serine has been researched along with Cardiomegaly in 22 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To study the role of leptin-mediated STAT3 activation during obesity-induced cardiac remodeling, mice in which tyrosine residue 1138 within LepR had been replaced with a serine (LepRS1138) were also analyzed." | 7.79 | Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity. ( Didié, M; Gogiraju, R; Hasenfuss, G; Konstantinides, S; Leifheit-Nestler, M; Schäfer, K; Wagner, NM, 2013) |
| "Quercetin (Q), a flavonoid found in berries and onions, can reduce blood pressure in hypertensive animals and inhibit signal transduction pathways in vitro that regulate cardiac hypertrophy." | 7.73 | Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction. ( Carlstrom, J; David Symons, J; Freeman, D; Jalili, T; Jin, H; Kim, S; Litwin, SE; Wu, TC, 2006) |
| "For example, cardiac hypertrophy in response to phenylephrine agonist infusion for 2 wk was largely blunted in Gata4-S105A mice, as was the hypertrophic response to pressure overload at 1 and 2 wk of applied stimulation." | 5.37 | Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. ( Aronow, BJ; Elrod, JW; Molkentin, JD; Pu, WT; van Berlo, JH, 2011) |
| " However, the contribution of tyrosine phosphorylation (pTyr) to the pathogenesis of cardiac hypertrophy remains unclear." | 4.12 | Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy. ( Ayati, M; Bermea, KC; Everett, AD; Foster, DB; Fu, Z; Gabrielson, K; Heravi, A; Kim, HB; Medina, A; Murphy, AM; Na, CH; Paolocci, N; Ramirez-Correa, GA; Xu, M; Yang, X; Zhang, X, 2022) |
| " To study the role of leptin-mediated STAT3 activation during obesity-induced cardiac remodeling, mice in which tyrosine residue 1138 within LepR had been replaced with a serine (LepRS1138) were also analyzed." | 3.79 | Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity. ( Didié, M; Gogiraju, R; Hasenfuss, G; Konstantinides, S; Leifheit-Nestler, M; Schäfer, K; Wagner, NM, 2013) |
| "Phosphorylation and translocation of serine 722 and serine 910 of phosphorylated FAK play an important role in the de-compensatory cardiac hypertrophy." | 3.74 | [Phosphorylation and nuclear translocation of serine 722 and serine 910 of focal adhesion kinase in hypertrophic cardiac myocytes of left ventricle of spontaneously hypertensive rats]. ( Faqian, L; Li, ZY; Yi, XP; Zhong, L, 2008) |
| "Quercetin (Q), a flavonoid found in berries and onions, can reduce blood pressure in hypertensive animals and inhibit signal transduction pathways in vitro that regulate cardiac hypertrophy." | 3.73 | Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction. ( Carlstrom, J; David Symons, J; Freeman, D; Jalili, T; Jin, H; Kim, S; Litwin, SE; Wu, TC, 2006) |
| "Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure." | 1.42 | Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity. ( Burmeister, BT; Carnegie, GK; Gold, MG; O'Bryan, JP; Skidgel, RA; Wang, L, 2015) |
| "Cardiac hypertrophy is characterized by transcriptional reprogramming of fetal gene expression, and histone deacetylases (HDACs) are tightly linked to the regulation of those genes." | 1.37 | Casein kinase-2α1 induces hypertrophic response by phosphorylation of histone deacetylase 2 S394 and its activation in the heart. ( Cho, YK; Choe, N; Eom, GH; Joung, H; Kee, HJ; Kim, HS; Kim, Y; Ko, JH; Kook, H; Nam, KI; Shin, S, 2011) |
| "For example, cardiac hypertrophy in response to phenylephrine agonist infusion for 2 wk was largely blunted in Gata4-S105A mice, as was the hypertrophic response to pressure overload at 1 and 2 wk of applied stimulation." | 1.37 | Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. ( Aronow, BJ; Elrod, JW; Molkentin, JD; Pu, WT; van Berlo, JH, 2011) |
