serine has been researched along with Cancer of Lung in 113 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Imaging of breast cancer cell lines revealed that WFA induces perinuclear vimentin accumulation followed by rapid vimentin depolymerization." | 5.37 | Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. ( Bender, L; Ganesh, T; Garcia, A; Harvey, RD; Kline, E; Liu, Y; Marcus, AI; Patel, P; Thaiparambil, JT; Tighiouart, M; Vertino, PM, 2011) |
| " Here, we revealed the mechanism by which skeletal protein Emerin (EMD) promoted glucose metabolism to induce lung adenocarcinoma (LUAD)." | 4.12 | ISGylation of EMD promotes its interaction with PDHA to inhibit aerobic oxidation in lung adenocarcinoma. ( Cao, L; Cui, J; Guo, W; Ma, L; Miao, Y; Qiu, S; Tian, X; Wang, Y; Xia, J; Zhang, C; Zhang, X, 2022) |
| "5-35 mg/m2) in combination with docetaxel (60 or 75 mg/m2) and cisplatin (75 mg/m2), agents were administered 24 h apart every 3 weeks to Japanese patients with advanced solid tumors." | 2.87 | Phase 1 study of ombrabulin in combination with docetaxel and cisplatin in Japanese patients with advanced solid tumors. ( Ecstein-Fraisse, E; Hida, T; Horiike, A; Horio, Y; Nishio, M; Satouchi, M; Sunaga, Y, 2018) |
| "Ganoderic acid is a triterpene from basiodiomycetes fungus Ganoderma lucidum with numerous therapeutic effects." | 1.46 | Ganoderic acid targeting nuclear factor erythroid 2-related factor 2 in lung cancer. ( Gill, BS; Kumar, S, 2017) |
| "Irinotecan has also displayed efficacy in clinical trials of NSCLC." | 1.42 | Topoisomerase-I PS506 as a Dual Function Cancer Biomarker. ( Gjerset, RA; Zhao, M, 2015) |
| "Our results define a role for PCK2 in cancer cell metabolic reprogramming that promotes glucose-independent cell growth and metabolic stress resistance in human tumors." | 1.42 | Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. ( Artyomov, MN; Avizonis, D; Blagih, J; Bridon, G; Choinière, L; Coelho, PP; Elder, DJ; Flynn, BR; Gingras, MC; Griss, T; Jones, RG; Loginicheva, E; Ntimbane, T; Pause, A; Raissi, TC; Samborska, B; Sergushichev, A; Tavaré, JM; Thomas, EC; Vincent, EE, 2015) |
| "In addition, LY2603618-treated lung cancer cells transitioned from LC3-I to LC3-II, a hallmark of autophagy." | 1.40 | The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. ( Cui, YJ; Fei, HR; Li, ZM; Sun, BL; Sun, YK; Wang, FZ; Wang, XY; Yang, XY; Zhang, JG, 2014) |
| "Cowden's syndrome is a rare autosomal dominant disorder that has been linked to germline mutations in the phosphatase and TENsin homolog (PTEN) gene." | 1.39 | Primary lung adenocarcinoma occurring in a PTEN related syndrome (Cowden's disease): routine EGFR sequencing also highlights two rare somatic mutations S768I and V769L. ( Boespflug, A; Bringuier, PP; Couraud, S; Durieu, I; Edery, P; Gérinière, L; Isaac, S; Perrot, E; Souquet, PJ, 2013) |
| "TICs from primary NSCLC tumors express high levels of the oncogenic stem cell factor LIN28B and GLDC, which are both required for TIC growth and tumorigenesis." | 1.38 | Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. ( Ahmed, DA; Ang, HS; Bhakoo, KK; Jayapal, SR; Kaldis, P; Lim, B; Lim, EH; Ma, S; Mitchell, W; Nga, ME; Nichane, M; Noghabi, MS; Pang, YH; Rai, A; Robson, P; Shyh-Chang, N; Sing, WP; Soh, BS; Soo, RA; Sun, LL; Swarup, S; Tai, BC; Tam, J; Tan, C; Thirugananam, A; Umashankar, S; Yang, H; Yu, Q; Zhang, WC, 2012) |
| "Imaging of breast cancer cell lines revealed that WFA induces perinuclear vimentin accumulation followed by rapid vimentin depolymerization." | 1.37 | Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. ( Bender, L; Ganesh, T; Garcia, A; Harvey, RD; Kline, E; Liu, Y; Marcus, AI; Patel, P; Thaiparambil, JT; Tighiouart, M; Vertino, PM, 2011) |
| "Although hyperoxia is known to cause DNA base modifications and strand breaks, the DNA damage response has not been adequately investigated." | 1.35 | Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation. ( Das, KC; Kulkarni, A, 2008) |
| " This combination effect was found over wide dosage ranges of AC-7700 (20-80 mg/kg) and CDDP (2." | 1.32 | Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo. ( Ehara, S; Harada, K; Morinaga, Y; Nihei, Y; Suga, Y; Suzuki, M, 2003) |
| "Hyperoxia has been shown to cause DNA damage resulting in growth arrest of cells in p53-dependent, as well as p53-independent, pathways." | 1.32 | Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites. ( Das, KC; Dashnamoorthy, R, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (6.19) | 18.7374 |
