serine has been researched along with Cataract in 15 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many human connexin50 (Cx50) mutants have been linked to cataracts including two carboxyl terminus serine mutants that are known phosphorylation sites in the lens (Cx50S258F and Cx50S259Y)." | 8.12 | Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation. ( Berthoud, VM; Beyer, EC; Ebihara, L; Minogue, PJ; Mysliwiec, H; Tong, JJ; Wichmann, K, 2022) |
| "Many human connexin50 (Cx50) mutants have been linked to cataracts including two carboxyl terminus serine mutants that are known phosphorylation sites in the lens (Cx50S258F and Cx50S259Y)." | 4.12 | Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation. ( Berthoud, VM; Beyer, EC; Ebihara, L; Minogue, PJ; Mysliwiec, H; Tong, JJ; Wichmann, K, 2022) |
| "There was a gradual decrease in the quantity of various amino acids associated with cataract formation due to reduced concentrations of glutamic acid, threonine, serine, glycine, alanine, leucine, isoleucine, phenylalanine and tyrosine in stages of cataract formation." | 3.67 | Study of the relationship between free amino acids and cataract in human lenses. ( Bhatnagar, R; Chauhan, BS; Desai, NC; Garg, SP, 1984) |
| "Cataract is a common cause of childhood blindness worldwide." | 1.35 | Cataract mutation P20S of alphaB-crystallin impairs chaperone activity of alphaA-crystallin and induces apoptosis of human lens epithelial cells. ( Ke, T; Li, C; Li, DW; Li, H; Liu, J; Liu, M; Lu, Q; Ren, X; Su, T; Wang, QK; Yuan, M; Zeng, S; Zhang, Z, 2008) |
| ""Ant-egg" cataract is a rare, distinct variety of congenital/infantile cataract that was reported in a large Danish family in 1967." | 1.33 | The congenital "ant-egg" cataract phenotype is caused by a missense mutation in connexin46. ( Eiberg, H; Funding, M; Hansen, L; Hejtmancik, JF; Kjaer, KW; Riise, R; Rosenberg, T; Yao, W, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Minogue, PJ | 1 |
| Tong, JJ | 1 |
| Wichmann, K | 1 |
| Mysliwiec, H | 1 |
| Ebihara, L | 1 |
| Beyer, EC | 1 |
| Berthoud, VM | 1 |
| Wang, Z | 1 |
| Schey, KL | 1 |
| López-Lera, A | 1 |
| Torres-Canizales, JM | 1 |
| Garrido, S | 1 |
| Morales, A | 1 |
| López-Trascasa, M | 1 |
| Zhang, LY | 1 |
| Gong, B | 1 |
| Tong, JP | 1 |
| Fan, DS | 1 |
| Chiang, SW | 1 |
| Lou, D | 1 |
| Lam, DS | 1 |
| Yam, GH | 1 |
| Pang, CP | 1 |
| Huang, CH | 1 |
| Wang, YT | 1 |
| Tsai, CF | 1 |
| Chen, YJ | 1 |
| Lee, JS | 1 |
| Chiou, SH | 1 |
| Hansen, L | 2 |
| Yao, W | 1 |
| Eiberg, H | 2 |
| Funding, M | 1 |
| Riise, R | 1 |
| Kjaer, KW | 1 |
| Hejtmancik, JF | 1 |
| Rosenberg, T | 2 |
| Plotnikova, OV | 1 |
| Kondrashov, FA | 1 |
| Vlasov, PK | 1 |
| Grigorenko, AP | 1 |
| Ginter, EK | 1 |
| Rogaev, EI | 1 |
| Li, H | 1 |
| Li, C | 1 |
| Lu, Q | 1 |
| Su, T | 1 |
| Ke, T | 1 |
| Li, DW | 1 |
| Yuan, M | 1 |
| Liu, J | 1 |
| Ren, X | 1 |
| Zhang, Z | 1 |
| Zeng, S | 1 |
| Wang, QK | 1 |
| Liu, M | 1 |
| Chauhan, BS | 1 |
| Desai, NC | 1 |
| Bhatnagar, R | 1 |
| Garg, SP | 1 |
| Heckenlively, J | 1 |
| Asherie, N | 1 |
| Pande, J | 1 |
| Pande, A | 1 |
| Zarutskie, JA | 1 |
| Lomakin, J | 1 |
| Lomakin, A | 1 |
| Ogun, O | 1 |
| Stern, LJ | 1 |
| King, J | 1 |
| Benedek, GB | 1 |
| Kern, HL | 1 |
| Rowe, VD | 1 |
| Zigler, S | 1 |
| Andersen, AE | 1 |
| Sidbury, JB | 1 |
| Guroff, G | 1 |
| Harris, JE | 1 |
| Gruber, L | 1 |
1 review available for serine and Cataract
| Article | Year |
|---|---|
Transport of organic solutes in the lens.
