serine has been researched along with Carcinoma, Squamous Cell in 41 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Most oral cancers are squamous cell carcinomas that predominantly develop from cell hyperplasias and dysplasias." | 1.46 | S4S8-RPA phosphorylation as an indicator of cancer progression in oral squamous cell carcinomas. ( Byrne, BM; DiMaio, DJ; Giannini, P; Glanzer, JG; Kapil, S; Kumm, P; Liu, S; Oakley, GG; Rector, J; Smith, LM; Smith, RB; Treude, KJ, 2017) |
| "Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by high resistance to radiotherapy, which critically depends on both altered signaling pathways within tumor cells and their dynamic interaction with the tumor microenvironment." | 1.42 | Phosphorylation of AKT(Ser473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma. ( Dyckhoff, G; Freier, K; Freudlsperger, C; Grabe, N; Hess, J; Hoffmann, J; Horn, D; Plinkert, P; Saure, D; Sharma, S; Weber, KJ; Weichert, W; Weißfuß, S, 2015) |
| "A panel of HNSCC cell lines was determined with anoikis assays, and orthotopic mouse experiments were performed." | 1.39 | Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells. ( Brennan, RG; Jasser, SA; Myers, JN; Sano, D; Xie, TX; Zhao, M; Zhou, G, 2013) |
| "During squamous cell carcinoma (SCC) invasion, there is a reduction in the number of HDs, which may facilitate dissemination." | 1.37 | Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration. ( Germain, E; Kashyap, T; Lyle, S; Rabinovitz, I; Roche, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.32) | 18.7374 |
| 1990's | 3 (7.32) | 18.2507 |
| 2000's | 14 (34.15) | 29.6817 |
| 2010's | 16 (39.02) | 24.3611 |
| 2020's | 5 (12.20) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, Z | 1 |
| Chang, X | 1 |
| Xie, L | 1 |
| Wang, Y | 1 |
| Hou, Y | 1 |
| Chen, GS | 1 |
| Chen, SY | 1 |
| Liu, ST | 1 |
| Hsieh, CC | 1 |
| Lee, SP | 1 |
| Huang, SM | 1 |
| Grenda, A | 1 |
| Krawczyk, P | 1 |
| Targowska-Duda, KM | 1 |
| Kieszko, R | 1 |
| Paśnik, I | 1 |
| Milanowski, J | 1 |
| Baksh, SC | 1 |
| Todorova, PK | 1 |
| Gur-Cohen, S | 1 |
| Hurwitz, B | 1 |
| Ge, Y | 1 |
| Novak, JSS | 1 |
| Tierney, MT | 1 |
| Dela Cruz-Racelis, J | 1 |
| Fuchs, E | 1 |
| Finley, LWS | 1 |
| Sharif Siam, MK | 1 |
| Sarker, A | 1 |
| Sayeem, MMS | 1 |
| Zhang, X | 1 |
| Wu, X | 1 |
| Zhang, F | 1 |
| Mo, S | 1 |
| Lu, Y | 2 |
| Wei, W | 1 |
| Chen, X | 1 |
| Lan, L | 1 |
| Lu, B | 1 |
| Liu, Y | 1 |
| Li, LY | 1 |
| Xie, YH | 1 |
| Xie, YM | 1 |
| Liao, LD | 1 |
| Xu, XE | 2 |
| Zhang, Q | 1 |
| Zeng, FM | 1 |
| Tao, LH | 1 |
| Xie, WM | 1 |
| Xie, JJ | 2 |
| Xu, LY | 2 |
| Li, EM | 2 |
| Xie, TX | 1 |
| Zhou, G | 1 |
| Zhao, M | 1 |
| Sano, D | 1 |
| Jasser, SA | 1 |
| Brennan, RG | 1 |
| Myers, JN | 1 |
| Gao, J | 1 |
| Li, X | 1 |
| Jiang, J | 1 |
| Zhang, J | 1 |
| Zhou, J | 1 |
| Zhang, P | 1 |
| Wang, W | 1 |
| Tao, S | 1 |
| Wang, M | 1 |
| Bernard, JJ | 1 |
| Lou, YR | 1 |
| Peng, QY | 1 |
| Li, T | 1 |
| Conney, AH | 1 |
| Lu, YP | 1 |
| Song, L | 1 |
| Smith, MA | 1 |
| Doshi, P | 1 |
| Sasser, K | 1 |
| Fulp, W | 1 |
| Altiok, S | 1 |
| Haura, EB | 1 |
