Page last updated: 2024-11-08

serine and Carcinogenesis

serine has been researched along with Carcinogenesis in 35 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.

Research Excerpts

ExcerptRelevanceReference
" Linc01564 functions to facilitate hepatocellular carcinoma cell survival under glucose deprivation by activating the serine synthesis pathway."8.02Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis. ( Hu, H; Li, B; Liu, K; Mei, Y; Wang, Z; Wu, Q; Yang, Y; Zhang, G; Zhu, Y, 2021)
"However, how PYCR2 promotes colon carcinogenesis remains ill understood."5.91Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling. ( Ahmad, A; Ahmad, R; Bastola, DK; Becker, DF; Dhawan, P; Kumar, B; Kumar, V; Lama Tamang, R; Patel, SM; Singh, AB; Thapa, I, 2023)
"However, its role in mammary oncogenesis remains an unsettled debate as STAT5a exhibits functional dichotomy with both pro-differentiative and pro-proliferative target genes."5.62Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer. ( Clevenger, CV; Grible, JM; Harrell, JC; Idowu, M; Olex, AL; Woock, AE; Zot, P, 2021)
"Osteosarcoma is the major malignant primary bone cancer in children and adolescents, which is highly aggressive with frequent acquisition of chemoresistance phenotypes."5.46A novel mechanism of mTORC1-mediated serine/glycine metabolism in osteosarcoma development. ( Bi, ZG; Cao, Y; E, XQ; Ji, G; Liu, W; Wang, DW; Wu, L; Yang, L, 2017)
"In this review, we summarize layers of evidence demonstrating that disordered metabolisms in glucose, glutamine, lipid, and serine caused by LKB1 deficiency promote carcinogenesis and non-neoplastic diseases."5.12LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases. ( Meng, Q; Sun, Q; Wang, Y; Xu, ZX; Zhang, Y; Zhou, H, 2021)
" Linc01564 functions to facilitate hepatocellular carcinoma cell survival under glucose deprivation by activating the serine synthesis pathway."4.02Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis. ( Hu, H; Li, B; Liu, K; Mei, Y; Wang, Z; Wu, Q; Yang, Y; Zhang, G; Zhu, Y, 2021)
"The vital role of serine metabolism in oncogenesis, tumor stemness, tumor immunity, and therapeutic resistance is outlined."3.01Serine Metabolic Reprogramming in Tumorigenesis, Tumor Immunity, and Clinical Treatment. ( Guanbin, S; Junyu, J; Li, Y; Shunxi, W; Wanqian, L; Xiaoxue, Y, 2023)
"However, how PYCR2 promotes colon carcinogenesis remains ill understood."1.91Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling. ( Ahmad, A; Ahmad, R; Bastola, DK; Becker, DF; Dhawan, P; Kumar, B; Kumar, V; Lama Tamang, R; Patel, SM; Singh, AB; Thapa, I, 2023)
"We examined LATS1 expression in breast carcinogenesis and compared it with clinicopathological parameters and survival information of breast cancer patients using immunohistochemistry, western blotting, RT-PCR, and bioinformatics analysis."1.72The clinicopathological and prognostic significances of LATS1 expression in breast cancer. ( Cui, ZG; E, Y; Xiang, LW; Xue, H; Zhao, MZ; Zheng, HC, 2022)
"Our pancancer study provided a relatively comprehensive description of the carcinogenic effects of RIPK2 in different tumours, and provided useful information for further study of RIPK2."1.72A pancancer analysis of the carcinogenic role of receptor-interacting serine/threonine protein kinase-2 (RIPK2) in human tumours. ( Liu, R; Luo, H; Ma, Y; Wang, X; Zhang, H; Zhang, Q, 2022)
"However, its role in mammary oncogenesis remains an unsettled debate as STAT5a exhibits functional dichotomy with both pro-differentiative and pro-proliferative target genes."1.62Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer. ( Clevenger, CV; Grible, JM; Harrell, JC; Idowu, M; Olex, AL; Woock, AE; Zot, P, 2021)
"Osteosarcoma is the major malignant primary bone cancer in children and adolescents, which is highly aggressive with frequent acquisition of chemoresistance phenotypes."1.46A novel mechanism of mTORC1-mediated serine/glycine metabolism in osteosarcoma development. ( Bi, ZG; Cao, Y; E, XQ; Ji, G; Liu, W; Wang, DW; Wu, L; Yang, L, 2017)
"Tumorigenesis is a multistep process involving co-operation between several deregulated oncoproteins."1.43Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells. ( Corthals, G; Imanishi, SY; Koskinen, PJ; Landor, SK; Lendahl, U; Manoharan, GB; Paloniemi, E; Sahlgren, C; Santio, NM; Uri, A; Vahtera, L; Varjosalo, M; Ylä-Pelto, J, 2016)
"In lung cancer the anti-phospho-Ser522 signal is positive in squamous cell carcinoma more frequently than adenocarcinoma."1.42Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis. ( Bray, SE; Carey, FA; Coates, PJ; Grant, NJ; Hastie, CJ; Lamont, DJ; Morrice, NA; Sutherland, C; Woods, YL, 2015)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.86)18.7374
1990's0 (0.00)18.2507
2000's1 (2.86)29.6817
2010's11 (31.43)24.3611
2020's22 (62.86)2.80

