Compounds > serine
Page last updated: 2024-11-08

serine and Breast Neoplasms

serine has been researched along with Breast Neoplasms in 242 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Breast Neoplasms: Tumors or cancer of the human BREAST.

Research Excerpts

ExcerptRelevanceReference
"In vitro, p21-activated kinase 1 (Pak1) phosphorylates the serine 305 residue of the estrogen receptor alpha (ERalpha) and influences the response of breast cancer cells to tamoxifen."9.14Estrogen receptor-alpha phosphorylation at serine 305, nuclear p21-activated kinase 1 expression, and response to tamoxifen in postmenopausal breast cancer. ( Bostner, J; Fornander, T; Nordenskjöld, B; Skoog, L; Stål, O, 2010)
"Although estrogen receptor-alpha (ER) [corrected] is a marker used to identify breast cancer patients most likely to benefit from endocrine therapy, approximately 50% of ER-positive [corrected] breast carcinomas are resistant to tamoxifen."9.14Estrogen receptor-alpha phosphorylation at serine-118 and tamoxifen response in breast cancer. ( Hauptmann, M; Holm-Wigerup, C; Kok, M; Landberg, G; Linn, S; Michalides, R; Stål, O, 2009)
"We tested the hypothesis that Akt-Ser473 phosphorylation (pAkt) predicts benefit from the sequential addition of paclitaxel to adjuvant doxorubicin plus cyclophosphamide (AC) chemotherapy in patients with node-positive breast cancer participating in the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 trial."9.14Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer. ( Costantino, JP; Jeong, JH; Kidwell, K; Kim, C; Mamounas, EP; Nguyen, D; Paik, S; Swain, SM; Wolmark, N; Yang, SX, 2010)
" Here we discovered that missense mutant p53 oncoproteins stimulate de novo serine/glycine synthesis and essential amino acids intake, promoting breast cancer growth."8.31Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth. ( Audano, M; Baldassarre, G; Belletti, B; Bertolio, R; Bicciato, S; Blandino, G; Cancila, V; Caputo, M; Del Sal, G; Donzelli, S; Mantovani, F; Mitro, N; Pedretti, S; Piazza, S; Rustighi, A; Segatto, I; Tombari, C; Triboli, L; Tripodo, C; Vacca, D; Vodret, S; Zannini, A, 2023)
" In particular, leucine and glutamine have been shown to be important for growth and proliferation of some breast cancers, and therefore targeting the primary cell-surface transporters that mediate their uptake, L-type amino acid transporter 1 (LAT1) and alanine, serine, cysteine-preferring transporter 2 (ASCT2), is a potential therapeutic strategy."7.88Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways. ( Freidman, N; Guan, YF; Holst, J; Krycer, JR; Pang, A; Quek, LE; Ryan, R; Turner, N; van Geldermalsen, M; Wang, Q, 2018)
"We used western blotting and immunohistochemistry to examine five serine-/glycine-metabolism-associated proteins (PHGDH, PSAT, PSPH, SHMT, and GLDC) in six breast cancer cell lines and 709 breast cancer cases using tissue microarray (TMA)."7.80Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes. ( Jung, WH; Kim, SK; Koo, JS, 2014)
"Potential interactions between prolactin (PRL) and estradiol (E2) in breast cancer cells were explored by examining the effect of PRL on estrogen receptor (ER) serine-118 phosphorylation, ER down-regulation, and E2-stimulated cell proliferation."7.76Prolactin and estradiol utilize distinct mechanisms to increase serine-118 phosphorylation and decrease levels of estrogen receptor alpha in T47D breast cancer cells. ( Chen, KE; Chen, Y; Huang, K; Walker, AM, 2010)
" We show here for the first time that a stilbene, resveratrol, induces nuclear accumulation of COX-2 protein in human breast cancer MCF-7 and MDA-MB-231 cell cultures."7.73Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. ( Cao, HJ; Davis, FB; Davis, PJ; Lin, HY; Shih, A; Tang, HY, 2006)
"A naturally occurring, cocoa-derived pentameric procyanidin (pentamer) was previously shown to cause G0/G1 cell cycle arrest in human breast cancer cells by an unknown molecular mechanism."7.73Pentameric procyanidin from Theobroma cacao selectively inhibits growth of human breast cancer cells. ( Dickson, RB; Galperin, M; Knezevic, V; Metheny-Barlow, LJ; Ramesh, A; Ramljak, D; Romanczyk, LJ; Thompson, N, 2005)
" The molecular mechanism(s) by which hypoxia/reoxygenation (H/R) regulates p56lck-dependent activation of NFkappaB through tyrosine phosphorylation of IkappaBalpha and modulates the expression of downstream genes that are involved in cell migration in human breast cancer cells are not well defined."7.72Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation. ( Kundu, GC; Mahabeleshwar, GH, 2003)
"The effects of estrone, estradiol, and estriol on MCF-7 human breast cancer are compared."7.65Effects of estrone, estradiol, and estriol on hormone-responsive human breast cancer in long-term tissue culture. ( Bolan, G; Lippman, M; Monaco, ME, 1977)
"However, its role in mammary oncogenesis remains an unsettled debate as STAT5a exhibits functional dichotomy with both pro-differentiative and pro-proliferative target genes."5.62Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer. ( Clevenger, CV; Grible, JM; Harrell, JC; Idowu, M; Olex, AL; Woock, AE; Zot, P, 2021)
"Breast cancer is the most common cancer among American women and a major cause of mortality."5.56Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. ( Curtis, C; Ducker, GS; Graves, EE; Li, AM; Li, Y; Liu, L; Massagué, J; Melemenidis, S; Rabinowitz, JD; Rankin, EB; Seoane, JA; Thompson, CB; Vanharanta, S; Xiao, Y; Ye, J; Zhou, Y, 2020)
"In 1755 early stage breast cancers, DDR signalling [ATM, ATR, total Ckh1, Chk1 phosphorylated at serine(345) (pChk1), Chk2, p53], base excision repair [PARP1, POLβ, XRCC1, FEN1, SMUG1], non-homologous end joining (Ku70/Ku80, DNA-PKcs) and homologous recombination [RAD51, BRCA1, γH2AX, BLM, WRN, RECQL5, PTEN] protein expression was correlated to time to early local recurrence."5.43Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer. ( Abdel-Fatah, TM; Aleskandarany, MA; Alsubhi, N; Arora, A; Chan, SY; Curtin, NJ; Doherty, R; Ellis, IO; Green, AR; Madhusudan, S; Martin, SG; Middleton, F; Moseley, PM; Rakha, EA; Stephens, P, 2016)
"Imaging of breast cancer cell lines revealed that WFA induces perinuclear vimentin accumulation followed by rapid vimentin depolymerization."5.37Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. ( Bender, L; Ganesh, T; Garcia, A; Harvey, RD; Kline, E; Liu, Y; Marcus, AI; Patel, P; Thaiparambil, JT; Tighiouart, M; Vertino, PM, 2011)