| Freudlsperger, C | 1 |
| Horn, D | 1 |
| Weißfuß, S | 1 |
| Weichert, W | 1 |
| Weber, KJ | 1 |
| Saure, D | 1 |
| Sharma, S | 1 |
| Dyckhoff, G | 1 |
| Grabe, N | 1 |
| Plinkert, P | 1 |
| Hoffmann, J | 1 |
| Freier, K | 1 |
| Hess, J | 1 |
| Rector, J | 1 |
| Kapil, S | 1 |
| Treude, KJ | 1 |
| Kumm, P | 1 |
| Glanzer, JG | 1 |
| Byrne, BM | 1 |
| Liu, S | 1 |
| Smith, LM | 1 |
| DiMaio, DJ | 1 |
| Giannini, P | 1 |
| Smith, RB | 1 |
| Oakley, GG | 1 |
| Gkouveris, I | 1 |
| Nikitakis, N | 1 |
| Avgoustidis, D | 1 |
| Karanikou, M | 1 |
| Rassidakis, G | 1 |
| Sklavounou, A | 1 |
| Lu, H | 1 |
| Cai, Y | 1 |
| Yu, YN | 1 |
| Yang, H | 1 |
| Arun, P | 1 |
| Brown, MS | 1 |
| Ehsanian, R | 1 |
| Chen, Z | 1 |
| Van Waes, C | 1 |
| Okasaka, T | 1 |
| Matsuo, K | 1 |
| Suzuki, T | 1 |
| Ito, H | 1 |
| Hosono, S | 1 |
| Kawase, T | 1 |
| Watanabe, M | 1 |
| Yatabe, Y | 1 |
| Hida, T | 1 |
| Mitsudomi, T | 1 |
| Tanaka, H | 1 |
| Yokoi, K | 1 |
| Tajima, K | 2 |
| Wang, Z | 1 |
| Trope, CG | 1 |
| Flørenes, VA | 1 |
| Suo, Z | 1 |
| Nesland, JM | 1 |
| Holm, R | 1 |
| Zhao, Q | 1 |
| Shen, JH | 1 |
| Shen, ZY | 1 |
| Wu, ZY | 1 |
| Wu, JY | 1 |
| Huang, Q | 1 |
| Lu, XF | 1 |
| Tsai, WC | 1 |
| Lin, YC | 1 |
| Tsai, ST | 1 |
| Shen, WH | 1 |
| Chao, TL | 1 |
| Lee, SL | 1 |
| Wu, LW | 1 |
| Bachelor, MA | 1 |
| Owens, DM | 1 |
| Kashyap, T | 1 |
| Germain, E | 1 |
| Roche, M | 1 |
| Lyle, S | 1 |
| Rabinovitz, I | 1 |
| Clémenson, C | 1 |
| Jouannot, E | 1 |
| Merino-Trigo, A | 1 |
| Rubin-Carrez, C | 1 |
| Deutsch, E | 1 |
| Sun, P | 1 |
| Wang, XQ | 1 |
| Lopatka, K | 1 |
| Bangash, S | 1 |
| Paller, AS | 1 |
| Holownia, A | 2 |
| Mroz, RM | 2 |
| Kozlowski, M | 1 |
| Chyczewska, E | 2 |
| Laudanski, J | 1 |
| Chyczewski, L | 2 |
| Braszko, JJ | 2 |
| Matsumoto, M | 2 |
| Furihata, M | 2 |
| Kurabayashi, A | 2 |
| Ohtsuki, Y | 2 |
| Sasaguri, S | 1 |
| Araki, K | 1 |
| Hayashi, H | 1 |
| Ichwan, SJ | 1 |
| Yamada, S | 1 |
| Sumrejkanchanakij, P | 1 |
| Ibrahim-Auerkari, E | 1 |
| Eto, K | 1 |
| Ikeda, MA | 1 |
| Hashimoto, T | 1 |
| Uchida, K | 1 |
| Okayama, N | 1 |
| Imate, Y | 1 |
| Suehiro, Y | 1 |
| Hamanaka, Y | 1 |
| Ueyama, Y | 1 |
| Yamashita, H | 1 |
| Hinoda, Y | 1 |
| Solodovnikova, AS | 1 |
| Merkulova, NA | 1 |
| Perova, AA | 1 |
| Sedova, VM | 1 |
| Popanda, O | 1 |
| Edler, L | 1 |
| Waas, P | 1 |
| Schattenberg, T | 1 |
| Butkiewicz, D | 1 |
| Muley, T | 1 |
| Dienemann, H | 1 |
| Risch, A | 1 |
| Bartsch, H | 1 |
| Schmezer, P | 1 |
| Mo, JS | 1 |
| Kim, MY | 1 |
| Han, SO | 1 |
| Kim, IS | 1 |
| Ann, EJ | 1 |
| Lee, KS | 1 |
| Seo, MS | 1 |
| Kim, JY | 1 |
| Lee, SC | 1 |
| Park, JW | 1 |
| Choi, EJ | 1 |
| Seong, JY | 1 |
| Joe, CO | 1 |
| Faessler, R | 1 |
| Park, HS | 1 |
| Zhou, Q | 1 |
| Hakomori, S | 1 |
| Kitamura, K | 1 |
| Igarashi, Y | 1 |
| Carter, S | 1 |
| Auer, KL | 1 |
| Reardon, DB | 1 |
| Birrer, M | 1 |
| Fisher, PB | 1 |
| Valerie, K | 1 |
| Schmidt-Ullrich, R | 1 |
| Mikkelsen, R | 1 |
| Dent, P | 1 |
| Sugimura, H | 1 |
| Kohno, T | 1 |
| Wakai, K | 1 |
| Nagura, K | 1 |
| Genka, K | 1 |
| Igarashi, H | 1 |