| "In severe pressure overload-induced cardiac hypertrophy, a dense, stabilized microtubule network forms that interferes with cardiocyte contraction and microtubule-based transport." | 1.36 | Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy. ( Ablonczy, Z; Baicu, CF; Bethard, JR; Cheng, G; Chinnakkannu, P; Cooper, G; Kuppuswamy, D; Menick, DR; Samanna, V, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 12 (54.55) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Robinson, EL | 1 |
| Drawnel, FM | 1 |
| Mehdi, S | 1 |
| Archer, CR | 1 |
| Liu, W | 1 |
| Okkenhaug, H | 1 |
| Alkass, K | 1 |
| Aronsen, JM | 1 |
| Nagaraju, CK | 1 |
| Sjaastad, I | 1 |
| Sipido, KR | 1 |
| Bergmann, O | 1 |
| Arthur, JSC | 1 |
| Wang, X | 1 |
| Roderick, HL | 1 |
| Xu, M | 3 |
| Bermea, KC | 3 |
| Ayati, M | 3 |
| Kim, HB | 3 |
| Yang, X | 3 |
| Medina, A | 3 |
| Fu, Z | 3 |
| Heravi, A | 3 |
| Zhang, X | 3 |
| Na, CH | 3 |
| Everett, AD | 3 |
| Gabrielson, K | 3 |
| Foster, DB | 3 |
| Paolocci, N | 3 |
| Murphy, AM | 3 |
| Ramirez-Correa, GA | 3 |
| Padrón-Barthe, L | 1 |
| Villalba-Orero, M | 1 |
| Gómez-Salinero, JM | 1 |
| Acín-Pérez, R | 1 |
| Cogliati, S | 1 |
| López-Olañeta, M | 1 |
| Ortiz-Sánchez, P | 1 |
| Bonzón-Kulichenko, E | 1 |
| Vázquez, J | 1 |
| García-Pavía, P | 1 |
| Rosenthal, N | 1 |
| Enríquez, JA | 1 |
| Lara-Pezzi, E | 1 |
| Shaw, RM | 1 |
| Nikolova, AP | 1 |
| Walker, LA | 1 |
| Fullerton, DA | 1 |
| Buttrick, PM | 1 |
| Leifheit-Nestler, M | 1 |
| Wagner, NM | 1 |
| Gogiraju, R | 1 |
| Didié, M | 1 |
| Konstantinides, S | 1 |
| Hasenfuss, G | 1 |
| Schäfer, K | 1 |
| Burmeister, BT | 1 |
| Wang, L | 1 |
| Gold, MG | 1 |
| Skidgel, RA | 1 |
| O'Bryan, JP | 1 |
| Carnegie, GK | 1 |
| Zhong, L | 1 |
| Yi, XP | 1 |
| Li, ZY | 1 |
| Faqian, L | 1 |
| Nakajima-Takenaka, C | 1 |
| Zhang, GX | 1 |
| Obata, K | 1 |
| Tohne, K | 1 |
| Matsuyoshi, H | 1 |
| Nagai, Y | 1 |
| Nishiyama, A | 1 |
| Takaki, M | 1 |
| Sartoretto, JL | 1 |
| Jin, BY | 1 |
| Bauer, M | 1 |
| Gertler, FB | 1 |
| Liao, R | 1 |
| Michel, T | 1 |
| Choy, MK | 1 |
| Movassagh, M | 1 |
| Bennett, MR | 1 |
| Foo, RS | 1 |
| Chinnakkannu, P | 1 |
| Samanna, V | 1 |
| Cheng, G | 1 |
| Ablonczy, Z | 1 |
| Baicu, CF | 1 |
| Bethard, JR | 1 |
| Menick, DR | 1 |
| Kuppuswamy, D | 1 |
| Cooper, G | 1 |
| Belke, DD | 1 |
| Eom, GH | 1 |
| Cho, YK | 1 |
| Ko, JH | 1 |
| Shin, S | 1 |
| Choe, N | 1 |
| Kim, Y | 1 |
| Joung, H | 1 |
| Kim, HS | 1 |
| Nam, KI | 1 |
| Kee, HJ | 1 |
| Kook, H | 1 |
| van Berlo, JH | 1 |
| Elrod, JW | 1 |
| Aronow, BJ | 1 |
| Pu, WT | 1 |
| Molkentin, JD | 1 |
| Respress, JL | 1 |
| van Oort, RJ | 1 |
| Li, N | 1 |
| Rolim, N | 1 |
| Dixit, SS | 1 |
| deAlmeida, A | 1 |
| Voigt, N | 1 |
| Lawrence, WS | 1 |
| Skapura, DG | 1 |
| Skårdal, K | 1 |
| Wisløff, U | 1 |
| Wieland, T | 1 |
| Ai, X | 1 |
| Pogwizd, SM | 1 |
| Dobrev, D | 1 |
| Wehrens, XH | 2 |
| Zouein, FA | 1 |
| Zgheib, C | 1 |
| Hamza, S | 1 |
| Fuseler, JW | 1 |
| Hall, JE | 1 |
| Soljancic, A | 1 |
| Lopez-Ruiz, A | 1 |
| Kurdi, M | 1 |
| Booz, GW | 1 |
| Jalili, T | 1 |
| Carlstrom, J | 1 |
| Kim, S | 1 |
| Freeman, D | 1 |
| Jin, H | 1 |
| Wu, TC | 1 |
| Litwin, SE | 1 |
| David Symons, J | 1 |
| Chen-Izu, Y | 1 |
| Ward, CW | 1 |
| Stark, W | 1 |
| Banyasz, T | 1 |
| Sumandea, MP | 1 |
| Balke, CW | 1 |
| Izu, LT | 1 |
| Kemi, OJ | 1 |
| Ceci, M | 1 |
| Wisloff, U | 1 |
| Grimaldi, S | 1 |
| Gallo, P | 1 |
| Smith, GL | 1 |
| Condorelli, G | 1 |
| Ellingsen, O | 1 |
| Gillespie-Brown, J | 1 |
| Fuller, SJ | 1 |
| Bogoyevitch, MA | 1 |
| Cowley, S | 1 |
| Sugden, PH | 1 |
| Huxtable, R | 1 |
| Chubb, J | 1 |
22 other studies available for serine and Cardiomegaly
| Article | Year |
|---|---|
MSK-Mediated Phosphorylation of Histone H3 Ser28 Couples MAPK Signalling with Early Gene Induction and Cardiac Hypertrophy.
