serine has been researched along with Cardiovascular Stroke in 26 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A mutation in the lipoprotein lipase (LPL) gene, resulting in the substitution of asparagine by serine at residue 291 (LPL-S291), was found to occur in young survivors of a myocardial infarction from Sweden, combined hyperlipidemic subjects from the United Kingdom, and type III hyperlipidemic subjects from Germany at allelic carrier frequencies no different from those found in companion healthy control subjects (3." | 7.69 | Interaction of the lipoprotein lipase asparagine 291-->serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: a study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults. ( Beisiegel, U; Feussner, G; Fisher, RM; Hamsten, A; Humphries, SE; Mailly, F; Miller, G; Peacock, RE; Seed, M; Yudkin, JS, 1995) |
| "In the European population, alanine and serine were inversely associated with angina pectoris (AP) and chronic heart failure, respectively." | 4.31 | Causal relationships of circulating amino acids with cardiovascular disease: a trans-ancestry Mendelian randomization analysis. ( Guo, TT; Hu, MJ; Hu, S; Hua, L; Huang, X; Lin, Z; Tan, JS, 2023) |
| " Using quantitative phosphoproteomics technology, we identified that SGK3 (serine/threonine-protein kinase 3) in the neonatal heart is highly expressed and activated after myocardial infarction." | 4.02 | Serine/Threonine-Protein Kinase 3 Facilitates Myocardial Repair After Cardiac Injury Possibly Through the Glycogen Synthase Kinase-3β/β-Catenin Pathway. ( Chen, BR; Chen, F; Du, C; Fan, Y; Gu, LF; Guo, XJ; Kong, XQ; Li, YF; Liu, L; Ma, Y; Shan, TK; Sun, JT; Sun, R; Wang, H; Wang, LS; Wang, ZM; Wei, TW; Wei, YY; Yang, TT, 2021) |
| "A mutation in the lipoprotein lipase (LPL) gene, resulting in the substitution of asparagine by serine at residue 291 (LPL-S291), was found to occur in young survivors of a myocardial infarction from Sweden, combined hyperlipidemic subjects from the United Kingdom, and type III hyperlipidemic subjects from Germany at allelic carrier frequencies no different from those found in companion healthy control subjects (3." | 3.69 | Interaction of the lipoprotein lipase asparagine 291-->serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: a study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults. ( Beisiegel, U; Feussner, G; Fisher, RM; Hamsten, A; Humphries, SE; Mailly, F; Miller, G; Peacock, RE; Seed, M; Yudkin, JS, 1995) |
| "Ventricular arrhythmia is the most important risk factor for sudden cardiac death (SCD) after acute myocardial infarction (MI) worldwide." | 1.56 | Cardiac-Specific Caveolin-3 Overexpression Prevents Post-Myocardial Infarction Ventricular Arrhythmias by Inhibiting Ryanodine Receptor-2 Hyperphosphorylation. ( Chen, G; Du, T; Fang, Q; Wang, DW; Wang, Y; Zhang, Z, 2020) |
