serine has been researched along with Cancer of Prostate in 54 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prostate cancer is the leading cause of cancer in men, and its incidence increases with age." | 2.82 | Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer. ( Juárez-López, D; Schcolnik-Cabrera, A, 2022) |
| "Odds ratios (ORs) for prostate cancer were estimated by unconditional logistic and polytomous regression." | 2.42 | ELAC2/HPC2 polymorphisms, prostate-specific antigen levels, and prostate cancer. ( Boyle, P; English, DR; Giles, GG; Hopper, JL; McCredie, MR; Morris, H; Neufing, P; Severi, G; Southey, MC; Tesoriero, A; Tilley, W, 2003) |
| "Functional analysis of AR in prostate cancer PC-3 cells showed ligand-induced AR nuclear translocation and transactivation were disturbed by its phosphorylation at Ser815." | 1.62 | Androgen receptor phosphorylated at Ser815: The expression and function in the prostate and tumor-derived cells. ( Kakizaki, S; Kawasaki, Y; Negishi, M; Nobusawa, S; Sakaki, T; Sekine, Y; Yokobori, K, 2021) |
| "The SPOP-mutated subtype of prostate cancer shows high genomic instability, but the underlying mechanisms causing this phenotype are still largely unknown." | 1.62 | Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis. ( Cao, X; Cong, L; Fang, S; Gao, K; Gong, Z; Jin, X; Li, J; Li, Q; Lin, T; Lin, Z; Ma, Q; Meng, X; Qi, H; Qing, S; Shen, L; Wang, C; Wang, J; Wang, S; Xi, Y; Yang, J; Ye, M; Zhuang, H, 2021) |
| "Tumorigenesis is a multistep process involving co-operation between several deregulated oncoproteins." | 1.43 | Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells. ( Corthals, G; Imanishi, SY; Koskinen, PJ; Landor, SK; Lendahl, U; Manoharan, GB; Paloniemi, E; Sahlgren, C; Santio, NM; Uri, A; Vahtera, L; Varjosalo, M; Ylä-Pelto, J, 2016) |
| "We apply multiple prostate cancer cell models to demonstrate that enzalutamide induces differential activation of protein phosphatase-1 (PP-1) and Akt kinase depending on the gene context of cancer cells." | 1.42 | AR-v7 protein expression is regulated by protein kinase and phosphatase. ( Dong, X; Gleave, ME; Li, Y; Rennie, PS; Xie, N, 2015) |
| "Mahanine treatment causes a time- and dose-dependent decline in AR protein levels, including truncated AR splice variants, in a panel of androgen-responsive and -independent prostate cancer cells." | 1.40 | A naturally derived small molecule disrupts ligand-dependent and ligand-independent androgen receptor signaling in human prostate cancer cells. ( Amin, KS; Baishya, G; Banerjee, PP; Barua, NC; Bhattacharya, S; Jagadeesh, S; Rao, PG, 2014) |
| "Immunohistochemical analysis of prostate cancer tissue microarrays showed significant P-AR S213 expression that was associated with hormone refractory prostate cancers, likely identifying cells with catalytically active PIM1." | 1.39 | Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer. ( Garabedian, MJ; Gerald, WL; Ha, S; Iqbal, NJ; Lee, P; Lepor, H; Logan, SK; Melamed, J; Mita, P; Ruoff, R; Taneja, SS, 2013) |
