serine has been researched along with Carcinoma, Hepatocellular in 100 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serine and arginine-rich splicing factor 9 (SRSF9) has been linked to the occurrence and progression of various cancers; however, its effects and mechanism of action hepatocellular carcinoma (HCC) have not been reported." | 8.12 | High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis. ( Li, S; Liu, B; Shang, H; Wang, L; Wang, S; Wang, Z; Wu, D; Wu, G; Yuan, J; Zhang, G, 2022) |
| " Linc01564 functions to facilitate hepatocellular carcinoma cell survival under glucose deprivation by activating the serine synthesis pathway." | 8.02 | Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis. ( Hu, H; Li, B; Liu, K; Mei, Y; Wang, Z; Wu, Q; Yang, Y; Zhang, G; Zhu, Y, 2021) |
| "Our previous study discovered that isoliensinine (isolie) triggers hepatocellular carcinoma (HCC) cell apoptosis via inducing p65 dephosphorylation at Ser536 and inhibition of NF-κB." | 7.83 | Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction. ( Cheng, Z; Huang, X; Jiang, S; Shu, G; Wang, G; Yang, X; Zhang, L, 2016) |
| "5 cells either infected with HCV or ectopically expressing HCV NS5A alone have the potential to induce insulin resistance by the phosphorylation of IRS-1 at serine residue (Ser(307)) followed by decreased phosphorylation of Akt Thr(308), Fox01 Ser(256) and GSK3β Ser(9), the downstream players of the insulin signaling pathway." | 7.81 | Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis. ( Imran, M; Iqbal, J; Manzoor, S; Parvaiz, F; Sarkar-Dutta, M; Waris, G, 2015) |
| " Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1." | 7.74 | Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis. ( Fan, ST; Kwong, YL; Lee, TK; Pang, R; Poon, RT; Tse, E; Wong, KB, 2007) |
| "Specifically, the level of serine in hepatocellular carcinoma (HCC) tissues is increased, whereas the expression of phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme in serine biosynthesis pathway, is markedly downregulated." | 5.91 | PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. ( Chen, HN; Dai, L; Dong, L; Fu, S; Huang, C; Luo, L; Nice, EC; Peng, Y; Shen, G; Wang, K; Wang, M; Wang, Z; Wei, X; Wu, X, 2023) |
| "Smoking was linked to the risk of HCC with an increased dose-response effect." | 5.62 | p53 Mutation at Serine 249 and Its Gain of Function Are Highly Related to Hepatocellular Carcinoma after Smoking Exposure. ( Chen, L; Wang, H; Zeng, C; Zhang, Z; Zhou, T, 2021) |
| "Regorafenib has been approved to treat patients who have HCC progression after sorafenib failure, however, regorafenib also faces the risk of drug resistance and subsequent progression of HCC patients." | 5.51 | Suppression of LSD1 enhances the cytotoxic and apoptotic effects of regorafenib in hepatocellular carcinoma cells. ( Lin, NM; Wu, LW; Zhang, C; Zhang, JK; Zhang, ZY; Zhou, DM; Zhu, HJ, 2019) |
| "Hepatocellular carcinoma is mainly associated with viral hepatitis B and C." | 5.37 | Serine 204 phosphorylation and O-β-GlcNAC interplay of IGFBP-6 as therapeutic indicator to regulate IGF-II functions in viral mediated hepatocellular carcinoma. ( Ahmad, W; Asad, S; Fouzia, K; Gull, S; Hassan, S; Ijaz, B; Kausar, H; Nazar, N; Nazar, S; Sarwar, MT; Shabbiri, K; Shahid, I, 2011) |
| "Serine and arginine-rich splicing factor 9 (SRSF9) has been linked to the occurrence and progression of various cancers; however, its effects and mechanism of action hepatocellular carcinoma (HCC) have not been reported." | 4.12 | High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis. ( Li, S; Liu, B; Shang, H; Wang, L; Wang, S; Wang, Z; Wu, D; Wu, G; Yuan, J; Zhang, G, 2022) |
| " Linc01564 functions to facilitate hepatocellular carcinoma cell survival under glucose deprivation by activating the serine synthesis pathway." | 4.02 | Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis. ( Hu, H; Li, B; Liu, K; Mei, Y; Wang, Z; Wu, Q; Yang, Y; Zhang, G; Zhu, Y, 2021) |