| "On leptin treatment, mitochondrial permeability transition pore opening was delayed by 43% (P < 0." | 1.35 | The cardioprotective actions of leptin are lost in the Zucker obese (fa/fa) rat. ( Davidson, SM; Dixon, RA; Smith, CC; Wynne, AM; Yellon, DM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.85) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 9 (34.62) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Li, YF | 1 |
| Wei, TW | 1 |
| Fan, Y | 1 |
| Shan, TK | 1 |
| Sun, JT | 1 |
| Chen, BR | 1 |
| Wang, ZM | 1 |
| Gu, LF | 1 |
| Yang, TT | 1 |
| Liu, L | 1 |
| Du, C | 1 |
| Ma, Y | 1 |
| Wang, H | 2 |
| Sun, R | 1 |
| Wei, YY | 1 |
| Chen, F | 1 |
| Guo, XJ | 1 |
| Kong, XQ | 1 |
| Wang, LS | 1 |
| Hu, S | 1 |
| Lin, Z | 1 |
| Hu, MJ | 1 |
| Tan, JS | 1 |
| Guo, TT | 1 |
| Huang, X | 1 |
| Hua, L | 1 |
| Zhang, Z | 1 |
| Fang, Q | 1 |
| Du, T | 1 |
| Chen, G | 1 |
| Wang, Y | 1 |
| Wang, DW | 1 |
| Dubois-Deruy, E | 1 |
| Belliard, A | 1 |
| Mulder, P | 1 |
| Chwastyniak, M | 1 |
| Beseme, O | 1 |
| Henry, JP | 1 |
| Thuillez, C | 1 |
| Amouyel, P | 1 |
| Richard, V | 1 |
| Pinet, F | 1 |
| Ding, Y | 1 |
| Pedersen, ER | 1 |
| Svingen, GF | 1 |
| Helgeland, Ø | 1 |
| Gregory, JF | 1 |
| Løland, KH | 1 |
| Meyer, K | 1 |
| Tell, GS | 1 |
| Ueland, PM | 1 |
| Nygård, OK | 1 |
| Dixon, RA | 1 |
| Davidson, SM | 1 |
| Wynne, AM | 1 |
| Yellon, DM | 1 |
| Smith, CC | 1 |
| Walker, LA | 1 |
| Walker, JS | 1 |
| Ambler, SK | 1 |
| Buttrick, PM | 1 |
| Jang, SH | 1 |
| Han, TH | 1 |
| Hwang, IK | 1 |
| Park, SA | 1 |
| Kwak, YG | 1 |
| Park, JB | 1 |
| Han, SK | 1 |
| Ryu, PD | 1 |
| Lee, SY | 1 |
| Wei, J | 1 |
| Wang, W | 2 |
| Chopra, I | 1 |
| Li, HF | 1 |
| Dougherty, CJ | 1 |
| Adi, J | 1 |
| Adi, N | 1 |
| Webster, KA | 1 |
| Mälarstig, A | 1 |
| Silveira, A | 1 |
| Wågsäter, D | 1 |
| Öhrvik, J | 1 |
| Bäcklund, A | 1 |
| Samnegård, A | 1 |
| Khademi, M | 1 |
| Hellenius, ML | 1 |
| Leander, K | 1 |
| Olsson, T | 1 |
| Uhlén, M | 1 |
| de Faire, U | 1 |
| Eriksson, P | 1 |
| Hamsten, A | 2 |
| Lv, L | 1 |
| Jiang, SS | 1 |
| Xu, J | 1 |
| Gong, JB | 1 |
| Cheng, Y | 1 |
| Zhang, H | 1 |
| Makarewich, CA | 1 |
| Kubo, H | 1 |
| Duran, JM | 1 |
| Li, Y | 1 |
| Berretta, RM | 1 |
| Koch, WJ | 1 |
| Chen, X | 1 |
| Gao, E | 1 |
| Valdivia, HH | 1 |
| Houser, SR | 1 |
| Yang, C | 1 |
| Talukder, MA | 1 |
| Varadharaj, S | 1 |
| Velayutham, M | 1 |
| Zweier, JL | 1 |
| Joiner, ML | 1 |
| Koval, OM | 1 |
| Li, J | 1 |
| He, BJ | 1 |
| Allamargot, C | 1 |
| Gao, Z | 1 |
| Luczak, ED | 1 |
| Hall, DD | 1 |
| Fink, BD | 1 |
| Chen, B | 1 |
| Yang, J | 1 |
| Moore, SA | 1 |
| Scholz, TD | 1 |
| Strack, S | 1 |
| Mohler, PJ | 1 |
| Sivitz, WI | 1 |
| Song, LS | 1 |
| Anderson, ME | 1 |
| Stephanou, A | 1 |
| Scarabelli, TM | 1 |
| Townsend, PA | 1 |
| Bell, R | 1 |
| Yellon, D | 1 |
| Knight, RA | 1 |
| Latchman, DS | 1 |
| Narizhneva, NV | 1 |
| Byers-Ward, VJ | 1 |
| Quinn, MJ | 1 |
| Zidar, FJ | 1 |
| Plow, EF | 1 |
| Topol, EJ | 1 |
| Byzova, TV | 1 |
| Shu, E | 1 |
| Matsuno, H | 1 |
| Akamastu, S | 1 |
| Kanno, Y | 1 |
| Suga, H | 1 |
| Nakajima, K | 1 |
| Ishisaki, A | 1 |
| Takai, S | 1 |
| Kato, K | 1 |