| "We studied 402 prostate cancer patients for the presence of the 1772C > T (P582S) and 1790G > A (A588T) mutations within the oxygen-dependent domain of HIF-1 alpha." | 1.34 | The homozygous P582S mutation in the oxygen-dependent degradation domain of HIF-1 alpha is associated with increased risk for prostate cancer. ( Bar-Shira, A; Mabjeesh, NJ; Matzkin, H; Orr-Urtreger, A, 2007) |
| "The management of locally advanced prostate cancer is difficult because the cancer often becomes hormone insensitive and unresponsive to current chemotherapeutic agents." | 1.34 | Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. ( Aziz, MH; Church, DR; Dreckschmidt, NE; Manoharan, HT; Oberley, TD; Verma, AK; Wilding, G; Zhong, W, 2007) |
| "These data imply that COX-2-positive prostate cancer cells can have impaired p53 function even in the presence of wild-type p53 and that p53 activity can be restored in these cells via inhibition of COX-2 activity." | 1.33 | Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. ( Kirschenbaum, A; Levine, AC; Liu, XH; Yao, S; Yu, K, 2005) |
| "In LNCaP prostate cancer cells, activation of either MAPK kinase (MKK) 4:c-Jun N-terminal kinase (JNK) or MKK6:p38 signaling pathways increased Ser 650 phosphorylation, whereas pharmacologic inhibition of JNK or p38 signaling led to a reduction of AR Ser 650 phosphorylation." | 1.33 | Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization. ( Black, BE; Eblen, ST; Gioeli, D; Gordon, V; Kesler, CT; Paschal, BM; Spencer, A; Weber, MJ, 2006) |
| "Resveratrol causes apoptosis in DU 145 prostate cancer cells." | 1.31 | Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. ( Bennett, JA; Davis, FB; Davis, PJ; Lin, HY; Martino, LJ; Shih, A; Tang, HY, 2002) |
| "We treated three human prostate cancer cell lines with etoposide, a toposiomerase II inhibitor with activity against various tumors including prostate cancer." | 1.31 | Phosphorylation of Fas-associated death domain contributes to enhancement of etoposide-induced apoptosis in prostate cancer cells. ( Ishida, E; Kishi, M; Konishi, N; Nakamura, M; Shimada, K; Yonehara, S, 2002) |
| "In a cohort of 1253 prostate cancer patients and age-matched controls, the presence of the polymorphism was associated with a 1." | 1.31 | Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function. ( Abbaszadegan, M; Ahronovitz, N; Brown, KM; Gelmann, EP; Hayes, RB; Ma, J; Stampfer, MJ; Steadman, DJ; Strand, K; Swope, S; Voeller, HJ, 2002) |
| "GGT activity of the androgen-responsive prostate cancer cell line LNCaP increases >50% above that of the control after a 72-h exposure to 1 nM R1881." | 1.30 | Alteration in gamma-glutamyl transpeptidase activity and messenger RNA of human prostate carcinoma cells by androgen. ( Pickhardt, PA; Ripple, MO; Wilding, G, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (3.70) | 18.2507 |