| "O-GlcNAcylation of ribosomal receptor for activated C-kinase 1 at the amino acid serine122 promotes its stability, ribosome localization and interaction with the protein kinase, PKCβII, thus driving the translation of oncogenes and tumorigenesis of hepatocellular carcinoma." | 3.88 | O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis. ( Duan, F; Gu, J; Guo, X; Jia, D; Liu, F; Ren, S; Ruan, Y; Song, S; Wang, L; Wu, H; Wu, W, 2018) |
| "Transmembrane protease serine 4 is a well known cell surface protease facilitating the extracellular matrix degradation and epithelial mesenchymal transition in hepatocellular carcinoma." | 3.83 | Identification of potential transmembrane protease serine 4 inhibitors as anti-cancer agents by integrated computational approach. ( Hemanth, R; Ilamathi, M; Nishanth, S; Sivaramakrishnan, V, 2016) |
| "Our previous study discovered that isoliensinine (isolie) triggers hepatocellular carcinoma (HCC) cell apoptosis via inducing p65 dephosphorylation at Ser536 and inhibition of NF-κB." | 3.83 | Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction. ( Cheng, Z; Huang, X; Jiang, S; Shu, G; Wang, G; Yang, X; Zhang, L, 2016) |
| "5 cells either infected with HCV or ectopically expressing HCV NS5A alone have the potential to induce insulin resistance by the phosphorylation of IRS-1 at serine residue (Ser(307)) followed by decreased phosphorylation of Akt Thr(308), Fox01 Ser(256) and GSK3β Ser(9), the downstream players of the insulin signaling pathway." | 3.81 | Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis. ( Imran, M; Iqbal, J; Manzoor, S; Parvaiz, F; Sarkar-Dutta, M; Waris, G, 2015) |
| " Here, we show that inhibition of HMG-CoA reductase by atorvastatin (AT) blocks both MYC phosphorylation and activation, suppressing tumor initiation and growth in vivo in a transgenic model of MYC-induced hepatocellular carcinoma (HCC) as well as in human HCC-derived cell lines." | 3.77 | MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase. ( Arzeno, J; Bellovin, DI; Cao, Z; Fan-Minogue, H; Felsher, DW; Gambhir, SS; Yang, Q; Yevtodiyenko, A, 2011) |
| " Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1." | 3.74 | Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis. ( Fan, ST; Kwong, YL; Lee, TK; Pang, R; Poon, RT; Tse, E; Wong, KB, 2007) |
| "A selective mutation, an arginine-to-serine substitution in codon 249, of the p53 gene has been identified as a "hotspot" mutation in hepatocellular carcinoma (HCC)." | 3.70 | Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia. ( Bréchot, C; Camus-Randon, AM; Goedert, JJ; Hainaut, P; Kirk, GD; Mendy, M; Merle, P; Montesano, R; Trépo, C, 2000) |
| "The best substrate for the hepatoma enzyme is reduced glutathione." | 2.36 | Isolation and properties of gamma-glutamyltranspeptidase from Morris hepatoma 5123D. ( Milnerowicz, H; Sobiech, KA; Szewczuk, A, 1978) |
| "Specifically, the level of serine in hepatocellular carcinoma (HCC) tissues is increased, whereas the expression of phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme in serine biosynthesis pathway, is markedly downregulated." | 1.91 | PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. ( Chen, HN; Dai, L; Dong, L; Fu, S; Huang, C; Luo, L; Nice, EC; Peng, Y; Shen, G; Wang, K; Wang, M; Wang, Z; Wei, X; Wu, X, 2023) |
| "Smoking was linked to the risk of HCC with an increased dose-response effect." | 1.62 | p53 Mutation at Serine 249 and Its Gain of Function Are Highly Related to Hepatocellular Carcinoma after Smoking Exposure. ( Chen, L; Wang, H; Zeng, C; Zhang, Z; Zhou, T, 2021) |
| "Chemoresistance developed in hepatoma cancer cells is associated with autophagy initiation." | 1.56 | 14-3-3ζ binds to and stabilizes phospho-beclin 1 ( Cheng, S; Li, L; Liu, S; Sun, Z; Tang, Y; Wang, C; Zhang, Y; Zhou, W, 2020) |
| "Regorafenib has been approved to treat patients who have HCC progression after sorafenib failure, however, regorafenib also faces the risk of drug resistance and subsequent progression of HCC patients." | 1.51 | Suppression of LSD1 enhances the cytotoxic and apoptotic effects of regorafenib in hepatocellular carcinoma cells. ( Lin, NM; Wu, LW; Zhang, C; Zhang, JK; Zhang, ZY; Zhou, DM; Zhu, HJ, 2019) |