| 1990's | 4 (3.54) | 18.2507 |
| 2000's | 34 (30.09) | 29.6817 |
| 2010's | 43 (38.05) | 24.3611 |
| 2020's | 25 (22.12) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, P | 1 |
| Qin, Z | 1 |
| Sun, X | 5 |
| Yang, J | 1 |
| Lv, J | 1 |
| Diao, M | 1 |
| Huang, YL | 1 |
| Chen, YJ | 1 |
| Juan, YH | 1 |
| Wu, SG | 1 |
| Chung, KP | 1 |
| He, L | 1 |
| Endress, J | 1 |
| Cho, S | 1 |
| Li, Z | 4 |
| Zheng, Y | 1 |
| Asara, JM | 2 |
| Blenis, J | 1 |
| Chen, L | 1 |
| Kang, Y | 1 |
| Jiang, Y | 1 |
| You, J | 1 |
| Huang, C | 1 |
| Xu, X | 1 |
| Chen, F | 1 |
| Li, L | 2 |
| Li, P | 1 |
| Ma, X | 1 |
| Zeng, S | 2 |
| Peng, Y | 2 |
| Zhang, G | 2 |
| Li, G | 1 |
| Xu, Z | 2 |
| Peng, J | 1 |
| Yan, Y | 1 |
| Liu, Y | 4 |
| Zhang, X | 4 |
| Qiu, Y | 1 |
| Fu, C | 1 |
| Du, W | 1 |
| Wang, H | 1 |
| Zhao, Y | 2 |
| Huang, Z | 1 |
| Zhang, C | 2 |
| Cui, J | 2 |
| Cao, L | 1 |
| Tian, X | 1 |
| Miao, Y | 1 |
| Wang, Y | 4 |
| Qiu, S | 1 |
| Guo, W | 1 |
| Ma, L | 1 |
| Xia, J | 1 |
| Faltus, C | 1 |
| Lahnsteiner, A | 1 |
| Barrdahl, M | 1 |
| Assenov, Y | 1 |
| Hüsing, A | 1 |
| Bogatyrova, O | 1 |
| Laplana, M | 1 |
| Johnson, T | 1 |
| Muley, T | 2 |
| Meister, M | 1 |
| Warth, A | 1 |
| Thomas, M | 1 |
| Plass, C | 1 |
| Kaaks, R | 1 |
| Risch, A | 2 |
| Valencia, K | 1 |
| Echepare, M | 1 |
| Teijeira, Á | 1 |
| Pasquier, A | 1 |
| Bértolo, C | 1 |
| Sainz, C | 1 |
| Tamayo, I | 1 |
| Picabea, B | 1 |
| Bosco, G | 1 |
| Thomas, R | 1 |
| Agorreta, J | 1 |
| López-Picazo, JM | 1 |
| Frigola, J | 1 |
| Amat, R | 1 |
| Calvo, A | 1 |
| Felip, E | 1 |
| Melero, I | 1 |
| Montuenga, LM | 1 |
| Li, D | 1 |
| Ding, Z | 1 |
| Ai, R | 1 |
| Shi, L | 1 |
| Wang, Z | 1 |
| He, Q | 1 |
| Dong, Y | 1 |
| Zhu, Y | 4 |
| Ouyang, W | 1 |
| He, Y | 3 |
| Hao, D | 1 |
| Li, Y | 2 |
| Shi, J | 2 |
| Jiang, J | 1 |
| Xu, M | 3 |
| Ding, L | 3 |
| Yang, G | 3 |
| Kong, J | 3 |
| Chen, X | 4 |
| Xu, L | 3 |
| Shan, Y | 3 |
| Xu, Y | 4 |
| Grenda, A | 1 |
| Krawczyk, P | 1 |
| Targowska-Duda, KM | 1 |
| Kieszko, R | 1 |
| Paśnik, I | 1 |
| Milanowski, J | 1 |
| Heylen, E | 1 |
| Verstraete, P | 1 |
| Van Aerschot, L | 1 |
| Geeraerts, SL | 1 |
| Venken, T | 1 |
| Timcheva, K | 1 |
| Nittner, D | 1 |
| Verbeeck, J | 1 |
| Royaert, J | 1 |
| Gijbels, M | 1 |
| Uyttebroeck, A | 1 |
| Segers, H | 1 |
| Lambrechts, D | 1 |
| Cools, J | 1 |
| De Keersmaecker, K | 1 |
| Kampen, KR | 1 |
| Park, SM | 1 |
| Seo, EH | 1 |
| Bae, DH | 1 |
| Kim, SS | 1 |
| Kim, J | 1 |
| Lin, W | 1 |
| Kim, KH | 1 |
| Park, JB | 1 |
| Kim, YS | 1 |
| Yin, J | 1 |
| Kim, SY | 1 |
| Volz, C | 1 |
| Breid, S | 1 |
| Selenz, C | 1 |
| Zaplatina, A | 1 |
| Golfmann, K | 1 |
| Meder, L | 1 |
| Dietlein, F | 1 |
| Borchmann, S | 1 |
| Chatterjee, S | 1 |
| Siobal, M | 1 |
| Schöttle, J | 1 |
| Florin, A | 1 |
| Koker, M | 1 |
| Nill, M | 1 |
| Ozretić, L | 1 |
| Uhlenbrock, N | 1 |
| Smith, S | 1 |
| Büttner, R | 1 |
| Miao, H | 1 |
| Wang, B | 1 |
| Reinhardt, HC | 1 |
| Rauh, D | 1 |
| Hallek, M | 1 |
| Acker-Palmer, A | 1 |
| Heukamp, LC | 1 |
| Ullrich, RT | 1 |
| Liu, J | 1 |
| Wu, H | 1 |
| Sun, XX | 1 |
| Huang, S | 1 |
| Yue, X | 1 |
| Lu, SE | 1 |
| Shen, Z | 1 |
| Su, X | 1 |
| White, E | 1 |
| Haffty, BG | 1 |
| Hu, W | 1 |
| Feng, Z | 1 |
| Tong, J | 1 |
| Krieger, JR | 1 |
| Taylor, P | 1 |
| Bagshaw, R | 1 |
| Kang, J | 1 |
| Jeedigunta, S | 1 |
| Wybenga-Groot, LE | 1 |
| Zhang, W | 1 |
| Badr, H | 1 |
| Mirhadi, S | 1 |
| Pham, NA | 1 |
| Coyaud, É | 1 |
| Yu, M | 1 |
| Li, M | 1 |
| Cabanero, M | 1 |
| Raught, B | 1 |
| Maynes, JT | 1 |
| Hawkins, C | 1 |
| Tsao, MS | 1 |
| Moran, MF | 1 |
| Krassikova, L | 1 |
| Zhang, B | 2 |
| Nagarajan, D | 1 |
| Queiroz, AL | 1 |
| Kacal, M | 1 |
| Samakidis, E | 1 |
| Vakifahmetoglu-Norberg, H | 2 |
| Norberg, E | 2 |
| Kim, YJ | 1 |
| Kang, MJ | 1 |
| Kim, E | 1 |
| Kweon, TH | 1 |
| Park, YS | 1 |
| Ji, S | 1 |
| Yang, WH | 1 |
| Yi, EC | 1 |
| Cho, JW | 1 |
| Rinaldi, G | 1 |
| Pranzini, E | 1 |
| Van Elsen, J | 1 |
| Broekaert, D | 1 |
| Funk, CM | 1 |
| Planque, M | 1 |
| Doglioni, G | 1 |
| Altea-Manzano, P | 1 |
| Rossi, M | 1 |
| Geldhof, V | 1 |
| Teoh, ST | 1 |
| Ross, C | 1 |
| Hunter, KW | 1 |
| Lunt, SY | 1 |
| Grünewald, TGP | 1 |
| Fendt, SM | 1 |
| Lee, JH | 2 |
| Yoo, SS | 1 |
| Hong, MJ | 1 |
| Choi, JE | 1 |
| Kim, S | 1 |
| Kang, HG | 1 |
| Do, SK | 1 |
| Kim, JH | 1 |