"These results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets."5.37Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. ( Barretina, J; Barrett, FG; Birsoy, K; Brachtel, EF; Chan, AM; Chen, WW; Cowley, GS; Driggers, EM; Garraway, LA; Hsu, PP; Jang, HG; Jha, AK; Kalaany, NY; Kim, D; Marks, KM; Mino-Kenudson, M; Ottina, K; Pacold, ME; Possemato, R; Root, DE; Sabatini, DM; Sethumadhavan, S; Shaul, YD; Stransky, N; Tsun, ZY; Woo, HK; Yuan, B, 2011)
"DIM inhibited the breast cancer cell growth in vitro and in vivo, and caused cell-cycle arrest by down-regulating protein levels of cell-cycle related kinases CDK1, CDK2, CDK4, and CDK6, as well as Cyclin B1 and Cdc25A."5.373,3'-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation. ( Jin, Y, 2011)
"Since bone metastatic breast cancer is an incurable disease, causing significant morbidity and mortality, an understanding of the underlying molecular mechanisms would be highly valuable."5.37Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. ( Edgren, H; Guise, T; Käkönen, SM; Kallioniemi, O; Kohonen, P; Nees, M; Pollari, S; Sara, H; Wolf, M, 2011)
"Nuclear S105-ERbeta was observed in breast carcinoma and was associated with better survival (Allred score > or =3), even in tamoxifen-resistant cases, and additionally correlated with ERbeta1 and ERbeta2 expression."5.36Phosphorylation of estrogen receptor beta at serine 105 is associated with good prognosis in breast cancer. ( Coleman, L; Cummings, M; Green, CA; Hamilton-Burke, W; Holliday, DL; Horgan, K; Maraqa, L; Peter, MB; Pollock, S; Shaaban, AM; Smith, L; Speirs, V, 2010)
"Basal-like breast cancers (BLBC) frequently overexpress the epidermal growth factor receptor (EGFR) and subsequently have high levels of signaling through the MAP kinase pathway, which is thought to contribute to their aggressive behavior."5.35Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells. ( Berquin, IM; Cho, YY; Davies, AH; Desilets, C; Dong, Z; Dunn, SE; Fry, CJ; Li, Y; Roux, PP; Stratford, AL, 2008)
"The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied."5.33Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity. ( Colomer, R; Lupu, R; Menendez, JA; Vellon, L, 2005)
"A common phenotype in breast cancer is the expansion of the estrogen receptor-alpha (ER+) cell population and an inappropriate elevation of ERalpha protein, the latter predisposing patients for a poorer prognosis than those with lower levels of the receptor."5.32Increases in estrogen receptor-alpha concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen. ( Alarid, ET; Fowler, AM; Lee, AV; Preisler-Mashek, MT; Solodin, N; Zhang, P, 2004)
"In vitro, p21-activated kinase 1 (Pak1) phosphorylates the serine 305 residue of the estrogen receptor alpha (ERalpha) and influences the response of breast cancer cells to tamoxifen."5.14Estrogen receptor-alpha phosphorylation at serine 305, nuclear p21-activated kinase 1 expression, and response to tamoxifen in postmenopausal breast cancer. ( Bostner, J; Fornander, T; Nordenskjöld, B; Skoog, L; Stål, O, 2010)
"Although estrogen receptor-alpha (ER) [corrected] is a marker used to identify breast cancer patients most likely to benefit from endocrine therapy, approximately 50% of ER-positive [corrected] breast carcinomas are resistant to tamoxifen."5.14Estrogen receptor-alpha phosphorylation at serine-118 and tamoxifen response in breast cancer. ( Hauptmann, M; Holm-Wigerup, C; Kok, M; Landberg, G; Linn, S; Michalides, R; Stål, O, 2009)
"We tested the hypothesis that Akt-Ser473 phosphorylation (pAkt) predicts benefit from the sequential addition of paclitaxel to adjuvant doxorubicin plus cyclophosphamide (AC) chemotherapy in patients with node-positive breast cancer participating in the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 trial."5.14Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer. ( Costantino, JP; Jeong, JH; Kidwell, K; Kim, C; Mamounas, EP; Nguyen, D; Paik, S; Swain, SM; Wolmark, N; Yang, SX, 2010)
"The anti-estrogen, tamoxifen is the most commonly used treatment for patients with estrogen receptor (ER)-alpha-positive breast cancer."4.84Sliding p21-activated kinase 1 to nucleus impacts tamoxifen sensitivity. ( Kumar, R; Rayala, SK, 2007)
" Here we discovered that missense mutant p53 oncoproteins stimulate de novo serine/glycine synthesis and essential amino acids intake, promoting breast cancer growth."4.31Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth. ( Audano, M; Baldassarre, G; Belletti, B; Bertolio, R; Bicciato, S; Blandino, G; Cancila, V; Caputo, M; Del Sal, G; Donzelli, S; Mantovani, F; Mitro, N; Pedretti, S; Piazza, S; Rustighi, A; Segatto, I; Tombari, C; Triboli, L; Tripodo, C; Vacca, D; Vodret, S; Zannini, A, 2023)
" In particular, leucine and glutamine have been shown to be important for growth and proliferation of some breast cancers, and therefore targeting the primary cell-surface transporters that mediate their uptake, L-type amino acid transporter 1 (LAT1) and alanine, serine, cysteine-preferring transporter 2 (ASCT2), is a potential therapeutic strategy."3.88Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways. ( Freidman, N; Guan, YF; Holst, J; Krycer, JR; Pang, A; Quek, LE; Ryan, R; Turner, N; van Geldermalsen, M; Wang, Q, 2018)
"We used western blotting and immunohistochemistry to examine five serine-/glycine-metabolism-associated proteins (PHGDH, PSAT, PSPH, SHMT, and GLDC) in six breast cancer cell lines and 709 breast cancer cases using tissue microarray (TMA)."3.80Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes. ( Jung, WH; Kim, SK; Koo, JS, 2014)
" Here, we show that epidermal growth factor (EGF) stimulation increases the ability of PTPα to activate Src by dephosphorylating Tyr530 in BT-20 and SKBR3 breast cancer cell lines."3.79PTPα-mediated Src activation by EGF in human breast cancer cells. ( Wang, J; Yu, L; Zheng, X, 2013)
" Two recent studies found subsets of human melanoma and breast cancers to have high levels of phosphoglycerate dehydrogenase (PHGDH), a key enzyme for serine biosynthesis, and these cancer cells are dependent on PHGDH for their growth and survival."3.77Cancer's sweet tooth for serine. ( Luo, J, 2011)