| "We constructed hepatocellular carcinoma (HCC) cells that stably express stathmin with a Ser25 phosphorylation site mutation (stathmin S25A)." | 1.42 | Construction of a hepatocellular carcinoma cell line that stably expresses stathmin with a Ser25 phosphorylation site mutation. ( Du, J; Gan, L; Li, J; Liu, YK; Tao, ZH, 2015) |
| "Hepatocellular carcinoma is mainly associated with viral hepatitis B and C." | 1.37 | Serine 204 phosphorylation and O-β-GlcNAC interplay of IGFBP-6 as therapeutic indicator to regulate IGF-II functions in viral mediated hepatocellular carcinoma. ( Ahmad, W; Asad, S; Fouzia, K; Gull, S; Hassan, S; Ijaz, B; Kausar, H; Nazar, N; Nazar, S; Sarwar, MT; Shabbiri, K; Shahid, I, 2011) |
| "Incubation of rat hepatoma Fao cells with insulin leads to a transient rise in Tyr phosphorylation of insulin receptor substrate (IRS) proteins." | 1.31 | Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. ( Alt, A; Herschkovitz, A; Kuroki, T; LeRoith, D; Liu, YF; Ohba, M; Paz, K; Sampson, SR; Tennenbaum, T; Zick, Y, 2001) |
| "We report here that p53-deficient hepatoma cells (Hep3B) transfected with mutant p53-249ser (codon 249 Arg-->Ser) acquire a new phenotype with an increased in vitro survival and mitotic activity." | 1.29 | Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis. ( Fontanière, B; Frébourg, T; Fröschl, G; Michot, JP; Morel, AP; Oberhammer, F; Ozturk, M; Ponchel, F; Puisieux, A; Tabone, E, 1994) |
| "The human hepatoma cell line Hep G2 was used to investigate amino acid transport systems in human liver tissue." | 1.28 | Amino acid transport systems in the human hepatoma cell line Hep G2. ( Boutron, A; Goenner, S; Lemonnier, A; Moatti, N; Soni, T, 1992) |
| "The serine proteases in rat liver and hepatoma 8999 were restricted to the inner membranes of the mitochondrial fraction." | 1.26 | The serine protease from rat liver and hepatoma 8999. Location and role in mitochondrial protein degradation. ( Banno, Y; Katunuma, N; Morris, HP, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (29.00) | 18.7374 |
| 1990's | 13 (13.00) | 18.2507 |
| 2000's | 22 (22.00) | 29.6817 |
| 2010's | 22 (22.00) | 24.3611 |
| 2020's | 14 (14.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, JC | 1 |
| Chen, DP | 1 |
| Lu, SX | 1 |
| Chen, JB | 1 |
| Wei, Y | 1 |
| Liu, XC | 1 |
| Tang, YH | 1 |
| Zhang, R | 1 |
| Chen, JC | 1 |
| Kan, A | 1 |
| Xu, L | 1 |
| Zhang, YJ | 1 |
| Hou, J | 1 |
| Kuang, DM | 1 |
| Chen, MS | 1 |
| Zhou, ZG | 1 |
| Zhang, G | 2 |
| Liu, B | 1 |
| Shang, H | 1 |
| Wu, G | 2 |
| Wu, D | 1 |
| Wang, L | 2 |
| Li, S | 1 |
| Wang, Z | 3 |
| Wang, S | 1 |
| Yuan, J | 1 |
| Kusunoki, H | 1 |
| Hamaguchi, I | 1 |
| Kobayashi, N | 1 |
| Nagata, T | 1 |
| Kim, HY | 1 |
| Min, HK | 1 |
| Song, HW | 1 |
| Yoo, A | 1 |
| Lee, S | 1 |
| Kim, KP | 1 |
| Park, JO | 1 |
| Choi, YH | 1 |
| Choi, E | 1 |
| Zong, Z | 1 |
| Dang, Y | 1 |
| Zhang, Y | 2 |
| Yu, L | 2 |
| Liu, C | 1 |
| Wang, J | 2 |
| Chu, YD | 1 |
| Fan, TC | 1 |
| Lai, MW | 1 |
| Yeh, CT | 1 |
| Chen, W | 3 |
| Yang, W | 3 |
| Zhang, C | 6 |
| Liu, T | 3 |
| Zhu, J | 3 |
| Wang, H | 4 |
| Li, T | 3 |
| Jin, A | 3 |
| Ding, L | 3 |
| Xian, J | 3 |
| Tian, T | 3 |
| Pan, B | 3 |
| Guo, W | 3 |
| Wang, B | 3 |
| Wang, K | 2 |
| Luo, L | 1 |
| Fu, S | 1 |
| Wang, M | 1 |
| Dong, L | 1 |
| Wu, X | 1 |
| Dai, L | 1 |
| Peng, Y | 1 |
| Shen, G | 1 |
| Chen, HN | 1 |
| Nice, EC | 1 |
| Wei, X | 2 |
| Huang, C | 1 |
| Wu, YQ | 1 |
| Zhang, CS | 1 |
| Xiong, J | 1 |
| Cai, DQ | 1 |
| Wang, CZ | 1 |
| Wang, Y | 4 |
| Liu, YH | 1 |
| Li, Y | 1 |
| Wu, J | 2 |
| Lan, B | 1 |
| Wang, X | 2 |
| Chen, S | 1 |
| Cao, X | 1 |
| Hu, HH | 1 |
| Guo, H | 2 |
| Yu, Y | 1 |
| Ghafoor, A | 1 |
| Xie, C | 1 |
| Wu, Y | 1 |
| Xu, Z | 3 |
| Zhu, M | 1 |
| Huang, X | 3 |
| Sun, X | 1 |
| Lin, SY | 1 |
| Piao, HL | 1 |
| Zhou, J | 1 |
| Lin, SC | 1 |
| Xu, J | 1 |
| Zheng, Q | 1 |
| He, J | 1 |
| Zhou, W | 2 |
| Fan, Q | 1 |
| Ma, J | 1 |
| Cheng, J | 1 |
| Mei, W | 1 |
| Xing, R | 1 |
| Cai, R | 1 |
| Tang, Y | 1 |
| Liu, S | 1 |
| Sun, Z | 1 |
| Wang, C | 1 |
| Li, L | 1 |
| Cheng, S | 1 |
| Hamano, M | 1 |
| Tomonaga, S | 1 |
| Osaki, Y | 1 |
| Oda, H | 1 |
| Kato, H | 1 |
| Furuya, S | 1 |
| Broadfield, LA | 1 |
