Page last updated: 2024-11-08

serine and Carcinoma, Non-Small Cell Lung

serine has been researched along with Carcinoma, Non-Small Cell Lung in 32 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"5-35 mg/m2) in combination with docetaxel (60 or 75 mg/m2) and cisplatin (75 mg/m2), agents were administered 24 h apart every 3 weeks to Japanese patients with advanced solid tumors."2.87Phase 1 study of ombrabulin in combination with docetaxel and cisplatin in Japanese patients with advanced solid tumors. ( Ecstein-Fraisse, E; Hida, T; Horiike, A; Horio, Y; Nishio, M; Satouchi, M; Sunaga, Y, 2018)
"Irinotecan has also displayed efficacy in clinical trials of NSCLC."1.42Topoisomerase-I PS506 as a Dual Function Cancer Biomarker. ( Gjerset, RA; Zhao, M, 2015)
"Our results define a role for PCK2 in cancer cell metabolic reprogramming that promotes glucose-independent cell growth and metabolic stress resistance in human tumors."1.42Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. ( Artyomov, MN; Avizonis, D; Blagih, J; Bridon, G; Choinière, L; Coelho, PP; Elder, DJ; Flynn, BR; Gingras, MC; Griss, T; Jones, RG; Loginicheva, E; Ntimbane, T; Pause, A; Raissi, TC; Samborska, B; Sergushichev, A; Tavaré, JM; Thomas, EC; Vincent, EE, 2015)
"In addition, LY2603618-treated lung cancer cells transitioned from LC3-I to LC3-II, a hallmark of autophagy."1.40The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. ( Cui, YJ; Fei, HR; Li, ZM; Sun, BL; Sun, YK; Wang, FZ; Wang, XY; Yang, XY; Zhang, JG, 2014)
"TICs from primary NSCLC tumors express high levels of the oncogenic stem cell factor LIN28B and GLDC, which are both required for TIC growth and tumorigenesis."1.38Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. ( Ahmed, DA; Ang, HS; Bhakoo, KK; Jayapal, SR; Kaldis, P; Lim, B; Lim, EH; Ma, S; Mitchell, W; Nga, ME; Nichane, M; Noghabi, MS; Pang, YH; Rai, A; Robson, P; Shyh-Chang, N; Sing, WP; Soh, BS; Soo, RA; Sun, LL; Swarup, S; Tai, BC; Tam, J; Tan, C; Thirugananam, A; Umashankar, S; Yang, H; Yu, Q; Zhang, WC, 2012)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (21.88)29.6817
2010's17 (53.13)24.3611
2020's8 (25.00)2.80