| Morris, BJ | 1 |
| Baba, S | 1 |
| Ohno, Y | 1 |
| Gao, C | 1 |
| Li, Z | 1 |
| Wang, J | 1 |
| Takezaki, T | 1 |
| Varga, T | 1 |
| Sawaguchi, T | 1 |
| Lum, JK | 1 |
| Martinson, JJ | 1 |
| Tsugane, S | 1 |
| Iwamasa, T | 1 |
| Shinmura, K | 1 |
| Yokota, J | 1 |
| Huang, YT | 1 |
| Hwang, JJ | 1 |
| Lee, LT | 1 |
| Liebow, C | 1 |
| Lee, PP | 1 |
| Ke, FC | 1 |
| Lo, TB | 1 |
| Schally, AV | 1 |
| Lee, MT | 1 |
| Nishimura, M | 1 |
| Nakada, H | 1 |
| Kawamura, I | 1 |
| Mizota, T | 1 |
| Shimomura, K | 1 |
| Nakahara, K | 1 |
| Goto, T | 1 |
| Yamaguchi, I | 1 |
| Okuhara, M | 1 |
| Davis, RJ | 1 |
| Johnson, GL | 1 |
| Kelleher, DJ | 1 |
| Anderson, JK | 1 |
| Mole, JE | 1 |
| Czech, MP | 1 |
| Yudelevich, S | 1 |
| Grado, C | 1 |
| Icekson, I | 1 |
| Contreras, G | 1 |
2 reviews available for serine and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Efficacy of Dabrafenib and Trametinib in a Patient with Squamous-Cell Carcinoma, with Mutation p.D594G in
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Extracellular Signal-Regulated MAP K | 2023 |
A meta-analysis of the association between the hOGG1 Ser326Cys polymorphism and the risk of esophageal squamous cell carcinoma.
Topics: Aged; Alleles; Carcinoma, Squamous Cell; Case-Control Studies; Cysteine; DNA Glycosylases; Esophagea | 2013 |
39 other studies available for serine and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Increased expression of SRPK1 (serine/arginine-rich protein-specific kinase 1) is associated with progression and unfavorable prognosis in cervical squamous cell carcinoma.
Topics: Arginine; Carcinoma, Squamous Cell; Female; Humans; Prognosis; Protein Serine-Threonine Kinases; Ret | 2022 |
Stabilization of the c-Myc Protein via the Modulation of Threonine 58 and Serine 62 Phosphorylation by the Disulfiram/Copper Complex in Oral Cancer Cells.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Copper; Disulfiram; Humans; Mouth Neoplasms; Phosphoryla | 2022 |
Extracellular serine controls epidermal stem cell fate and tumour initiation.
Topics: Animals; Carcinoma, Squamous Cell; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cul | 2020 |
Topics: Carcinoma, Squamous Cell; Cytochrome P-450 Enzyme System; Drug Design; Head and Neck Neoplasms; Huma | 2021 |
Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Respo | 2017 |
Ezrin Ser66 phosphorylation regulates invasion and metastasis of esophageal squamous cell carcinoma cells by mediating filopodia formation.
Topics: Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cytos | 2017 |
Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells.
Topics: Animals; Anoikis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Codon; Disease Prog | 2013 |
[The study of serine/threonine kinase signaling pathway-mediated inhibition of proliferation and invasion of oral squamous cell carcinoma transfected with p53 gene].
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Proliferation; Cyclin D1; Genes, p53; Humans; | 2013 |
Inverse relationship between p53 and phospho-Chk1 (Ser317) protein expression in UVB-induced skin tumors in SKH-1 mice.
