1 |
| Ding, Q | 1 |
| Xie, X | 1 |
| Lang, JY | 1 |
| Lai, CC | 1 |
| Chang, CJ | 1 |
| Huang, WC | 1 |
| Kuo, HP | 1 |
| Lee, DF | 1 |
| Li, LY | 1 |
| Lien, HC | 1 |
| Cheng, X | 1 |
| Chang, KJ | 1 |
| Hsiao, CD | 1 |
| Tsai, FJ | 1 |
| Tsai, CH | 1 |
| Muller, WJ | 1 |
| Mills, GB | 1 |
| Yu, D | 1 |
| Hortobagyi, GN | 1 |
| Dolloff, NG | 1 |
| El-Deiry, WS | 1 |
| Blomberg, J | 1 |
| Van de Ven, WJ | 1 |
| Reynolds, FH | 1 |
| Nalewaik, RP | 1 |
| Stephenson, JR | 1 |
| Mangel, WF | 1 |
| Livingston, DC | 1 |
| Brocklehurst, JR | 1 |
| Liu, HY | 1 |
| Peltz, GA | 1 |
| Cannon, JF | 1 |
| Leytus, SP | 1 |
| Wehrly, JA | 1 |
| Salter, BL | 1 |
| Mosher, JL | 1 |
| Okazaki, K | 1 |
| Sagata, N | 1 |
| Donzé, O | 1 |
| Jagus, R | 1 |
| Koromilas, AE | 1 |
| Sonenberg, N | 1 |
| Rothberg, PG | 1 |
| Otto, YM | 1 |
| Cowley, S | 1 |
| Paterson, H | 1 |
| Kemp, P | 1 |
| Marshall, CJ | 1 |
| Romero, P | 1 |
| Humphries, EH | 1 |
| Pulverer, BJ | 1 |
| Fisher, C | 1 |
| Vousden, K | 1 |
| Littlewood, T | 1 |
| Evan, G | 1 |
| Woodgett, JR | 1 |
| Kolch, W | 1 |
| Heidecker, G | 2 |
| Kochs, G | 1 |
| Hummel, R | 1 |
| Vahidi, H | 1 |
| Mischak, H | 1 |
| Finkenzeller, G | 1 |
| Marmé, D | 1 |
| Rapp, UR | 2 |
| Taylor, LK | 1 |
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5 reviews available for serine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Serine-Arginine Protein Kinase 1 (SRPK1): a systematic review of its multimodal role in oncogenesis.
Topics: Arginine; Arginine Kinase; Carcinogenesis; Cell Transformation, Neoplastic; Humans; Neoplasms; NF-ka | 2022 |
Protein phosphorylation and its role in the regulation of Annexin A2 function.
Topics: Annexin A2; Cell Transformation, Neoplastic; Exosomes; Gene Expression Regulation, Neoplastic; Human | 2017 |
STAT3 revs up the powerhouse.
Topics: Animals; Cell Transformation, Neoplastic; Genes, ras; Humans; Mitochondria; Models, Biological; Onco | 2009 |
Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation.
Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Conserved Sequence; Hematologic Neopl | 2011 |
Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Colorec | 2006 |
126 other studies available for serine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Glycine H | 2022 |
TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC.
Topics: Carcinoma, Renal Cell; Cell Transformation, Neoplastic; Humans; Kidney Neoplasms; Mitogen-Activated | 2022 |
SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT.
Topics: Amidophosphoribosyltransferase; Carbon; Carcinogenesis; Carcinoma, Renal Cell; Cell Proliferation; C | 2022 |
Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.
Topics: Apoptosis; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Humans; RNA-Binding Proteins; RNA | 2022 |
Extracellular serine controls epidermal stem cell fate and tumour initiation.
Topics: Animals; Carcinoma, Squamous Cell; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cul | 2020 |
Starve a cold, and perhaps a cancer.
Topics: Cell Transformation, Neoplastic; Epidermal Cells; Humans; Neoplasms; Serine; Stem Cells | 2020 |
Integrating serine with tumour initiation.
