serine has been researched along with Cardiac Hypertrophy in 22 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To study the role of leptin-mediated STAT3 activation during obesity-induced cardiac remodeling, mice in which tyrosine residue 1138 within LepR had been replaced with a serine (LepRS1138) were also analyzed." | 7.79 | Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity. ( Didié, M; Gogiraju, R; Hasenfuss, G; Konstantinides, S; Leifheit-Nestler, M; Schäfer, K; Wagner, NM, 2013) |
| "Quercetin (Q), a flavonoid found in berries and onions, can reduce blood pressure in hypertensive animals and inhibit signal transduction pathways in vitro that regulate cardiac hypertrophy." | 7.73 | Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction. ( Carlstrom, J; David Symons, J; Freeman, D; Jalili, T; Jin, H; Kim, S; Litwin, SE; Wu, TC, 2006) |
| "For example, cardiac hypertrophy in response to phenylephrine agonist infusion for 2 wk was largely blunted in Gata4-S105A mice, as was the hypertrophic response to pressure overload at 1 and 2 wk of applied stimulation." | 5.37 | Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. ( Aronow, BJ; Elrod, JW; Molkentin, JD; Pu, WT; van Berlo, JH, 2011) |
| " However, the contribution of tyrosine phosphorylation (pTyr) to the pathogenesis of cardiac hypertrophy remains unclear." | 4.12 | Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy. ( Ayati, M; Bermea, KC; Everett, AD; Foster, DB; Fu, Z; Gabrielson, K; Heravi, A; Kim, HB; Medina, A; Murphy, AM; Na, CH; Paolocci, N; Ramirez-Correa, GA; Xu, M; Yang, X; Zhang, X, 2022) |
| " To study the role of leptin-mediated STAT3 activation during obesity-induced cardiac remodeling, mice in which tyrosine residue 1138 within LepR had been replaced with a serine (LepRS1138) were also analyzed." | 3.79 | Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity. ( Didié, M; Gogiraju, R; Hasenfuss, G; Konstantinides, S; Leifheit-Nestler, M; Schäfer, K; Wagner, NM, 2013) |
| "Phosphorylation and translocation of serine 722 and serine 910 of phosphorylated FAK play an important role in the de-compensatory cardiac hypertrophy." | 3.74 | [Phosphorylation and nuclear translocation of serine 722 and serine 910 of focal adhesion kinase in hypertrophic cardiac myocytes of left ventricle of spontaneously hypertensive rats]. ( Faqian, L; Li, ZY; Yi, XP; Zhong, L, 2008) |
| "Quercetin (Q), a flavonoid found in berries and onions, can reduce blood pressure in hypertensive animals and inhibit signal transduction pathways in vitro that regulate cardiac hypertrophy." | 3.73 | Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction. ( Carlstrom, J; David Symons, J; Freeman, D; Jalili, T; Jin, H; Kim, S; Litwin, SE; Wu, TC, 2006) |
| "Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure." | 1.42 | Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity. ( Burmeister, BT; Carnegie, GK; Gold, MG; O'Bryan, JP; Skidgel, RA; Wang, L, 2015) |
| "Cardiac hypertrophy is characterized by transcriptional reprogramming of fetal gene expression, and histone deacetylases (HDACs) are tightly linked to the regulation of those genes." | 1.37 | Casein kinase-2α1 induces hypertrophic response by phosphorylation of histone deacetylase 2 S394 and its activation in the heart. ( Cho, YK; Choe, N; Eom, GH; Joung, H; Kee, HJ; Kim, HS; Kim, Y; Ko, JH; Kook, H; Nam, KI; Shin, S, 2011) |
| "For example, cardiac hypertrophy in response to phenylephrine agonist infusion for 2 wk was largely blunted in Gata4-S105A mice, as was the hypertrophic response to pressure overload at 1 and 2 wk of applied stimulation." | 1.37 | Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. ( Aronow, BJ; Elrod, JW; Molkentin, JD; Pu, WT; van Berlo, JH, 2011) |