Topics: Animals; Blotting, Western; Carcinoma, Squamous Cell; Checkpoint Kinase 1; Female; Mice; Mice, Hairl | 2014 |
Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chem | 2014 |
Phosphorylation of AKT(Ser473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Chromones; Enzyme Inhib | 2015 |
S4S8-RPA phosphorylation as an indicator of cancer progression in oral squamous cell carcinomas.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Damage; DNA Repair; Head and Neck | 2017 |
ERK1/2, JNK and STAT3 activation and correlation with tumor differentiation in oral SCC.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Differentiation; Female; Humans; Immu | 2017 |
[The over-expression of serine/threonine kinase 15 protein in oral carcinogenesis].
Topics: Aurora Kinase A; Carcinogenesis; Carcinoma, Squamous Cell; Humans; Immunohistochemistry; Lymphatic M | 2009 |
Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer.
Topics: Carcinoma, Squamous Cell; Cell Cycle; Cell Nucleus; Cell Proliferation; Cyclic AMP-Dependent Protein | 2009 |
hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Case-Control Studies; | 2009 |
Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes.
Topics: Adult; Aged; Aged, 80 and over; Antibody Specificity; Blotting, Western; Carcinoma, Squamous Cell; c | 2010 |
Phosphorylation of fascin decreases the risk of poor survival in patients with esophageal squamous cell carcinoma.
Topics: Adult; Aged; Animals; Antibody Specificity; Carcinoma, Squamous Cell; Carrier Proteins; Cell Line, T | 2010 |
Lack of modulatory function of coding nucleotide polymorphism S100A2_185G>A in oral squamous cell carcinoma.
Topics: Adenine; Adult; Aged; Alleles; Amino Acid Substitution; Asparagine; Carcinoma, Squamous Cell; Cell L | 2011 |
L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis.
Topics: Animals; Apoptosis; Base Sequence; Carcinoma, Squamous Cell; Cell Proliferation; Dimerization; DNA P | 2011 |
Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration.
Topics: Basement Membrane; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Drug Stability; Hemide | 2011 |
The vascular disrupting agent ombrabulin (AVE8062) enhances the efficacy of standard therapies in head and neck squamous cell carcinoma xenograft models.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosi | 2013 |
Ganglioside loss promotes survival primarily by activating integrin-linked kinase/Akt without phosphoinositide 3-OH kinase signaling.
Topics: Apoptosis; bcl-Associated Death Protein; Carcinoma, Squamous Cell; Carrier Proteins; Caspase 9; Casp | 2002 |
Therapy increases poly-ADP-ribose and p53-Ser392-P levels in recurrent squamous cell lung cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Carcinoma, Squamous Cell; Cisplatin; C | 2003 |
p53 N-terminal Ser-15 approximately P and Ser-20 approximately P levels in squamous cell lung cancer after radio/chemotherapy.
Topics: Aged; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; DNA Damage; Humans; Ki-67 Anti | 2004 |
Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors.
Topics: Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Gene Expression Regulation, Neopla | 2004 |
Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Proli | 2004 |
Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.
Topics: Adenoviridae; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Humans; Lung Neop | 2006 |
Interaction of OGG1 Ser326Cys polymorphism with cigarette smoking in head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Carcinoma, Squamous Cell; Cysteine; DNA Glycosylas | 2006 |
[Subunits of human holoenzyme of DNA dependent RNA polymerase III phosphorylated in vivo].
Topics: Carcinoma, Squamous Cell; Catalytic Domain; Cell Line, Tumor; Cell Nucleus; Chromatography, DEAE-Cel | 2005 |
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Carcinoma, Squamo | 2007 |
Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase.
Topics: Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Nucleus; Down-Regulation; Humans; Mel | 2007 |
GM3 directly inhibits tyrosine phosphorylation and de-N-acetyl-GM3 directly enhances serine phosphorylation of epidermal growth factor receptor, independently of receptor-receptor interaction.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Dogs; ErbB Receptors; Erythrocytes; G(M | 1994 |
Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells.
Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell De | 1998 |
hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Carcinoma, Squamous Cell; Case-Control Studies; Cysteine; D | 1999 |
Inhibitory effects of a luteinizing hormone-releasing hormone agonist on basal and epidermal growth factor-induced cell proliferation and metastasis-associated properties in human epidermoid carcinoma A431 cells.
Topics: Antineoplastic Agents, Hormonal; Carcinoma, Squamous Cell; Caspases; Cell Division; DNA Fragmentatio | 2002 |
A new antitumor antibiotic, FR900840. III. Antitumor activity against experimental tumors.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Carcinoma, Small Cell; Carcinoma, Squamous Cel | 1989 |
Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C.
Topics: Amino Acid Sequence; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Humans; Molecular Weight; P | 1986 |
Chromatographic analysis of aminoacyl tRNAs of poliovirus infected HEp-2 cells.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Arginine; Carbon Radioisotopes; Carcinoma, Squa | 1974 |