Authors

AuthorsStudies
Zheng, HC1
Xiang, LW1
Cui, ZG1
Xue, H1
E, Y1
Zhao, MZ1
Fan, L1
Lu, C1
Fan, Y1
Tian, X1
Lu, S1
Zhang, P1
Li, Z2
Xue, M1
Tao, W1
Peng, F1
Chen, R1
Tang, J1
Zhao, M1
Daniel, CJ1
Pelz, C1
Wang, X2
Munks, MW1
Ko, A1
Murugan, D1
Byers, SA1
Juarez, E1
Taylor, KL1
Fan, G1
Coussens, LM1
Link, JM1
Sears, RC1
Zhang, H2
Ma, Y2
Zhang, Q3
Liu, R1
Luo, H1
Duggan, WP1
O'Connell, E1
Prehn, JHM1
Burke, JP1
Colyn, L1
Alvarez-Sola, G1
Latasa, MU1
Uriarte, I1
Herranz, JM1
Arechederra, M1
Vlachogiannis, G1
Rae, C1
Pineda-Lucena, A1
Casadei-Gardini, A1
Pedica, F1
Aldrighetti, L1
López-López, A1
López-Gonzálvez, A1
Barbas, C1
Ciordia, S1
Van Liempd, SM1
Falcón-Pérez, JM1
Urman, J1
Sangro, B1
Vicent, S1
Iraburu, MJ1
Prosper, F1
Nelson, LJ1
Banales, JM1
Martinez-Chantar, ML1
Marin, JJG1
Braconi, C1
Trautwein, C1
Corrales, FJ1
Cubero, FJ1
Berasain, C1
Fernandez-Barrena, MG1
Avila, MA1
Yang, Y2
Zhu, Y2
Zhou, S1
Tang, P1
Xu, R1
Zhang, Y3
Wei, D1
Wen, J1
Thorne, RF1
Zhang, XD1
Guan, JL1
Liu, L1
Wu, M1
Chen, S2
Huo, FC1
Xie, M1
Zhu, ZM1
Zheng, JN1
Pei, DS1
Van Meenen, D1
Doege, A1
Alefeld, E1
Haase, A1
Beier, M1
Kiefer, T1
Biewald, E1
Metz, K1
Dräger, O1
Busch, MA1
Dünker, N1
Shu, Y1
Hao, Y1
Feng, J2
Liu, H1
Li, ST1
Jiang, Z1
Ye, L1
Zhou, Y1
Sun, Y1
Zhou, Z1
Wei, H1
Gao, P1
Sun, L1
Sun, W1
Zhao, E1
Cui, H1
Yoon, SJ1
Combs, JA1
Falzone, A1
Prieto-Farigua, N1
Caldwell, S1
Ackerman, HD1
Flores, ER1
DeNicola, GM1
Shunxi, W1
Xiaoxue, Y1
Guanbin, S1
Li, Y2
Junyu, J1
Wanqian, L1
Li, J1
Luo, X1
Wei, M1
Zhao, H1
Miyagishi, M1
Kasim, V1
Wu, S1
Lama Tamang, R1
Kumar, B1
Patel, SM1
Thapa, I1
Ahmad, A1
Kumar, V1
Ahmad, R1
Becker, DF1
Bastola, DK1
Dhawan, P1
Singh, AB1
Yang, J1
Cao, D1
Ou, R1
Yin, Z1
Liu, Y2
Huang, G1
Gu, C1
Fei, J1
Komar, D1
Juszczynski, P1
Meng, Q1
Sun, Q2
Xu, ZX1
Zhou, H1
Wang, Y1
Pan, S1
Fan, M1
Liu, Z1
Li, X1
Wang, H1
Vaughan, CA1
Singh, S1
Subler, MA1
Windle, JJ1
Inoue, K1
Fry, EA1
Pillappa, R1