| Baek, SA | 1 |
| Lee, WK | 1 |
| Do Yoo, J | 1 |
| Choi, SH | 1 |
| Lee, YH | 1 |
| Seo, H | 1 |
| Lee, J | 1 |
| Lee, SY | 2 |
| Cha, SI | 1 |
| Kim, CH | 1 |
| Park, JY | 1 |
| Audet-Delage, Y | 1 |
| St-Pierre, J | 1 |
| Vaughan, CA | 1 |
| Singh, S | 1 |
| Subler, MA | 1 |
| Windle, JJ | 1 |
| Inoue, K | 2 |
| Fry, EA | 1 |
| Pillappa, R | 1 |
| Grossman, SR | 2 |
| Windle, B | 1 |
| Andrew Yeudall, W | 1 |
| Deb, SP | 1 |
| Deb, S | 2 |
| Broggi, G | 1 |
| Angelico, G | 1 |
| Filetti, V | 1 |
| Ledda, C | 1 |
| Lombardo, C | 1 |
| Vitale, E | 1 |
| Rapisarda, V | 1 |
| Loreto, C | 1 |
| Caltabiano, R | 1 |
| Gill, BS | 1 |
| Kumar, S | 1 |
| Zheng, A | 1 |
| Hydbring, P | 1 |
| Ambroise, G | 1 |
| Ouchida, AT | 1 |
| Goiny, M | 1 |
| Yao, K | 1 |
| Peng, C | 1 |
| Zhang, Y | 3 |
| Zykova, TA | 1 |
| Lee, MH | 1 |
| Rao, E | 1 |
| Chen, H | 1 |
| Ryu, J | 1 |
| Wang, L | 1 |
| Gao, G | 1 |
| He, W | 1 |
| Ma, WY | 1 |
| Liu, K | 1 |
| Bode, AM | 1 |
| Dong, Z | 2 |
| Li, B | 1 |
| Nishio, M | 1 |
| Satouchi, M | 1 |
| Horiike, A | 1 |
| Horio, Y | 1 |
| Sunaga, Y | 1 |
| Ecstein-Fraisse, E | 1 |
| Hida, T | 2 |
| Tramonti, A | 2 |
| Paiardini, A | 3 |
| Paone, A | 3 |
| Bouzidi, A | 2 |
| Giardina, G | 3 |
| Guiducci, G | 2 |
| Magnifico, MC | 2 |
| Rinaldo, S | 3 |
| McDermott, L | 1 |
| Menendez, JA | 1 |
| Contestabile, R | 3 |
| Cutruzzolà, F | 3 |
| Lucchi, R | 1 |
| Marani, M | 2 |
| Pontecorvi, V | 1 |
| Zamparelli, C | 1 |
| Yang, B | 1 |
| Wang, X | 1 |
| Mu, Y | 1 |
| Zhou, Y | 2 |
| Li, W | 1 |
| Zhou, L | 1 |
| Lu, X | 2 |
| Gao, P | 1 |
| Gao, M | 1 |
| Wang, Q | 1 |
| Xu, G | 1 |
| Shi, S | 1 |
| Zhang, J | 1 |
| Liu, M | 1 |
| Dong, H | 1 |
| Li, N | 1 |
| Jeon, YH | 1 |
| Park, YH | 1 |
| Kwon, JH | 1 |
| Kim, IY | 1 |
| Yu, L | 1 |
| Amelio, I | 1 |
| Markert, EK | 1 |
| Rufini, A | 1 |
| Antonov, AV | 1 |
| Sayan, BS | 1 |
| Tucci, P | 1 |
| Agostini, M | 1 |
| Mineo, TC | 1 |
| Levine, AJ | 1 |
| Melino, G | 1 |
| von Pawel, J | 1 |
| Gorbounova, V | 1 |
| Reck, M | 1 |
| Kowalski, DM | 1 |
| Allard, A | 1 |
| Chadjaa, M | 1 |
| Rey, A | 1 |
| Bennouna, J | 1 |
| Grossi, F | 1 |
| Park, HR | 1 |
| Shi, Z | 1 |
| Pham, CD | 1 |
| Du, Y | 1 |
| Khuri, FR | 2 |
| Han, Q | 1 |
| Fu, H | 1 |
| Krześniak, M | 1 |
| Zajkowicz, A | 2 |
| Matuszczyk, I | 1 |
| Rusin, M | 2 |
| Song, L | 1 |
| Smith, MA | 1 |
| Doshi, P | 1 |
| Sasser, K | 1 |
| Fulp, W | 1 |
| Altiok, S | 1 |
| Haura, EB | 1 |
| Wang, FZ | 1 |
| Fei, HR | 1 |
| Cui, YJ | 1 |
| Sun, YK | 1 |
| Li, ZM | 1 |
| Wang, XY | 1 |
| Yang, XY | 1 |
| Zhang, JG | 1 |
| Sun, BL | 1 |
| Xin, M | 1 |
| Li, R | 1 |
| Xie, M | 1 |
| Park, D | 1 |
| Owonikoko, TK | 1 |
| Sica, GL | 1 |
| Corsino, PE | 1 |
| Zhou, J | 1 |
| Ding, C | 1 |
| White, MA | 1 |
| Magis, AT | 1 |
| Ramalingam, SS | 1 |
| Curran, WJ | 1 |
| Deng, X | 1 |
| Fiascarelli, A | 1 |
| Butkiewicz, D | 2 |
| Drosik, A | 1 |
| Giglok, M | 1 |
| Suwiński, R | 1 |
| Fukasawa, T | 1 |
| Enomoto, A | 1 |
| Miyagawa, K | 1 |
| Yamada, N | 1 |
| Tanaka, T | 2 |
| Hori, T | 1 |
| Yokoyama, S | 1 |
| Hayakawa, Y | 1 |
| Yano, S | 1 |
| Fukuoka, J | 1 |
| Koizumi, K | 1 |
| Saiki, I | 1 |
| Sakurai, H | 1 |
| Zhao, M | 1 |
| Gjerset, RA | 2 |
| Hu, S | 1 |
| Lu, Y | 1 |
| Orr, B | 1 |
| Godek, K | 1 |
| Mustachio, LM | 1 |
| Kawakami, M | 1 |
| Sekula, D | 1 |
| Compton, DA | 1 |
| Freemantle, S | 1 |
| Dmitrovsky, E | 1 |
| Vincent, EE | 2 |
| Sergushichev, A | 1 |
| Griss, T | 1 |
| Gingras, MC | 1 |
| Samborska, B | 1 |
| Ntimbane, T | 1 |
| Coelho, PP | 1 |
| Blagih, J | 1 |
| Raissi, TC | 1 |
| Choinière, L | 1 |
| Bridon, G | 1 |
| Loginicheva, E | 1 |
| Flynn, BR | 1 |
| Thomas, EC | 2 |
| Tavaré, JM | 2 |
| Avizonis, D | 1 |
| Pause, A | 1 |
| Elder, DJ | 2 |
| Artyomov, MN | 1 |
| Jones, RG | 1 |
| DeNicola, GM | 1 |
| Chen, PH | 1 |
| Mullarky, E | 1 |
| Sudderth, JA | 1 |
| Hu, Z | 1 |
| Wu, D | 1 |
| Tang, H | 1 |
| Xie, Y | 1 |
| Huffman, KE | 1 |
| Wistuba, II | 1 |
| Minna, JD | 1 |
| DeBerardinis, RJ | 1 |
| Cantley, LC | 1 |
| Frum, RA | 1 |
| Love, IM | 1 |
| Damle, PK | 1 |
| Mukhopadhyay, ND | 1 |
| Palit Deb, S | 1 |
| Gao, X | 1 |
| Feng, J | 1 |
| Xu, F | 1 |
| Fan, X | 1 |
| Huang, W | 1 |
| Xiong, H | 1 |
| Liu, Q | 1 |
| Liu, W | 1 |
| Liu, X | 1 |
| He, QY | 1 |
| Zhang, Q | 1 |
| Liu, L | 1 |
| Kuang, XY | 1 |
| Jiang, HS | 1 |
| Li, K | 1 |
| Zheng, YZ | 1 |
| Liu, YR | 1 |
| Qiao, F | 1 |
| Li, S | 2 |
| Hu, X | 1 |
| Shao, ZM | 1 |