"Potential interactions between prolactin (PRL) and estradiol (E2) in breast cancer cells were explored by examining the effect of PRL on estrogen receptor (ER) serine-118 phosphorylation, ER down-regulation, and E2-stimulated cell proliferation."3.76Prolactin and estradiol utilize distinct mechanisms to increase serine-118 phosphorylation and decrease levels of estrogen receptor alpha in T47D breast cancer cells. ( Chen, KE; Chen, Y; Huang, K; Walker, AM, 2010)
"N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene), a potent chemopotentiating drug currently in Phase III clinical trials of metastatic breast cancer, increases cytotoxicity of anthracyclines and taxanes in a variety of multi-drug resistance expressing (MDR+) tumor cell lines in vitro; inhibits binding of histamine to CYP3A4, a lipid/prostanoid-regulatory P450; and modulates serum levels of HDL/LDL cholesterol and phospholipids in vivo."3.74The phospholipidosis-lnducing potential of the chemopotentiating drug, N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene) correlates with its stimulation of phosphatidylserine synthesis and exposure on the plasma membrane in MCF-7 breas ( Brandes, L; Hatch, GM; Queen, G; Xu, FY, 2007)
" We show here for the first time that a stilbene, resveratrol, induces nuclear accumulation of COX-2 protein in human breast cancer MCF-7 and MDA-MB-231 cell cultures."3.73Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. ( Cao, HJ; Davis, FB; Davis, PJ; Lin, HY; Shih, A; Tang, HY, 2006)
"A naturally occurring, cocoa-derived pentameric procyanidin (pentamer) was previously shown to cause G0/G1 cell cycle arrest in human breast cancer cells by an unknown molecular mechanism."3.73Pentameric procyanidin from Theobroma cacao selectively inhibits growth of human breast cancer cells. ( Dickson, RB; Galperin, M; Knezevic, V; Metheny-Barlow, LJ; Ramesh, A; Ramljak, D; Romanczyk, LJ; Thompson, N, 2005)
"Although it is known that STAT3 transcriptional activity is modulated by phosphorylation at serine residue 727, the role of STAT3 serine phosphorylation in breast cancer remains mostly unexplored."3.73STAT3 ser727 phosphorylation and its association with negative estrogen receptor status in breast infiltrating ductal carcinoma. ( Chen, IF; Chuang, HY; Hou, MF; Ou-Yang, F; Su, JH; Wang, YY; Yang, SF; Yeh, YT; Yuan, SS, 2006)
" The molecular mechanism(s) by which hypoxia/reoxygenation (H/R) regulates p56lck-dependent activation of NFkappaB through tyrosine phosphorylation of IkappaBalpha and modulates the expression of downstream genes that are involved in cell migration in human breast cancer cells are not well defined."3.72Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation. ( Kundu, GC; Mahabeleshwar, GH, 2003)
" Anti-estrogens such as tamoxifen inhibit the growth of ER-positive breast cancers by reducing the expression of estrogen-regulated genes."3.71Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. ( Ali, S; Bhat-Nakshatri, P; Campbell, RA; Constantinidou, D; Nakshatri, H; Patel, NM, 2001)
" MDA-MB-435 human breast carcinoma cells were transfected with a control expression vector (pCMVBamneo), the vector containing the wild type nm23-H1, or the nm23-H1 vector encoding mutations at the following amino acids: serine 44, a phosphorylation site; proline 96, the k-pn mutation in the Drosophila nm23 homolog that causes developmental defects; histidine 118, involved in Nm23's nucleoside diphosphate kinase activity; and serine 120, a site of mutation in human neuroblastomas and phosphorylation."3.69Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells. ( Freije, JM; MacDonald, NJ; Manrow, RE; Steeg, PS; Stracke, ML, 1996)
"The effects of estrone, estradiol, and estriol on MCF-7 human breast cancer are compared."3.65Effects of estrone, estradiol, and estriol on hormone-responsive human breast cancer in long-term tissue culture. ( Bolan, G; Lippman, M; Monaco, ME, 1977)
"The tissue array with human breast cancer specimens showed elevated expression of HIF-2α as well as Pin1 compared to adjacent normal tissues."1.91Oxygen-independent stabilization of HIF-2α in breast cancer through direct interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1. ( Chelakkot, C; Fang, X; Guillen-Quispe, YN; Kim, SH; Kim, SJ; Rios-Castillo, ME; Saeidi, S; Shin, YK; Surh, YJ; Zheng, J; Zhou, T, 2023)
"Metastatic breast cancer (MBC) patients were enrolled between 03/2010 and 09/2016 at the beginning of a new systemic therapy."1.72How previous treatment changes the metabolomic profile in patients with metastatic breast cancer. ( Burwinkel, B; Golatta, M; Hartkopf, A; Nees, J; Schafferer, S; Scheffler, M; Schneeweiß, A; Tang, Q; Wallwiener, M; Yuan, B, 2022)
"The tumor cells in some forms of breast cancer produce more of this protein than normal, suggesting that S6K1 benefits these cells’ survival."1.72S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair. ( Abu-Odeh, M; Amar-Schwartz, A; Aqeilan, R; Arbib, E; Barnabas, GD; Ben Hur, V; Berger, M; Cohen, Y; Geiger, T; Hassouna, F; Jbara, A; Karni, R; Mashahreh, B; Shilo, A; Siegfried, Z; Wiener, R, 2022)
"Our data demonstrate that luminal breast tumors are auxotrophic for serine and may be uniquely sensitive to therapies targeting serine availability."1.72Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors. ( Burns, PA; Choi, BH; Coloff, JL; Conger, KO; Högström, J; Mehta, TS; Muranen, T; Ozgurses, ME; Patel, JM; Rawat, V; Selfors, LM; Warren, A, 2022)
"LATS1 expression was downregulated in breast cancer at both mRNA and protein levels (P<0."1.72The clinicopathological and prognostic significances of LATS1 expression in breast cancer. ( Cui, ZG; E, Y; Xiang, LW; Xue, H; Zhao, MZ; Zheng, HC, 2022)
"However, its role in mammary oncogenesis remains an unsettled debate as STAT5a exhibits functional dichotomy with both pro-differentiative and pro-proliferative target genes."1.62Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer. ( Clevenger, CV; Grible, JM; Harrell, JC; Idowu, M; Olex, AL; Woock, AE; Zot, P, 2021)
"Knockdown of PHGDH expression in breast cancer cells in vitro resulted in a decrease in cell proliferation, reduction in cells entering the S phase of the cell cycle, and downregulation of various cell cycle regulatory genes."1.62Prognostic significance of phosphoglycerate dehydrogenase in breast cancer. ( Bay, BH; Chandrika, M; Chua, PJ; Huang, RYJ; Muniasamy, U; Ng, CT; Tan, PH; Thike, AA; Yip, GW, 2021)
"Estrogen receptor-positive breast cancer (ER+ BC) is the most common form of breast carcinoma accounting for approximately 70% of all diagnoses."1.62Serine synthesis influences tamoxifen response in ER+ human breast carcinoma. ( Clem, BF; Dougherty, S; Green, B; Klinge, CM; Kruer, T; Metcalf, S; Petri, BJ; Wittliff, JL, 2021)