Authors

AuthorsStudies
Chen, P1
Qin, Z1
Sun, X1
Yang, J1
Lv, J1
Diao, M1
Li, L2
Li, P1
Ma, X1
Zeng, S2
Peng, Y2
Zhang, G2
Du, W1
Wang, H1
Zhao, Y2
Huang, Z1
Valencia, K1
Echepare, M1
Teijeira, Á1
Pasquier, A1
Bértolo, C1
Sainz, C1
Tamayo, I1
Picabea, B1
Bosco, G1
Thomas, R1
Agorreta, J1
López-Picazo, JM1
Frigola, J1
Amat, R1
Calvo, A1
Felip, E1
Melero, I1
Montuenga, LM1
Li, D1
Zhang, X1
Ding, Z1
Ai, R1
Shi, L1
Wang, Z1
He, Q1
Dong, Y1
Zhu, Y1
Ouyang, W1
He, Y2
Grenda, A1
Krawczyk, P1
Targowska-Duda, KM1
Kieszko, R1
Paśnik, I1
Milanowski, J1
Volz, C1
Breid, S1
Selenz, C1
Zaplatina, A1
Golfmann, K1
Meder, L1
Dietlein, F1
Borchmann, S1
Chatterjee, S1
Siobal, M1
Schöttle, J1
Florin, A1
Koker, M1
Nill, M1
Ozretić, L1
Uhlenbrock, N1
Smith, S1
Büttner, R1
Miao, H1
Wang, B1
Reinhardt, HC1
Rauh, D1
Hallek, M1
Acker-Palmer, A1
Heukamp, LC1
Ullrich, RT1
Krassikova, L1
Zhang, B1
Nagarajan, D1
Queiroz, AL1
Kacal, M1
Samakidis, E1
Vakifahmetoglu-Norberg, H1
Norberg, E1
Nishio, M1
Satouchi, M1
Horiike, A1
Horio, Y1
Sunaga, Y1
Ecstein-Fraisse, E1
Hida, T1
Mu, Y1
Zhou, Y2
Wang, Y2
Li, W1
Zhou, L1
Lu, X2
Gao, P1
Gao, M1
Wang, Q1
Xu, G1
Shi, S1
Zhang, J1
Liu, M1
Dong, H1
Li, N1
von Pawel, J1
Gorbounova, V1
Reck, M1
Kowalski, DM1
Allard, A1
Chadjaa, M1
Rey, A1
Bennouna, J1
Grossi, F1
Song, L1
Smith, MA1
Doshi, P1
Sasser, K1
Fulp, W1
Altiok, S1
Haura, EB1
Wang, FZ1
Fei, HR1
Cui, YJ1
Sun, YK1
Li, ZM1
Wang, XY1
Yang, XY1
Zhang, JG1
Sun, BL1
Zajkowicz, A1
Butkiewicz, D1
Drosik, A1
Giglok, M1
Suwiński, R1
Rusin, M1
Yamada, N1
Tanaka, T2
Hori, T1
Yokoyama, S1
Hayakawa, Y1
Yano, S1
Fukuoka, J1
Koizumi, K1
Saiki, I1
Sakurai, H1
Zhao, M1
Gjerset, RA2
Vincent, EE2
Sergushichev, A1
Griss, T1
Gingras, MC1
Samborska, B1
Ntimbane, T1
Coelho, PP1
Blagih, J1
Raissi, TC1
Choinière, L1
Bridon, G1
Loginicheva, E1
Flynn, BR1
Thomas, EC2
Tavaré, JM2
Avizonis, D1
Pause, A1
Elder, DJ2
Artyomov, MN1
Jones, RG1
DeNicola, GM1
Chen, PH1
Mullarky, E1
Sudderth, JA1
Hu, Z1
Wu, D1
Tang, H1
Xie, Y1
Asara, JM1
Huffman, KE1
Wistuba, II1
Minna, JD1
DeBerardinis, RJ1
Cantley, LC1
Riscal, R1
Schrepfer, E1
Arena, G1
Cissé, MY1
Bellvert, F1
Heuillet, M1
Rambow, F1
Bonneil, E1
Sabourdy, F1
Vincent, C1
Ait-Arsa, I1
Levade, T1
Thibaut, P1
Marine, JC1
Portais, JC1
Sarry, JE1
Le Cam, L1
Linares, LK1
Kreager, DA1
Ragan, DT1
Nguyen, H1
Staff, J1
Bartosh, TJ1
Ylostalo, JH1
Dutta, NK1
He, R1
Pinn, ML1
Burrows, F1
Zhang, ZY1
Karakousis, PC1
Jin, YJ1
Wang, S1
Cho, J1
Selim, MA1
Wright, T1
Mosialos, G1
Zhang, JY1
Roy, S1
Karmakar, T1
Nagappa, LK1
Prahlada Rao, VS1
Balasubramanian, S1
Balaram, H1
Mazuquin, BF1
Dela Bela, LF1
Pelegrinelli, AR1
Dias, JM1
Carregaro, RL1
Moura, FA1
Selfe, J1
Richards, J1
Brown, LE1
Cardoso, JR1
Naeem, MA1
Armutlulu, A1
Broda, M1
Lebedev, D1
Müller, CR1
Jin, X1
Liang, N1
Wang, M1
Meng, Y1
Jia, B1
Shi, X1
Li, S1
Luo, J1
Luo, Y1
Cui, Q1
Zheng, K1
Liu, Z1
Shi, J1
Li, F1
Wang, F1
Zhu, Z1
Gallo, S1
Woolfrey, AE1
Burroughs, LM1
Storer, BE1
Flowers, ME1
Hari, P1
Pulsipher, MA1
Heimfeld, S1
Kiem, HP1
Sandmaier, BM1
Storb, R1
Cho, KJ1
Casteel, DE1
Prakash, P1
Tan, L1
van der Hoeven, D1
Salim, AA1
Kim, C1
Capon, RJ1
Lacey, E1
Cunha, SR1
Gorfe, AA1
Hancock, JF1
Ko, E1
Kim, Y1
Lee, BB1
Han, J1
Song, SY1
Shim, YM1
Park, J1
Kim, DH1
Phillips, L1
Morgan, C1
Pawade, J1
Sohail, M1
May, MT1
Hetzel, MR1
Zhang, WC1
Shyh-Chang, N1
Yang, H1
Rai, A1
Umashankar, S1
Ma, S1
Soh, BS1
Sun, LL1
Tai, BC1
Nga, ME1
Bhakoo, KK1
Jayapal, SR1
Nichane, M1
Yu, Q1
Ahmed, DA1
Tan, C1
Sing, WP1
Tam, J1
Thirugananam, A1
Noghabi, MS1
Pang, YH1
Ang, HS1
Mitchell, W1
Robson, P1
Kaldis, P1
Soo, RA1
Swarup, S1
Lim, EH1
Lim, B1
Rettig, M1
Trinidad, K1
Pezeshkpour, G1
Frost, P1
Sharma, S1
Moatamed, F1
Tamanoi, F1
Mortazavi, F1
Yap, DB1
Hsieh, JK1
Zhong, S1
Heath, V1
Gusterson, B1
Crook, T1
Ichwan, SJ1
Yamada, S1
Sumrejkanchanakij, P1
Ibrahim-Auerkari, E1
Eto, K1
Ikeda, MA1
Scaglioni, PP1
Yung, TM1
Cai, LF1
Erdjument-Bromage, H1
Kaufman, AJ1
Singh, B1
Teruya-Feldstein, J1
Tempst, P1
Pandolfi, PP1
Yuan, BZ1
Jefferson, AM1
Millecchia, L1
Popescu, NC1
Reynolds, SH1
Bandyopadhyay, K1
Lee, C1
Haghighi, A1
Banères, JL1
Parello, J1
Oda, K1
Arakawa, H1
Matsuda, K1
Tanikawa, C1
Mori, T1
Nishimori, H1
Tamai, K1
Tokino, T1
Nakamura, Y1
Taya, Y1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-label, Dose-escalation, Safety and Pharmacokinetics Phase I Study of Ombrabulin in Combination With Docetaxel and Cisplatin Every 3 Weeks in Patients With Advanced Solid Tumors[NCT01095302]Phase 111 participants (Actual)Interventional2010-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for serine and Carcinoma, Non-Small Cell Lung