Grossman, SR1
Windle, B1
Andrew Yeudall, W1
Deb, SP1
Deb, S1
Zhang, G1
Hu, H1
Liu, K1
Li, B1
Wang, Z1
Wu, Q1
Mei, Y1
Woock, AE1
Grible, JM1
Olex, AL1
Harrell, JC1
Zot, P1
Idowu, M1
Clevenger, CV1
Li, LY1
Xie, YH1
Xie, YM1
Liao, LD1
Xu, XE1
Zeng, FM1
Tao, LH1
Xie, WM1
Xie, JJ1
Xu, LY1
Li, EM1
Stauffer, S1
Zeng, Y2
Zhou, J1
Chen, X1
Chen, Y2
Dong, J2
Yin, L1
Xiao, Y1
Shen, H1
Su, S1
Chien, M1
Lin, C1
Chen, M1
Yang, S1
Wang, G1
Song, Y1
Liu, T1
Wang, C1
Liu, F1
Cai, X1
Miao, Z1
Xu, H2
Cao, L1
Li, F1
Suzuki, R1
Fukui, T1
Kishimoto, M1
Miyamoto, S1
Takahashi, Y1
Takeo, M1
Mitsuyama, T1
Sakaguchi, Y1
Uchida, K1
Nishio, A1
Okazaki, K1
Corkery, DP1
Holly, AC1
Lahsaee, S1
Dellaire, G1
Li, C1
Zhou, X1
Chen, J1
Lu, Y1
Tao, D1
Hu, W1
Zheng, X1
Bian, S1
Grant, NJ1
Coates, PJ1
Woods, YL1
Bray, SE1
Morrice, NA1
Hastie, CJ1
Lamont, DJ1
Carey, FA1
Sutherland, C1
Santio, NM1
Landor, SK1
Vahtera, L1
Ylä-Pelto, J1
Paloniemi, E1
Imanishi, SY1
Corthals, G1
Varjosalo, M1
Manoharan, GB1
Uri, A1
Lendahl, U1
Sahlgren, C1
Koskinen, PJ1
Wang, DW1
Wu, L1
Cao, Y1
Yang, L1
Liu, W1
E, XQ1
Ji, G1
Bi, ZG1
Lu, H1
Cai, Y1
Yu, YN1
Yang, H1
KIZER, DE1
LACEY, DE1

Reviews

7 reviews available for serine and Carcinogenesis

ArticleYear
Serine-Arginine Protein Kinase 1 (SRPK1): a systematic review of its multimodal role in oncogenesis.
    Molecular and cellular biochemistry, 2022, Volume: 477, Issue:10

    Topics: Arginine; Arginine Kinase; Carcinogenesis; Cell Transformation, Neoplastic; Humans; Neoplasms; NF-ka

2022
Target enzymes in serine-glycine-one-carbon metabolic pathway for cancer therapy.
    International journal of cancer, 2023, 06-15, Volume: 152, Issue:12

    Topics: Carbon; Carcinogenesis; Glycine; Humans; Metabolic Networks and Pathways; Neoplasms; Serine

2023
Serine Metabolic Reprogramming in Tumorigenesis, Tumor Immunity, and Clinical Treatment.
    Advances in nutrition (Bethesda, Md.), 2023, Volume: 14, Issue:5

