serine has been researched along with Cancer of Pancreas in 43 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We examined the role of ILK in determining pancreatic adenocarcinoma cellular chemoresistance to the nucleoside analogue gemcitabine." | 7.73 | RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. ( Ashley, SW; Benoit, E; Duxbury, MS; Ito, H; Waseem, T; Whang, EE, 2005) |
| "Azaserine was selected because it behaves as a direct-acting mutagen in two bacterial test systems and because tissue distribution studies showed concentration especially in kidney and pancreas." | 5.25 | Adenocarcinoma of the pancreas in azaserine-treated rats. ( Curphey, TJ; Longnecker, DS, 1975) |
| " We examined the role of ILK in determining pancreatic adenocarcinoma cellular chemoresistance to the nucleoside analogue gemcitabine." | 3.73 | RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. ( Ashley, SW; Benoit, E; Duxbury, MS; Ito, H; Waseem, T; Whang, EE, 2005) |
| " To address this problem, we have measured the synthetic rate of fibrinogen (perhaps the major acute phase protein) and plasma amino acid profiles in a group of patients with adenocarcinoma of the pancreas and an ongoing inflammatory response (serum C-reactive protein >10 mg/L in the absence of any other obvious infective or inflammatory cause)." | 3.70 | Fibrinogen synthesis is elevated in fasting cancer patients with an acute phase response. ( Falconer, JS; Fearon, KC; McMillan, DC; Preston, T; Shenkin, A; Slater, C, 1998) |
| "We exposed colorectal, breast and pancreatic cancer cell lines/organoids to radiation in vitro and in vivo in the presence and absence of exogenous serine and glycine." | 1.72 | Sensitisation of cancer cells to radiotherapy by serine and glycine starvation. ( Athineos, D; Blyth, K; Chalmers, AJ; Del Latto, M; Falcone, M; Gao, Y; Kierstead, M; Kim, JK; Maddocks, ODK; Newman, AC; Papalazarou, V; Romesser, PB; Sauvé, CG; Smith, JJ; Stevenson, K; Uribe, AH; Wu, C, 2022) |
| "Using in vitro and in vivo pancreatic cancer models, we show that IDO1 expression is highly context dependent, influenced by attachment-independent growth and the canonical activator IFNγ." | 1.62 | Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells. ( Athineos, D; Blyth, K; Falcone, M; Huerta Uribe, A; Maddocks, ODK; Newman, AC; Pietzke, M; Vazquez, A; Zhang, T, 2021) |
| "Pancreatic cancer is one of the most malignant cancers." | 1.51 | Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E. ( Fu, Y; Li, B; Liu, J; Luo, Y; Ma, X, 2019) |
| "The incidence of pancreatic cancer (PC) continues to increase in the world, while most patients are diagnosed with advanced stages and survive <12 months." | 1.42 | A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile. ( Fukutake, N; Hiraoka, N; Imaizumi, A; Ito, T; Katayama, K; Kikuchi, S; Ono, N; Saruki, N; Shimada, K; Shiraishi, K; Ueno, M; Yamakado, M; Yamamoto, H, 2015) |