"These effects were mediated by the breast cancer oncogene IKKε and its downstream target-the serine biosynthesis pathway as demonstrated by genetic or pharmacological tools."1.56Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. ( Bentham, RB; Bianchi, K; Carter, E; Dalli, J; Godinho, SA; Grose, R; Hodivala-Dilke, K; Holdsworth, J; Ironside, A; Jones, L; Jones, W; Mataloni, I; Moreno Béjar, R; Szabadkai, G; Uhlik, L; Wilcz-Villega, E; Xu, R, 2020)
"Breast cancer is the most common cancer among American women and a major cause of mortality."1.56Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. ( Curtis, C; Ducker, GS; Graves, EE; Li, AM; Li, Y; Liu, L; Massagué, J; Melemenidis, S; Rabinowitz, JD; Rankin, EB; Seoane, JA; Thompson, CB; Vanharanta, S; Xiao, Y; Ye, J; Zhou, Y, 2020)
"Stable overexpression of PAK1S204A in breast cancer cells, impedes migration, invasion, and NFĸB activity."1.51Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1. ( Abdelkarim, H; Das, S; Gaponenko, V; Mishra, R; Nair, RS; Rana, A; Rana, B; Sondarva, G; Viswakarma, N, 2019)
"The expression of ALX4 in breast cancer cell lines and patients' tissues were detected by RT-PCR, qPCR and western blot."1.46ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway. ( Cao, J; Chen, H; Han, F; Hao, X; Huang, Y; Jiang, X; Liu, J; Liu, W; Yang, J; Yin, L; Zhang, H, 2017)
"Protein kinases commonly activated in breast cancers phosphorylate steroid hormone receptors (SRs) and profoundly impact their activities."1.46Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. ( Brady, NJ; Knutson, TP; Lange, CA; Ma, S; Raj, G; Schwertfeger, KL; Sullivan, ME; Truong, TH, 2017)
"Secretion of 12(S)-HETE by breast cancer emboli provokes "circular chemorepellent induced defects" (CCIDs) in the adjacent lymphatic vasculature facilitating their intravasation and lymph node metastasis which determines prognosis."1.4312(S)-HETE increases intracellular Ca(2+) in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply. ( Atanasov, AG; Brenner, S; Dirsch, VM; Dolznig, H; Fristiohardy, A; Giessrigl, B; Holzner, S; Huttary, N; Jäger, W; Krieger, S; Krupitza, G; Li, Y; Milovanovic, D; Nguyen, CH; Riha, J; Saiko, P; Simonitsch-Klupp, I; Stadler, S; Szekeres, T, 2016)
"Tumorigenesis is a multistep process involving co-operation between several deregulated oncoproteins."1.43Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells. ( Corthals, G; Imanishi, SY; Koskinen, PJ; Landor, SK; Lendahl, U; Manoharan, GB; Paloniemi, E; Sahlgren, C; Santio, NM; Uri, A; Vahtera, L; Varjosalo, M; Ylä-Pelto, J, 2016)
"Breast cancer is the leading cause of cancer-related deaths among women."1.43mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation. ( Alayev, A; Berger, SM; Cuesta, R; Holz, MK; Salamon, RS; Schwartz, NS; Snyder, RB, 2016)
"In 1755 early stage breast cancers, DDR signalling [ATM, ATR, total Ckh1, Chk1 phosphorylated at serine(345) (pChk1), Chk2, p53], base excision repair [PARP1, POLβ, XRCC1, FEN1, SMUG1], non-homologous end joining (Ku70/Ku80, DNA-PKcs) and homologous recombination [RAD51, BRCA1, γH2AX, BLM, WRN, RECQL5, PTEN] protein expression was correlated to time to early local recurrence."1.43Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer. ( Abdel-Fatah, TM; Aleskandarany, MA; Alsubhi, N; Arora, A; Chan, SY; Curtin, NJ; Doherty, R; Ellis, IO; Green, AR; Madhusudan, S; Martin, SG; Middleton, F; Moseley, PM; Rakha, EA; Stephens, P, 2016)
"Breast cancer is increasing among young women in Tunisia."1.42A novel BRCA2 in frame deletion in a Tunisian woman with early onset sporadic breast cancer. ( Choura, M; Daoud, J; Frikha, M; Hadiji-Abbes, N; Khabir, A; Mokdad-Gargouri, R; Sellami-Boudawara, T; Trifa, F, 2015)
"The mechanism of Shh involved in breast cancer carcinogenesis remains unclear."1.42Sonic hedgehog stimulates glycolysis and proliferation of breast cancer cells: Modulation of PFKFB3 activation. ( Cao, Z; Fu, C; Ge, X; Gu, Y; Li, J; Li, L; Lyu, P; Wang, Y; Zhang, L, 2015)
"We find in mouse xenografts of breast cancer cells that mimicking Ser-137 phosphorylation abolishes cell cycle arrest and apoptotic sensitization by Pfn1 and confers a growth advantage to tumors."1.42Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1. ( Bissell, M; Boudreau, A; Cai, S; Carey, CJ; Diamond, MI; Lyle, N; Pappu, RV; Piwnica-Worms, H; Shao, J; Swamidass, SJ, 2015)
"glycine, tumor grade, metabolism, phyllodes tumor, serine."1.40Expression of serine and glycine-related enzymes in phyllodes tumor. ( Jung, WH; Kim, DH; Koo, JS; Kwon, JE, 2014)
"MCF-7 human breast cancer cells were cultured in standard conditions."1.3917β-estradiol activates glucose uptake via GLUT4 translocation and PI3K/Akt signaling pathway in MCF-7 cells. ( Alonso, A; Garrido, P; González, C; González, S; Morán, J, 2013)
"In hormone receptor-positive breast cancers, most tumors in the early stages of development depend on the activity of the estrogen receptor and its ligand, estradiol."1.39The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer. ( Caligiuri, I; Giordano, A; Lucchetti, C; Rizzolio, F; Toffoli, G, 2013)
"ERα is critical in many breast tumors and is inhibited by antiestrogens such as tamoxifen in cancer therapy."1.38Serine-305 phosphorylation modulates estrogen receptor alpha binding to a coregulator peptide array, with potential application in predicting responses to tamoxifen. ( de Leeuw, R; Houtman, R; Martens, JW; Melchers, D; Michalides, R; Neefjes, J; Rondaij, M; Ruijtenbeek, R; Verwoerd, D, 2012)
"Since bone metastatic breast cancer is an incurable disease, causing significant morbidity and mortality, an understanding of the underlying molecular mechanisms would be highly valuable."1.37Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. ( Edgren, H; Guise, T; Käkönen, SM; Kallioniemi, O; Kohonen, P; Nees, M; Pollari, S; Sara, H; Wolf, M, 2011)
"T47D breast cancer cells stably expressing a PR-B mutant receptor that cannot be phosphorylated at Ser79/81 (S79/81A) formed fewer soft agar colonies."1.37ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells. ( Dressing, GE; Hagan, CR; Lange, CA; Regan, TM, 2011)
"Imaging of breast cancer cell lines revealed that WFA induces perinuclear vimentin accumulation followed by rapid vimentin depolymerization."1.37Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. ( Bender, L; Ganesh, T; Garcia, A; Harvey, RD; Kline, E; Liu, Y; Marcus, AI; Patel, P; Thaiparambil, JT; Tighiouart, M; Vertino, PM, 2011)