ArticleYear
Efficacy of Dabrafenib and Trametinib in a Patient with Squamous-Cell Carcinoma, with Mutation p.D594G in
    International journal of molecular sciences, 2023, Jan-07, Volume: 24, Issue:2

    Topics: Aged; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Extracellular Signal-Regulated MAP K

2023

Trials

2 trials available for serine and Carcinoma, Non-Small Cell Lung

ArticleYear
Phase 1 study of ombrabulin in combination with docetaxel and cisplatin in Japanese patients with advanced solid tumors.
    Japanese journal of clinical oncology, 2018, Apr-01, Volume: 48, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asian People; Ca

2018
DISRUPT: a randomised phase 2 trial of ombrabulin (AVE8062) plus a taxane-platinum regimen as first-line therapy for metastatic non-small cell lung cancer.
    Lung cancer (Amsterdam, Netherlands), 2014, Volume: 85, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bridged-Ring Compoun

2014

Other Studies

29 other studies available for serine and Carcinoma, Non-Small Cell Lung

ArticleYear
Expression and Clinical Significance of lncRNA OSER1-AS1 in Peripheral Blood of Patients with Non-Small Cell Lung Cancer.
    Cells, tissues, organs, 2022, Volume: 211, Issue:5

    Topics: Carcinoma, Non-Small-Cell Lung; Chondroitin Sulfates; Gene Expression Regulation, Neoplastic; Humans

2022
Therapeutic restoring p53 function with small molecule for oncogene-driven non-small cell lung cancer by targeting serine 392 phosphorylation.
    Biochemical pharmacology, 2022, Volume: 203

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Humans; Lung Neoplasms;

2022
Small-molecule MX-C2/3 suppresses non-small cell lung cancer progression via p53 activation.
    Chemico-biological interactions, 2022, Oct-01, Volume: 366

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neopla

2022
DSTYK inhibition increases the sensitivity of lung cancer cells to T cell-mediated cytotoxicity.
    The Journal of experimental medicine, 2022, 12-05, Volume: 219, Issue:12

    Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Receptor-Interacting Protein Serine-Threonin