| "Reduced growth of tumors composed of cells expressing the nonphosphorylatable KRAS S181A mutant was correlated with increased apoptosis." | 1.40 | Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth. ( Agell, N; Alvarez-Moya, B; Barceló, C; Bota-Rabassedas, N; Capella, G; Jaumot, M; Morell, M; Paco, N; Vilardell, F, 2014) |
| "The level of leukotriene B₄ is high in pancreatic cancers." | 1.38 | Novel involvement of leukotriene B₄ receptor 2 through ERK activation by PP2A down-regulation in leukotriene B₄-induced keratin phosphorylation and reorganization of pancreatic cancer cells. ( Kim, S; Lee, CH; Lee, HJ; Park, MK; Park, Y; Shim, J, 2012) |
| "Gemcitabine suppressed pancreatic cancer cell growth and induced apoptosis." | 1.37 | Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells. ( Adachi, S; Hirose, Y; Itani, M; Kawaguchi, J; Kozawa, O; Matsushima-Nishiwaki, R; Moriwaki, H; Nakashima, M; Yamauchi, T; Yasuda, I; Yoshioka, T, 2011) |
| " Finally, glucagon-stimulated insulin secretion by RIN cells expressing the mutant receptor was decreased such that the dose-response curve was shifted to the right in comparison to that obtained with cells expressing the wild type receptor." | 1.29 | The Gly40Ser mutation in the human glucagon receptor gene associated with NIDDM results in a receptor with reduced sensitivity to glucagon. ( Abrahamsen, N; Froguel, P; Hager, J; Hansen, LH; Jelinek, L; Kindsvogel, W; Nishimura, E, 1996) |
| "Azaserine was selected because it behaves as a direct-acting mutagen in two bacterial test systems and because tissue distribution studies showed concentration especially in kidney and pancreas." | 1.25 | Adenocarcinoma of the pancreas in azaserine-treated rats. ( Curphey, TJ; Longnecker, DS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.98) | 18.7374 |
| 1990's | 3 (6.98) | 18.2507 |
| 2000's | 4 (9.30) | 29.6817 |
| 2010's | 19 (44.19) | 24.3611 |
| 2020's | 14 (32.56) | 2.80 |
| Authors | Studies |
|---|---|
| Itoyama, R | 1 |
| Yasuda-Yoshihara, N | 1 |
| Kitamura, F | 1 |
| Yasuda, T | 1 |
| Bu, L | 1 |
| Yonemura, A | 1 |
| Uchihara, T | 1 |
| Arima, K | 1 |
| Hu, X | 1 |
| Jun, Z | 1 |
| Okamoto, Y | 1 |
| Akiyama, T | 1 |
| Yamashita, K | 1 |
| Nakao, Y | 1 |
| Yusa, T | 1 |
| Kitano, Y | 1 |
| Higashi, T | 1 |
| Miyata, T | 1 |
| Imai, K | 2 |
| Hayashi, H | 2 |
| Yamashita, YI | 2 |
| Mikawa, T | 1 |
| Kondoh, H | 1 |
| Baba, H | 2 |
| Ishimoto, T | 1 |
| Wang, W | 1 |
| Pan, H | 1 |
| Ren, F | 1 |
| Chen, H | 1 |
| Ren, P | 1 |
| He, X | 1 |
| Li, Y | 1 |
| Chen, Q | 1 |
| Zheng, L | 1 |
| Lou, J | 1 |
| Lin, C | 1 |
| Gong, J | 1 |
| Zhu, Y | 1 |
| Wu, Y | 1 |
| Zhu, Q | 1 |
| Zhou, H | 1 |
| Wu, L | 1 |
| Lai, Z | 1 |
| Geng, D | 1 |
| Yang, W | 1 |
| Zhang, J | 1 |
| Fan, Z | 1 |
| Qin, W | 1 |
| Wang, Y | 1 |
| Zhou, R | 1 |
| Yi, W | 1 |
| Falcone, M | 2 |
| Uribe, AH | 1 |
| Papalazarou, V | 1 |
| Newman, AC | 2 |
| Athineos, D | 3 |
| Stevenson, K | 1 |
| Sauvé, CG | 1 |
| Gao, Y | 1 |
| Kim, JK | 1 |
| Del Latto, M | 1 |
| Kierstead, M | 1 |
| Wu, C | 1 |
| Smith, JJ | 1 |
| Romesser, PB | 1 |
| Chalmers, AJ | 1 |