Topics: Cell Transformation, Neoplastic; Humans; Serine; Stem Cells | 2020 |
Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Citric Acid Cycle; Diet, High-F | 2021 |
Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Proliferation; Cell Transformation, Neoplastic; | 2017 |
Examination of VDR/RXR/DRIP205 Interaction, Intranuclear Localization, and DNA Binding in Ras-Transformed Keratinocytes and Its Implication for Designing Optimal Vitamin D Therapy in Cancer.
Topics: Cell Nucleus; Cell Transformation, Neoplastic; Chromatin; DNA; Genes, ras; Humans; Keratinocytes; Me | 2018 |
Ectopic expression of aquaporin-5 in noncancerous epithelial MDCK cells changes cellular morphology and actin fiber formation without inducing epithelial-to-mesenchymal transition.
Topics: Actins; Animals; Aquaporin 5; Cell Shape; Cell Transformation, Neoplastic; Dogs; Epithelial Cells; E | 2018 |
Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation.
Topics: Alkylating Agents; Animals; Apoptosis; Blotting, Western; Butyrate Response Factor 1; Cell Adhesion; | 2013 |
Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Mutational Analys | 2013 |
The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.
Topics: Adenine; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; | 2014 |
Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth.
Topics: Animals; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Humans | 2014 |
Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells.
Topics: Animals; bcl-X Protein; Brain Neoplasms; Casein Kinase II; Cell Line, Tumor; Cell Movement; Cell Tra | 2014 |
Phosphorylation of PAX3 contributes to melanoma phenotypes by affecting proliferation, invasion, and transformation.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Melanocytes; Melanoma | 2014 |
Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs.
Topics: 14-3-3 Proteins; Adenocarcinoma; Amino Acid Motifs; Animals; Apoptosis; Blotting, Western; Cell Line | 2014 |
Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation.
Topics: Caspases; Cell Cycle; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inh | 2014 |
Crucial role of c-Jun phosphorylation at Ser63/73 mediated by PHLPP protein degradation in the cheliensisin a inhibition of cell transformation.
Topics: Animals; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Ep | 2014 |
Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Dynamins; GTP Phosphohydrolases; HT29 Ce | 2015 |
PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis.
Topics: Animals; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neop | 2015 |
Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S.
Topics: Amino Acid Substitution; Animals; Cell Line; Cell Transformation, Neoplastic; Cysteine; Female; Fibr | 2015 |
Pro-Tumorigenic Phosphorylation of p120 Catenin in Renal and Breast Cancer.
Topics: Blotting, Western; Breast Neoplasms; Carcinoma, Renal Cell; Catenins; Cell Transformation, Neoplasti | 2015 |
The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival.
Topics: ATPase Inhibitory Protein; Cell Transformation, Neoplastic; Cellular Reprogramming; Cyclic AMP-Depen | 2016 |
Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation.
Topics: Adaptor Proteins, Signal Transducing; Animals; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line; | 2016 |
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Cell Culture Technique | 2016 |
Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.
Topics: Animals; Cell Cycle; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin D; Cyclins; Dimerization; | 2008 |
Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Human | 2008 |
AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Transformation, Neoplastic; Chromones; Eukaryotic Init | 2009 |
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclic AMP; Cyclic | 2008 |
Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation.
Topics: Animals; Cell Adhesion; Cell Growth Processes; Cell Line; Cell Transformation, Neoplastic; Cyclin-De | 2009 |
Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclin D | 2009 |
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Line; Cell Transformation, Neoplastic; Deubiqui | 2009 |
Phosphorylation of histone H3 at Ser10: its role in cell transformation by v-Src.
Topics: Animals; Cell Transformation, Neoplastic; Enzyme Inhibitors; Farnesyltranstransferase; Histones; Hum | 2009 |
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cellular Senescence; Cyclin E; Cyclin-De | 2010 |
Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Apoptosis; Apoptosis Regulatory Protein | 2010 |
Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; D | 2010 |
Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation.
Topics: Adult; Aged; Animals; Blotting, Western; Bone Marrow Transplantation; Cell Lineage; Cell Proliferati | 2010 |
Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Adhesion; Cell Cycle Proteins; Cell Growth Processes; C | 2011 |
Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis Regulatory Proteins; Breast Neoplasms; Calcium-Ca | 2011 |
Phosphorylation of histone H2B serine 32 is linked to cell transformation.
