serine has been researched along with Carcinoma, Non-Small Cell Lung in 32 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Excerpt | Relevance | Reference |
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"5-35 mg/m2) in combination with docetaxel (60 or 75 mg/m2) and cisplatin (75 mg/m2), agents were administered 24 h apart every 3 weeks to Japanese patients with advanced solid tumors." | 2.87 | Phase 1 study of ombrabulin in combination with docetaxel and cisplatin in Japanese patients with advanced solid tumors. ( Ecstein-Fraisse, E; Hida, T; Horiike, A; Horio, Y; Nishio, M; Satouchi, M; Sunaga, Y, 2018) |
"Irinotecan has also displayed efficacy in clinical trials of NSCLC." | 1.42 | Topoisomerase-I PS506 as a Dual Function Cancer Biomarker. ( Gjerset, RA; Zhao, M, 2015) |
"Our results define a role for PCK2 in cancer cell metabolic reprogramming that promotes glucose-independent cell growth and metabolic stress resistance in human tumors." | 1.42 | Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. ( Artyomov, MN; Avizonis, D; Blagih, J; Bridon, G; Choinière, L; Coelho, PP; Elder, DJ; Flynn, BR; Gingras, MC; Griss, T; Jones, RG; Loginicheva, E; Ntimbane, T; Pause, A; Raissi, TC; Samborska, B; Sergushichev, A; Tavaré, JM; Thomas, EC; Vincent, EE, 2015) |
"In addition, LY2603618-treated lung cancer cells transitioned from LC3-I to LC3-II, a hallmark of autophagy." | 1.40 | The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. ( Cui, YJ; Fei, HR; Li, ZM; Sun, BL; Sun, YK; Wang, FZ; Wang, XY; Yang, XY; Zhang, JG, 2014) |
"TICs from primary NSCLC tumors express high levels of the oncogenic stem cell factor LIN28B and GLDC, which are both required for TIC growth and tumorigenesis." | 1.38 | Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. ( Ahmed, DA; Ang, HS; Bhakoo, KK; Jayapal, SR; Kaldis, P; Lim, B; Lim, EH; Ma, S; Mitchell, W; Nga, ME; Nichane, M; Noghabi, MS; Pang, YH; Rai, A; Robson, P; Shyh-Chang, N; Sing, WP; Soh, BS; Soo, RA; Sun, LL; Swarup, S; Tai, BC; Tam, J; Tan, C; Thirugananam, A; Umashankar, S; Yang, H; Yu, Q; Zhang, WC, 2012) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 7 (21.88) | 29.6817 |
2010's | 17 (53.13) | 24.3611 |
2020's | 8 (25.00) | 2.80 |
Authors | Studies |
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Chen, P | 1 |
Qin, Z | 1 |
Sun, X | 1 |
Yang, J | 1 |
Lv, J | 1 |
Diao, M | 1 |
Li, L | 2 |
Li, P | 1 |
Ma, X | 1 |
Zeng, S | 2 |
Peng, Y | 2 |
Zhang, G | 2 |
Du, W | 1 |
Wang, H | 1 |
Zhao, Y | 2 |
Huang, Z | 1 |
Valencia, K | 1 |
Echepare, M | 1 |
Teijeira, Á | 1 |
Pasquier, A | 1 |
Bértolo, C | 1 |
Sainz, C | 1 |
Tamayo, I | 1 |
Picabea, B | 1 |
Bosco, G | 1 |
Thomas, R | 1 |
Agorreta, J | 1 |
López-Picazo, JM | 1 |
Frigola, J | 1 |
Amat, R | 1 |
Calvo, A | 1 |
Felip, E | 1 |
Melero, I | 1 |
Montuenga, LM | 1 |
Li, D | 1 |
Zhang, X | 1 |
Ding, Z | 1 |
Ai, R | 1 |
Shi, L | 1 |
Wang, Z | 1 |
He, Q | 1 |
Dong, Y | 1 |
Zhu, Y | 1 |
Ouyang, W | 1 |
He, Y | 2 |
Grenda, A | 1 |
Krawczyk, P | 1 |
Targowska-Duda, KM | 1 |
Kieszko, R | 1 |
Paśnik, I | 1 |
Milanowski, J | 1 |
Volz, C | 1 |
Breid, S | 1 |
Selenz, C | 1 |
Zaplatina, A | 1 |
Golfmann, K | 1 |
Meder, L | 1 |
Dietlein, F | 1 |
Borchmann, S | 1 |
Chatterjee, S | 1 |
Siobal, M | 1 |
Schöttle, J | 1 |
Florin, A | 1 |
Koker, M | 1 |
Nill, M | 1 |
Ozretić, L | 1 |
Uhlenbrock, N | 1 |
Smith, S | 1 |
Büttner, R | 1 |
Miao, H | 1 |
Wang, B | 1 |
Reinhardt, HC | 1 |
Rauh, D | 1 |
Hallek, M | 1 |
Acker-Palmer, A | 1 |
Heukamp, LC | 1 |
Ullrich, RT | 1 |
Krassikova, L | 1 |