| Blyth, K | 3 |
| Maddocks, ODK | 3 |
| Xiao, Y | 1 |
| Zhang, B | 1 |
| Cloyd, JM | 1 |
| Xu, G | 1 |
| Du, S | 1 |
| Mao, Y | 1 |
| Pawlik, TM | 1 |
| Lan, C | 1 |
| Tsukamoto, M | 1 |
| Nakagawa, S | 1 |
| Liu, Z | 1 |
| Wu, X | 1 |
| Mima, K | 1 |
| Kaida, T | 1 |
| Dekhne, AS | 1 |
| Ning, C | 1 |
| Nayeen, MJ | 1 |
| Shah, K | 1 |
| Kalpage, H | 1 |
| Frühauf, J | 1 |
| Wallace-Povirk, A | 1 |
| O'Connor, C | 1 |
| Hou, Z | 1 |
| Kim, S | 2 |
| Hüttemann, M | 1 |
| Gangjee, A | 1 |
| Matherly, LH | 1 |
| Banh, RS | 1 |
| Biancur, DE | 1 |
| Yamamoto, K | 1 |
| Sohn, ASW | 1 |
| Walters, B | 1 |
| Kuljanin, M | 1 |
| Gikandi, A | 1 |
| Wang, H | 1 |
| Mancias, JD | 1 |
| Schneider, RJ | 1 |
| Pacold, ME | 1 |
| Kimmelman, AC | 1 |
| Hindson, J | 1 |
| Harjes, U | 1 |
| Huerta Uribe, A | 1 |
| Zhang, T | 2 |
| Pietzke, M | 1 |
| Vazquez, A | 1 |
| Omori, Y | 1 |
| Ono, Y | 1 |
| Morikawa, T | 1 |
| Motoi, F | 1 |
| Higuchi, R | 1 |
| Yamamoto, M | 1 |
| Hayakawa, Y | 1 |
| Karasaki, H | 1 |
| Mizukami, Y | 1 |
| Unno, M | 1 |
| Furukawa, T | 1 |
| Cheung, EC | 1 |
| Lee, P | 1 |
| van den Broek, NJF | 1 |
| Mackay, GM | 1 |
| Labuschagne, CF | 1 |
| Gay, D | 1 |
| Kruiswijk, F | 1 |
| Blagih, J | 1 |
| Vincent, DF | 1 |
| Campbell, KJ | 1 |
| Ceteci, F | 1 |
| Sansom, OJ | 1 |
| Vousden, KH | 1 |
| Shin, H | 1 |
| Cha, HJ | 1 |
| Na, K | 1 |
| Lee, MJ | 1 |
| Cho, JY | 1 |
| Kim, CY | 1 |
| Kim, EK | 1 |
| Kang, CM | 1 |
| Kim, H | 1 |
| Paik, YK | 1 |
| Ma, X | 1 |
| Li, B | 1 |
| Liu, J | 1 |
| Fu, Y | 1 |
| Luo, Y | 1 |
| Wu, HY | 1 |
| Yang, MC | 1 |
| Ding, LY | 1 |
| Chen, CS | 1 |
| Chu, PC | 1 |
| Barceló, C | 1 |
| Paco, N | 1 |
| Morell, M | 1 |
| Alvarez-Moya, B | 1 |
| Bota-Rabassedas, N | 1 |
| Jaumot, M | 1 |
| Vilardell, F | 1 |
| Capella, G | 1 |
| Agell, N | 1 |
| Kamphorst, JJ | 1 |
| Nofal, M | 1 |
| Commisso, C | 1 |
| Hackett, SR | 1 |
| Lu, W | 1 |
| Grabocka, E | 1 |
| Vander Heiden, MG | 1 |
| Miller, G | 1 |
| Drebin, JA | 1 |
| Bar-Sagi, D | 1 |
| Thompson, CB | 1 |
| Rabinowitz, JD | 1 |
| Kashatus, JA | 1 |
| Nascimento, A | 1 |
| Myers, LJ | 1 |
| Sher, A | 1 |
| Byrne, FL | 1 |
| Hoehn, KL | 1 |
| Counter, CM | 1 |
| Kashatus, DF | 1 |
| Fukutake, N | 1 |
| Ueno, M | 1 |
| Hiraoka, N | 1 |
| Shimada, K | 1 |
| Shiraishi, K | 1 |
| Saruki, N | 1 |
| Ito, T | 1 |
| Yamakado, M | 1 |
| Ono, N | 1 |
| Imaizumi, A | 1 |
| Kikuchi, S | 1 |
| Yamamoto, H | 1 |
| Katayama, K | 1 |
| Park, MK | 3 |
| Lee, CH | 3 |
| Dai, T | 1 |
| Li, N | 1 |
| Zhang, L | 1 |
| Zhang, Y | 1 |
| Liu, Q | 1 |
| Bogyo, M | 1 |
| Murakami, Y | 1 |
| Hosoi, F | 1 |
| Izumi, H | 1 |
| Maruyama, Y | 1 |
| Ureshino, H | 1 |
| Watari, K | 1 |
| Kohno, K | 1 |
| Kuwano, M | 1 |
| Ono, M | 1 |
| Yamauchi, T | 2 |
| Adachi, S | 2 |
| Yasuda, I | 2 |
| Nakashima, M | 2 |
| Kawaguchi, J | 2 |
| Nishii, Y | 1 |
| Yoshioka, T | 2 |
| Okano, Y | 1 |
| Hirose, Y | 2 |
| Kozawa, O | 2 |
| Moriwaki, H | 2 |
| Lee, HJ | 2 |
| Shin, J | 1 |
| Noh, M | 1 |
| Kim, SY | 1 |
| Itani, M | 1 |