Topics: Amino Acid Substitution; Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; Epidermi | 2011 |
Genetic selection for enhanced serine metabolism in cancer development.
Topics: Biosynthetic Pathways; Cell Transformation, Neoplastic; Gene Amplification; Gene Dosage; Glucose; Gl | 2011 |
Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis.
Topics: Animals; Cell Transformation, Neoplastic; HeLa Cells; Humans; I-kappa B Kinase; Mice; Mice, Nude; NF | 2012 |
The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis.
Topics: Animals; Cell Transformation, Neoplastic; Dasatinib; Gene Expression Regulation, Neoplastic; Gene Kn | 2011 |
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.
Topics: Amino Acid Sequence; Antigens, CD; Carcinoma, Non-Small-Cell Lung; Cell Adhesion Molecules, Neuronal | 2012 |
Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Catalysis; Cell Cycle; Cell Nucleus; Cell Transfor | 2012 |
Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cell Prolifera | 2014 |
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Topics: Animals; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzym | 2012 |
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.
Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Biosynthetic Pathways; Cell Tr | 2013 |
ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Blotting, Northern; Bone Marrow; Cell Nu | 2003 |
Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours.
Topics: Blotting, Western; Cell Transformation, Neoplastic; DNA-Binding Proteins; Electrophoresis, Polyacryl | 2003 |
Expression, localization, and activity of glycogen synthase kinase 3beta during mouse skin tumorigenesis.
Topics: Animals; Blotting, Western; Cell Transformation, Neoplastic; Female; Glycogen Synthase Kinase 3; Gly | 2002 |
MafA has strong cell transforming ability but is a weak transactivator.
Topics: Amino Acid Sequence; Animals; Avian Proteins; Binding Sites; Cell Transformation, Neoplastic; Cells, | 2003 |
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
Topics: Amino Acid Sequence; Animals; Antigens, Polyomavirus Transforming; Cell Line; Cell Transformation, N | 2004 |
Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.
Topics: Alanine; Apoptosis; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell Cycle; Cell Division | 2004 |
Ser392 phosphorylation regulates the oncogenic function of mutant p53.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; | 2004 |
Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms.
Topics: Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression Regulatio | 2004 |
Cell cycle-dependent phosphorylation of C/EBPbeta mediates oncogenic cooperativity between C/EBPbeta and H-RasV12.
Topics: Amino Acid Sequence; Animals; CCAAT-Enhancer-Binding Protein-beta; CDC2-CDC28 Kinases; Cell Cycle; C | 2004 |
Organization of functional domains in the docking protein p130Cas.
Topics: 14-3-3 Proteins; Animals; Cell Transformation, Neoplastic; Circular Dichroism; Crk-Associated Substr | 2004 |
Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.
Topics: Aging; Animals; BRCA1 Protein; Carcinogens; Cell Cycle; Cell Transformation, Neoplastic; Checkpoint | 2004 |
Stimulation of the Ras-MAPK pathway leads to independent phosphorylation of histone H3 on serine 10 and 28.
Topics: Animals; Cell Transformation, Neoplastic; Fibroblasts; Fluorescent Antibody Technique, Indirect; Gen | 2005 |
The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle.
Topics: 14-3-3 Proteins; alpha Catenin; Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Cell | 2005 |
Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Transformation, Neoplastic; Epidermal Growth Facto | 2005 |
Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling.
Topics: Agar; Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Binding Sites; Blotting, | 2006 |
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; Chromones; COS | 2005 |
Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; GTP-Binding Prote | 2006 |
Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Cell Cycle Proteins; Cell Line; Cell Nucleus; | 2006 |
A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.
Topics: Aged; Alleles; Case-Control Studies; Cell Transformation, Neoplastic; Cyclin D1; DNA, Neoplasm; Fema | 2006 |
Involvement of the paxillin pathway in JB6 Cl41 cell transformation.
Topics: Animals; Base Sequence; Cell Growth Processes; Cell Line; Cell Transformation, Neoplastic; Down-Regu | 2006 |
Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.
Topics: Animals; Carcinoma, Medullary; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Famil | 2007 |
Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis.
Topics: Amino Acid Motifs; Animals; bcl-X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolife | 2007 |
PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.