| Duarte, JAG | 1 |
| Schmieder, R | 1 |
| Broekaert, D | 1 |
| Veys, K | 1 |
| Planque, M | 1 |
| Vriens, K | 1 |
| Karasawa, Y | 1 |
| Napolitano, F | 1 |
| Fujita, S | 1 |
| Fujii, M | 1 |
| Eto, M | 1 |
| Holvoet, B | 1 |
| Vangoitsenhoven, R | 1 |
| Fernandez-Garcia, J | 1 |
| Van Elsen, J | 1 |
| Dehairs, J | 1 |
| Zeng, J | 1 |
| Dooley, J | 1 |
| Rubio, RA | 1 |
| van Pelt, J | 1 |
| Grünewald, TGP | 1 |
| Liston, A | 1 |
| Mathieu, C | 1 |
| Deroose, CM | 1 |
| Swinnen, JV | 1 |
| Lambrechts, D | 1 |
| di Bernardo, D | 1 |
| Kuroda, S | 1 |
| De Bock, K | 1 |
| Fendt, SM | 1 |
| Yang, Y | 1 |
| Hu, H | 1 |
| Liu, K | 1 |
| Li, B | 1 |
| Zhu, Y | 1 |
| Wu, Q | 1 |
| Mei, Y | 1 |
| Chen, L | 1 |
| Zhou, T | 1 |
| Zhang, Z | 1 |
| Zeng, C | 1 |
| Liao, P | 1 |
| Zeng, SX | 1 |
| Zhou, X | 1 |
| Chen, T | 1 |
| Zhou, F | 1 |
| Cao, B | 1 |
| Jung, JH | 1 |
| Del Sal, G | 1 |
| Luo, S | 1 |
| Lu, H | 1 |
| Duan, F | 1 |
| Wu, H | 2 |
| Jia, D | 1 |
| Wu, W | 1 |
| Ren, S | 1 |
| Song, S | 1 |
| Guo, X | 1 |
| Liu, F | 2 |
| Ruan, Y | 1 |
| Gu, J | 1 |
| Wu, LW | 1 |
| Zhou, DM | 1 |
| Zhang, ZY | 1 |
| Zhang, JK | 1 |
| Zhu, HJ | 1 |
| Lin, NM | 1 |
| Zhu, XX | 1 |
| Li, JH | 1 |
| Cai, JP | 1 |
| Hou, X | 1 |
| Huang, CS | 1 |
| Huang, XT | 1 |
| Wang, JQ | 1 |
| Li, SJ | 1 |
| Xu, QC | 1 |
| Yin, XY | 1 |
| Sun, L | 1 |
| Song, L | 1 |
| Wan, Q | 1 |
| Li, X | 2 |
| Liu, Z | 1 |
| Zhong, X | 1 |
| He, X | 1 |
| Shen, S | 2 |
| Pan, X | 1 |
| Li, A | 1 |
| Gao, P | 1 |
| Tang, H | 1 |
| Zhang, H | 1 |
| Du, J | 1 |
| Tao, ZH | 1 |
| Li, J | 2 |
| Liu, YK | 1 |
| Gan, L | 1 |
| Ilamathi, M | 1 |
| Hemanth, R | 1 |
| Nishanth, S | 1 |
| Sivaramakrishnan, V | 1 |
| Parvaiz, F | 1 |
| Manzoor, S | 1 |
| Iqbal, J | 1 |
| Sarkar-Dutta, M | 1 |
| Imran, M | 1 |
| Waris, G | 1 |
| Shu, G | 1 |
| Zhang, L | 1 |
| Jiang, S | 1 |
| Cheng, Z | 1 |
| Wang, G | 1 |
| Yang, X | 1 |
| Bae, JS | 1 |
| Noh, SJ | 1 |
| Kim, KM | 1 |
| Jang, KY | 1 |
| Park, HS | 1 |
| Chung, MJ | 1 |
| Park, BH | 1 |
| Moon, WS | 1 |
| Liu, Q | 1 |
| Tao, T | 1 |
| Ni, R | 1 |
| Lu, C | 1 |
| Shen, A | 1 |
| Wong, KF | 1 |
| Liu, AM | 1 |
| Hong, W | 1 |
| Luk, JM | 1 |
| Shu, Y | 1 |
| Lu, Y | 1 |
| Pang, X | 1 |
| Zheng, W | 1 |
| Huang, Y | 1 |
| Ji, J | 1 |
| Shen, P | 1 |
| Yu, W | 1 |
| Ding, X | 1 |
| Chen, F | 1 |
| Liu, M | 1 |
| Gu, X | 1 |
| Moehlenbrink, J | 1 |
| Bitomsky, N | 1 |
| Hofmann, TG | 1 |
| Chen, Y | 1 |
| Kung, HN | 1 |
| Chen, CH | 1 |
| Huang, SH | 1 |
| Chen, KH | 1 |
| Wang, SM | 1 |
| Cao, Z | 1 |
| Fan-Minogue, H | 1 |
| Bellovin, DI | 1 |
| Yevtodiyenko, A | 1 |
| Arzeno, J | 1 |
| Yang, Q | 1 |
| Gambhir, SS | 1 |
| Felsher, DW | 1 |
| Ahmad, W | 1 |
| Shabbiri, K | 1 |
| Ijaz, B | 1 |
| Asad, S | 1 |
| Nazar, N | 1 |
| Nazar, S | 1 |
| Fouzia, K | 1 |
| Kausar, H | 1 |
| Gull, S | 1 |
| Sarwar, MT | 1 |
| Shahid, I | 1 |
| Hassan, S | 1 |
| Wei, Z | 1 |
| Hurtt, R | 1 |
| Ciccarelli, M | 1 |
| Koch, WJ | 1 |
| Doria, C | 1 |
| Bayram, S | 1 |
| Hong, A | 1 |
| Han, DD | 1 |
| Wright, CJ | 1 |
| Burch, T | 1 |
| Piper, J | 1 |
| Osiowy, C | 1 |
| Gao, C | 1 |
| Chiang, S | 1 |
| Magill, T | 1 |
| Dick, K | 1 |
| Booth, TF | 1 |
| He, R | 1 |
| Miyakoshi, M | 1 |
| Yamamoto, M | 1 |
| Tanaka, H | 1 |
| Ogawa, K | 1 |
| Desbois-Mouthon, C | 2 |
| Blivet-Van Eggelpoël, MJ | 2 |
| Beurel, E | 2 |
| Boissan, M | 1 |
| Delélo, R | 1 |
| Cadoret, A | 2 |
| Capeau, J | 3 |
| Datta, R | 1 |
| Choudhury, P | 1 |
| Ghosh, A | 1 |
| Datta, B | 1 |
| KIZER, DE | 1 |
| LACEY, DE | 1 |
| BOTTOMLEY, RH | 1 |
| PITOT, HC | 3 |
| MORRIS, HP | 4 |
| WAGLE, SR | 1 |
| WEBER, G | 1 |
| INOUYE, M | 1 |
| MORSE, PA | 1 |
| POTTER, VR | 2 |
| Ma, DZ | 1 |
| Wang, LY | 1 |
| Su, JM | 1 |
| Zha, XL | 1 |
| Kao, CF | 1 |
| Chen, SY | 1 |
| Chen, JY | 1 |
| Wu Lee, YH | 1 |
| Szymańska, K | 1 |
| Lesi, OA | 1 |
| Kirk, GD | 2 |
| Sam, O | 1 |
| Taniere, P | 1 |
| Scoazec, JY | 1 |
| Mendy, M | 2 |
| Friesen, MD | 1 |
| Whittle, H | 1 |
| Montesano, R | 2 |
| Hainaut, P | 2 |
| Oxombre, B | 1 |
| Kouach, M | 1 |
| Moerman, E | 1 |
| Formstecher, P | 1 |
| Laine, B | 1 |
| Arrisi-Mercado, P | 1 |
| Romano, M | 1 |