| Kitajima, Y | 1 |
| Kozawa, O | 1 |
| Huang, F | 1 |
| Shan, J | 1 |
| Reiken, S | 1 |
| Wehrens, XH | 1 |
| Marks, AR | 1 |
| März, W | 1 |
| Seelhorst, U | 1 |
| Wellnitz, B | 1 |
| Tiran, B | 1 |
| Obermayer-Pietsch, B | 1 |
| Renner, W | 1 |
| Boehm, BO | 1 |
| Ritz, E | 1 |
| Hoffmann, MM | 1 |
| Rajasingh, J | 1 |
| Bord, E | 1 |
| Hamada, H | 1 |
| Lambers, E | 1 |
| Qin, G | 1 |
| Losordo, DW | 1 |
| Kishore, R | 1 |
| Fisher, RM | 1 |
| Mailly, F | 1 |
| Peacock, RE | 1 |
| Seed, M | 1 |
| Yudkin, JS | 1 |
| Beisiegel, U | 1 |
| Feussner, G | 1 |
| Miller, G | 1 |
| Humphries, SE | 1 |
| Jemaa, R | 1 |
| Fumeron, F | 1 |
| Poirier, O | 1 |
| Lecerf, L | 1 |
| Evans, A | 1 |
| Arveiler, D | 1 |
| Luc, G | 1 |
| Cambou, JP | 1 |
| Bard, JM | 1 |
| Fruchart, JC | 1 |
| Sasaoka, T | 1 |
| Kimura, A | 1 |
| Hohta, SA | 1 |
| Fukuda, N | 1 |
| Kurosawa, T | 1 |
| Izumi, T | 1 |
| Rauchhaus, M | 1 |
| Gross, M | 1 |
| Schulz, S | 1 |
| Francis, DP | 1 |
| Greiser, P | 1 |
| Norwig, A | 1 |
| Weidhase, L | 1 |
| Coats, AJ | 1 |
| Dietz, R | 1 |
| Anker, SD | 1 |
| Gläser, C | 1 |
| Tenkanen, H | 1 |
| Koskinen, P | 1 |
| Metso, J | 1 |
| Baumann, M | 1 |
| Lukka, M | 1 |
| Kauppinen-Mäkelin, R | 1 |
| Kontula, K | 1 |
| Taskinen, MR | 1 |
| Mänttäri, M | 1 |
| Manninen, V | 1 |
| Samofalova, MS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Double Blind Study of the Effects of Homocysteine Lowering Therapy on Mortality and Cardiac Events in Patients Undergoing Coronary Angiography[NCT00354081] | Phase 3 | 3,096 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for serine and Cardiovascular Stroke
| Article | Year |
|---|---|
Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms Modify the Associations of Plasma Glycine and Serine With Risk of Acute Myocardial Infarction in Patients With Stable Angina Pectoris in WENBIT (Western Norway B Vitamin Intervention Trial).
Topics: Aged; Angina, Stable; Coronary Angiography; Female; Gene Frequency; Genetic Predisposition to Diseas | 2016 |
25 other studies available for serine and Cardiovascular Stroke
| Article | Year |
|---|---|
Serine/Threonine-Protein Kinase 3 Facilitates Myocardial Repair After Cardiac Injury Possibly Through the Glycogen Synthase Kinase-3β/β-Catenin Pathway.
Topics: Animals; Apoptosis; beta Catenin; Glycogen Synthase Kinase 3 beta; Mice; Myocardial Infarction; Myoc | 2021 |
Causal relationships of circulating amino acids with cardiovascular disease: a trans-ancestry Mendelian randomization analysis.
Topics: Amino Acids; Angina Pectoris; Cardiovascular Diseases; Coronary Artery Disease; Genome-Wide Associat | 2023 |
Cardiac-Specific Caveolin-3 Overexpression Prevents Post-Myocardial Infarction Ventricular Arrhythmias by Inhibiting Ryanodine Receptor-2 Hyperphosphorylation.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Caveolin 3; Death, Sudden, Cardiac; Male; Mice; Mice, Inbred | 2020 |
Circulating plasma serine208-phosphorylated troponin T levels are indicator of cardiac dysfunction.