"These results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets."1.37Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. ( Barretina, J; Barrett, FG; Birsoy, K; Brachtel, EF; Chan, AM; Chen, WW; Cowley, GS; Driggers, EM; Garraway, LA; Hsu, PP; Jang, HG; Jha, AK; Kalaany, NY; Kim, D; Marks, KM; Mino-Kenudson, M; Ottina, K; Pacold, ME; Possemato, R; Root, DE; Sabatini, DM; Sethumadhavan, S; Shaul, YD; Stransky, N; Tsun, ZY; Woo, HK; Yuan, B, 2011)
"DIM inhibited the breast cancer cell growth in vitro and in vivo, and caused cell-cycle arrest by down-regulating protein levels of cell-cycle related kinases CDK1, CDK2, CDK4, and CDK6, as well as Cyclin B1 and Cdc25A."1.373,3'-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation. ( Jin, Y, 2011)
"An analysis of human breast cancer cases revealed a decrease of eEF1A1 phosphorylation at Ser300 in malignant tumor cells as compared to epithelial cells in noncancerous tissues."1.36Phosphorylation of eEF1A1 at Ser300 by TβR-I results in inhibition of mRNA translation. ( Jia, M; Lin, KW; Souchelnytskyi, S; Yakymovych, I; Yakymovych, M, 2010)
"The prognostic abilities of breast cancer gene expression signatures are due mostly to the detection of proliferation activity."1.36Serine 2481-autophosphorylation of mammalian target of rapamycin (mTOR) couples with chromosome condensation and segregation during mitosis: confocal microscopy characterization and immunohistochemical validation of PP-mTOR(Ser2481) as a novel high-contra ( Bernadó, L; Lopez-Bonet, E; Menendez, JA; Oliveras-Ferraros, C; Pérez-Bueno, F; Pérez-Martínez, MC; Vazquez-Martin, A, 2010)
"This cooperation may be targeted in breast cancer treatment by a combination of mTOR and MAPK inhibitors."1.36mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor alpha serine 167 phosphorylation. ( Holz, MK; Yamnik, RL, 2010)
"In the breast cancer cell line, MDA-MB231 cells and MCF7 cells, where the endogenous AKIP1 is abundant, the PKA signal was found to be synergized with NF-kappaB activation; PKA-activating agents enhanced NF-kappaB-dependent transcriptional activity and the interaction between p65 and PKAc and augmented the phosphorylation of p65 on Ser-276."1.36A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling. ( Asamitsu, K; Cueno, M; Gao, N; Hibi, Y; Okamoto, T, 2010)
"Nuclear S105-ERbeta was observed in breast carcinoma and was associated with better survival (Allred score > or =3), even in tamoxifen-resistant cases, and additionally correlated with ERbeta1 and ERbeta2 expression."1.36Phosphorylation of estrogen receptor beta at serine 105 is associated with good prognosis in breast cancer. ( Coleman, L; Cummings, M; Green, CA; Hamilton-Burke, W; Holliday, DL; Horgan, K; Maraqa, L; Peter, MB; Pollock, S; Shaaban, AM; Smith, L; Speirs, V, 2010)
"In pair-matched high grade breast cancer samples we observed retention of only the Ser allele from heterozygous patients (identical results were observed in a pair-matched normal and tumor cell line)."1.35Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. ( Brognard, J; Newton, AC; Niederst, M; Reyes, G; Warfel, N, 2009)
"Gene-expression profiling analysis of breast cancer cells, semi-quantitative RT-PCR, Northern blotting and Western blotting confirmed RQCD1 to be frequently up-regulated in breast cancer specimens and breast cancer cell lines."1.35Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells. ( Ajiro, M; Daigo, Y; Fukukawa, C; Katagiri, T; Lin, ML; Nakagawa, H; Nakamura, Y; Nishidate, T; Park, JH; Ueda, K, 2009)
"Finally we show that human breast cancers lacking Wnt-5a protein have a significantly lower level of membrane-associated beta-catenin."1.35Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells. ( Andersson, T; Landberg, G; Leandersson, K; Medrek, C, 2009)
"Basal-like breast cancers (BLBC) frequently overexpress the epidermal growth factor receptor (EGFR) and subsequently have high levels of signaling through the MAP kinase pathway, which is thought to contribute to their aggressive behavior."1.35Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells. ( Berquin, IM; Cho, YY; Davies, AH; Desilets, C; Dong, Z; Dunn, SE; Fry, CJ; Li, Y; Roux, PP; Stratford, AL, 2008)
"Treatment of MCF-7 human breast cancer cells with glucose oxidase (GO, 0."1.35Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha. ( Murphy, LC; Ung, K; Weebadda, W; Weitsman, GE, 2009)
"The allele may predispose to breast cancers of certain histologic subtypes, but further studies are needed to confirm these findings."1.35BARD1 and breast cancer in Poland. ( Byrski, T; Cybulski, C; Debniak, T; Górski, B; Gronwald, J; Huzarski, T; Jakubowska, A; Kowalska, E; Lubiński, J; Narod, SA; Szymańska, A, 2008)
"Finally, breast cancer cells with stable overexpression of NRIF3 showed increased proliferation and enhanced anchorage-independent growth."1.35Serine 28 phosphorylation of NRIF3 confers its co-activator function for estrogen receptor-alpha transactivation. ( Kumar, R; Li, DQ; Manavathi, B; Talukder, AH, 2008)
"Oncogenesis in breast cancer often requires the overexpression of the nuclear receptor coactivator AIB1/SRC-3 acting in conjunction with estrogen receptor-alpha (ERalpha)."1.35CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions. ( Castellano, L; Coombes, RC; Feng, Q; Giamas, G; Jacob, J; Jiao, LR; Knippschild, U; Smith, CL; Stebbing, J; Thomas, RS, 2009)
"Human MCF-7 breast cancer cells are relatively resistant to conventional chemotherapy due to the lack of caspase-3 activity."1.34Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells. ( Ranftler, C; Schmitz, ML; Wesierska-Gadek, J, 2007)
"Here, we show that breast-ovarian cancer susceptibility 1 (BRCA1) interacts directly with ATR-interacting protein (ATRIP), an obligate partner of ATR."1.34Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function. ( Halazonetis, TD; Snyder, A; Venere, M; Zgheib, O, 2007)
"In addition associations with breast cancer were studied in 751 breast cancer patients."1.34Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer. ( Berns, EM; Look, MP; Piersma, D; Pols, HA; Themmen, AP; Uitterlinden, AG; Verhoef-Post, M, 2007)