| Riscal, R | 1 |
| Schrepfer, E | 1 |
| Arena, G | 1 |
| Cissé, MY | 1 |
| Bellvert, F | 1 |
| Heuillet, M | 1 |
| Rambow, F | 1 |
| Bonneil, E | 1 |
| Sabourdy, F | 1 |
| Vincent, C | 1 |
| Ait-Arsa, I | 1 |
| Levade, T | 1 |
| Thibaut, P | 1 |
| Marine, JC | 1 |
| Portais, JC | 1 |
| Sarry, JE | 1 |
| Le Cam, L | 1 |
| Linares, LK | 1 |
| Lukic, A | 1 |
| Ji, J | 1 |
| Idborg, H | 1 |
| Samuelsson, B | 1 |
| Palmberg, L | 1 |
| Gabrielsson, S | 1 |
| Rådmark, O | 1 |
| Kreager, DA | 1 |
| Ragan, DT | 1 |
| Nguyen, H | 1 |
| Staff, J | 1 |
| Bartosh, TJ | 1 |
| Ylostalo, JH | 1 |
| Dutta, NK | 1 |
| He, R | 1 |
| Pinn, ML | 1 |
| Burrows, F | 1 |
| Zhang, ZY | 1 |
| Karakousis, PC | 1 |
| Jin, YJ | 1 |
| Wang, S | 1 |
| Cho, J | 1 |
| Selim, MA | 1 |
| Wright, T | 1 |
| Mosialos, G | 1 |
| Zhang, JY | 1 |
| Roy, S | 1 |
| Karmakar, T | 1 |
| Nagappa, LK | 1 |
| Prahlada Rao, VS | 1 |
| Balasubramanian, S | 1 |
| Balaram, H | 1 |
| Mazuquin, BF | 1 |
| Dela Bela, LF | 1 |
| Pelegrinelli, AR | 1 |
| Dias, JM | 1 |
| Carregaro, RL | 1 |
| Moura, FA | 1 |
| Selfe, J | 1 |
| Richards, J | 1 |
| Brown, LE | 1 |
| Cardoso, JR | 1 |
| Naeem, MA | 1 |
| Armutlulu, A | 1 |
| Broda, M | 1 |
| Lebedev, D | 1 |
| Müller, CR | 1 |
| Jin, X | 1 |
| Liang, N | 1 |
| Wang, M | 1 |
| Meng, Y | 1 |
| Jia, B | 1 |
| Shi, X | 1 |
| Luo, J | 1 |
| Luo, Y | 1 |
| Cui, Q | 1 |
| Zheng, K | 1 |
| Liu, Z | 1 |
| Li, F | 1 |
| Wang, F | 1 |
| Zhu, Z | 1 |
| Gallo, S | 1 |
| Woolfrey, AE | 1 |
| Burroughs, LM | 1 |
| Storer, BE | 1 |
| Flowers, ME | 1 |
| Hari, P | 1 |
| Pulsipher, MA | 1 |
| Heimfeld, S | 1 |
| Kiem, HP | 1 |
| Sandmaier, BM | 1 |
| Storb, R | 1 |
| Cho, KJ | 1 |
| Casteel, DE | 1 |
| Prakash, P | 1 |
| Tan, L | 1 |
| van der Hoeven, D | 1 |
| Salim, AA | 1 |
| Kim, C | 1 |
| Capon, RJ | 1 |
| Lacey, E | 1 |
| Cunha, SR | 1 |
| Gorfe, AA | 1 |
| Hancock, JF | 1 |
| Ko, E | 1 |
| Kim, Y | 1 |
| Lee, BB | 1 |
| Han, J | 1 |
| Song, SY | 1 |
| Shim, YM | 1 |
| Park, J | 1 |
| Kim, DH | 1 |
| Yeh, HH | 1 |
| Giri, R | 1 |
| Chang, TY | 1 |
| Chou, CY | 1 |
| Su, WC | 1 |
| Liu, HS | 1 |
| Okasaka, T | 1 |
| Matsuo, K | 1 |
| Suzuki, T | 1 |
| Ito, H | 1 |
| Hosono, S | 1 |
| Kawase, T | 1 |
| Watanabe, M | 1 |
| Yatabe, Y | 1 |
| Mitsudomi, T | 1 |
| Tanaka, H | 1 |
| Yokoi, K | 1 |
| Tajima, K | 2 |
| Oh, HL | 1 |
| Lee, DK | 1 |
| Lim, H | 1 |
| Lee, CH | 1 |
| Yamada, C | 1 |
| Ozaki, T | 1 |
| Ando, K | 1 |
| Suenaga, Y | 1 |
| Ito, Y | 1 |
| Okoshi, R | 1 |
| Kageyama, H | 1 |
| Kimura, H | 1 |
| Miyazaki, M | 1 |
| Nakagawara, A | 1 |
| Zhang, PX | 1 |
| Jiang, GY | 1 |
| Li, QC | 1 |
| Wang, EH | 1 |
| Phillips, L | 1 |
| Morgan, C | 1 |
| Pawade, J | 1 |
| Sohail, M | 1 |
| May, MT | 1 |
| Hetzel, MR | 1 |
| Thaiparambil, JT | 1 |
| Bender, L | 1 |
| Ganesh, T | 1 |
| Kline, E | 1 |
| Patel, P | 1 |
| Tighiouart, M | 1 |
| Vertino, PM | 1 |
| Harvey, RD | 1 |
| Garcia, A | 1 |
| Marcus, AI | 1 |
| Zhang, WC | 1 |
| Shyh-Chang, N | 1 |
| Yang, H | 1 |
| Rai, A | 1 |
| Umashankar, S | 1 |
| Ma, S | 1 |
| Soh, BS | 1 |
| Sun, LL | 1 |
| Tai, BC | 1 |
| Nga, ME | 1 |
| Bhakoo, KK | 1 |
| Jayapal, SR | 1 |
| Nichane, M | 1 |
| Yu, Q | 1 |
| Ahmed, DA | 1 |
| Tan, C | 1 |
| Sing, WP | 1 |
| Tam, J | 1 |
| Thirugananam, A | 1 |
| Noghabi, MS | 1 |
| Pang, YH | 1 |
| Ang, HS | 1 |
| Mitchell, W | 1 |
| Robson, P | 1 |
| Kaldis, P | 1 |
| Soo, RA | 1 |
| Swarup, S | 1 |
| Lim, EH | 1 |
| Lim, B | 1 |
| Assiddiq, BF | 1 |
| Tan, KY | 1 |
| Toy, W | 1 |
| Chan, SP | 1 |
| Chong, PK | 1 |
| Lim, YP | 1 |
| Rettig, M | 1 |
| Trinidad, K | 1 |
| Pezeshkpour, G | 1 |
| Frost, P | 1 |
| Sharma, S | 1 |
| Moatamed, F | 1 |
| Tamanoi, F | 1 |
| Mortazavi, F | 1 |
| Boespflug, A | 1 |
| Couraud, S | 1 |
| Bringuier, PP | 1 |
| Isaac, S | 1 |
| Gérinière, L | 1 |
| Perrot, E | 1 |
| Edery, P | 1 |
| Durieu, I | 1 |
| Souquet, PJ | 1 |
| Su, L | 1 |
| Liu, G | 1 |
| Zhou, W | 1 |
| Xu, LL | 1 |
| Miller, DP | 1 |
| Park, S | 1 |
| Lynch, TJ | 1 |
| Wain, JC | 1 |
| Christiani, DC | 1 |
| Morinaga, Y | 1 |
| Suga, Y | 1 |
| Ehara, S | 1 |
| Harada, K | 1 |
| Nihei, Y | 1 |
| Suzuki, M | 1 |
| Ding, H | 1 |
| Duan, W | 1 |
| Zhu, WG | 1 |
| Ju, R | 1 |
| Srinivasan, K | 1 |
| Otterson, GA | 1 |
| Villalona-Calero, MA | 1 |
| Lillehoj, EP | 1 |
| Han, F | 1 |
| Kim, KC | 1 |
| Holownia, A | 2 |
| Mroz, RM | 2 |
| Kozlowski, M | 1 |
| Chyczewska, E | 2 |
| Laudanski, J | 1 |
| Chyczewski, L | 2 |
| Braszko, JJ | 2 |