| 2000's | 26 (48.15) | 29.6817 |
| 2010's | 20 (37.04) | 24.3611 |
| 2020's | 6 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Yokobori, K | 1 |
| Kawasaki, Y | 1 |
| Sekine, Y | 1 |
| Nobusawa, S | 1 |
| Sakaki, T | 1 |
| Negishi, M | 1 |
| Kakizaki, S | 1 |
| Schcolnik-Cabrera, A | 1 |
| Juárez-López, D | 1 |
| Mangangcha, IR | 1 |
| Brojen Singh, RK | 1 |
| Lebeche, D | 1 |
| Ali, S | 1 |
| Falegan, OS | 1 |
| Jarvi, K | 1 |
| Vogel, HJ | 1 |
| Hyndman, ME | 1 |
| Jin, X | 1 |
| Qing, S | 1 |
| Li, Q | 1 |
| Zhuang, H | 1 |
| Shen, L | 1 |
| Li, J | 1 |
| Qi, H | 1 |
| Lin, T | 1 |
| Lin, Z | 1 |
| Wang, J | 1 |
| Cao, X | 1 |
| Yang, J | 1 |
| Ma, Q | 1 |
| Cong, L | 1 |
| Xi, Y | 1 |
| Fang, S | 1 |
| Meng, X | 1 |
| Gong, Z | 1 |
| Ye, M | 1 |
| Wang, S | 1 |
| Wang, C | 1 |
| Gao, K | 1 |
| Schirmer, AU | 1 |
| Driver, LM | 1 |
| Zhao, MT | 1 |
| Wells, CI | 1 |
| Pickett, JE | 1 |
| O'Bryne, SN | 1 |
| Eduful, BJ | 1 |
| Yang, X | 1 |
| Howard, L | 1 |
| You, S | 1 |
| Devi, GR | 1 |
| DiGiovanni, J | 1 |
| Freedland, SJ | 1 |
| Chi, JT | 1 |
| Drewry, DH | 1 |
| Macias, E | 1 |
| Reina-Campos, M | 1 |
| Linares, JF | 1 |
| Duran, A | 1 |
| Cordes, T | 1 |
| L'Hermitte, A | 1 |
| Badur, MG | 1 |
| Bhangoo, MS | 1 |
| Thorson, PK | 1 |
| Richards, A | 1 |
| Rooslid, T | 1 |
| Garcia-Olmo, DC | 1 |
| Nam-Cha, SY | 1 |
| Salinas-Sanchez, AS | 1 |
| Eng, K | 1 |
| Beltran, H | 1 |
| Scott, DA | 1 |
| Metallo, CM | 1 |
| Moscat, J | 1 |
| Diaz-Meco, MT | 1 |
| Gao, X | 1 |
| Locasale, JW | 1 |
| Reid, MA | 1 |
| Haiping, C | 1 |
| Qi, X | 1 |
| Dawei, L | 1 |
| Qiang, W | 1 |
| Feola, A | 1 |
| Cimini, A | 1 |
| Migliucci, F | 1 |
| Iorio, R | 1 |
| Zuchegna, C | 1 |
| Rothenberger, R | 1 |
| Cito, L | 1 |
| Porcellini, A | 1 |
| Unteregger, G | 1 |
| Tombolini, V | 1 |
| Giordano, A | 1 |
| Di Domenico, M | 1 |
| Hong, SK | 1 |
| Jeong, JH | 1 |
| Chan, AM | 1 |
| Park, JI | 1 |
| de Vogel, S | 1 |
| Ulvik, A | 1 |
| Meyer, K | 1 |
| Ueland, PM | 1 |
| Nygård, O | 1 |
| Vollset, SE | 1 |
| Tell, GS | 1 |
| Gregory, JF | 1 |
| Tretli, S | 1 |
| Bjørge, T | 1 |
| Lee, SL | 1 |
| Chou, CC | 1 |
| Chuang, HC | 1 |
| Hsu, EC | 1 |
| Chiu, PC | 1 |
| Kulp, SK | 1 |
| Byrd, JC | 1 |
| Chen, CS | 1 |
| Hsu, FN | 1 |
| Chen, MC | 1 |
| Lin, KC | 1 |
| Peng, YT | 1 |
| Li, PC | 1 |
| Lin, E | 1 |
| Chiang, MC | 1 |
| Hsieh, JT | 2 |
| Lin, H | 1 |
| Amin, KS | 1 |
| Jagadeesh, S | 1 |
| Baishya, G | 1 |
| Rao, PG | 1 |
| Barua, NC | 1 |
| Bhattacharya, S | 1 |
| Banerjee, PP | 1 |
| Castoria, G | 1 |
| Giovannelli, P | 1 |
| Di Donato, M | 1 |
| Ciociola, A | 1 |
| Hayashi, R | 1 |
| Bernal, F | 1 |
| Appella, E | 1 |
| Auricchio, F | 1 |
| Migliaccio, A | 1 |
| Thakur, N | 1 |
| Gudey, SK | 1 |
| Marcusson, A | 1 |