Topics: Animals; Biomarkers; Humans; Male; Myocardial Infarction; Phosphorylation; Rats; Rats, Wistar; Serin | 2013 |
The cardioprotective actions of leptin are lost in the Zucker obese (fa/fa) rat.
Topics: Animals; Cardiotonic Agents; Heart Ventricles; Leptin; Male; Mitochondrial Membrane Transport Protei | 2009 |
Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice.
Topics: Animals; Disease Models, Animal; Disease Progression; Echocardiography; Hemodynamics; Mice; Myocardi | 2010 |
Increased αB-crystallin in hypothalamic paraventricular nucleus of rats with myocardial infarction.
Topics: Animals; Crystallins; Disease Models, Animal; Gene Expression Regulation; Male; Microtubule-Associat | 2010 |
c-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Catalysis; Glucose; Ischemia; Male; Mice; Mice, Inbred C | 2011 |
Plasma CD93 concentration is a potential novel biomarker for coronary artery disease.
Topics: Aged; Biomarkers; Case-Control Studies; Coronary Artery Disease; Enzyme-Linked Immunosorbent Assay; | 2011 |
Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase.
Topics: Animals; Apoptosis; Cardiotonic Agents; Caspase 3; Enzyme Inhibitors; Male; Myocardial Infarction; M | 2012 |
Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Calcium Channels, L-Type; Cyclic AMP-Dependent Protein Kinas | 2012 |
Early ischaemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation.
Topics: Animals; Blotting, Western; Coronary Vessels; Cyclic AMP-Dependent Protein Kinases; Disease Models, | 2013 |
CaMKII determines mitochondrial stress responses in heart.
Topics: Animals; Apoptosis; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclosporine; Femal | 2012 |
The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes.
Topics: Animals; Animals, Newborn; Apoptosis; Binding Sites; DNA-Binding Proteins; Genotype; In Situ Nick-En | 2002 |
Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction.
Topics: Asparagine; Circular Dichroism; Genetic Variation; Humans; Myocardial Infarction; Platelet Aggregati | 2004 |
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
Topics: alpha-Crystallin B Chain; Animals; Becaplermin; Blotting, Western; Disease Models, Animal; Enzyme In | 2005 |
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice.
Topics: Animals; Aspartic Acid; Catalysis; Disease Models, Animal; Electrophysiology; Gene Expression Regula | 2006 |
Alanine to serine polymorphism at position 986 of the calcium-sensing receptor associated with coronary heart disease, myocardial infarction, all-cause, and cardiovascular mortality.
Topics: Adult; Aged; Alanine; Calcium; Cause of Death; Coronary Angiography; Coronary Disease; Female; Genet | 2007 |
STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction.
Topics: Animals; Biomarkers; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Butadienes; Capillar | 2007 |
Interaction of the lipoprotein lipase asparagine 291-->serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: a study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults.
Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Arginine; Base Sequence; Body Mass Index; Case-Control | 1995 |
Lipoprotein lipase gene polymorphisms: associations with myocardial infarction and lipoprotein levels, the ECTIM study. Etude Cas Témoin sur l'Infarctus du Myocarde.
Topics: Adult; Asparagine; Base Sequence; Case-Control Studies; Deoxyribonuclease HindIII; Deoxyribonuclease | 1995 |
Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, associated with myocardial infarction in the Japanese.
Topics: Amino Acid Substitution; Antigens, CD; Arginine; Asian People; Asparagine; Coronary Stenosis; Female | 2001 |
The E-selectin SER128ARG gene polymorphism and restenosis after successful coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Arginine; Coronary Angiography; Coronary Disease; Coronary Restenosi | 2002 |
A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127.
Topics: Alleles; Amino Acid Sequence; Apolipoproteins A; Asparagine; Base Sequence; Cholesterol; Codon; Geno | 1992 |
[Levels of free amino acids in the blood and heart muscle in the human at various periods of myocardial infarct (clinical anatomical parallels)].
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Chromatography; Erythrocytes; Glutamates; Glycine; Hi | 1968 |