    Topics: Carcinogenesis; Humans; Neoplasms; Proteins; Serine

2023
Rebelled epigenome: histone H3S10 phosphorylation and H3S10 kinases in cancer biology and therapy.
    Clinical epigenetics, 2020, 10-14, Volume: 12, Issue:1

    Topics: Biology; Carcinogenesis; Chromatin; Clinical Trials as Topic; DNA Methylation; Epigenesis, Genetic;

2020
LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases.
    Molecular metabolism, 2021, Volume: 44

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Apoptosis; Carcinogene

2021
Serine, glycine and one‑carbon metabolism in cancer (Review).
    International journal of oncology, 2021, Volume: 58, Issue:2

    Topics: Animals; Antineoplastic Agents; Carbon; Carcinogenesis; Disease Models, Animal; Glycine; Humans; Met

2021
Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response.
    Nucleus (Austin, Tex.), 2015, Volume: 6, Issue:4

    Topics: Alternative Splicing; Arginine; Carcinogenesis; Cell Line, Tumor; Gene Regulatory Networks; Humans;

2015

Other Studies

28 other studies available for serine and Carcinogenesis

ArticleYear
The clinicopathological and prognostic significances of LATS1 expression in breast cancer.
    Histology and histopathology, 2022, Volume: 37, Issue:7

    Topics: Breast Neoplasms; Carcinogenesis; Female; Gene Expression Regulation, Neoplastic; Humans; Prognosis;

2022
High-fat diet promotes colorectal carcinogenesis through SERCA2 mediated serine phosphorylation of Annexin A2.
    The international journal of biochemistry & cell biology, 2022, Volume: 145

    Topics: Animals; Annexin A2; Carcinogenesis; Colorectal Neoplasms; Diet, High-Fat; Humans; Mice; Mice, Inbre

2022
T-cell Dysfunction upon Expression of MYC with Altered Phosphorylation at Threonine 58 and Serine 62.
    Molecular cancer research : MCR, 2022, 07-06, Volume: 20, Issue:7

    Topics: Animals; Carcinogenesis; Lymphoma, T-Cell; Mice; Phosphorylation; Proto-Oncogene Proteins c-myc; Ser

2022
A pancancer analysis of the carcinogenic role of receptor-interacting serine/threonine protein kinase-2 (RIPK2) in human tumours.
    BMC medical genomics, 2022, 04-26, Volume: 15, Issue:1

    Topics: Carcinogenesis; Carcinogens; Humans; Neoplasms; NF-kappa B; Receptor-Interacting Protein Serine-Thre

2022
New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming.
    Journal of experimental & clinical cancer research : CR, 2022, May-26, Volume: 41, Issue:1

    Topics: Animals; Arachnodactyly; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinogenesis; Cholangiocar

2022
TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.
    The EMBO journal, 2022, 07-18, Volume: 41, Issue:14

    Topics: Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Carcinogenesis; DNA-Binding Proteins; Human

2022
SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT.
    Genomics, 2022, Volume: 114, Issue:4

    Topics: Amidophosphoribosyltransferase; Carbon; Carcinogenesis; Carcinoma, Renal Cell; Cell Proliferation; C

2022
ADAM10 and ADAM17-Novel Players in Retinoblastoma Carcinogenesis.
    International journal of molecular sciences, 2022, Oct-20, Volume: 23, Issue:20

    Topics: ADAM10 Protein; ADAM17 Protein; Amyloid Precursor Protein Secretases; Carcinogenesis; Disintegrins;

2022
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
    The EMBO journal, 2022, 12-01, Volume: 41, Issue:23

    Topics: Carcinogenesis; Cell Line, Tumor; DNA, Mitochondrial; Humans; Liver Neoplasms; Phosphoglycerate Dehy

2022
Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors.
    Cancer research, 2023, 05-02, Volume: 83, Issue:9

    Topics: Animals; Carcinogenesis; Cysteine; Cystine; Glutathione; Mammals; Mice; Neoplasms; Serine

2023
YY2/PHGDH axis suppresses tumorigenesis by inhibiting tumor cell de novo serine biosynthesis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 165