| "In severe pressure overload-induced cardiac hypertrophy, a dense, stabilized microtubule network forms that interferes with cardiocyte contraction and microtubule-based transport." | 1.36 | Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy. ( Ablonczy, Z; Baicu, CF; Bethard, JR; Cheng, G; Chinnakkannu, P; Cooper, G; Kuppuswamy, D; Menick, DR; Samanna, V, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 12 (54.55) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Robinson, EL | 1 |
| Drawnel, FM | 1 |
| Mehdi, S | 1 |
| Archer, CR | 1 |
| Liu, W | 1 |
| Okkenhaug, H | 1 |
| Alkass, K | 1 |
| Aronsen, JM | 1 |
| Nagaraju, CK | 1 |
| Sjaastad, I | 1 |
| Sipido, KR | 1 |
| Bergmann, O | 1 |
| Arthur, JSC | 1 |
| Wang, X | 1 |
| Roderick, HL | 1 |
| Xu, M | 3 |
| Bermea, KC | 3 |
| Ayati, M | 3 |
| Kim, HB | 3 |
| Yang, X | 3 |
| Medina, A | 3 |
| Fu, Z | 3 |
| Heravi, A | 3 |
| Zhang, X | 3 |
| Na, CH | 3 |
| Everett, AD | 3 |
| Gabrielson, K | 3 |
| Foster, DB | 3 |
| Paolocci, N | 3 |
| Murphy, AM | 3 |
| Ramirez-Correa, GA | 3 |
| Padrón-Barthe, L | 1 |
| Villalba-Orero, M | 1 |
| Gómez-Salinero, JM | 1 |
| Acín-Pérez, R | 1 |
| Cogliati, S | 1 |
| López-Olañeta, M | 1 |
| Ortiz-Sánchez, P | 1 |
| Bonzón-Kulichenko, E | 1 |
| Vázquez, J | 1 |
| García-Pavía, P | 1 |
| Rosenthal, N | 1 |
| Enríquez, JA | 1 |
| Lara-Pezzi, E | 1 |
| Shaw, RM | 1 |
| Nikolova, AP | 1 |
| Walker, LA | 1 |
| Fullerton, DA | 1 |
| Buttrick, PM | 1 |
| Leifheit-Nestler, M | 1 |
| Wagner, NM | 1 |
| Gogiraju, R | 1 |
| Didié, M | 1 |
| Konstantinides, S | 1 |
| Hasenfuss, G | 1 |
| Schäfer, K | 1 |
| Burmeister, BT | 1 |
| Wang, L | 1 |
| Gold, MG | 1 |
| Skidgel, RA | 1 |
| O'Bryan, JP | 1 |
| Carnegie, GK | 1 |
| Zhong, L | 1 |
| Yi, XP | 1 |
| Li, ZY | 1 |
| Faqian, L | 1 |
| Nakajima-Takenaka, C | 1 |
| Zhang, GX | 1 |
| Obata, K | 1 |
| Tohne, K | 1 |
| Matsuyoshi, H | 1 |
| Nagai, Y | 1 |
| Nishiyama, A | 1 |
| Takaki, M | 1 |
| Sartoretto, JL | 1 |
| Jin, BY | 1 |
| Bauer, M | 1 |
| Gertler, FB | 1 |
| Liao, R | 1 |
| Michel, T | 1 |
| Choy, MK | 1 |
| Movassagh, M | 1 |
| Bennett, MR | 1 |
| Foo, RS | 1 |
| Chinnakkannu, P | 1 |
| Samanna, V | 1 |
| Cheng, G | 1 |
| Ablonczy, Z | 1 |
| Baicu, CF | 1 |
| Bethard, JR | 1 |
| Menick, DR | 1 |
| Kuppuswamy, D | 1 |
| Cooper, G | 1 |
| Belke, DD | 1 |
| Eom, GH | 1 |
| Cho, YK | 1 |
| Ko, JH | 1 |
| Shin, S | 1 |
| Choe, N | 1 |
| Kim, Y | 1 |
| Joung, H | 1 |
| Kim, HS | 1 |
| Nam, KI | 1 |
| Kee, HJ | 1 |
| Kook, H | 1 |
| van Berlo, JH | 1 |
| Elrod, JW | 1 |
| Aronow, BJ | 1 |
| Pu, WT | 1 |
| Molkentin, JD | 1 |
| Respress, JL | 1 |
| van Oort, RJ | 1 |
| Li, N | 1 |
| Rolim, N | 1 |
| Dixit, SS | 1 |
| deAlmeida, A | 1 |
| Voigt, N | 1 |
| Lawrence, WS | 1 |
| Skapura, DG | 1 |
| Skårdal, K | 1 |
| Wisløff, U | 1 |
| Wieland, T | 1 |
| Ai, X | 1 |
| Pogwizd, SM | 1 |
| Dobrev, D | 1 |
| Wehrens, XH | 2 |
| Zouein, FA | 1 |
| Zgheib, C | 1 |
| Hamza, S | 1 |
| Fuseler, JW | 1 |
| Hall, JE | 1 |
| Soljancic, A | 1 |
| Lopez-Ruiz, A | 1 |
| Kurdi, M | 1 |
| Booz, GW | 1 |
| Jalili, T | 1 |
| Carlstrom, J | 1 |
| Kim, S | 1 |
| Freeman, D | 1 |
| Jin, H | 1 |
| Wu, TC | 1 |
| Litwin, SE | 1 |
| David Symons, J | 1 |
| Chen-Izu, Y | 1 |
| Ward, CW | 1 |
| Stark, W | 1 |
| Banyasz, T | 1 |
| Sumandea, MP | 1 |
| Balke, CW | 1 |
| Izu, LT | 1 |
| Kemi, OJ | 1 |
| Ceci, M | 1 |
| Wisloff, U | 1 |
| Grimaldi, S | 1 |
| Gallo, P | 1 |
| Smith, GL | 1 |
| Condorelli, G | 1 |
| Ellingsen, O | 1 |
| Gillespie-Brown, J | 1 |
| Fuller, SJ | 1 |
| Bogoyevitch, MA | 1 |
| Cowley, S | 1 |
| Sugden, PH | 1 |
| Huxtable, R | 1 |
| Chubb, J | 1 |
22 other studies available for serine and Cardiac Hypertrophy
| Article | Year |
|---|---|
MSK-Mediated Phosphorylation of Histone H3 Ser28 Couples MAPK Signalling with Early Gene Induction and Cardiac Hypertrophy.