| Matsushima-Nishiwaki, R | 1 |
| Busch, T | 1 |
| Armacki, M | 1 |
| Eiseler, T | 1 |
| Joodi, G | 1 |
| Temme, C | 1 |
| Jansen, J | 1 |
| von Wichert, G | 1 |
| Omary, MB | 1 |
| Spatz, J | 1 |
| Seufferlein, T | 1 |
| Yu, R | 1 |
| Chen, CR | 1 |
| Liu, X | 1 |
| Kodra, JT | 1 |
| Kossow, C | 1 |
| Jose, D | 1 |
| Jaster, R | 1 |
| Wolkenhauer, O | 1 |
| Rateitschak, K | 1 |
| Park, Y | 1 |
| Shim, J | 1 |
| Venkatasubbarao, K | 1 |
| Choudary, A | 1 |
| Freeman, JW | 1 |
| Duxbury, MS | 1 |
| Ito, H | 1 |
| Benoit, E | 1 |
| Waseem, T | 1 |
| Ashley, SW | 1 |
| Whang, EE | 1 |
| Giamas, G | 1 |
| Hirner, H | 1 |
| Shoshiashvili, L | 1 |
| Grothey, A | 1 |
| Gessert, S | 1 |
| Kühl, M | 1 |
| Henne-Bruns, D | 1 |
| Vorgias, CE | 1 |
| Knippschild, U | 1 |
| Ollila, S | 1 |
| Dermadi Bebek, D | 1 |
| Greenblatt, M | 1 |
| Nyström, M | 1 |
| Feldman, JM | 1 |
| Vervaert, C | 1 |
| Klatt, C | 1 |
| Seigler, HF | 1 |
| Finkelstein, SD | 1 |
| Przygodzki, R | 1 |
| Pricolo, VE | 1 |
| Sayegh, R | 1 |
| Bakker, A | 1 |
| Swalsky, PA | 1 |
| Keller, G | 1 |
| Hansen, LH | 1 |
| Abrahamsen, N | 1 |
| Hager, J | 1 |
| Jelinek, L | 1 |
| Kindsvogel, W | 1 |
| Froguel, P | 1 |
| Nishimura, E | 1 |
| Preston, T | 1 |
| Slater, C | 1 |
| McMillan, DC | 1 |
| Falconer, JS | 1 |
| Shenkin, A | 1 |
| Fearon, KC | 1 |
| Longnecker, DS | 1 |
| Curphey, TJ | 1 |
| Barreto, M | 1 |
| Sener, A | 1 |
| Malaisse, WJ | 1 |
| Valverde, I | 1 |
43 other studies available for serine and Cancer of Pancreas
| Article | Year |
|---|---|
Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; CpG Islands; DNA Methylation; Enzyme Induct | 2021 |
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell | 2022 |
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell | 2022 |
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell | 2022 |
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell | 2022 |
O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction.
Topics: Autoantigens; Carcinoma, Pancreatic Ductal; Cell Proliferation; Humans; N-Acetylglucosaminyltransfer | 2022 |
O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction.
Topics: Autoantigens; Carcinoma, Pancreatic Ductal; Cell Proliferation; Humans; N-Acetylglucosaminyltransfer | 2022 |
O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction.
Topics: Autoantigens; Carcinoma, Pancreatic Ductal; Cell Proliferation; Humans; N-Acetylglucosaminyltransfer | 2022 |
O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction.
Topics: Autoantigens; Carcinoma, Pancreatic Ductal; Cell Proliferation; Humans; N-Acetylglucosaminyltransfer | 2022 |
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1.
Topics: Acetylglucosamine; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Glutamine; Malate Dehydr | 2022 |
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1.
Topics: Acetylglucosamine; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Glutamine; Malate Dehydr | 2022 |
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1.