Topics: Aging; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Calcium; Carbohydrate Meta | 1979 |
14 other studies available for serine and Cataract
| Article | Year |
|---|---|
Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation.
Topics: Cataract; Connexins; Eye Proteins; Gap Junctions; HeLa Cells; Humans; Lens, Crystalline; Lysosomes; | 2022 |
Quantification of thioether-linked glutathione modifications in human lens proteins.
Topics: Adolescent; Alanine; Aminobutyrates; Cataract; Cellular Senescence; Chromatography, Liquid; Crystall | 2018 |
Rothmund-Thomson syndrome and glomerulonephritis in a homozygous C1q-deficient patient due to a Gly164Ser C1qC mutation.
Topics: Adult; Cataract; Cohort Studies; Complement C1q; Erythema; Exons; Glomerulonephritis; Glycine; Homoz | 2014 |
A novel gammaD-crystallin mutation causes mild changes in protein properties but leads to congenital coralliform cataract.
Topics: Adult; Amino Acid Sequence; Arginine; Asian People; Base Sequence; Cataract; Child; Child, Preschool | 2009 |
Phosphoproteomics characterization of novel phosphorylated sites of lens proteins from normal and cataractous human eye lenses.
Topics: Adult; Aged; Cataract; Chromatography, Liquid; Crystallins; Humans; Lens, Crystalline; Phosphoprotei | 2011 |
The congenital "ant-egg" cataract phenotype is caused by a missense mutation in connexin46.
Topics: Amino Acid Sequence; Base Sequence; Cataract; Connexins; Female; Haplotypes; Humans; Leucine; Lod Sc | 2006 |
Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cataract; Crystallins; Evolution, Molecular; Female; ga | 2007 |
Novel MAF mutation in a family with congenital cataract-microcornea syndrome.
Topics: Amino Acid Substitution; Arginine; Cataract; Cornea; DNA; Eye Abnormalities; Female; Humans; Infant, | 2007 |
Cataract mutation P20S of alphaB-crystallin impairs chaperone activity of alphaA-crystallin and induces apoptosis of human lens epithelial cells.
Topics: alpha-Crystallin A Chain; alpha-Crystallin B Chain; Apoptosis; Cataract; Epithelial Cells; Humans; L | 2008 |
Study of the relationship between free amino acids and cataract in human lenses.
Topics: Adult; Aged; Alanine; Amino Acids; Cataract; Glutamates; Glutamic Acid; Glycine; Humans; Lens, Cryst | 1984 |
Possible syndrome of high myopia with retinal degeneration, cataract, manic depression, and elevated plasma amino acids.
Topics: Aged; Amino Acids; Bipolar Disorder; Cataract; Female; Humans; Lysine; Male; Middle Aged; Myopia; Or | 1980 |
Enhanced crystallization of the Cys18 to Ser mutant of bovine gammaB crystallin.
Topics: Amino Acid Substitution; Animals; Cataract; Cattle; Crystallins; Crystallization; Crystallography, X | 2001 |
Some characteristics of the p-chlorophenylalanine-induced cataract.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Cataract; Chromatography, Gas; Crystallins; Electroph | 1973 |
The reversal of triparanol-induced cataracts in the rat. 3. Amino acid content and uptake of 14 C -AIB in cataractous and clearing lenses.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Aspartic Acid; Carbon Isotopes; Cata | 1973 |