"In ER-positive breast cancer patients, Ser(167) phosphorylation was associated with low tumor grade (P = 0."1.34Phosphorylation of estrogen receptor-alpha at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients. ( Ali, S; Coombes, RC; Jiang, J; Kulinskaya, E; Peston, D; Sarwar, N; Shousha, S, 2007)
"The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied."1.33Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity. ( Colomer, R; Lupu, R; Menendez, JA; Vellon, L, 2005)
"Treatment of a ZR-75-1 breast cancer cell line stably transfected with AND-34 plus 2 micromol/L LY294002 or 10 micromol/L NSC23766, a Rac-specific inhibitor, abrogated AND-34-induced resistance to ICI 182,780."1.33AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. ( Castro, AF; Felekkis, KN; Lerner, A; Narsimhan, RP; Near, R; Quilliam, LA; Zheng, Y, 2005)
"Primary breast carcinomas lacking PTEN expression and having elevated AKT phosphorylation had increased cytoplasmic CHK1 and displayed aneuploidy (p <0."1.33Lack of PTEN sequesters CHK1 and initiates genetic instability. ( Choudhury, AD; Gaciong, Z; Hibshoosh, H; Keniry, M; Li, HS; Mansukhani, M; Meek, SE; Memeo, L; Murty, VV; Pandita, TK; Parsons, R; Piwnica-Worms, H; Puc, J, 2005)
"Acquired resistance to tamoxifen in breast cancer patients is a serious therapeutic problem."1.33Activation function-1 domain of estrogen receptor regulates the agonistic and antagonistic actions of tamoxifen. ( Atanaskova, N; Glaros, S; Reddy, KB; Skafar, DF; Zhao, C, 2006)
"A common phenotype in breast cancer is the expansion of the estrogen receptor-alpha (ER+) cell population and an inappropriate elevation of ERalpha protein, the latter predisposing patients for a poorer prognosis than those with lower levels of the receptor."1.32Increases in estrogen receptor-alpha concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen. ( Alarid, ET; Fowler, AM; Lee, AV; Preisler-Mashek, MT; Solodin, N; Zhang, P, 2004)
"Human breast cancer (MCF-7) cells were incubated with physiological concentrations of l-T(4) or 17beta-estradiol (E(2)) for 15 min to 24 h, and nuclear ERalpha and serine-118-phosphorylated ERalpha were identified by Western blotting."1.32Thyroid hormone causes mitogen-activated protein kinase-dependent phosphorylation of the nuclear estrogen receptor. ( Davis, FB; Davis, PJ; Lin, HY; Tang, HY; Zhang, S, 2004)
"Since many breast tumors and cancer cell lines overexpress IGF-IR, we tested IGF-I effects on chemotherapy-treated breast cancer cells."1.32An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer. ( Mamay, CL; Mingo-Sion, AM; Molina, MD; Van Den Berg, CL; Wolf, DM, 2003)
"Human breast cancer cells T47D release great amount of nitric oxide (NO), but its relation to tumor suppressor Rb is unknown."1.32Inactivated tumor suppressor Rb by nitric oxide promotes mitosis in human breast cancer cells. ( Radisavljevic, Z, 2004)
"To study PKR function in human breast cancer, PKR activity was measured in mammary carcinoma cell lines and nontransformed mammary epithelial cell lines."1.31Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR. ( Forman, AP; Gunnery, S; Kim, SH; Mathews, MB, 2000)
"We report that compared with breast cancer cells expressing a low level of HER2, HER2-overexpressing breast cancer cells contained significantly higher levels of acetylated and phosphorylated histone H3, and acetylated histone H4 associated with the HER2 promoter."1.31Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells. ( Kumar, R; Mandal, M; Mazumdar, A; Mishra, SK, 2001)
"Further study of breast cancers revealed 83% of tumors with high pS70-Bcl-2 expression responded to paclitaxel or docetaxel treatment, whereas 57% of those with low expression not respond."1.31Dissociation of Bax from a Bcl-2/Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2. ( Matsuo, Y; Shibasaki, F; Shibata, M; Shitashige, M; Toi, M; Yano, T, 2001)
"MCF-7 hormone-dependent breast cancer cells were transfected with an expression vector for the wild-type RIalpha or mutant RIalpha-p."1.30Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth. ( Cho-Chung, YS; Hong, SH; Kim, SN; Lee, GR; Noguchi, K; Park, SD, 1999)

Research

Studies (242)

TimeframeStudies, this research(%)All Research%
pre-19909 (3.72)18.7374
1990's15 (6.20)18.2507
2000's97 (40.08)29.6817
2010's91 (37.60)24.3611
2020's30 (12.40)2.80

Authors

AuthorsStudies
Girimanchanaika, SS1
Dukanya, D1
Swamynayaka, A1
Govindachar, DM1
Madegowda, M1
Periyasamy, G1
Rangappa, KS1
Pandey, V1
Lobie, PE1
Basappa, B1
Choi, BH1
Rawat, V1
Högström, J1
Burns, PA1
Conger, KO1
Ozgurses, ME1
Patel, JM1
Mehta, TS1
Warren, A1
Selfors, LM1
Muranen, T1
Coloff, JL1
Zheng, HC1
Xiang, LW1
Cui, ZG1
Xue, H1
E, Y1
Zhao, MZ1
Nees, J1
Schafferer, S1
Yuan, B2
Tang, Q1
Scheffler, M1
Hartkopf, A1
Golatta, M1
Schneeweiß, A1
Burwinkel, B2
Wallwiener, M1
Kiweler, N1
Delbrouck, C1
Pozdeev, VI1
Neises, L1
Soriano-Baguet, L1
Eiden, K1
Xian, F1
Benzarti, M1
Haase, L1
Koncina, E1
Schmoetten, M1
Jaeger, C1
Noman, MZ1
Vazquez, A1
Janji, B1
Dittmar, G1
Brenner, D1
Letellier, E1
Meiser, J1
Rossi, M2
Altea-Manzano, P2
Demicco, M1
Doglioni, G2
Bornes, L1
Fukano, M1
Vandekeere, A1
Cuadros, AM1
Fernández-García, J1
Riera-Domingo, C1
Jauset, C1
Planque, M3
Alkan, HF1
Nittner, D1
Zuo, D1
Broadfield, LA1
Parik, S1
Pane, AA1
Rizzollo, F1
Rinaldi, G3
Zhang, T1
Teoh, ST2
Aurora, AB1
Karras, P1
Vermeire, I1
Broekaert, D2
Elsen, JV1
Knott, MML1
Orth, MF1
Demeyer, S1
Eelen, G1
Dobrolecki, LE1
Bassez, A1
Brussel, TV1
Sotlar, K1
Lewis, MT1
Bartsch, H1
Wuhrer, M1
Veelen, PV1
Carmeliet, P1
Cools, J1
Morrison, SJ1
Marine, JC1
Lambrechts, D1
Mazzone, M1
Hannon, GJ1
Lunt, SY2
Grünewald, TGP2
Park, M1
Rheenen, JV1
Fendt, SM3
Preston, SEJ1
Bartish, M1
Richard, VR1
Aghigh, A1
Gonçalves, C1
Smith-Voudouris, J1
Huang, F1
Thébault, P1
Cleret-Buhot, A1
Lapointe, R1
Légaré, F1
Postovit, LM1
Zahedi, RP1
Borchers, CH1
Miller, WH1
Del Rincón, SV1
Vuorinen, SI1
Okolicsanyi, RK1
Gyimesi, M1
Meyjes-Brown, J1
Saini, D1
Pham, SH1
Griffiths, LR1
Haupt, LM1
Ripamonti, M1
Lamarca, A1
Davey, NE1
Tonoli, D1
Surini, S1
de Curtis, I1
Amar-Schwartz, A1
Ben Hur, V1
Jbara, A1
Cohen, Y1
Barnabas, GD1
Arbib, E1
Siegfried, Z1
Mashahreh, B1
Hassouna, F1
Shilo, A1
Abu-Odeh, M1
Berger, M1
Wiener, R1
Aqeilan, R1
Geiger, T1
Karni, R1
Pankevičiūtė-Bukauskienė, M1
Mikalayeva, V1
Žvikas, V1
Skeberdis, VA1
Bordel, S1
Guillen-Quispe, YN1
Kim, SJ1
Saeidi, S1
Zhou, T1
Zheng, J1
Kim, SH2
Fang, X1
Chelakkot, C1
Rios-Castillo, ME1
Shin, YK1
Surh, YJ1
de la Peña Avalos, B1
Tropée, R1
Duijf, PHG1
Dray, E1
Liang, P1
Zhang, J3