| Das, KC | 2 |
| Dashnamoorthy, R | 1 |
| RYAN, WL | 1 |
| LORINCZ, AB | 1 |
| Hori, K | 2 |
| Saito, S | 2 |
| Kittiniyom, K | 1 |
| Mastronardi, M | 1 |
| Roemer, M | 1 |
| Wells, WA | 1 |
| Greenberg, ER | 1 |
| Titus-Ernstoff, L | 1 |
| Newsham, IF | 1 |
| Ishii, T | 1 |
| Fujishiro, M | 1 |
| Masuda, M | 1 |
| Goshima, Y | 1 |
| Kitamura, H | 1 |
| Teramoto, S | 1 |
| Matsuse, T | 1 |
| Yap, DB | 1 |
| Hsieh, JK | 1 |
| Zhong, S | 1 |
| Heath, V | 1 |
| Gusterson, B | 1 |
| Crook, T | 1 |
| Hung, RJ | 1 |
| Brennan, P | 1 |
| Canzian, F | 1 |
| Szeszenia-Dabrowska, N | 1 |
| Zaridze, D | 1 |
| Lissowska, J | 1 |
| Rudnai, P | 1 |
| Fabianova, E | 1 |
| Mates, D | 1 |
| Foretova, L | 1 |
| Janout, V | 1 |
| Bencko, V | 1 |
| Chabrier, A | 1 |
| Borel, S | 1 |
| Hall, J | 1 |
| Boffetta, P | 1 |
| Oleinik, NV | 1 |
| Krupenko, NI | 1 |
| Priest, DG | 1 |
| Krupenko, SA | 1 |
| Chen, G | 1 |
| Bhojani, MS | 1 |
| Heaford, AC | 1 |
| Chang, DC | 1 |
| Laxman, B | 1 |
| Thomas, DG | 1 |
| Griffin, LB | 1 |
| Yu, J | 1 |
| Coppola, JM | 1 |
| Giordano, TJ | 1 |
| Lin, L | 1 |
| Adams, D | 1 |
| Orringer, MB | 1 |
| Ross, BD | 1 |
| Beer, DG | 1 |
| Rehemtulla, A | 1 |
| Ichwan, SJ | 1 |
| Yamada, S | 1 |
| Sumrejkanchanakij, P | 1 |
| Ibrahim-Auerkari, E | 1 |
| Eto, K | 1 |
| Ikeda, MA | 1 |
| Besson, A | 1 |
| Gurian-West, M | 1 |
| Kelly-Spratt, KS | 1 |
| Kemp, CJ | 1 |
| Roberts, JM | 1 |
| Gu, J | 1 |
| Wu, X | 1 |
| Dong, Q | 1 |
| Romeo, MJ | 1 |
| Lin, X | 1 |
| Gutkind, JS | 1 |
| Berman, DM | 1 |
| Claudio, PP | 1 |
| Ghafouri, M | 1 |
| Mariano, C | 1 |
| White, MK | 1 |
| Safak, M | 1 |
| Sheffield, JB | 1 |
| Giordano, A | 1 |
| Khalili, K | 1 |
| Amini, S | 1 |
| Sawaya, BE | 1 |
| Scaglioni, PP | 1 |
| Yung, TM | 1 |
| Cai, LF | 1 |
| Erdjument-Bromage, H | 1 |
| Kaufman, AJ | 1 |
| Singh, B | 1 |
| Teruya-Feldstein, J | 1 |
| Tempst, P | 1 |
| Pandolfi, PP | 1 |
| Sørensen, M | 2 |
| Raaschou-Nielsen, O | 2 |
| Hansen, RD | 1 |
| Tjønneland, A | 2 |
| Overvad, K | 2 |
| Vogel, U | 2 |
| Asahina, H | 1 |
| Yamazaki, K | 1 |
| Kinoshita, I | 1 |
| Yokouchi, H | 1 |
| Dosaka-Akita, H | 1 |
| Nishimura, M | 3 |
| Popanda, O | 1 |
| Edler, L | 1 |
| Waas, P | 1 |
| Schattenberg, T | 1 |
| Dienemann, H | 1 |
| Bartsch, H | 1 |
| Schmezer, P | 1 |
| Yuan, BZ | 1 |
| Jefferson, AM | 1 |
| Millecchia, L | 1 |
| Popescu, NC | 1 |
| Reynolds, SH | 1 |
| Bandyopadhyay, K | 1 |
| Lee, C | 1 |
| Haghighi, A | 1 |
| Banères, JL | 1 |
| Parello, J | 1 |
| Hatt, L | 1 |
| Loft, S | 1 |
| Risom, L | 1 |
| Møller, P | 1 |
| Yamada, T | 1 |
| Komoto, J | 1 |
| Kasuya, T | 1 |
| Takata, Y | 1 |
| Ogawa, H | 1 |
| Mori, H | 1 |
| Takusagawa, F | 1 |
| Kulkarni, A | 1 |
| Wessel, I | 1 |
| Jensen, PB | 1 |
| Falck, J | 1 |
| Mirski, SE | 1 |
| Cole, SP | 1 |
| Sehested, M | 1 |
| Kohno, T | 2 |
| Shinmura, K | 2 |
| Tosaka, M | 1 |
| Tani, M | 1 |
| Kim, SR | 1 |
| Sugimura, H | 2 |
| Nohmi, T | 1 |
| Kasai, H | 1 |
| Yokota, J | 2 |
| Kurian, MS | 1 |
| de la Cuesta, RS | 1 |
| Waneck, GL | 1 |
| MacLaughlin, DT | 1 |
| Manganaro, TF | 1 |
| Donahoe, PK | 1 |
| Wakai, K | 1 |
| Nagura, K | 1 |
| Genka, K | 1 |
| Igarashi, H | 1 |
| Morris, BJ | 1 |
| Baba, S | 1 |
| Ohno, Y | 1 |
| Gao, C | 1 |
| Wang, J | 1 |
| Takezaki, T | 1 |
| Varga, T | 1 |
| Sawaguchi, T | 1 |
| Lum, JK | 1 |
| Martinson, JJ | 1 |
| Tsugane, S | 1 |
| Iwamasa, T | 1 |
| Yang, CP | 1 |
| Horwitz, SB | 1 |
| Oda, K | 1 |
| Arakawa, H | 1 |
| Matsuda, K | 1 |
| Tanikawa, C | 1 |
| Mori, T | 1 |
| Nishimori, H | 1 |
| Tamai, K | 1 |
| Tokino, T | 1 |
| Nakamura, Y | 1 |
| Taya, Y | 1 |
| Le Marchand, L | 1 |
| Donlon, T | 1 |
| Lum-Jones, A | 1 |
| Seifried, A | 1 |
| Wilkens, LR | 1 |
| Kubota, K | 1 |
| Nakada, H | 2 |
| Nakajima, H | 1 |
| Hori, Y | 1 |
| Ezaki, M | 1 |
| Goto, T | 2 |
| Okuhara, M | 2 |
| Kawamura, I | 1 |
| Mizota, T | 1 |
| Shimomura, K | 1 |
| Nakahara, K | 1 |
| Yamaguchi, I | 1 |
| Yue, XF | 1 |
| Wu, FG | 1 |
| Xu, B | 1 |
| Fujita, M | 1 |
| Taniguchi, N | 1 |
| Makita, A | 1 |
| Ono, M | 1 |
| Oikawa, K | 1 |
| Spellman, CM | 1 |
| Fottrell, PF | 1 |
| Wolberg, WH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label, Dose-escalation, Safety and Pharmacokinetics Phase I Study of Ombrabulin in Combination With Docetaxel and Cisplatin Every 3 Weeks in Patients With Advanced Solid Tumors[NCT01095302] | Phase 1 | 11 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