| Fu, JY | 1 |
| Bergh, A | 1 |
| Heldin, CH | 2 |
| Landström, M | 2 |
| Zhou, Y | 1 |
| Yamada, N | 1 |
| Tanaka, T | 1 |
| Hori, T | 1 |
| Yokoyama, S | 1 |
| Hayakawa, Y | 1 |
| Yano, S | 1 |
| Fukuoka, J | 1 |
| Koizumi, K | 1 |
| Saiki, I | 1 |
| Sakurai, H | 1 |
| Li, Y | 1 |
| Xie, N | 1 |
| Gleave, ME | 1 |
| Rennie, PS | 1 |
| Dong, X | 1 |
| Santio, NM | 1 |
| Landor, SK | 1 |
| Vahtera, L | 1 |
| Ylä-Pelto, J | 1 |
| Paloniemi, E | 1 |
| Imanishi, SY | 1 |
| Corthals, G | 1 |
| Varjosalo, M | 1 |
| Manoharan, GB | 1 |
| Uri, A | 1 |
| Lendahl, U | 1 |
| Sahlgren, C | 1 |
| Koskinen, PJ | 1 |
| Mirkheshti, N | 1 |
| Park, S | 1 |
| Jiang, S | 1 |
| Cropper, J | 1 |
| Werner, SL | 1 |
| Song, CS | 1 |
| Chatterjee, B | 1 |
| Patek, S | 1 |
| Willder, J | 1 |
| Heng, J | 1 |
| Taylor, B | 1 |
| Horgan, P | 1 |
| Leung, H | 1 |
| Underwood, M | 1 |
| Edwards, J | 2 |
| Ponguta, LA | 1 |
| Gregory, CW | 1 |
| French, FS | 1 |
| Wilson, EM | 1 |
| Qin, HR | 1 |
| Kim, HJ | 1 |
| Kim, JY | 1 |
| Hurt, EM | 1 |
| Klarmann, GJ | 1 |
| Kawasaki, BT | 1 |
| Duhagon Serrat, MA | 1 |
| Farrar, WL | 1 |
| Shigemura, K | 1 |
| Isotani, S | 1 |
| Wang, R | 1 |
| Fujisawa, M | 1 |
| Gotoh, A | 1 |
| Marshall, FF | 1 |
| Zhau, HE | 1 |
| Chung, LW | 1 |
| Smith, FD | 1 |
| Samelson, BK | 1 |
| Scott, JD | 1 |
| Ha, S | 1 |
| Iqbal, NJ | 1 |
| Mita, P | 1 |
| Ruoff, R | 1 |
| Gerald, WL | 1 |
| Lepor, H | 1 |
| Taneja, SS | 1 |
| Lee, P | 1 |
| Melamed, J | 1 |
| Garabedian, MJ | 1 |
| Logan, SK | 1 |
| Choi, HK | 1 |
| Yoo, JY | 1 |
| Jeong, MH | 1 |
| Park, SY | 1 |
| Shin, DM | 1 |
| Jang, SW | 1 |
| Yoon, HG | 1 |
| Choi, KC | 1 |
| Willder, JM | 1 |
| Heng, SJ | 1 |
| McCall, P | 1 |
| Adams, CE | 1 |
| Tannahill, C | 1 |
| Fyffe, G | 1 |
| Seywright, M | 1 |
| Horgan, PG | 1 |
| Leung, HY | 1 |
| Underwood, MA | 1 |
| Lin, HY | 1 |
| Shih, A | 1 |
| Davis, FB | 1 |
| Tang, HY | 1 |
| Martino, LJ | 1 |
| Bennett, JA | 1 |
| Davis, PJ | 1 |
| Shimada, K | 1 |
| Nakamura, M | 1 |
| Ishida, E | 1 |
| Kishi, M | 1 |
| Yonehara, S | 1 |
| Konishi, N | 1 |
| Tyagi, A | 1 |
| Agarwal, C | 1 |
| Agarwal, R | 1 |
| Severi, G | 1 |
| Giles, GG | 1 |
| Southey, MC | 1 |
| Tesoriero, A | 1 |
| Tilley, W | 1 |
| Neufing, P | 1 |
| Morris, H | 1 |
| English, DR | 1 |
| McCredie, MR | 1 |
| Boyle, P | 1 |
| Hopper, JL | 1 |
| Liu, J | 1 |
| Rothermund, CA | 1 |
| Ayala-Sanmartin, J | 1 |
| Vishwanatha, JK | 1 |
| Adler, D | 1 |
| Kanji, N | 1 |
| Trpkov, K | 1 |
| Fick, G | 1 |
| Hughes, RM | 1 |
| Huang, H | 1 |
| Zegarra-Moro, OL | 1 |
| Benson, D | 1 |
| Tindall, DJ | 1 |
| Song, JJ | 1 |
| Lee, YJ | 1 |
| Jiang, C | 1 |
| Hu, H | 1 |
| Malewicz, B | 1 |
| Wang, Z | 2 |
| Lü, J | 1 |
| Kim, YY | 1 |
| Park, BJ | 1 |
| Kim, DJ | 1 |
| Kim, WH | 1 |
| Kim, S | 1 |
| Oh, KS | 1 |
| Lim, JY | 1 |
| Kim, J | 1 |
| Park, C | 1 |
| Park, SI | 1 |
| Liu, XH | 1 |