    Topics: Carcinogenesis; Cell Line, Tumor; Humans; Phosphoglycerate Dehydrogenase; Serine; Transcription Fact

2023
Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling.
    Cells, 2023, 07-18, Volume: 12, Issue:14

    Topics: beta Catenin; Carcinogenesis; Chromatography, Liquid; Colonic Neoplasms; Humans; Microtubule-Associa

2023
The role of phosphorylation of MLF2 at serine 24 in BCR-ABL leukemogenesis.
    Cancer gene therapy, 2020, Volume: 27, Issue:1-2

    Topics: Animals; Apoptosis; Carcinogenesis; Cell Proliferation; Colony-Forming Units Assay; Drug Resistance,

2020
The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.
    Nature communications, 2021, 01-29, Volume: 12, Issue:1

    Topics: Animals; Carcinogenesis; Cell Line, Tumor; Disease Models, Animal; Female; Gain of Function Mutation

2021
Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis.
    Oncogene, 2021, Volume: 40, Issue:16

    Topics: Carcinogenesis; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; RNA, Long Noncoding; Serine; Tra

2021
Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer.
    Scientific reports, 2021, 06-29, Volume: 11, Issue:1

    Topics: Breast Neoplasms; Carcinogenesis; Female; Humans; MCF-7 Cells; Neoplasm Proteins; Phosphorylation; P

2021
Ezrin Ser66 phosphorylation regulates invasion and metastasis of esophageal squamous cell carcinoma cells by mediating filopodia formation.
    The international journal of biochemistry & cell biology, 2017, Volume: 88

    Topics: Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cytos

2017
CDK1-mediated mitotic phosphorylation of PBK is involved in cytokinesis and inhibits its oncogenic activity.
    Cellular signalling, 2017, Volume: 39

    Topics: Carcinogenesis; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Cytokinesis; HEK293 Cells

2017
Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity.
    Cell death & disease, 2019, 05-16, Volume: 10, Issue:6

    Topics: Carcinogenesis; CDC2 Protein Kinase; Cell Line, Tumor; Cell Movement; DNA-Binding Proteins; Gene Del

2019
RAGE gene polymorphism and environmental factor in the risk of oral cancer.
    Journal of dental research, 2015, Volume: 94, Issue:3

    Topics: Adenine; Areca; Base Pairing; Base Sequence; Carcinogenesis; Case-Control Studies; Cytosine; Female;

2015
PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis.
    Oncotarget, 2015, Volume: 6, Issue:12

    Topics: Animals; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neop

2015
Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.
    Journal of Crohn's & colitis, 2015, Volume: 9, Issue:7

    Topics: Animals; Azoxymethane; beta Catenin; Biomarkers, Tumor; Carcinogenesis; Colitis; Colorectal Neoplasm

2015
PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of Stathmin1.
    Oncotarget, 2015, Sep-29, Volume: 6, Issue:29

    Topics: Argonaute Proteins; Blotting, Western; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Prolife

2015
Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.
    BMC cancer, 2015, Nov-10, Volume: 15

    Topics: Amino Acid Sequence; Biomarkers, Tumor; Carcinogenesis; Cyclin-Dependent Kinase 5; Humans; Intercell

2015
Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.
    Oncotarget, 2016, Jul-12, Volume: 7, Issue:28

    Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Movement; Chick Embryo; Female; Humans; Male; MCF-7

2016
A novel mechanism of mTORC1-mediated serine/glycine metabolism in osteosarcoma development.
    Cellular signalling, 2017, Volume: 29

    Topics: Apoptosis; Carbon; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Glycine; Humans; Mechanisti

2017
[The over-expression of serine/threonine kinase 15 protein in oral carcinogenesis].
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2009, Volume: 27, Issue:1

    Topics: Aurora Kinase A; Carcinogenesis; Carcinoma, Squamous Cell; Humans; Immunohistochemistry; Lymphatic M

2009
Deletion of serine dehydrase and cystathionine synthetase activities during azo-dye carcinogenesis.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1961, Volume: 106

    Topics: Amino Acids; Animals; Azo Compounds; Carcinogenesis; Carcinoma, Hepatocellular; Cystathionine beta-S

1961