2022
Identification and Exploration of Serine Peptidase Inhibitor Kazal Type I (SPINK1) as a Potential Biomarker Correlated with the Progression of Non-Small Cell Lung Cancer.
    Cell biochemistry and biophysics, 2022, Volume: 80, Issue:4

    Topics: Biomarkers; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Gene Expression Re

2022
Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC.
    Cell reports, 2020, 04-28, Volume: 31, Issue:4

    Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis;

2020
The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
    Cell death and differentiation, 2021, Volume: 28, Issue:3

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Endopeptidases; Femal

2021
Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry.
    Journal of proteome research, 2019, 05-03, Volume: 18, Issue:5

    Topics: Adult; Aged; Amino Acids; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; C

2019
Ras-ERK signalling represses H1.4 phosphorylation at serine 36 to promote non-small-cell lung carcinoma cells growth and migration.
    Artificial cells, nanomedicine, and biotechnology, 2019, Volume: 47, Issue:1

    Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Cyclic AMP-Dependent

2019
Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014, Volume: 9, Issue:7

    Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chem

2014
The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells.
    Apoptosis : an international journal on programmed cell death, 2014, Volume: 19, Issue:9

    Topics: Antineoplastic Agents; Antirheumatic Agents; Autophagy; Carcinoma, Non-Small-Cell Lung; Caspases; Ce

2014
Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients.
    British journal of cancer, 2015, Mar-17, Volume: 112, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Codon, Nonsense; DNA Damage; DNA, Ne

2015
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.
    Nature communications, 2015, Jul-09, Volume: 6

    Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Catalysis; Cell Line, Tumor; Cell Movement; Cytoki

2015
Topoisomerase-I PS506 as a Dual Function Cancer Biomarker.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Carcinoma,

2015
Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.
    Molecular cell, 2015, Oct-15, Volume: 60, Issue:2

    Topics: Adaptation, Physiological; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Prolifera

2015
NRF2 regulates serine biosynthesis in non-small cell lung cancer.
    Nature genetics, 2015, Volume: 47, Issue:12

    Topics: Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Carcinoma, Non-Small-Cell

2015
Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.
    Molecular cell, 2016, 06-16, Volume: 62, Issue:6

    Topics: Activating Transcription Factor 4; Animals; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell P

2016
    Journal of developmental and life-course criminology, 2016, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Amino Acid Substitution; Anemia, Aplastic; Athletes; Athletic

2016
AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.
    Molecular and cellular biology, 2016, 12-15, Volume: 36, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor;

2016
Relationship of phospho-pRb (Ser-807/811) level to exposure to tobacco smoke in primary non-small cell lung cancer.
    Cancer letters, 2009, Feb-18, Volume: 274, Issue:2

    Topics: Carcinoma, Non-Small-Cell Lung; DNA Methylation; Female; Humans; Immunohistochemistry; Lung Neoplasm

2009
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer.
    British journal of cancer, 2011, May-24, Volume: 104, Issue:11

    Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Enzyme Activation; Female; Humans; Lung Neoplasms

2011
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.
    Cell, 2012, Jan-20, Volume: 148, Issue:1-2

    Topics: Amino Acid Sequence; Antigens, CD; Carcinoma, Non-Small-Cell Lung; Cell Adhesion Molecules, Neuronal

2012
PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Carcinoma, Non-Small-Cell Lung; Catenins; Cell Line, Tumor; Cell Movement; Delta Catenin; Gene Expre

2012
Ser392 phosphorylation regulates the oncogenic function of mutant p53.
    Cancer research, 2004, Jul-15, Volume: 64, Issue:14

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor;

2004
Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.
    Oncogene, 2006, Feb-23, Volume: 25, Issue:8

    Topics: Adenoviridae; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Humans; Lung Neop

2006
A CK2-dependent mechanism for degradation of the PML tumor suppressor.
    Cell, 2006, Jul-28, Volume: 126, Issue:2

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Ca

2006
Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells.
    Experimental cell research, 2007, Nov-01, Volume: 313, Issue:18

    Topics: Actins; Amino Acid Sequence; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movem

2007
Serine phosphorylation-dependent coregulation of topoisomerase I by the p14ARF tumor suppressor.
    Biochemistry, 2007, Dec-11, Volume: 46, Issue:49

    Topics: Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Damage; DNA Topoisomerases, Type

2007
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.
    Cell, 2000, Sep-15, Volume: 102, Issue:6

    Topics: Adenocarcinoma; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoma, Non-

2000