| Muro, AF | 1 |
| Baralle, FE | 1 |
| Kornprobst, M | 1 |
| Qi, XJ | 1 |
| Wildey, GM | 1 |
| Howe, PH | 1 |
| Benson, MD | 1 |
| Kluve-Beckerman, B | 1 |
| Zeldenrust, SR | 1 |
| Siesky, AM | 1 |
| Bodenmiller, DM | 1 |
| Showalter, AD | 1 |
| Sloop, KW | 1 |
| Machida, K | 1 |
| Cheng, KT | 1 |
| Lai, CK | 1 |
| Jeng, KS | 1 |
| Sung, VM | 1 |
| Lai, MM | 1 |
| Sakamoto, T | 1 |
| Higaki, Y | 1 |
| Hara, M | 1 |
| Ichiba, M | 1 |
| Horita, M | 1 |
| Mizuta, T | 1 |
| Eguchi, Y | 1 |
| Yasutake, T | 1 |
| Ozaki, I | 1 |
| Yamamoto, K | 1 |
| Onohara, S | 1 |
| Kawazoe, S | 1 |
| Shigematsu, H | 1 |
| Koizumi, S | 1 |
| Tanaka, K | 1 |
| Pang, R | 1 |
| Lee, TK | 1 |
| Poon, RT | 1 |
| Fan, ST | 1 |
| Wong, KB | 1 |
| Kwong, YL | 1 |
| Tse, E | 1 |
| Pazienza, V | 1 |
| Clément, S | 1 |
| Pugnale, P | 1 |
| Conzelman, S | 1 |
| Foti, M | 1 |
| Mangia, A | 1 |
| Negro, F | 1 |
| Proud, CG | 1 |
| Zick, Y | 2 |
| Grunberger, G | 1 |
| Podskalny, JM | 1 |
| Moncada, V | 1 |
| Taylor, SI | 1 |
| Gorden, P | 1 |
| Roth, J | 1 |
| Ghebranious, N | 1 |
| Knoll, BJ | 1 |
| Lozano, G | 1 |
| Sell, S | 1 |
| Trautwein, C | 1 |
| Walker, DL | 1 |
| Plümpe, J | 1 |
| Manns, MP | 1 |
| Ernst, A | 1 |
| Helmhold, M | 1 |
| Brunner, C | 1 |
| Pethö-Schramm, A | 1 |
| Armstrong, VW | 1 |
| Müller, HJ | 1 |
| Ponchel, F | 1 |
| Puisieux, A | 1 |
| Tabone, E | 1 |
| Michot, JP | 1 |
| Fröschl, G | 1 |
| Morel, AP | 1 |
| Frébourg, T | 1 |
| Fontanière, B | 1 |
| Oberhammer, F | 1 |
| Ozturk, M | 1 |
| Lu, X | 1 |
| Badiani, K | 1 |
| Arthur, G | 1 |
| Bismut, H | 1 |
| Caron, M | 1 |
| Coudray-Lucas, C | 1 |
| Omichi, K | 1 |
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| Minamida, S | 1 |
| Hase, S | 1 |
| Luo, K | 1 |
| Lodish, HF | 1 |
| Viollet, B | 1 |
| Kahn, A | 1 |
| Raymondjean, M | 1 |
| Stone, SJ | 1 |
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| Vance, JE | 1 |
| Pocuca, N | 1 |
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| Demonacos, C | 1 |
| Kanazir, D | 1 |
| Krstic-Demonacos, M | 1 |
| Camus-Randon, AM | 1 |
| Goedert, JJ | 1 |
| Merle, P | 1 |
| Trépo, C | 1 |
| Bréchot, C | 1 |
| Schuringa, JJ | 2 |
| Jonk, LJ | 1 |
| Dokter, WH | 1 |
| Vellenga, E | 2 |
| Kruijer, W | 2 |
| Liu, YF | 1 |
| Paz, K | 1 |
| Herschkovitz, A | 1 |
| Alt, A | 1 |
| Tennenbaum, T | 1 |
| Sampson, SR | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Changes in Circulating Tumor-Specific DNA (ctDNA) in Patients With Non-Metastatic Non-Small Cell Lung Cancer[NCT03746262] | 40 participants (Actual) | Observational | 2016-05-13 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for serine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Isolation and properties of gamma-glutamyltranspeptidase from Morris hepatoma 5123D.
Topics: Animals; Borates; Carcinoma, Hepatocellular; Enzyme Activation; gamma-Glutamyltransferase; Glutathio | 1978 |
99 other studies available for serine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma.
Topics: Carcinoma, Hepatocellular; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Liver Neoplasms; Mac | 2022 |
High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis.
Topics: Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; DNA Methylation; | 2022 |
Chemical shift assignments of a fusion protein comprising the C-terminal-deleted hepatitis B virus X protein BH3-like motif peptide and Bcl-x
Topics: Apoptosis Regulatory Proteins; bcl-X Protein; Carcinoma, Hepatocellular; Dipeptides; Glycine; Hepati | 2022 |
Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Exosomes; Humans; Kille | 2022 |
Promotion effect on liver tumor progression of microcystin-LR at environmentally relevant levels in female krasV12 transgenic zebrafish.
Topics: Animals; Animals, Genetically Modified; beta Catenin; Carcinoma, Hepatocellular; Doxycycline; Female | 2022 |
GALNT14-mediated O-glycosylation on PHB2 serine-161 enhances cell growth, migration and drug resistance by activating IGF1R cascade in hepatoma cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Resistance; Glycosylation; Humans; Liver Neoplasms | 2022 |
Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10.