| Kirschenbaum, A | 1 |
| Yu, K | 1 |
| Yao, S | 1 |
| Levine, AC | 1 |
| Edlund, S | 1 |
| Lee, SY | 1 |
| Grimsby, S | 1 |
| Zhang, S | 1 |
| Aspenström, P | 1 |
| Zerbini, LF | 1 |
| Wang, Y | 1 |
| Correa, RG | 1 |
| Cho, JY | 1 |
| Libermann, TA | 1 |
| Gioeli, D | 2 |
| Black, BE | 1 |
| Gordon, V | 1 |
| Spencer, A | 1 |
| Kesler, CT | 1 |
| Eblen, ST | 1 |
| Paschal, BM | 1 |
| Weber, MJ | 2 |
| Götz, C | 1 |
| Kartarius, S | 1 |
| Schetting, S | 1 |
| Montenarh, M | 1 |
| Park, HY | 1 |
| Kim, MK | 1 |
| Moon, SI | 1 |
| Cho, YH | 1 |
| Lee, CH | 1 |
| Orr-Urtreger, A | 1 |
| Bar-Shira, A | 1 |
| Matzkin, H | 1 |
| Mabjeesh, NJ | 1 |
| Ho, YK | 1 |
| Bargagna-Mohan, P | 1 |
| Wehenkel, M | 1 |
| Mohan, R | 1 |
| Kim, KB | 1 |
| Aziz, MH | 1 |
| Manoharan, HT | 1 |
| Church, DR | 1 |
| Dreckschmidt, NE | 1 |
| Zhong, W | 1 |
| Oberley, TD | 1 |
| Wilding, G | 2 |
| Verma, AK | 1 |
| Ripple, MO | 1 |
| Pickhardt, PA | 1 |
| Tseng, CP | 1 |
| Ely, BD | 1 |
| Pong, RC | 1 |
| Zhou, J | 1 |
| Wen, Y | 1 |
| Hu, MC | 1 |
| Makino, K | 1 |
| Spohn, B | 1 |
| Bartholomeusz, G | 1 |
| Yan, DH | 1 |
| Hung, MC | 1 |
| Lin, HK | 1 |
| Yeh, S | 1 |
| Kang, HY | 1 |
| Chang, C | 1 |
| Gelmann, EP | 1 |
| Steadman, DJ | 1 |
| Ma, J | 1 |
| Ahronovitz, N | 1 |
| Voeller, HJ | 1 |
| Swope, S | 1 |
| Abbaszadegan, M | 1 |
| Brown, KM | 1 |
| Strand, K | 1 |
| Hayes, RB | 1 |
| Stampfer, MJ | 1 |
| Ficarro, SB | 1 |
| Kwiek, JJ | 1 |
| Aaronson, D | 1 |
| Hancock, M | 1 |
| Catling, AD | 1 |
| White, FM | 1 |
| Christian, RE | 1 |
| Settlage, RE | 1 |
| Shabanowitz, J | 1 |
| Hunt, DF | 1 |
2 reviews available for serine and Cancer of Prostate
| Article | Year |
|---|---|
Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer.
Topics: Amino Acids; Arginine; Carbohydrates; Glutamine; Humans; Leucine; Lipids; Male; Proline; Prostatic N | 2022 |
ELAC2/HPC2 polymorphisms, prostate-specific antigen levels, and prostate cancer.
Topics: Aged; Alanine; Case-Control Studies; Genetic Predisposition to Disease; Heterozygote; Homozygote; Hu | 2003 |
52 other studies available for serine and Cancer of Prostate
| Article | Year |
|---|---|
Androgen receptor phosphorylated at Ser815: The expression and function in the prostate and tumor-derived cells.
Topics: Animals; Chlorocebus aethiops; COS Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Ma | 2021 |
Xanthone glucoside 2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one binds to the ATP-binding pocket of glycogen synthase kinase 3β and inhibits its activity: implications in prostate cancer and associated cardiovascular disease risk.
Topics: Androgen Antagonists; Androgens; Cardiovascular Diseases; Glucosides; Glycogen Synthase Kinase 3; Gl | 2022 |
Seminal plasma metabolomics reveals lysine and serine dysregulation as unique features distinguishing between prostate cancer tumors of Gleason grades 6 and 7.