Topics: Cardiomegaly; Chromatin Assembly and Disassembly; Gene Expression; Histones; Humans; Phosphorylation | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function.
Topics: Animals; Calcineurin; Cardiomegaly; Humans; Male; Mice; Mice, Transgenic; Myocytes, Cardiac; One-Car | 2018 |
A Surprising Noncanonical Role for Calcineurin in Pressure-Induced Cardiac Hypertrophy.
Topics: Calcineurin; Carbon; Cardiomegaly; Humans; Serine; Ventricular Function | 2018 |
Contractile protein phosphorylation predicts human heart disease phenotypes.
Topics: Aged; Aortic Valve Stenosis; Biopsy; Cardiac Myosins; Cardiomegaly; Case-Control Studies; Female; Ge | 2013 |
Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity.
Topics: Animals; Cardiomegaly; Echocardiography; Immunohistochemistry; Leptin; Mice; Mice, Transgenic; Mutat | 2013 |
Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity.
Topics: Animals; Cardiomegaly; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; HEK293 Cells; Humans; | 2015 |
[Phosphorylation and nuclear translocation of serine 722 and serine 910 of focal adhesion kinase in hypertrophic cardiac myocytes of left ventricle of spontaneously hypertensive rats].
Topics: Animals; Cardiomegaly; Cell Nucleus; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinase | 2008 |
Left ventricular function of isoproterenol-induced hypertrophied rat hearts perfused with blood: mechanical work and energetics.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Blotting, Western; Calcium-Binding Proteins; Card | 2009 |
Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiomegaly; Cell A | 2009 |
PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.
Topics: Animals; Cardiomegaly; Cell Line; Cell Size; Chromones; Deferoxamine; Disease Models, Animal; Fibrob | 2010 |
Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Cats; DNA, Complementary; Mass Spectrometry; Microscopy, Confocal; Microtubul | 2010 |
Swim-exercised mice show a decreased level of protein O-GlcNAcylation and expression of O-GlcNAc transferase in heart.
Topics: Acetylglucosamine; Adaptation, Physiological; Animals; Cardiomegaly; Down-Regulation; Gene Expressio | 2011 |
Casein kinase-2α1 induces hypertrophic response by phosphorylation of histone deacetylase 2 S394 and its activation in the heart.
Topics: Alanine; Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Casein Kinase II; Enzyme Activation; H | 2011 |
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.
Topics: Amino Acid Substitution; Animals; Cardiomegaly; GATA4 Transcription Factor; Gene Expression; Gene Kn | 2011 |
Role of RyR2 phosphorylation at S2814 during heart failure progression.
Topics: Adult; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cardiomyopathy, Di | 2012 |
Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Collagen; Cytokines; Electrocardiography; Fib | 2013 |
Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction.
Topics: Animals; Aorta; Blood Pressure; Blotting, Western; Cardiomegaly; Constriction, Pathologic; Diet; Ext | 2006 |
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.
Topics: Animals; Blotting, Western; Calcium; Cardiomegaly; Computer Simulation; Cyclic AMP-Dependent Protein | 2007 |
Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aorta, Thoracic; Cardiomegaly; Carrier Proteins; Cell | 2008 |
The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes.
Topics: Amino Acid Sequence; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinase | 1995 |
Taurine and isoproterenol toxicity.
Topics: Animals; Cardiomegaly; Glycine; Isoproterenol; Male; Myocardium; Organ Size; Rats; Serine; Taurine; | 1976 |