Topics: Anisomycin; Carcinoma, Hepatocellular; Ferroptosis; Histones; Humans; Liver Neoplasms; p38 Mitogen-A | 2022 |
Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10.
Topics: Anisomycin; Carcinoma, Hepatocellular; Ferroptosis; Histones; Humans; Liver Neoplasms; p38 Mitogen-A | 2022 |
Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10.
Topics: Anisomycin; Carcinoma, Hepatocellular; Ferroptosis; Histones; Humans; Liver Neoplasms; p38 Mitogen-A | 2022 |
Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10.
Topics: Anisomycin; Carcinoma, Hepatocellular; Ferroptosis; Histones; Humans; Liver Neoplasms; p38 Mitogen-A | 2022 |
PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Humans; Liver Neoplasm | 2023 |
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Liver Neoplasms; Mice; Phosphoglycerate Dehydr | 2023 |
NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Hep G2 Cells; Humans; Liver Neoplasms; | 2019 |
14-3-3ζ binds to and stabilizes phospho-beclin 1
Topics: 14-3-3 Proteins; Autophagy; Beclin-1; Carcinoma, Hepatocellular; Gene Expression Regulation, Neoplas | 2020 |
Transcriptional Activation of
Topics: Activating Transcription Factor 4; Animals; Biological Availability; Carcinoma, Hepatocellular; Cell | 2020 |
Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Citric Acid Cycle; Diet, High-F | 2021 |
Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis.
Topics: Carcinogenesis; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; RNA, Long Noncoding; Serine; Tra | 2021 |
p53 Mutation at Serine 249 and Its Gain of Function Are Highly Related to Hepatocellular Carcinoma after Smoking Exposure.
Topics: Carcinoma, Hepatocellular; Gain of Function Mutation; Humans; Liver Neoplasms; Mutation; Serine; Smo | 2021 |
Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding.
Topics: Carcinoma, Hepatocellular; Cell Proliferation; Cyclin-Dependent Kinase 4; Humans; Liver Neoplasms; M | 2017 |
O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis.
Topics: Amino Acid Substitution; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease | 2018 |
Suppression of LSD1 enhances the cytotoxic and apoptotic effects of regorafenib in hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatoc | 2019 |
EYA4 inhibits hepatocellular carcinoma by repressing MYCBP by dephosphorylating β-catenin at Ser552.
Topics: Adult; beta Catenin; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; C | 2019 |
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Food Deprivation; Gene Expression | 2015 |
Construction of a hepatocellular carcinoma cell line that stably expresses stathmin with a Ser25 phosphorylation site mutation.
Topics: Carcinoma, Hepatocellular; Humans; Mutation; Phosphorylation; Serine; Stathmin | 2015 |
Identification of potential transmembrane protease serine 4 inhibitors as anti-cancer agents by integrated computational approach.
Topics: Administration, Oral; Algorithms; Amino Acids; Antineoplastic Agents; Binding Sites; Carcinoma, Hepa | 2016 |
Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Forkhead Box Protein O1; Forkhead Transcription Factors | 2015 |
Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Catalytic Domain; DNA-Binding Proteins; He | 2016 |
PIN1 in hepatocellular carcinoma is associated with TP53 gene status.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Proliferation; Female; Gene Exp | 2016 |
Hyper-O-GlcNAcylation of YB-1 affects Ser102 phosphorylation and promotes cell proliferation in hepatocellular carcinoma.
Topics: Acetylglucosamine; Adult; Aged; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Female | 2016 |
Integrin α2β1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Co | 2016 |
Phosphorylation of PPARγ at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expres | 2016 |
The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation.
Topics: Base Sequence; Blotting, Northern; Carcinoma, Hepatocellular; Casein Kinase II; Cell Line, Tumor; Ce | 2009 |
Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation.
Topics: Carcinoma, Hepatocellular; Carrier Proteins; Cell Hypoxia; Cell Line, Tumor; Doxorubicin; Drug Resis | 2010 |
Acidic extracellular pH induces p120-catenin-mediated disruption of adherens junctions via the Src kinase-PKCδ pathway.
Topics: Adherens Junctions; Calcium Signaling; Carcinoma, Hepatocellular; Catenins; Delta Catenin; Enzyme In | 2011 |
MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase.
Topics: Animals; Atorvastatin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Drug Resista | 2011 |
Serine 204 phosphorylation and O-β-GlcNAC interplay of IGFBP-6 as therapeutic indicator to regulate IGF-II functions in viral mediated hepatocellular carcinoma.
Topics: Acetylglucosamine; Amino Acid Sequence; Carcinoma, Hepatocellular; Glycosylation; Hepacivirus; Hepat | 2011 |
Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.
Topics: Adenoviridae; Animals; Carcinoma, Hepatocellular; Cattle; Cell Cycle Checkpoints; Cell Proliferation | 2012 |
RASSF1A Ala133Ser polymorphism is associated with increased susceptibility to hepatocellular carcinoma in a Turkish population.
Topics: Aged; Alanine; Amino Acid Substitution; Carcinoma, Hepatocellular; Case-Control Studies; Female; Gen | 2012 |
The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction.
Topics: Amino Acid Sequence; Carcinogens; Carcinoma, Hepatocellular; Cell Line, Tumor; Conserved Sequence; H | 2012 |
Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine.
Topics: Animals; Animals, Newborn; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cell Prolifera | 2014 |
Dysregulation of glycogen synthase kinase-3beta signaling in hepatocellular carcinoma cells.
Topics: Animals; Antigens, Polyomavirus Transforming; beta Catenin; Carcinoma, Hepatocellular; Cytoskeletal | 2002 |
A glycosylation site, 60SGTS63, of p67 is required for its ability to regulate the phosphorylation and activity of eukaryotic initiation factor 2alpha.