Wu, Y1
Zheng, S1
Xu, Z1
Yang, S1
Wang, J2
Ma, S3
Xiao, L1
Hu, T1
Jiang, W1
Huang, C2
Xing, Q1
Kundu, M1
Wang, B1
Tombari, C1
Zannini, A1
Bertolio, R1
Pedretti, S1
Audano, M1
Triboli, L1
Cancila, V1
Vacca, D1
Caputo, M1
Donzelli, S1
Segatto, I1
Vodret, S1
Piazza, S1
Rustighi, A1
Mantovani, F1
Belletti, B1
Baldassarre, G1
Blandino, G1
Tripodo, C1
Bicciato, S1
Mitro, N1
Del Sal, G1
Wilcz-Villega, E2
Carter, E1
Ironside, A1
Xu, R2
Mataloni, I1
Holdsworth, J1
Jones, W2
Moreno Béjar, R1
Uhlik, L1
Bentham, RB2
Godinho, SA1
Dalli, J1
Grose, R1
Szabadkai, G2
Jones, L1
Hodivala-Dilke, K1
Bianchi, K2
Li, AM1
Ducker, GS1
Li, Y8
Seoane, JA1
Xiao, Y1
Melemenidis, S1
Zhou, Y2
Liu, L1
Vanharanta, S1
Graves, EE1
Rankin, EB1
Curtis, C1
Massagué, J1
Rabinowitz, JD1
Thompson, CB1
Ye, J1
Liu, J3
Zhang, C1
Wu, H1
Sun, XX1
Huang, S1
Yue, X1
Lu, SE1
Shen, Z1
Su, X1
White, E1
Haffty, BG1
Hu, W1
Feng, Z2
Costa, AS1
Rajeeve, V1
Bryson, K1
Nagano, A1
Yaman, B1
Olendo Barasa, S1
Wang, Y5
Chelala, C1
Cutillas, P1
Frezza, C1
Wu, L1
Crawley, CD1
Garofalo, A1
Nichols, JW1
Campbell, PA1
Khramtsova, GF1
Olopade, OI1
Weichselbaum, RR1
Yamini, B1
Metcalf, S1
Petri, BJ1
Kruer, T1
Green, B1
Dougherty, S1
Wittliff, JL1
Klinge, CM1
Clem, BF1
Kinslow, CJ1
Sun, RC1
Chaudhary, KR1
Cheng, SK1
Kim, YJ1
Kang, MJ1
Kim, E1
Kweon, TH1
Park, YS1
Ji, S1
Yang, WH1
Yi, EC1
Cho, JW1
Geeraerts, SL1
Kampen, KR1
Gupta, P1
Louros, N1
Heylen, E1
De Cremer, K1
De Brucker, K1
Vereecke, S1
Verbelen, B1
Vermeersch, P1
Schymkowitz, J1
Rousseau, F1
Cassiman, D1
Voet, A1
Cammue, BPA1
Thevissen, K1
De Keersmaecker, K1
Xin, ZC1
Hu, HW1
Lao, ZH1
Zhu, LQ1
Biskup, E1
Zhang, HW1
Pranzini, E1
Van Elsen, J1
Funk, CM1
Geldhof, V1
Ross, C1
Hunter, KW1
Audet-Delage, Y1
St-Pierre, J1
Machado, RAC1
Stojevski, D1
De Landtsheer, S1
Lucarelli, P1
Baron, A1
Sauter, T2
Schaffner-Reckinger, E2
Chandrika, M1
Chua, PJ1
Muniasamy, U1
Huang, RYJ1
Thike, AA1
Ng, CT1
Tan, PH1
Yip, GW1
Bay, BH1
Woock, AE1
Grible, JM1
Olex, AL1
Harrell, JC1
Zot, P1
Idowu, M1
Clevenger, CV2
Knutson, TP2
Truong, TH1
Brady, NJ1
Sullivan, ME1
Raj, G1
Schwertfeger, KL1
Lange, CA5
Wu, Q1
Li, J2
Sun, S2
Chen, X2
Zhang, H2
Li, B1
Collier, MEW1
Ettelaie, C1
Goult, BT1
Maraveyas, A1
Goodall, AH1
Yang, J1
Han, F2
Liu, W1
Chen, H1
Hao, X1
Jiang, X2
Yin, L1
Huang, Y1
Cao, J1
Zhong, R1
Liang, B1
Xin, R1
Zhu, X1
Liu, Z1
Chen, Q1
Hou, Y1
Jin, Z1
Qi, M1
Liu, X1
Minton, DR1
Nam, M1
McLaughlin, DJ1
Shin, J1
Bayraktar, EC1
Alvarez, SW1
Sviderskiy, VO1
Papagiannakopoulos, T1
Sabatini, DM2
Birsoy, K2
Possemato, R2
van Geldermalsen, M1
Quek, LE1
Turner, N1
Freidman, N1
Pang, A1
Guan, YF1
Krycer, JR1
Ryan, R1
Wang, Q1
Holst, J1
Murphy, JP1
Giacomantonio, MA1
Paulo, JA1
Everley, RA1
Kennedy, BE1
Pathak, GP1
Clements, DR1
Kim, Y1
Dai, C1
Sharif, T1
Gygi, SP1
Gujar, S1
Chang, L1
Shen, L1
Zhou, H2
Gao, J1
Pan, H1
Zheng, L1
Armstrong, B1
Peng, Y1
Peng, G1
Zhou, BP1
Rosen, ST1
Shen, B1
Brix, DM1
Tvingsholm, SA1
Hansen, MB1
Clemmensen, KB1
Ohman, T1
Siino, V1
Lambrughi, M1
Hansen, K1
Puustinen, P1
Gromova, I1
James, P1
Papaleo, E1
Varjosalo, M2
Moreira, J1
Jäättelä, M1
Kallunki, T1
Kastrati, I1
Semina, S1
Gordon, B1
Smart, E1
Das, S2
Nair, RS1
Mishra, R2
Sondarva, G2
Viswakarma, N1
Abdelkarim, H1
Gaponenko, V1
Rana, B2
Rana, A2
Cai, G2
Yu, W1
Song, D1
Zhang, W1
Guo, J1
Zhu, J1
Ren, Y1
Kong, L1
Kumar, A1
Rajendran, V1
Sethumadhavan, R1
Purohit, R1
Yu, L1
Zheng, X1
Garrido, P1
Morán, J1
Alonso, A1
González, S1
González, C1
Zhang, Y2
Zhao, Y1
Li, H1
Cai, X1
Shen, Y2
Shi, H1
Li, L4
Liu, Q1
Zhang, X2
Ye, L1
Jeon, YH1
Park, YH1
Kwon, JH1
Lee, JH1
Kim, IY1
Lee, SL1
Chou, CC1
Chuang, HC1
Hsu, EC1
Chiu, PC1
Kulp, SK1
Byrd, JC1
Chen, CS1
Montero, JC1
Seoane, S1
Pandiella, A1
Hagan, CR2
Storci, G1
Bertoni, S1
De Carolis, S1
Papi, A1
Nati, M1
Ceccarelli, C1
Pirazzini, C1
Garagnani, P1
Ferrarini, A1
Buson, G1
Delledonne, M1
Fiorentino, M1
Capizzi, E1
Gruppioni, E1
Taffurelli, M1
Santini, D1
Franceschi, C1
Bandini, G1
Bonifazi, F1
Bonafé, M1
Vilasco, M1
Communal, L1
Hugon-Rodin, J1
Penault-Llorca, F1
Mourra, N1
Wu, Z2
Forgez, P1
Gompel, A1
Kim, SK1
Jung, WH2
Koo, JS2
Kwon, JE1
Kim, DH1
Xu, F1
Yang, T1
Sheng, Y1
Zhong, T1
Yang, M2
Chen, Y2
Thakur, N1
Gudey, SK1
Marcusson, A1
Fu, JY1
Bergh, A1
Heldin, CH1
Landström, M1
Diamond, MI1
Cai, S1
Boudreau, A1
Carey, CJ1
Lyle, N1
Pappu, RV1
Swamidass, SJ1
Bissell, M1
Piwnica-Worms, H3
Shao, J1
Kourtidis, A1
Yanagisawa, M1
Huveldt, D1
Copland, JA1
Anastasiadis, PZ1
Yamada, N1
Tanaka, T2
Hori, T1
Yokoyama, S1
Hayakawa, Y1
Yano, S1
Fukuoka, J1
Koizumi, K1
Saiki, I1
Sakurai, H1
Ge, X1
Lyu, P1
Gu, Y1
Zhang, L2
Fu, C1
Cao, Z1
Hadiji-Abbes, N1
Trifa, F1
Choura, M1
Khabir, A1
Sellami-Boudawara, T1
Frikha, M1
Daoud, J1
Mokdad-Gargouri, R1
Döppler, H1
Bastea, L1
Borges, S1
Geiger, X1
Storz, P1
Zwart, W2
Flach, KD1
Rudraraju, B1
Abdel-Fatah, TM2
Gojis, O1
Canisius, S1
Moore, D1
Nevedomskaya, E1
Opdam, M1
Droog, M1
Hofland, I1
Chan, S1
Shaw, J1
Ellis, IO2
Coombes, RC6
Carroll, JS1
Ali, S8
Palmieri, C1
Alsubhi, N1
Middleton, F1
Stephens, P1
Doherty, R1
Arora, A1
Moseley, PM1
Chan, SY1
Aleskandarany, MA1
Green, AR1
Rakha, EA1
Martin, SG1
Curtin, NJ1
Madhusudan, S1
Alayev, A1
Salamon, RS1
Berger, SM1
Schwartz, NS1
Cuesta, R1
Snyder, RB1
Holz, MK2
Lommel, MJ1
Trairatphisan, P1
Gäbler, K1
Laurini, C1
Muller, A1
Kaoma, T1
Vallar, L1
Geck, RC1
Toker, A2
Sun, T1
Fu, J2
Shen, T1
Lin, X1
Liao, L2
Feng, XH1
Xu, J2
Guo, Y1
Lin, D1
Zhang, M1
Yang, R1
Lu, Y1
Jin, X1
Wang, M1
Zhao, S1
Quan, C1
Kuang, XY1
Jiang, HS1
Li, K1
Zheng, YZ1
Liu, YR1
Qiao, F1
Li, S1
Hu, X1
Shao, ZM1
Santio, NM1
Landor, SK1
Vahtera, L1
Ylä-Pelto, J1
Paloniemi, E1
Imanishi, SY1
Corthals, G1
Manoharan, GB1
Uri, A1
Lendahl, U1
Sahlgren, C1
Koskinen, PJ1
Werden, SJ1
Sphyris, N1
Sarkar, TR1
Paranjape, AN1
LaBaff, AM1
Taube, JH1
Hollier, BG1
Ramirez-Peña, EQ1
Soundararajan, R1
den Hollander, P2
Powell, E1
Echeverria, GV1
Miura, N1
Chang, JT1
Rosen, JM1
Mani, SA1
Nguyen, CH1
Brenner, S1
Huttary, N1
Atanasov, AG1
Dirsch, VM1
Holzner, S1
Stadler, S1
Riha, J1
Krieger, S1
Milovanovic, D1
Fristiohardy, A1
Simonitsch-Klupp, I1
Dolznig, H1
Saiko, P1
Szekeres, T1
Giessrigl, B1
Jäger, W1
Krupitza, G1
Feng, J1
Xu, G1
Zhang, N1
Ji, J1
Wang, G1
Wang, X1
Tan, J1
Huang, B1
Lu, J1
Bu, Y1
Zeng, X1
Cao, Y1
Cai, C1
Huang, D1
Liao, DF1
Cao, D1
Harrod, A1
Fulton, J1
Nguyen, VTM1
Periyasamy, M1
Ramos-Garcia, L1
Lai, CF1
Metodieva, G1
de Giorgio, A1
Williams, RL1
Santos, DB1
Gomez, PJ1
Lin, ML2
Metodiev, MV1
Stebbing, J2
Castellano, L2