Topics: Acetylglucosamine; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Glutamine; Malate Dehydr | 2022 |
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1.
Topics: Acetylglucosamine; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Glutamine; Malate Dehydr | 2022 |
Sensitisation of cancer cells to radiotherapy by serine and glycine starvation.
Topics: Amino Acids; Animals; Antioxidants; Glycine; Mice; Pancreatic Neoplasms; Serine | 2022 |
Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma.
Topics: Aurora Kinase A; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Computational Biology; Gene Expres | 2022 |
Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma.
Topics: Aurora Kinase A; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Computational Biology; Gene Expres | 2022 |
Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma.
Topics: Aurora Kinase A; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Computational Biology; Gene Expres | 2022 |
Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma.
Topics: Aurora Kinase A; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Computational Biology; Gene Expres | 2022 |
The Prognostic Role of Serine Racemase in Patients With Pancreatic Cancer: A New Marker in Cancer Metabolism.
Topics: Humans; Pancreatic Neoplasms; Prognosis; Racemases and Epimerases; Serine | 2023 |
The Prognostic Role of Serine Racemase in Patients With Pancreatic Cancer: A New Marker in Cancer Metabolism.
Topics: Humans; Pancreatic Neoplasms; Prognosis; Racemases and Epimerases; Serine | 2023 |
The Prognostic Role of Serine Racemase in Patients With Pancreatic Cancer: A New Marker in Cancer Metabolism.
Topics: Humans; Pancreatic Neoplasms; Prognosis; Racemases and Epimerases; Serine | 2023 |
The Prognostic Role of Serine Racemase in Patients With Pancreatic Cancer: A New Marker in Cancer Metabolism.
Topics: Humans; Pancreatic Neoplasms; Prognosis; Racemases and Epimerases; Serine | 2023 |
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Membrane; Cytosol; Drug Screening Assays, Antitumor; G | 2020 |
Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer.
Topics: Adenocarcinoma; Aged; Animals; Axons; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Prolifera | 2020 |
Recruited Nerves Supply Serine to Support Pancreatic Cancer Growth.
Topics: Humans; Neurons; Pancreatic Neoplasms; Protein Biosynthesis; Serine | 2021 |
Neuronal innervation supports PDAC growth via release of serine.
Topics: Humans; Neurons; Pancreatic Neoplasms; Protein Biosynthesis; Serine | 2021 |
The neuronal-metabolic interface.
Topics: Humans; Neurons; Pancreatic Neoplasms; Protein Biosynthesis; Serine | 2021 |
Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells.
Topics: Allografts; Animals; Antineoplastic Agents; Carbon; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; | 2021 |
Serine/Threonine Kinase 11 Plays a Canonical Role in Malignant Progression of KRAS -Mutant and GNAS -Wild-Type Intraductal Papillary Mucinous Neoplasms of the Pancreas.
Topics: AMP-Activated Protein Kinases; Carcinoma, Pancreatic Ductal; Chromogranins; GTP-Binding Protein alph | 2023 |
Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
Topics: Animals; Antioxidants; Biguanides; Cell Line, Tumor; Diet; Disease Models, Animal; Female; Food Depr | 2017 |
Topics: Apoptosis; Biomarkers, Tumor; Case-Control Studies; Cell Proliferation; Cyclin-Dependent Kinase Inhi | 2018 |
Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.
Topics: Animals; Antigens, CD; Cadherins; Cell Line, Tumor; Cell Proliferation; Eukaryotic Initiation Factor | 2019 |
p21-Activated kinase 3 promotes cancer stem cell phenotypes through activating the Akt-GSK3β-β-catenin signaling pathway in pancreatic cancer cells.
Topics: Animals; beta Catenin; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Enz | 2019 |
Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth.
Topics: Animals; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Humans | 2014 |
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein.
Topics: Albumins; Amino Acids; Animals; Carcinoma, Pancreatic Ductal; Cell Proliferation; Chromatography, Li | 2015 |
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.
Topics: Animals; Benzamides; Cell Line, Tumor; Diphenylamine; Dynamins; Gene Knockdown Techniques; GTP Phosp | 2015 |
A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Amino Acids; Area Under Curve; Asparagine; Body Mass Index; | 2015 |
Effects of cerulein on keratin 8 phosphorylation and perinuclear reorganization in pancreatic cancer cells: Involvement of downregulation of protein phosphatase 2A and alpha4.