Topics: Acetylglucosaminidase; Amino Acid Substitution; Aminopeptidases; Animals; Blotting, Western; Carcino | 2003 |
Deletion of serine dehydrase and cystathionine synthetase activities during azo-dye carcinogenesis.
Topics: Amino Acids; Animals; Azo Compounds; Carcinogenesis; Carcinoma, Hepatocellular; Cystathionine beta-S | 1961 |
Metabolic adaptations in rat hepatomas. IV. Regulation of threonine and serine dehydrase.
Topics: Animals; Carcinoma, Hepatocellular; Dietary Proteins; Hydro-Lyases; Liver Neoplasms; Oxidoreductases | 1963 |
COMPARATIVE BIOCHEMISTRY OF HEPATOMAS. V. STUDIES ON AMINO ACID INCORPORATION IN LIVER TUMORS OF DIFFERENT GROWTH RATES.
Topics: Alanine; Amino Acids; Aspartic Acid; Carcinoma, Hepatocellular; Glycine; Histocytochemistry; Isoleuc | 1963 |
EFFECT OF ACETONE ON ALKALINE PHOSPHATASE ACTIVITY.
Topics: Acetone; Alkaline Phosphatase; Amino Alcohols; Carcinoma, Hepatocellular; Glycerophosphates; Liver; | 1963 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liv | 1965 |
Transforming growth factor-beta1 stimulated protein kinase B serine-473 and focal adhesion kinase tyrosine phosphorylation dependent on cell adhesion in human hepatocellular carcinoma SMMC-7721 cells.
Topics: Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Dose-Response Relationship, Drug; Focal | 2003 |
Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein.
Topics: Acetylation; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Gene Expression Regulation, | 2004 |
Ser-249TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West Africa.
Topics: Adult; Aflatoxins; Aged; Aged, 80 and over; Antigens, Viral; Biopsy; Carcinoma, Hepatocellular; DNA; | 2004 |
The G115S mutation associated with maturity-onset diabetes of the young impairs hepatocyte nuclear factor 4alpha activities and introduces a PKA phosphorylation site in its DNA-binding domain.
Topics: Age of Onset; Amino Acid Substitution; Binding Sites; Carcinoma, Hepatocellular; Cell Line, Tumor; C | 2004 |
An exonic splicing enhancer offsets the atypical GU-rich 3' splice site of human apolipoprotein A-II exon 3.
Topics: Apolipoprotein A-II; Arginine; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromosom | 2004 |
GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Camptothecin; Carcinoma, Hepatocellular; Caspas | 2005 |
Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.
Topics: 14-3-3 Proteins; Alkaline Phosphatase; Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like | 2006 |
Targeted suppression of an amyloidogenic transthyretin with antisense oligonucleotides.
Topics: Alanine Transaminase; Amyloidosis, Familial; Animals; Aspartate Aminotransferases; Carcinoma, Hepato | 2006 |
Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; DNA Damage; DNA, Mitochondrial; Hepacivirus; Hepatiti | 2006 |
hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among Japanese.
Topics: Adult; Aged; Amino Acid Substitution; Carcinoma, Hepatocellular; Case-Control Studies; DNA Glycosyla | 2006 |
Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis.
Topics: Amino Acid Motifs; Animals; bcl-X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolife | 2007 |
The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms.
Topics: Amino Acid Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regulation; Hepacivirus; Huma | 2007 |
A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B.
Topics: Alanine; Amino Acid Substitution; Amino Acids; Animals; Carcinoma, Hepatocellular; Catalytic Domain; | 2008 |
Insulin stimulates phosphorylation of serine residues in soluble insulin receptors.
Topics: Carcinoma, Hepatocellular; Cell Line; Humans; Insulin; Kinetics; Liver Neoplasms; Molecular Weight; | 1983 |
Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure.
Topics: Aflatoxin B1; Amino Acid Sequence; Animals; Arginine; Base Sequence; Carcinoma, Hepatocellular; Codo | 1995 |
Transactivation of LAP/NF-IL6 is mediated by an acidic domain in the N-terminal part of the protein.
Topics: Base Sequence; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Line; Cell Nucleus; | 1995 |
Identification of two functionally distinct lysine-binding sites in kringle 37 and in kringles 32-36 of human apolipoprotein(a).
Topics: Amino Acid Sequence; Apolipoproteins; Apoprotein(a); Base Sequence; Binding Sites; Carcinoma, Hepato | 1995 |
Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis.
Topics: Amino Acid Sequence; Animals; Apoptosis; Arginine; Base Sequence; Carcinoma, Hepatocellular; Cell Di | 1994 |
3-Deazaadenosine and MDL29350 differentially affect the methylation of serine-and ethanolamine-derived phosphatidylethanolamine in Hep G2 cells.
Topics: Caproates; Carcinoma, Hepatocellular; Cell Line; Ethanolamine; Ethanolamines; Humans; Hypolipidemic | 1993 |
Glucose contribution to nucleic acid base synthesis in proliferating hepatoma cells: a glycine-biosynthesis-mediated pathway.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Cycloserine; Enzyme Inhibitors; | 1995 |
Presence of UDP-D-xylose: beta-D-glucoside alpha-1,3-D-xylosyltransferase involved in the biosynthesis of the Xyl alpha 1-3Glc beta-Ser structure of glycoproteins in the human hepatoma cell line HepG2.
Topics: Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Glucose; Glycoproteins; Humans; Hyd | 1997 |
Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues.
Topics: Activin Receptors, Type I; Amino Acid Sequence; B-Lymphocytes; Carcinoma, Hepatocellular; Cell Line; | 1997 |
Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4.
Topics: Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinoma | 1997 |
Cloning and expression of mouse liver phosphatidylserine synthase-1 cDNA. Overexpression in rat hepatoma cells inhibits the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Hepatocellular; CHO Cells; Cloning, Molecula | 1998 |
Using yeast to study glucocorticoid receptor phosphorylation.