Zhang, B | 1 |
Nagarajan, D | 1 |
Queiroz, AL | 1 |
Kacal, M | 1 |
Samakidis, E | 1 |
Vakifahmetoglu-Norberg, H | 1 |
Norberg, E | 1 |
Nishio, M | 1 |
Satouchi, M | 1 |
Horiike, A | 1 |
Horio, Y | 1 |
Sunaga, Y | 1 |
Ecstein-Fraisse, E | 1 |
Hida, T | 1 |
Mu, Y | 1 |
Zhou, Y | 2 |
Wang, Y | 2 |
Li, W | 1 |
Zhou, L | 1 |
Lu, X | 2 |
Gao, P | 1 |
Gao, M | 1 |
Wang, Q | 1 |
Xu, G | 1 |
Shi, S | 1 |
Zhang, J | 1 |
Liu, M | 1 |
Dong, H | 1 |
Li, N | 1 |
von Pawel, J | 1 |
Gorbounova, V | 1 |
Reck, M | 1 |
Kowalski, DM | 1 |
Allard, A | 1 |
Chadjaa, M | 1 |
Rey, A | 1 |
Bennouna, J | 1 |
Grossi, F | 1 |
Song, L | 1 |
Smith, MA | 1 |
Doshi, P | 1 |
Sasser, K | 1 |
Fulp, W | 1 |
Altiok, S | 1 |
Haura, EB | 1 |
Wang, FZ | 1 |
Fei, HR | 1 |
Cui, YJ | 1 |
Sun, YK | 1 |
Li, ZM | 1 |
Wang, XY | 1 |
Yang, XY | 1 |
Zhang, JG | 1 |
Sun, BL | 1 |
Zajkowicz, A | 1 |
Butkiewicz, D | 1 |
Drosik, A | 1 |
Giglok, M | 1 |
Suwiński, R | 1 |
Rusin, M | 1 |
Yamada, N | 1 |
Tanaka, T | 2 |
Hori, T | 1 |
Yokoyama, S | 1 |
Hayakawa, Y | 1 |
Yano, S | 1 |
Fukuoka, J | 1 |
Koizumi, K | 1 |
Saiki, I | 1 |
Sakurai, H | 1 |
Zhao, M | 1 |
Gjerset, RA | 2 |
Vincent, EE | 2 |
Sergushichev, A | 1 |
Griss, T | 1 |
Gingras, MC | 1 |
Samborska, B | 1 |
Ntimbane, T | 1 |
Coelho, PP | 1 |
Blagih, J | 1 |
Raissi, TC | 1 |
Choinière, L | 1 |
Bridon, G | 1 |
Loginicheva, E | 1 |
Flynn, BR | 1 |
Thomas, EC | 2 |
Tavaré, JM | 2 |
Avizonis, D | 1 |
Pause, A | 1 |
Elder, DJ | 2 |
Artyomov, MN | 1 |
Jones, RG | 1 |
DeNicola, GM | 1 |
Chen, PH | 1 |
Mullarky, E | 1 |
Sudderth, JA | 1 |
Hu, Z | 1 |
Wu, D | 1 |
Tang, H | 1 |
Xie, Y | 1 |
Asara, JM | 1 |
Huffman, KE | 1 |
Wistuba, II | 1 |
Minna, JD | 1 |
DeBerardinis, RJ | 1 |
Cantley, LC | 1 |
Riscal, R | 1 |
Schrepfer, E | 1 |
Arena, G | 1 |
Cissé, MY | 1 |
Bellvert, F | 1 |
Heuillet, M | 1 |
Rambow, F | 1 |
Bonneil, E | 1 |
Sabourdy, F | 1 |
Vincent, C | 1 |
Ait-Arsa, I | 1 |
Levade, T | 1 |
Thibaut, P | 1 |
Marine, JC | 1 |
Portais, JC | 1 |
Sarry, JE | 1 |
Le Cam, L | 1 |
Linares, LK | 1 |
Kreager, DA | 1 |
Ragan, DT | 1 |
Nguyen, H | 1 |
Staff, J | 1 |
Bartosh, TJ | 1 |
Ylostalo, JH | 1 |
Dutta, NK | 1 |
He, R | 1 |
Pinn, ML | 1 |
Burrows, F | 1 |
Zhang, ZY | 1 |
Karakousis, PC | 1 |
Jin, YJ | 1 |
Wang, S | 1 |
Cho, J | 1 |
Selim, MA | 1 |
Wright, T | 1 |
Mosialos, G | 1 |
Zhang, JY | 1 |
Roy, S | 1 |
Karmakar, T | 1 |
Nagappa, LK | 1 |
Prahlada Rao, VS | 1 |
Balasubramanian, S | 1 |
Balaram, H | 1 |
Mazuquin, BF | 1 |
Dela Bela, LF | 1 |
Pelegrinelli, AR | 1 |
Dias, JM | 1 |
Carregaro, RL | 1 |
Moura, FA | 1 |
Selfe, J | 1 |
Richards, J | 1 |
Brown, LE | 1 |
Cardoso, JR | 1 |
Naeem, MA | 1 |
Armutlulu, A | 1 |
Broda, M | 1 |
Lebedev, D | 1 |
Müller, CR | 1 |
Jin, X | 1 |
Liang, N | 1 |
Wang, M | 1 |
Meng, Y | 1 |
Jia, B | 1 |
Shi, X | 1 |
Li, S | 1 |
Luo, J | 1 |
Luo, Y | 1 |
Cui, Q | 1 |
Zheng, K | 1 |
Liu, Z | 1 |
Shi, J | 1 |
Li, F | 1 |
Wang, F | 1 |
Zhu, Z | 1 |
Gallo, S | 1 |
Woolfrey, AE | 1 |
Burroughs, LM | 1 |
Storer, BE | 1 |
Flowers, ME | 1 |
Hari, P | 1 |
Pulsipher, MA | 1 |
Heimfeld, S | 1 |
Kiem, HP | 1 |
Sandmaier, BM | 1 |
Storb, R | 1 |
Cho, KJ | 1 |
Casteel, DE | 1 |
Prakash, P | 1 |
Tan, L | 1 |
van der Hoeven, D | 1 |
Salim, AA | 1 |
Kim, C | 1 |
Capon, RJ | 1 |
Lacey, E | 1 |
Cunha, SR | 1 |
Gorfe, AA | 1 |
Hancock, JF | 1 |
Ko, E | 1 |
Kim, Y | 1 |
Lee, BB | 1 |
Han, J | 1 |
Song, SY | 1 |
Shim, YM | 1 |
Park, J | 1 |
Kim, DH | 1 |
Phillips, L | 1 |
Morgan, C | 1 |
Pawade, J | 1 |
Sohail, M | 1 |
May, MT | 1 |
Hetzel, MR | 1 |
Zhang, WC | 1 |
Shyh-Chang, N | 1 |