Topics: Cardiomegaly; Chromatin Assembly and Disassembly; Gene Expression; Histones; Humans; Phosphorylation | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threon | 2022 |
Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function.
Topics: Animals; Calcineurin; Cardiomegaly; Humans; Male; Mice; Mice, Transgenic; Myocytes, Cardiac; One-Car | 2018 |
A Surprising Noncanonical Role for Calcineurin in Pressure-Induced Cardiac Hypertrophy.
Topics: Calcineurin; Carbon; Cardiomegaly; Humans; Serine; Ventricular Function | 2018 |
Contractile protein phosphorylation predicts human heart disease phenotypes.
Topics: Aged; Aortic Valve Stenosis; Biopsy; Cardiac Myosins; Cardiomegaly; Case-Control Studies; Female; Ge | 2013 |
Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity.
Topics: Animals; Cardiomegaly; Echocardiography; Immunohistochemistry; Leptin; Mice; Mice, Transgenic; Mutat | 2013 |
Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity.
Topics: Animals; Cardiomegaly; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; HEK293 Cells; Humans; | 2015 |
[Phosphorylation and nuclear translocation of serine 722 and serine 910 of focal adhesion kinase in hypertrophic cardiac myocytes of left ventricle of spontaneously hypertensive rats].
Topics: Animals; Cardiomegaly; Cell Nucleus; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinase | 2008 |
Left ventricular function of isoproterenol-induced hypertrophied rat hearts perfused with blood: mechanical work and energetics.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Blotting, Western; Calcium-Binding Proteins; Card | 2009 |
Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiomegaly; Cell A | 2009 |
PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.
Topics: Animals; Cardiomegaly; Cell Line; Cell Size; Chromones; Deferoxamine; Disease Models, Animal; Fibrob | 2010 |
Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Cats; DNA, Complementary; Mass Spectrometry; Microscopy, Confocal; Microtubul | 2010 |
Swim-exercised mice show a decreased level of protein O-GlcNAcylation and expression of O-GlcNAc transferase in heart.
Topics: Acetylglucosamine; Adaptation, Physiological; Animals; Cardiomegaly; Down-Regulation; Gene Expressio | 2011 |
Casein kinase-2α1 induces hypertrophic response by phosphorylation of histone deacetylase 2 S394 and its activation in the heart.
Topics: Alanine; Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Casein Kinase II; Enzyme Activation; H | 2011 |
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.
Topics: Amino Acid Substitution; Animals; Cardiomegaly; GATA4 Transcription Factor; Gene Expression; Gene Kn | 2011 |
Role of RyR2 phosphorylation at S2814 during heart failure progression.
Topics: Adult; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cardiomyopathy, Di | 2012 |
Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Collagen; Cytokines; Electrocardiography; Fib | 2013 |
Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction.
Topics: Animals; Aorta; Blood Pressure; Blotting, Western; Cardiomegaly; Constriction, Pathologic; Diet; Ext | 2006 |
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.
Topics: Animals; Blotting, Western; Calcium; Cardiomegaly; Computer Simulation; Cyclic AMP-Dependent Protein | 2007 |
Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aorta, Thoracic; Cardiomegaly; Carrier Proteins; Cell | 2008 |
The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes.
Topics: Amino Acid Sequence; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinase | 1995 |
Taurine and isoproterenol toxicity.
Topics: Animals; Cardiomegaly; Glycine; Isoproterenol; Male; Myocardium; Organ Size; Rats; Serine; Taurine; | 1976 |