Topics: Cell Transformation, Neoplastic; Cells, Cultured; Chromatin; Endothelial Cells; Enhancer Elements, G | 2007 |
Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Genes, Reporter; Humans; Mice; Mit | 2007 |
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cel | 2008 |
ERK and MDM2 prey on FOXO3a.
Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; Down-Regulation; Extracellular Signal- | 2008 |
Snyder-Theilen feline sarcoma virus P85 contains a single phosphotyrosine acceptor site recognized by its associated protein kinase.
Topics: Binding Sites; Cell Transformation, Neoplastic; Cell Transformation, Viral; Phosphorylation; Phospho | 1981 |
New assay for the plasminogen activator activity of transformed cells.
Topics: Binding Sites; Cell Line; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; Fibrinolys | 1980 |
The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; | 1995 |
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.
Topics: 3T3 Cells; Animals; Base Sequence; Cell Transformation, Neoplastic; eIF-2 Kinase; Eukaryotic Initiat | 1995 |
A polymorphic variant of human c-Myc: Asn11-->Ser.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Transformation, Neoplastic; Conserved Sequence; DN | 1995 |
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells.
Topics: 3T3 Cells; Alanine; Animals; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Ne | 1994 |
A mutant v-rel with increased ability to transform B lymphocytes.
Topics: Alanine; Amino Acid Sequence; Animals; B-Lymphocytes; Base Sequence; Cell Line; Cell Transformation, | 1995 |
Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Tran | 1994 |
Protein kinase C alpha activates RAF-1 by direct phosphorylation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecu | 1993 |
Identification of a nerve growth factor- and epidermal growth factor-regulated protein kinase that phosphorylates the protooncogene product c-Fos.
Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth F | 1993 |
The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.
Topics: Alleles; Animals; Base Sequence; Biological Transport; Biopolymers; Cell Nucleus; Cell Transformatio | 1993 |
A conserved cysteine residue in the runt homology domain of AML1 is required for the DNA binding ability and the transforming activity on fibroblasts.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Conserved Sequence; Core Binding Fac | 1996 |
Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells.
Topics: 3T3 Cells; Animals; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cysteine; Gene | 1996 |
Transcriptional activation and transformation by FosB protein require phosphorylation of the carboxyl-terminal activation domain.
Topics: Amino Acid Sequence; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Tr | 1997 |
IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Cell Transfo | 1997 |
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Transformation, Neoplastic; COS Cells; Enzyme Activati | 1997 |
Serine 257 phosphorylation regulates association of polyomavirus middle T antigen with 14-3-3 proteins.
Topics: 14-3-3 Proteins; 3T3 Cells; Animals; Antigens, Polyomavirus Transforming; Baculoviridae; Base Sequen | 1998 |
Biochemical and functional analysis of highly phosphorylated forms of c-Jun protein.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell | 1998 |
Mapping of a serine-rich domain essential for the transcriptional, antiapoptotic, and transforming activities of the v-Rel oncoprotein.
Topics: Amino Acid Sequence; Animals; Apoptosis; Aspartic Acid; Binding Sites; Cell Transformation, Neoplast | 1999 |
Cell transformation by ornithine decarboxylase is associated with phosphorylation of the transactivation domain of c-Jun.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; M | 1998 |
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
Topics: Alanine; Animals; Apoptosis; Binding Sites; Cell Transformation, Neoplastic; DNA; Gene Expression; H | 1999 |
Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha.
Topics: Animals; Anticarcinogenic Agents; Bexarotene; Calcitriol; Calcium-Calmodulin-Dependent Protein Kinas | 1999 |
Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; DNA-Binding Proteins; Gene Expression Regulatio | 1999 |
The NH2 terminus of galectin-3 governs cellular compartmentalization and functions in cancer cells.
Topics: Antigens, Differentiation; Binding Sites; Biological Transport; Casein Kinases; Cell Compartmentatio | 1999 |
Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells.
Topics: Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA-Binding Pro | 2000 |
Suppression of cell transformation and induction of apoptosis by caffeic acid phenethyl ester.
Topics: Animals; Apoptosis; Blotting, Western; Boron Compounds; Caffeic Acids; Carcinogens; Caspase 3; Caspa | 2001 |
MEN2A-RET-induced cellular transformation by activation of STAT3.