Topics: Butadienes; Cell Line, Tumor; Cell Movement; Ceruletide; Down-Regulation; Extracellular Signal-Regul | 2016 |
A new target ligand Ser-Glu for PEPT1-overexpressing cancer imaging.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Dipeptides; Female; Flow Cytometry; Fluor | 2016 |
Finding enzymes that are actively involved in cancer.
Topics: Cadherins; Carcinoma, Pancreatic Ductal; Cell Cycle Proteins; Humans; Hydrolases; Intracellular Sign | 2010 |
Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells.
Topics: Cell Cycle Proteins; Cell Line, Tumor; Chemokines, CXC; Humans; Immediate-Early Proteins; Intracellu | 2010 |
UVC radiation induces downregulation of EGF receptor via phosphorylation at serine 1046/1047 in human pancreatic cancer cells.
Topics: Cell Line, Tumor; Cell Proliferation; Down-Regulation; Enzyme Activation; Epithelial Cells; ErbB Rec | 2011 |
Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells.
Topics: Anthracenes; Cell Line, Tumor; Cell Movement; Cystamine; Cytoskeleton; Gene Expression Regulation, N | 2011 |
Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Enz | 2011 |
Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells.
Topics: Cell Line, Tumor; Cell Movement; Cytoskeleton; Epithelial Cells; Extracellular Signal-Regulated MAP | 2012 |
Rescue of a pathogenic mutant human glucagon receptor by pharmacological chaperones.
Topics: Alanine; Asparagine; Cell Membrane; Curcumin; Cyclic AMP; Drug Design; Glucagon; Green Fluorescent P | 2012 |
Mathematical modelling unravels regulatory mechanisms of interferon-γ-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells.
Topics: Animals; Cell Line, Tumor; Computer Simulation; Gene Expression Regulation, Neoplastic; Humans; Inte | 2012 |
Novel involvement of leukotriene B₄ receptor 2 through ERK activation by PP2A down-regulation in leukotriene B₄-induced keratin phosphorylation and reorganization of pancreatic cancer cells.
Topics: Anesthetics, Inhalation; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Down-R | 2012 |
Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases.
Topics: Adenocarcinoma; Alkyl and Aryl Transferases; Cell Cycle Proteins; Cell Growth Processes; Cyclin-Depe | 2005 |
RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Caspases; Cell Line, | 2005 |
Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo.
Topics: Animals; Blotting, Western; Casein Kinase Idelta; Cyclic AMP-Dependent Protein Kinases; Embryo, Nonm | 2007 |
Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification.
Topics: Asparagine; Aspartic Acid; Biliary Tract Neoplasms; Blotting, Western; Colorectal Neoplasms, Heredit | 2008 |
Therapy of malignant hamster insulinomas with monoamine precursors.
Topics: 5-Hydroxytryptophan; Adenoma, Islet Cell; Animals; Cricetinae; Dopamine; Droxidopa; Levodopa; Neopla | 1981 |
K-ras-2 topographic genotyping of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Alanine; Arginine; Aspartic Acid; Codon; Cysteine; DNA, Neoplasm; Exons; Forecasting | 1994 |
The Gly40Ser mutation in the human glucagon receptor gene associated with NIDDM results in a receptor with reduced sensitivity to glucagon.
Topics: Amino Acid Sequence; Animals; Cell Line; Cricetinae; Cyclic AMP; Diabetes Mellitus, Type 2; Exons; G | 1996 |
Fibrinogen synthesis is elevated in fasting cancer patients with an acute phase response.
Topics: Acute-Phase Reaction; Adenocarcinoma; Adult; Aged; Amino Acids; C-Reactive Protein; Cachexia; Fastin | 1998 |
Adenocarcinoma of the pancreas in azaserine-treated rats.
Topics: Adenocarcinoma; Adenoma; Animals; Azaserine; Dipeptides; Disease Models, Animal; Hyperplasia; Inject | 1975 |
Inhibition by a nonmetabolized analogue of L-leucine of protein biosynthesis in tumoral pancreatic islet cells.
Topics: Adenoma, Islet Cell; Amino Acids; Amino Acids, Cyclic; Keto Acids; Leucine; Neoplasm Proteins; Pancr | 1989 |