Yang, H | 1 |
Rai, A | 1 |
Umashankar, S | 1 |
Ma, S | 1 |
Soh, BS | 1 |
Sun, LL | 1 |
Tai, BC | 1 |
Nga, ME | 1 |
Bhakoo, KK | 1 |
Jayapal, SR | 1 |
Nichane, M | 1 |
Yu, Q | 1 |
Ahmed, DA | 1 |
Tan, C | 1 |
Sing, WP | 1 |
Tam, J | 1 |
Thirugananam, A | 1 |
Noghabi, MS | 1 |
Pang, YH | 1 |
Ang, HS | 1 |
Mitchell, W | 1 |
Robson, P | 1 |
Kaldis, P | 1 |
Soo, RA | 1 |
Swarup, S | 1 |
Lim, EH | 1 |
Lim, B | 1 |
Rettig, M | 1 |
Trinidad, K | 1 |
Pezeshkpour, G | 1 |
Frost, P | 1 |
Sharma, S | 1 |
Moatamed, F | 1 |
Tamanoi, F | 1 |
Mortazavi, F | 1 |
Yap, DB | 1 |
Hsieh, JK | 1 |
Zhong, S | 1 |
Heath, V | 1 |
Gusterson, B | 1 |
Crook, T | 1 |
Ichwan, SJ | 1 |
Yamada, S | 1 |
Sumrejkanchanakij, P | 1 |
Ibrahim-Auerkari, E | 1 |
Eto, K | 1 |
Ikeda, MA | 1 |
Scaglioni, PP | 1 |
Yung, TM | 1 |
Cai, LF | 1 |
Erdjument-Bromage, H | 1 |
Kaufman, AJ | 1 |
Singh, B | 1 |
Teruya-Feldstein, J | 1 |
Tempst, P | 1 |
Pandolfi, PP | 1 |
Yuan, BZ | 1 |
Jefferson, AM | 1 |
Millecchia, L | 1 |
Popescu, NC | 1 |
Reynolds, SH | 1 |
Bandyopadhyay, K | 1 |
Lee, C | 1 |
Haghighi, A | 1 |
Banères, JL | 1 |
Parello, J | 1 |
Oda, K | 1 |
Arakawa, H | 1 |
Matsuda, K | 1 |
Tanikawa, C | 1 |
Mori, T | 1 |
Nishimori, H | 1 |
Tamai, K | 1 |
Tokino, T | 1 |
Nakamura, Y | 1 |
Taya, Y | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
An Open-label, Dose-escalation, Safety and Pharmacokinetics Phase I Study of Ombrabulin in Combination With Docetaxel and Cisplatin Every 3 Weeks in Patients With Advanced Solid Tumors[NCT01095302] | Phase 1 | 11 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for serine and Carcinoma, Non-Small Cell Lung
Article | Year |
---|---|
Efficacy of Dabrafenib and Trametinib in a Patient with Squamous-Cell Carcinoma, with Mutation p.D594G in
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Extracellular Signal-Regulated MAP K | 2023 |
2 trials available for serine and Carcinoma, Non-Small Cell Lung
Article | Year |
---|---|
Phase 1 study of ombrabulin in combination with docetaxel and cisplatin in Japanese patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asian People; Ca | 2018 |
DISRUPT: a randomised phase 2 trial of ombrabulin (AVE8062) plus a taxane-platinum regimen as first-line therapy for metastatic non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bridged-Ring Compoun | 2014 |
29 other studies available for serine and Carcinoma, Non-Small Cell Lung
Article | Year |
---|---|
Expression and Clinical Significance of lncRNA OSER1-AS1 in Peripheral Blood of Patients with Non-Small Cell Lung Cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Chondroitin Sulfates; Gene Expression Regulation, Neoplastic; Humans | 2022 |
Therapeutic restoring p53 function with small molecule for oncogene-driven non-small cell lung cancer by targeting serine 392 phosphorylation.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Humans; Lung Neoplasms; | 2022 |
Small-molecule MX-C2/3 suppresses non-small cell lung cancer progression via p53 activation.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neopla | 2022 |
DSTYK inhibition increases the sensitivity of lung cancer cells to T cell-mediated cytotoxicity.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Receptor-Interacting Protein Serine-Threonin | 2022 |
Identification and Exploration of Serine Peptidase Inhibitor Kazal Type I (SPINK1) as a Potential Biomarker Correlated with the Progression of Non-Small Cell Lung Cancer.
Topics: Biomarkers; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Gene Expression Re | 2022 |
Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; | 2020 |
The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Endopeptidases; Femal | 2021 |
Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry.
Topics: Adult; Aged; Amino Acids; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; C | 2019 |
Ras-ERK signalling represses H1.4 phosphorylation at serine 36 to promote non-small-cell lung carcinoma cells growth and migration.
Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Cyclic AMP-Dependent | 2019 |
Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chem | 2014 |
The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells.
Topics: Antineoplastic Agents; Antirheumatic Agents; Autophagy; Carcinoma, Non-Small-Cell Lung; Caspases; Ce | 2014 |
Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Codon, Nonsense; DNA Damage; DNA, Ne | 2015 |
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Catalysis; Cell Line, Tumor; Cell Movement; Cytoki | 2015 |
Topoisomerase-I PS506 as a Dual Function Cancer Biomarker.
Topics: Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Carcinoma, | 2015 |
Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.
Topics: Adaptation, Physiological; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Prolifera | 2015 |
NRF2 regulates serine biosynthesis in non-small cell lung cancer.
Topics: Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Carcinoma, Non-Small-Cell | 2015 |
Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.
Topics: Activating Transcription Factor 4; Animals; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell P | 2016 |
Topics: Adolescent; Adult; Age Factors; Aged; Amino Acid Substitution; Anemia, Aplastic; Athletes; Athletic | 2016 |
AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.
Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; | 2016 |
Relationship of phospho-pRb (Ser-807/811) level to exposure to tobacco smoke in primary non-small cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; DNA Methylation; Female; Humans; Immunohistochemistry; Lung Neoplasm | 2009 |
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer.
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Enzyme Activation; Female; Humans; Lung Neoplasms | 2011 |
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.
Topics: Amino Acid Sequence; Antigens, CD; Carcinoma, Non-Small-Cell Lung; Cell Adhesion Molecules, Neuronal | 2012 |
PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells.
Topics: Carcinoma, Non-Small-Cell Lung; Catenins; Cell Line, Tumor; Cell Movement; Delta Catenin; Gene Expre | 2012 |
Ser392 phosphorylation regulates the oncogenic function of mutant p53.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; | 2004 |
Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.
Topics: Adenoviridae; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Humans; Lung Neop | 2006 |
A CK2-dependent mechanism for degradation of the PML tumor suppressor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Ca | 2006 |
Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells.
Topics: Actins; Amino Acid Sequence; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movem | 2007 |
Serine phosphorylation-dependent coregulation of topoisomerase I by the p14ARF tumor suppressor.
Topics: Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Damage; DNA Topoisomerases, Type | 2007 |
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.
Topics: Adenocarcinoma; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoma, Non- | 2000 |