Topics: Aged; Biomarkers, Tumor; Biopsy; Diagnosis, Differential; Humans; Lysine; Magnetic Resonance Spectro | 2021 |
Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis.
Topics: Ataxia Telangiectasia Mutated Proteins; Carrier Proteins; Cell Line, Tumor; Chromobox Protein Homolo | 2021 |
Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.
Topics: Cell Line, Tumor; Humans; Intracellular Signaling Peptides and Proteins; Male; Prostatic Neoplasms; | 2022 |
Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer.
Topics: Activating Transcription Factor 4; Biosynthetic Pathways; Carcinoma, Neuroendocrine; Cell Line, Tumo | 2019 |
Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer.
Topics: Carbon; Humans; Male; Methionine; Neoplasm Recurrence, Local; Prostatic Neoplasms; Serine | 2019 |
[Citron Rho-interacting serine/threonine kinase knockdown suppresses prostate cancer cell proliferation and metastasis by blocking Hippo-YAP pathway].
Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Cell Movement; Cell Proliferation; Hippo Sig | 2019 |
The inhibition of p85αPI3KSer83 phosphorylation prevents cell proliferation and invasion in prostate cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Male; Microscopy, Confocal; Phosphatidylino | 2013 |
AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion.
Topics: Androgens; Animals; Cell Line, Tumor; Humans; Male; MAP Kinase Signaling System; Mice; Mitogen-Activ | 2013 |
Sarcosine and other metabolites along the choline oxidation pathway in relation to prostate cancer--a large nested case-control study within the JANUS cohort in Norway.
Topics: Betaine; Biomarkers, Tumor; Case-Control Studies; Choline; Chromatography, Liquid; Cohort Studies; G | 2014 |
Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.
Topics: Anilides; Benzoates; Breast Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Survival; Epithelial | 2013 |
Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser⁷²⁷ on STAT3 in prostate cancer cells.
Topics: Amino Acid Substitution; Animals; Biological Transport; Cell Line, Tumor; Cell Nucleus; Cyclin-Depen | 2013 |
A naturally derived small molecule disrupts ligand-dependent and ligand-independent androgen receptor signaling in human prostate cancer cells.
Topics: Androgens; Blotting, Western; Carbazoles; CDC2 Protein Kinase; Cytoplasm; Dihydrotestosterone; Dose- | 2014 |
Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells.
Topics: Animals; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase Inhibito | 2014 |
TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP | 2014 |
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Catalysis; Cell Line, Tumor; Cell Movement; Cytoki | 2015 |
AR-v7 protein expression is regulated by protein kinase and phosphatase.
Topics: Alternative Splicing; Benzamides; Cell Line, Tumor; Cytoplasm; Disease Progression; Gene Expression | 2015 |
Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.
Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Movement; Chick Embryo; Female; Humans; Male; MCF-7 | 2016 |
Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer.
Topics: AMP-Activated Protein Kinases; Androgen Receptor Antagonists; Animals; Antibiotics, Antineoplastic; | 2016 |
Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients.
Topics: Cell Line, Tumor; Cell Nucleus; Cytoplasm; Disease Progression; Humans; Male; Phosphorylation; Progn | 2017 |
Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer.
Topics: Animals; Cell Line; Cell Nucleus; Chlorocebus aethiops; Dependovirus; Epidermal Growth Factor; Gene | 2008 |
Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Human | 2008 |
Soluble factors derived from stroma activated androgen receptor phosphorylation in human prostate LNCaP cells: roles of ERK/MAP kinase.
Topics: Androgens; Cell Communication; Cell Division; Coculture Techniques; Culture Media, Conditioned; Epit | 2009 |
Discovery of cellular substrates for protein kinase A using a peptide array screening protocol.
Topics: Amino Acid Motifs; Amino Acid Sequence; Blotting, Western; Cell Proliferation; Cyclic AMP-Dependent | 2011 |
Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer.
Topics: Amino Acid Substitution; Antineoplastic Agents, Hormonal; Blotting, Western; Caveolin 2; Cell Line, | 2013 |
Protein kinase A phosphorylates NCoR to enhance its nuclear translocation and repressive function in human prostate cancer cells.