Topics: Animals; Carcinoma, Hepatocellular; Desoxycorticosterone; Dexamethasone; Gene Expression; Glucocorti | 1998 |
Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia.
Topics: Adult; Aflatoxins; Aged; Aged, 80 and over; Arginine; Black People; Carcinoma, Hepatocellular; Case- | 2000 |
Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components.
Topics: Amino Acid Substitution; Carcinoma, Hepatocellular; Cell Cycle Proteins; DNA-Binding Proteins; Enzym | 2000 |
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins.
Topics: Adenoviridae; Androstadienes; Animals; Carcinoma, Hepatocellular; Cell Line; Dose-Response Relations | 2001 |
Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation.
Topics: Amino Acid Substitution; Animals; Carcinoma, Hepatocellular; Cell Line; DNA-Binding Proteins; Humans | 2001 |
The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alanine; Amino Acid Sequence; Amino Acid S | 2001 |
Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Division; Humans; Ligands; Liver Neoplasms; Mitogen-Activated Protei | 2001 |
The isolation and characterization of glycopeptides and mucopolysaccharides from plasma membranes of an ascites hepatoma, AH 130.
Topics: Animals; Aspartic Acid; Carcinoma, Hepatocellular; Cell Membrane; Female; Glycopeptides; Glycosamino | 1975 |
The serine protease from rat liver and hepatoma 8999. Location and role in mitochondrial protein degradation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Fractionation; Immunodiffusion; Kinetics; Liver Neoplasms; | 1978 |
Amino acid transport systems in the human hepatoma cell line Hep G2.
Topics: Alanine; Amino Acids; Biological Transport; Carcinoma, Hepatocellular; Humans; Kinetics; Lithium; Li | 1992 |
Cyclic AMP-dependent protein kinase phosphorylates serine378 in vitronectin.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Blood Proteins; Carcinoma, Hepatocellular; Cell Line; E | 1991 |
Purification and some properties of gamma-glutamyl transpeptidase from azo dye-induced hepatoma.
Topics: Amino Acids; Animals; Azo Compounds; Carbohydrates; Carcinoma, Hepatocellular; Chromatography; Edeti | 1974 |
Phosphorylation of tyrosine aminotransferase in vivo.
Topics: Alkaline Phosphatase; Animals; Carcinoma, Hepatocellular; Electrophoresis, Paper; Electrophoresis, P | 1974 |
Cystathioninuria.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Carcinoma, Hepatocellular; Child, Preschoo | 1967 |
[Purine synthesis in the mouse hepatoma and liver tissue].
Topics: Adenine; Adenine Nucleotides; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Formates; Guanine | 1966 |
Phosphoserine phosphatase distribution in normal and neoplastic rat tissues.
Topics: Adenocarcinoma; Animals; Brain; Carcinoma, Hepatocellular; Female; Fetus; Fibrosarcoma; Kidney; Kine | 1969 |
Two enzymes of serine metabolism in rat liver and hepatomas.
Topics: Alcohol Oxidoreductases; Animals; Carcinoma, Hepatocellular; Dietary Proteins; Hydro-Lyases; Liver; | 1970 |
Transfer RNA modifications and synthesis in animal cells.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Differentiation; | 1971 |
Comparative studies on mammalian and yeast phenylalanine transfer ribonucleic acids.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Fractionation; Cell Nucleus; Chemical Phen | 1971 |
Alterations in the transfer RNA population of hepatoma 9618A as compared with normal rat liver.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; Histidine; Leucine; Liver; Live | 1971 |
Isolation of an electrophoretically homogeneous nonhistone nucleolar protein.
Topics: Amino Acid Sequence; Animals; Ascites; Carcinoma, Hepatocellular; Cell Nucleolus; Chromatography, Th | 1971 |
[Comparative study of transfer ribonucleic acids extracted from rat liver and Zajdela hepatoma. I. Study of the acceptor properties of tRNA].
Topics: Acylation; Alanine; Animals; Arginine; Ascites; Carcinoma, Hepatocellular; Cell Differentiation; Cel | 1972 |
[Isoenzyme spectrum of serine transoxymethylase in the liver and in hepatomas].
Topics: Agar; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Electrophoresis; Gels; Glycine; Isoenzyme | 1973 |
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma.
Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic | 1973 |
Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply.
Topics: Amino Acids; Animals; Arginine; Asparagine; Carbon Radioisotopes; Carboxy-Lyases; Carcinoma, Hepatoc | 1974 |
Phosphorylation of acid-soluble nucleolar proteins of Novikoff hepatoma ascites cells in vivo.
Topics: Amino Acids; Animals; Ascitic Fluid; Autoradiography; Carcinoma, Hepatocellular; Cell Fractionation; | 1974 |
Requirement of L-serine for enzymic activation of carcinogen, 4-hydroxyaminoquinoline 1-oxide.
Topics: Amino Acids; Carcinogens; Carcinoma, Hepatocellular; Cyclic N-Oxides; Enzyme Activation; Hydroxylami | 1974 |
Phosphorylation of proteins of ribosomes and nucleolar preribosomal particles in vivo in Novikoff hepatoma ascites cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleolus; Cell Nucleus; Chromatin; Electrophoresis, Polyac | 1974 |
Template stability of some enzymes in rat liver and hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Caseins; Dactinomycin; Hydro-Lyases; In Vitro Techniques; Liver; | 1965 |
Hormonal effects on enzyme activities in tissue culture and in whole animals.
Topics: Animals; Biological Clocks; Carcinoma, Hepatocellular; Corticosterone; Cortisone; Culture Techniques | 1967 |
Regulation of tyrosine- -ketoglutarate transaminase in rat liver.
Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Induction; | 1971 |