| A Phase I Study to Determine the Efficacy and Safety of CKD-516 Tablet Combined With Durvalumab(MEDI4736) in Patient Refractory Solid Tumors[NCT04696848] | Phase 1/Phase 2 | 25 participants (Actual) | Interventional | 2021-02-24 | Terminated (stopped due to Recruitment difficulty) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for serine and Cancer of Lung
| Article | Year |
|---|---|
Efficacy of Dabrafenib and Trametinib in a Patient with Squamous-Cell Carcinoma, with Mutation p.D594G in
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Extracellular Signal-Regulated MAP K | 2023 |
Association between the hOGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis based on 22,475 subjects.
Topics: Chi-Square Distribution; DNA Glycosylases; Gene Frequency; Genetic Predisposition to Disease; Hetero | 2013 |
3 trials available for serine and Cancer of Lung
| Article | Year |
|---|---|
Phase 1 study of ombrabulin in combination with docetaxel and cisplatin in Japanese patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asian People; Ca | 2018 |
DISRUPT: a randomised phase 2 trial of ombrabulin (AVE8062) plus a taxane-platinum regimen as first-line therapy for metastatic non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bridged-Ring Compoun | 2014 |
No association between the p21 codon 31 serine-arginine polymorphism and lung cancer risk.
Topics: Age Factors; Arginine; Case-Control Studies; Codon; Female; Genes, p53; Genetic Code; Genetic Marker | 2003 |
108 other studies available for serine and Cancer of Lung
| Article | Year |
|---|---|
Expression and Clinical Significance of lncRNA OSER1-AS1 in Peripheral Blood of Patients with Non-Small Cell Lung Cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Chondroitin Sulfates; Gene Expression Regulation, Neoplastic; Humans | 2022 |
Prognostic significance of dynamin-related protein 1 expression in advanced lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Dynamins; ErbB Receptors; Humans; Lung Neoplasms; Mutation; Prognosis; Prote | 2022 |
Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Carbon; Glycogen Synthase Kinase 3; Humans; Lung Neoplasms; Pr | 2022 |
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Carbon; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2022 |
Therapeutic restoring p53 function with small molecule for oncogene-driven non-small cell lung cancer by targeting serine 392 phosphorylation.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Humans; Lung Neoplasms; | 2022 |
The RIPK family: expression profile and prognostic value in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Biomarkers, Tumor; Disease-Free Survival; Humans; Lung Neoplasms; Prognosis; | 2022 |
Small-molecule MX-C2/3 suppresses non-small cell lung cancer progression via p53 activation.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neopla | 2022 |
ISGylation of EMD promotes its interaction with PDHA to inhibit aerobic oxidation in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; beta Catenin; Glucose; Humans; Lung Neoplasms; Lysine; Membrane Proteins; Nu | 2022 |
Identification of
Topics: Biomarkers; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenome; Genome-Wide Association St | 2022 |
DSTYK inhibition increases the sensitivity of lung cancer cells to T cell-mediated cytotoxicity.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Receptor-Interacting Protein Serine-Threonin | 2022 |
Identification and Exploration of Serine Peptidase Inhibitor Kazal Type I (SPINK1) as a Potential Biomarker Correlated with the Progression of Non-Small Cell Lung Cancer.
Topics: Biomarkers; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Gene Expression Re | 2022 |
Bioinformatic Analysis Identifies of Potential miRNA-mRNA Regulatory Networks Involved in the Pathogenesis of Lung Cancer.
Topics: Biomarkers; Computational Biology; Gene Expression Profiling; Gene Expression Regulation, Neoplastic | 2022 |
The amino acid and carnitine concentration changes in bronchoalveolar lavage fluid from lung cancer patients.
Topics: Amino Acids; Bronchoalveolar Lavage Fluid; Carnitine; Humans; Lung Neoplasms; Serine | 2022 |
The amino acid and carnitine concentration changes in bronchoalveolar lavage fluid from lung cancer patients.
Topics: Amino Acids; Bronchoalveolar Lavage Fluid; Carnitine; Humans; Lung Neoplasms; Serine | 2022 |
The amino acid and carnitine concentration changes in bronchoalveolar lavage fluid from lung cancer patients.