Topics: 3T3 Cells; Animals; Binding Sites; Cell Division; Cell Line; Cell Transformation, Neoplastic; COS Ce | 2001 |
Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; CHO Cells; Cricetinae; DNA-Binding Proteins; Fe | 2001 |
Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.
Topics: Adenylate Kinase; Animals; Aspartate Aminotransferases; Cell Line; Cell Transformation, Neoplastic; | 2001 |
Ser-10 phosphorylation of histone H3 and immediate early gene expression in oncogene-transformed mouse fibroblasts.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; E | 2002 |
Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases.
Topics: 3T3 Cells; Animals; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Cell Cycle; Cell Line; Cell Tr | 2002 |
Identification of two novel regulated serines in the N terminus of beta-catenin.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; beta Catenin; Calcium-Calmodulin-Dependent Pro | 2002 |
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.
Topics: 3T3 Cells; Alanine; Animals; Carrier Proteins; Cell Cycle; Cell Division; Cell Transformation, Neopl | 2002 |
Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells.
Topics: Adenomatous Polyposis Coli Protein; Amino Acid Sequence; Animals; beta Catenin; beta-Transducin Repe | 2002 |
Production of a serine-protease with macrophage migration-inhibitory factor activity by virus-transformed cells and human tumor cell lines.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Migration Inhibition; Cell Transformation, Neoplasti | 1975 |
Materials released into culture medium by normal and oncogenic virus-transformed mammalian cells.
Topics: Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media; Fucose; Gluc | 1976 |
Serine enzymes released by cultured neoplastic cells.
Topics: Binding Sites; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Inhibitors; Esterases; Human | 1978 |
Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site.
Topics: 3T3 Cells; Alanine; Animals; Cell Transformation, Neoplastic; Chick Embryo; Glutamates; Glutamic Aci | 1992 |
Phosphorylation of adenovirus E1A proteins by the p34cdc2 protein kinase.
Topics: Adenovirus Early Proteins; Adenoviruses, Human; CDC2 Protein Kinase; Cell Cycle; Cell Transformation | 1992 |
Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Line; Cell Transformation, Neoplastic; Electrophoresis | 1992 |
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Cell Transformation, Neoplastic; Gene Expres | 1991 |
Mutations of the human papillomavirus type 16 E7 gene that affect transformation, transactivation and phosphorylation by the E7 protein.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cysteine; DNA Mutat | 1990 |
gp140v-fms molecules expressed at the surface of cells transformed by the McDonough strain of feline sarcoma virus are phosphorylated in tyrosine and serine.
Topics: Animals; Cats; Cell Transformation, Neoplastic; Genes; Genes, Viral; Oncogene Protein gp140(v-fms); | 1986 |
Mutation of amino acids in pp60c-src that are phosphorylated by protein kinases C and A.
Topics: Amino Acids; Animals; Cell Transformation, Neoplastic; DNA Mutational Analysis; Gene Expression Regu | 1989 |
Antibodies specific for amino acid 12 of the ras oncogene product inhibit GTP binding.
Topics: Amino Acid Sequence; Antibodies; Cell Transformation, Neoplastic; Glycine; Guanosine Triphosphate; H | 1985 |
Cell density-dependent changes of glycolipid concentrations in fibroblasts, and loss of this response in virus-transformed cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chromatography, Thin Layer; Contact Inhibition; | 1970 |
[Comparative study of transfer ribonucleic acids extracted from rat liver and Zajdela hepatoma. I. Study of the acceptor properties of tRNA].
Topics: Acylation; Alanine; Animals; Arginine; Ascites; Carcinoma, Hepatocellular; Cell Differentiation; Cel | 1972 |
Release of specific protease during mitotic cycle of L5178Y murine leukaemic cells by sublethal autolysis.
Topics: Acetylation; Anhydrides; Animals; Cations, Divalent; Cell Line; Cell Membrane; Cell Transformation, | 1974 |
Secretion of plasminogen activator by stimulated macrophages.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Cell Transformation, Neoplastic; Cells, Cultured; Electr | 1974 |
Transfer RNA patterns in livers of rats fed diets containing 3'-methyl-4-dimethylaminoazobenzene.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cell Transformation, Neoplastic; Chemical and Drug | 1970 |