Topics: Active Transport, Cell Nucleus; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Gene Expres | 2013 |
Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients.
Topics: Aged; Biomarkers, Tumor; CDC2 Protein Kinase; Disease-Free Survival; Humans; Male; MAP Kinase Signal | 2013 |
Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; DNA Mutational Analysis; Enzyme Activation; Gene Expre | 2002 |
Phosphorylation of Fas-associated death domain contributes to enhancement of etoposide-induced apoptosis in prostate cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; bcl-X Protein; Carrier Proteins; CASP8 and FADD-Lik | 2002 |
Inhibition of retinoblastoma protein (Rb) phosphorylation at serine sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention.
Topics: Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; DNA-Binding Proteins; Dose-Res | 2002 |
Nuclear annexin II negatively regulates growth of LNCaP cells and substitution of ser 11 and 25 to glu prevents nucleo-cytoplasmic shuttling of annexin II.
Topics: Active Transport, Cell Nucleus; Amino Acid Substitution; Annexin A2; Cell Cycle; Cell Division; Cell | 2003 |
HPC2/ELAC2 gene variants associated with incident prostate cancer.
Topics: Age Factors; Alleles; Genetic Predisposition to Disease; Genetic Variation; Genotype; Heterozygote; | 2003 |
Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells.
Topics: Androgens; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Male; | 2004 |
Tryptophan 621 and serine 667 residues of Daxx regulate its nuclear export during glucose deprivation.
Topics: Active Transport, Cell Nucleus; Alanine; Antibiotics, Antineoplastic; Binding Sites; Cell Line, Tumo | 2004 |
Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Benzothiazoles; Caspase Inhibitors; Caspases; Cell Line, | 2004 |
Modification of serine 392 is a critical event in the regulation of p53 nuclear export and stability.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Amino Acid Substitution; Cell Line, Tumor; DNA | 2004 |
Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line.
Topics: Apoptosis; Cell Line, Tumor; Cell Nucleus; Cyclooxygenase 2; Gene Expression Regulation, Enzymologic | 2005 |
Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis.
Topics: Animals; Apoptosis; beta Catenin; Cell Fractionation; Chlorocebus aethiops; COS Cells; Cytoskeletal | 2005 |
Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells.
Topics: Adenoviridae; Anthracenes; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle Proteins; | 2005 |
Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization.
Topics: Active Transport, Cell Nucleus; Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Cell | 2006 |
Immunologically defined subclasses of the protein kinase CK2 beta-subunit in prostate carcinoma cell lines.
Topics: Blotting, Western; Casein Kinase II; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin B; Electrophoresi | 2005 |
Cell cycle arrest and apoptotic induction in LNCaP cells by MCS-C2, novel cyclin-dependent kinase inhibitor, through p53/p21WAF1/CIP1 pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependen | 2006 |
The homozygous P582S mutation in the oxygen-dependent degradation domain of HIF-1 alpha is associated with increased risk for prostate cancer.
Topics: Adult; Aged; Aged, 80 and over; Cell Hypoxia; Female; Gene Frequency; Genetic Predisposition to Dise | 2007 |
LMP2-specific inhibitors: chemical genetic tools for proteasome biology.
Topics: Adenocarcinoma; Animals; Catalytic Domain; Cell Line, Tumor; Chymotrypsin; Cysteine Endopeptidases; | 2007 |
Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.
Topics: Animals; Cell Line, Tumor; Cytokines; Humans; Male; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; | 2007 |
Alteration in gamma-glutamyl transpeptidase activity and messenger RNA of human prostate carcinoma cells by androgen.
Topics: Androgens; Borates; Cell Division; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; Glycyl | 1997 |
The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; An | 1999 |
HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Division; Cell Line; Cell Survival; Chromones; | 2000 |
Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.
Topics: Amino Acid Substitution; Androgen Receptor Antagonists; Apoptosis; Chromones; Dihydrotestosterone; E | 2001 |
Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function.
Topics: DNA, Neoplasm; Genetic Predisposition to Disease; Homeodomain Proteins; Humans; Male; Phosphorylatio | 2002 |
Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chromatography, Affinity; Colforsin; COS Cells; Epiderm | 2002 |