Topics: Amino Acids; Bronchoalveolar Lavage Fluid; Carnitine; Humans; Lung Neoplasms; Serine | 2022 |
The amino acid and carnitine concentration changes in bronchoalveolar lavage fluid from lung cancer patients.
Topics: Amino Acids; Bronchoalveolar Lavage Fluid; Carnitine; Humans; Lung Neoplasms; Serine | 2022 |
Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer.
Topics: Animals; Cell Line; Cell Line, Tumor; Glycine; Humans; Lung Neoplasms; Mice; Serine; Thyroid Nuclear | 2023 |
Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway.
Topics: A549 Cells; Animals; Disease Progression; Humans; Insulin Receptor Substrate Proteins; Lung Neoplasm | 2019 |
Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; | 2020 |
Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression.
Topics: A549 Cells; Animals; Breast Neoplasms; Female; Humans; Lung Neoplasms; MCF-7 Cells; Mice; Mice, Inbr | 2020 |
Cancer proteome and metabolite changes linked to SHMT2.
Topics: Animals; Antifungal Agents; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Gene Expression Regula | 2020 |
The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Endopeptidases; Femal | 2021 |
O-GlcNAc stabilizes SMAD4 by inhibiting GSK-3β-mediated proteasomal degradation.
Topics: Acetylglucosamine; Breast Neoplasms; Female; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms | 2020 |
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition.
Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Prolif | 2021 |
Impact of immune checkpoint gene CD155 Ala67Thr and CD226 Gly307Ser polymorphisms on small cell lung cancer clinical outcome.
Topics: Aged; Alanine; Amino Acid Substitution; Antigens, Differentiation, T-Lymphocyte; Carcinoma, Small Ce | 2021 |
Food for Growth: Distinct Nutrient Preferences between Primary Tumors and Metastases.
Topics: Breast Neoplasms; Humans; Lung Neoplasms; Mechanistic Target of Rapamycin Complex 1; Nutrients; Seri | 2021 |
The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Disease Models, Animal; Female; Gain of Function Mutation | 2021 |
Immunohistochemical Expression of Serine and Arginine-Rich Splicing Factor 1 (SRSF1) in Fluoro-Edenite-Induced Malignant Mesothelioma: A Preliminary Study.
Topics: Arginine; Asbestos, Amphibole; Biomarkers, Tumor; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma | 2021 |
Ganoderic acid targeting nuclear factor erythroid 2-related factor 2 in lung cancer.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cysteine; Humans; Lung Neoplasms | 2017 |
PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Proliferation; DNA, Neoplasm | 2017 |
RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth.
Topics: Animals; Bone Marrow Transplantation; Colonic Neoplasms; Female; Gene Expression Regulation, Neoplas | 2017 |
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.
Topics: Apoptosis; Cell Line, Tumor; Enzyme Inhibitors; Glycine; Glycine Hydroxymethyltransferase; Humans; H | 2018 |
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
Topics: Cell Nucleus; Cell Proliferation; Crystallography, X-Ray; Glycine Hydroxymethyltransferase; Humans; | 2018 |
A serine in exon 11 determines the full transcriptional activity of TCF-4 in lung carcinoma cells.
Topics: Animals; Base Sequence; Cell Line, Tumor; Cell Proliferation; Exons; Gene Expression Regulation, Neo | 2019 |
Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry.
Topics: Adult; Aged; Amino Acids; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; C | 2019 |
Ras-ERK signalling represses H1.4 phosphorylation at serine 36 to promote non-small-cell lung carcinoma cells growth and migration.
Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Cyclic AMP-Dependent | 2019 |
Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W.
Topics: 14-3-3 Proteins; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell Proliferation; Flow Cyt | 2013 |
p73 regulates serine biosynthesis in cancer.
Topics: Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; | 2014 |
Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs.
Topics: 14-3-3 Proteins; Adenocarcinoma; Amino Acid Motifs; Animals; Apoptosis; Blotting, Western; Cell Line | 2014 |
Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D.
Topics: Aging; Antibiotics, Antineoplastic; Cell Line, Tumor; Dactinomycin; Humans; Lung Neoplasms; Nuclear | 2014 |
Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chem | 2014 |
The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells.
Topics: Antineoplastic Agents; Antirheumatic Agents; Autophagy; Carcinoma, Non-Small-Cell Lung; Caspases; Ce | 2014 |
Small-molecule Bax agonists for cancer therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Binding Sites; Cell Line; Cel | 2014 |
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
Topics: Adenocarcinoma; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Gene Expression Regulation, Neo | 2014 |
Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Codon, Nonsense; DNA Damage; DNA, Ne | 2015 |
Serine-Threonine Kinase 38 regulates CDC25A stability and the DNA damage-induced G2/M checkpoint.
Topics: cdc25 Phosphatases; Cell Line, Tumor; DNA Damage; Enzyme Activation; Enzyme Stability; G2 Phase Cell | 2015 |
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Catalysis; Cell Line, Tumor; Cell Movement; Cytoki | 2015 |
Topoisomerase-I PS506 as a Dual Function Cancer Biomarker.
Topics: Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Camptothecin; Carcinoma, | 2015 |
Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
Topics: Anaphase; Animals; Binding Sites; Cell Cycle Proteins; Cell Line, Tumor; Centrosome; Cyclin-Dependen | 2015 |
Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.
Topics: Adaptation, Physiological; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Prolifera | 2015 |
NRF2 regulates serine biosynthesis in non-small cell lung cancer.
Topics: Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Carcinoma, Non-Small-Cell | 2015 |
Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; DNA Damage; Gene Expression Regulation, Ne | 2016 |
hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells.
Topics: Adenocarcinoma; Apoptosis; Blotting, Western; CASP8 and FADD-Like Apoptosis Regulating Protein; Casp | 2016 |
The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Decision Support Tech | 2016 |
Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.
Topics: Activating Transcription Factor 4; Animals; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell P | 2016 |
Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.
Topics: A549 Cells; Arachidonate 5-Lipoxygenase; Borates; Eosinophils; Epithelial Cells; Exosomes; gamma-Glu | 2016 |
Topics: Adolescent; Adult; Age Factors; Aged; Amino Acid Substitution; Anemia, Aplastic; Athletes; Athletic | 2016 |
AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.
Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; | 2016 |
Relationship of phospho-pRb (Ser-807/811) level to exposure to tobacco smoke in primary non-small cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; DNA Methylation; Female; Humans; Immunohistochemistry; Lung Neoplasm | 2009 |
Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclin D | 2009 |
hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Case-Control Studies; | 2009 |
HY253, a novel decahydrofluorene analog, from Aralia continentalis, induces cell cycle arrest at the G1 phase and cytochrome c-mediated apoptosis in human lung cancer A549 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Aralia; Blotting, Western; Caspases; Cell Cycle Protei | 2010 |
RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53.
Topics: Adenocarcinoma; Apoptosis; Cell Line, Tumor; Core Binding Factor Alpha 3 Subunit; DNA Damage; Gene E | 2010 |
p120-catenin isoform 3 regulates subcellular localization of Kaiso and promotes invasion in lung cancer cells via a phosphorylation-dependent mechanism.
Topics: Active Transport, Cell Nucleus; Amino Acid Substitution; Animals; Catenins; Cell Line, Tumor; Delta | 2011 |
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer.
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Enzyme Activation; Female; Humans; Lung Neoplasms | 2011 |
Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Differentiation; Cell Line | 2011 |
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.
Topics: Amino Acid Sequence; Antigens, CD; Carcinoma, Non-Small-Cell Lung; Cell Adhesion Molecules, Neuronal | 2012 |
EGFR S1166 phosphorylation induced by a combination of EGF and gefitinib has a potentially negative impact on lung cancer cell growth.
Topics: Amino Acid Motifs; Amino Acid Sequence; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; | 2012 |
PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells.
Topics: Carcinoma, Non-Small-Cell Lung; Catenins; Cell Line, Tumor; Cell Movement; Delta Catenin; Gene Expre | 2012 |
Primary lung adenocarcinoma occurring in a PTEN related syndrome (Cowden's disease): routine EGFR sequencing also highlights two rare somatic mutations S768I and V769L.
Topics: Adenocarcinoma; Adult; Chromosome Disorders; Diagnosis, Differential; DNA Mutational Analysis; ErbB | 2013 |
Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Col | 2003 |
P21 response to DNA damage induced by genistein and etoposide in human lung cancer cells.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Division; C | 2003 |
Mutagenesis of a Gly-Ser cleavage site in MUC1 inhibits ectodomain shedding.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; COS Cells; Glycine; Humans; Lung Neoplasms; Mice; Mu | 2003 |
Therapy increases poly-ADP-ribose and p53-Ser392-P levels in recurrent squamous cell lung cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Carcinoma, Squamous Cell; Cisplatin; C | 2003 |
Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.
Topics: Adenocarcinoma; Androstadienes; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Protein | 2004 |
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Gl | 1964 |
Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis.
Topics: Animals; Arterioles; Blood Flow Velocity; Blood Pressure; Lung Neoplasms; Male; Microcirculation; Mu | 2003 |
p53 N-terminal Ser-15 approximately P and Ser-20 approximately P levels in squamous cell lung cancer after radio/chemotherapy.
Topics: Aged; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; DNA Damage; Humans; Ki-67 Anti | 2004 |
Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation.
Topics: Adult; Alanine; Alleles; Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Breas | 2004 |
Effects of p27Kip1 on cell cycle status and viability in A549 lung adenocarcinoma cells.
Topics: Adenocarcinoma; Amino Acid Substitution; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell | 2004 |
Ser392 phosphorylation regulates the oncogenic function of mutant p53.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; | 2004 |
Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study.
Topics: Adenocarcinoma; Adult; Aged; Arginine; Case-Control Studies; Confounding Factors, Epidemiologic; Cys | 2005 |
Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression.
Topics: Adenosine Triphosphate; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Gene Expression; | 2005 |
Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Apoptosis; Cell Cycle; Cell Nucleus; Cell Prol | 2005 |
Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.
Topics: Adenoviridae; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Humans; Lung Neop | 2006 |
A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression.
Topics: Amino Acid Substitution; Animals; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dep | 2006 |
A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.
Topics: Aged; Alleles; Case-Control Studies; Cell Transformation, Neoplastic; Cyclin D1; DNA, Neoplasm; Fema | 2006 |
Cdk9 phosphorylates p53 on serine 392 independently of CKII.
Topics: Brain Neoplasms; Casein Kinase II; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Glioblastoma; HIV-1; | 2006 |
A CK2-dependent mechanism for degradation of the PML tumor suppressor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Ca | 2006 |
Interactions between the OGG1 Ser326Cys polymorphism and intake of fruit and vegetables in relation to lung cancer.
Topics: Cysteine; Diet; DNA Glycosylases; Female; Fruit; Genetic Predisposition to Disease; Humans; Lung Neo | 2006 |
Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.
Topics: Adenocarcinoma; DNA, Neoplasm; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Isoleuc | 2006 |
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Carcinoma, Squamo | 2007 |
Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells.
Topics: Actins; Amino Acid Sequence; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movem | 2007 |
Serine phosphorylation-dependent coregulation of topoisomerase I by the p14ARF tumor suppressor.
Topics: Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Damage; DNA Topoisomerases, Type | 2007 |
OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study.
Topics: Amino Acid Substitution; Case-Control Studies; Cohort Studies; Cysteine; DNA Glycosylases; DNA Repai | 2008 |
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Topics: Amino Acid Substitution; Catalysis; Catalytic Domain; Cell Line, Tumor; Crystallography, X-Ray; Huma | 2008 |
Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Apoptosis; Ataxia Telangiectasia Mutated Prote | 2008 |
Loss of amino acids 1490Lys-Ser-Lys1492 in the COOH-terminal region of topoisomerase IIalpha in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antigens, Neoplasm; ATP Binding Cassette Transporter, | 1997 |
Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alleles; Alternative Splicing; Cell Line; Codon; Cysteine; Deoxyguanosi | 1998 |
Cleavage of Müllerian inhibiting substance activates antiproliferative effects in vivo.
Topics: Animals; Anti-Mullerian Hormone; Arginine; Cell Division; Eye Neoplasms; Female; Fibrinolysin; Glyco | 1995 |
hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Carcinoma, Squamous Cell; Case-Control Studies; Cysteine; D | 1999 |
Taxol mediates serine phosphorylation of the 66-kDa Shc isoform.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Antineoplastic Agents, | 2000 |
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.
Topics: Adenocarcinoma; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoma, Non- | 2000 |
Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Asian People; Case-Control Studies; Cysteine; Diet | 2002 |
A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma; Drug Screening Assays, Antitumor; Heart Neopl | 2002 |
A new antitumor antibiotic, FR900840. I. Discovery, identification, isolation and characterization.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Female; Fermentation; Humans | 1989 |
A new antitumor antibiotic, FR900840. III. Antitumor activity against experimental tumors.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Carcinoma, Small Cell; Carcinoma, Squamous Cel | 1989 |
[Effect of oxalysine on pulmonary metastases of Lewis lung carcinoma in mice].
Topics: Amino Acids, Dicarboxylic; Animals; Antibiotics, Antineoplastic; Lung Neoplasms; Mice; Mice, Inbred | 1985 |
Protein phosphorylation of beta-glucuronidase in human lung cancer--identification of serine- and threonine-phosphates.
Topics: Adenocarcinoma; Chemical Phenomena; Chemistry; Electrophoresis, Polyacrylamide Gel; Glucuronidase; H | 1985 |
Similarities between pyruvate kinase from human placenta and tumours.
Topics: Adenosine Triphosphate; Alanine; Carcinoma; Chromatography, Gel; Chromatography, Ion Exchange; Elect | 1973 |
Response of DNA thymine synthesis in human tumor and normal tissue to 5-fluorouracil.
Topics: Breast Neoplasms; Carbon Isotopes; Chromatography, Paper; Colon; Colonic Neoplasms; Depression, Chem | 1972 |