Magnani, L1
Buluwela, L1
Phannasil, P1
Ansari, IH1
El Azzouny, M1
Longacre, MJ1
Rattanapornsompong, K1
Burant, CF1
MacDonald, MJ1
Jitrapakdee, S1
Gorska-Ponikowska, M1
Perricone, U1
Kuban-Jankowska, A1
Lo Bosco, G1
Barone, G1
Talukder, AH2
Li, DQ1
Manavathi, B1
Kumar, R7
Yamashita, H1
Nishio, M1
Toyama, T1
Sugiura, H1
Kondo, N1
Kobayashi, S1
Fujii, Y1
Iwase, H1
Ravid, D1
Chuderland, D1
Landsman, L1
Lavie, Y1
Reich, R1
Liscovitch, M1
Xu, FY1
Queen, G1
Brandes, L1
Hatch, GM1
Weitsman, GE2
Weebadda, W1
Ung, K2
Murphy, LC3
Holm, C2
Kok, M3
Michalides, R5
Fles, R2
Koornstra, RH1
Wesseling, J1
Hauptmann, M3
Neefjes, J4
Peterse, JL1
Stål, O5
Landberg, G4
Linn, SC2
Stratford, AL1
Fry, CJ1
Desilets, C1
Davies, AH1
Cho, YY1
Dong, Z1
Berquin, IM1
Roux, PP1
Dunn, SE2
Medrek, C1
Andersson, T1
Leandersson, K1
Brognard, J1
Niederst, M1
Reyes, G1
Warfel, N1
Newton, AC1
Giamas, G1
Feng, Q1
Knippschild, U1
Jacob, J1
Thomas, RS2
Smith, CL1
Jiao, LR1
Huang, K1
Chen, KE1
Walker, AM1
Makkinje, A1
Near, RI1
Infusini, G1
Vanden Borre, P1
Bloom, A1
Cai, D1
Costello, CE1
Lerner, A2
Hutti, JE1
Shen, RR1
Abbott, DW1
Zhou, AY1
Sprott, KM1
Asara, JM1
Hahn, WC1
Cantley, LC1
Hubackova, M1
Vaclavikova, R1
Mrhalova, M1
Kubackova, K1
Kodet, R1
Gut, I1
Soucek, P1
Ajiro, M1
Katagiri, T1
Ueda, K1
Nakagawa, H1
Fukukawa, C1
Park, JH2
Nishidate, T1
Daigo, Y1
Nakamura, Y2
Yamnik, RL1
Guo, JP1
Shu, SK1
Esposito, NN1
Coppola, D1
Koomen, JM1
Cheng, JQ1
Holm-Wigerup, C1
Linn, S1
Lopez-Bonet, E1
Vazquez-Martin, A1
Pérez-Martínez, MC1
Oliveras-Ferraros, C1
Pérez-Bueno, F1
Bernadó, L1
Menendez, JA2
Chua, BT1
Gallego-Ortega, D1
Ramirez de Molina, A1
Ullrich, A1
Lacal, JC1
Downward, J1
Barone, I1
Iacopetta, D1
Covington, KR1
Cui, Y1
Tsimelzon, A1
Beyer, A1
Andò, S1
Fuqua, SA1
McKeen, HD1
Byrne, C1
Jithesh, PV1
Donley, C1
Valentine, A1
Yakkundi, A1
O'Rourke, M1
Swanton, C1
McCarthy, HO1
Hirst, DG1
Robson, T1
Bostner, J2
Skoog, L2
Fornander, T2
Nordenskjöld, B2
Van't Veer, LJ1
Wessels, LF1
Keller-Pinter, A1
Bottka, S1
Timar, J1
Kulka, J1
Katona, R1
Dux, L1
Deak, F1
Szilak, L1
Pollari, S1
Käkönen, SM1
Edgren, H1
Wolf, M1
Kohonen, P1
Sara, H1
Guise, T1
Nees, M1
Kallioniemi, O1
Chin, YR1
Yang, SX1
Costantino, JP1
Kim, C1
Mamounas, EP1
Nguyen, D2
Jeong, JH1
Wolmark, N1
Kidwell, K1
Paik, S1
Swain, SM1
Gao, N1
Hibi, Y1
Cueno, M1
Asamitsu, K1
Okamoto, T1
Hamilton-Burke, W1
Coleman, L1
Cummings, M1
Green, CA1
Holliday, DL1
Horgan, K1
Maraqa, L1
Peter, MB1
Pollock, S1
Shaaban, AM1
Smith, L1
Speirs, V1
Dhillon, J1
Astanehe, A1
Lee, C1
Fotovati, A1
Hu, K1
Lin, KW1
Yakymovych, I1
Jia, M1
Yakymovych, M1
Souchelnytskyi, S1
Launay, N1
Tarze, A1
Vicart, P1
Lilienbaum, A1
Zhang, D2
Tari, AM1
Akar, U1
Arun, BK1
LaFortune, TA1
Nieves-Alicea, R1
Hortobagyi, GN2
Ueno, NT1
Motomura, K1
Ishitobi, M1
Komoike, Y1
Koyama, H1
Nagase, H1
Inaji, H1
Noguchi, S1
Węsierska-Gądek, J3
Gritsch, D1
Zulehner, N1
Komina, O1
Maurer, M1
Accardi, R1
Scalise, M1
Gheit, T1
Hussain, I1
Yue, J1
Carreira, C1
Collino, A1
Indiveri, C1
Gissmann, L1
Sylla, BS1
Tommasino, M1
Lee, TH2
Chen, CH1
Suizu, F1
Huang, P1
Schiene-Fischer, C1
Daum, S1
Zhang, YJ1
Goate, A1
Chen, RH1
Zhou, XZ1
Lu, KP2
Hong, J1
Zhou, J1
He, T1
Qin, J1
Wang, L1
Regan, TM1
Dressing, GE1
Thaiparambil, JT1
Bender, L1
Ganesh, T1
Kline, E1
Patel, P1
Liu, Y1
Tighiouart, M1
Vertino, PM1
Harvey, RD1
Garcia, A1
Marcus, AI1
Marks, KM1
Shaul, YD1
Pacold, ME1
Kim, D1
Sethumadhavan, S1
Woo, HK1
Jang, HG1
Jha, AK1
Chen, WW1
Barrett, FG1
Stransky, N1
Tsun, ZY1
Cowley, GS1
Barretina, J1
Kalaany, NY1
Hsu, PP1
Ottina, K1
Chan, AM1
Garraway, LA1
Root, DE1
Mino-Kenudson, M1
Brachtel, EF1
Driggers, EM1
Jin, Y1
Li, N1
Jiang, P1
Du, W1
Li, C1
Qiao, M1
Yang, X2
Wu, M1
Hawkes, WC1
Alkan, Z1
Fan, CF1
Mao, XY1
Wang, EH1
Luo, J1
Shahaf, G1
Rotem-Dai, N1
Koifman, G1
Raveh-Amit, H1
Frost, SA1
Livneh, E1
Houtman, R1
de Leeuw, R1
Rondaij, M1
Melchers, D1
Verwoerd, D2
Ruijtenbeek, R1
Martens, JW1
Donini, CF1
Di Zazzo, E1
Zuchegna, C1
Di Domenico, M1
D'Inzeo, S1
Nicolussi, A1
Avvedimento, EV1
Coppa, A1
Porcellini, A1
Rangasamy, V1
Bakowska, JC1
Tzivion, G1
Malter, JS1
Kanthasamy, A1
Held, JM2
Britton, DJ2
Scott, GK2
Lee, EL1
Schilling, B2
Baldwin, MA2
Gibson, BW2
Benz, CC2
Ray, D1
Murphy, KR1
Gal, S1
Doucette, CD1
Hilchie, AL1
Liwski, R1
Hoskin, DW1
Karlsson, E1
Pandiyan, MJ1
Westman, H1
McGlynn, LM1
Tovey, S1
Bartlett, JM1
Doughty, J1
Cooke, TG1
Edwards, J1
Hrstka, R1
Murray, E1
Brychtova, V1
Fabian, P1
Hupp, TR2
Vojtesek, B1
Lucchetti, C1
Caligiuri, I1
Toffoli, G1
Giordano, A1
Rizzolio, F1
Chen, D1
Washbrook, E1
Sarwar, N3
Bates, GJ1
Pace, PE1
Thirunuvakkarasu, V1
Taylor, J1
Epstein, RJ1
Fuller-Pace, FV1
Egly, JM1
Xu, B1
O'Donnell, AH1
Kim, ST1
Kastan, MB1
Chun, J1
Byun, HS1
Arthur, G1
Bittman, R1
Stoica, GE1
Franke, TF1
Wellstein, A1
Czubayko, F1
List, HJ1
Reiter, R1
Morgan, E1
Martin, MB1
Stoica, A1
Qiu, M1
Olsen, A1
Faivre, E1
Horwitz, KB1
Mamay, CL1
Mingo-Sion, AM2
Wolf, DM1
Molina, MD1
Van Den Berg, CL2
Martin, LA2
Farmer, I2
Johnston, SR2
Marshall, C1
Dowsett, M2
Choi, JY1
Hamajima, N1
Tajima, K1
Yoo, KY1
Yoon, KS1
Park, SK1
Kim, SU1
Lee, KM1
Noh, DY1
Ahn, SH1
Choe, KJ1
Han, W1
Hirvonen, A1
Kang, D1
Lillehoj, EP1
Kim, KC1
UCHIDA, M1
TAKAGI, H1
TARNOWSKI, GS1
STOCK, CC1
RYAN, WL1
LORINCZ, AB1
Mahabeleshwar, GH1
Kundu, GC1
Willers, H1
Ghosh, JC1
Kim, S1
Weaver, DT1
Chung, JH1
Powell, SN1
Xia, F1
Fowler, AM1
Solodin, N1
Preisler-Mashek, MT1
Zhang, P1
Lee, AV1
Alarid, ET1
Murphy, L1
Cherlet, T1
Adeyinka, A1
Niu, Y2
Snell, L2
Watson, P2
Tang, HY2
Lin, HY2
Zhang, S1
Davis, FB2
Davis, PJ2
Radisavljevic, Z1
Kittiniyom, K1
Mastronardi, M1
Roemer, M1
Wells, WA1
Greenberg, ER1
Titus-Ernstoff, L1
Newsham, IF1
Zou, Y2
Balasenthil, S3
Barnes, CJ2
Rayala, SK3
Vadlamudi, RK1
Bagheri-Yarmand, R1
Yang, Z1
Sahin, AA2
Griekspoor, A1
Balkenende, A1
Janssen, L1
Jalink, K1
Floore, A1
Velds, A1
van't Veer, L1
Ma, R1
Koulov, A1
Moulton, C1
Basu, M1
Banerjee, S1
Goodson, H1
Basu, S1
Yap, DB1
Hsieh, JK1
Zhong, S1
Heath, V1
Gusterson, B1
Crook, T1
Lu, X1
Karppinen, SM1
Heikkinen, K1
Rapakko, K1
Winqvist, R1
Pierson-Mullany, LK1
Zhang, DD1
Lo, SC1
Cross, JV1
Templeton, DJ1
Hannink, M1
Vellon, L1
Colomer, R1
Lupu, R1
Felekkis, KN1
Narsimhan, RP1
Near, R1
Castro, AF1
Zheng, Y2
Quilliam, LA1
Li, Z1
McNulty, DE1
Marler, KJ1
Lim, L1
Hall, C1
Annan, RS1
Sacks, DB1
Puc, J1
Keniry, M1
Li, HS1
Pandita, TK1
Choudhury, AD1
Memeo, L1
Mansukhani, M1
Murty, VV1
Gaciong, Z1
Meek, SE1
Hibshoosh, H1
Parsons, R1
Ramljak, D1
Romanczyk, LJ1
Metheny-Barlow, LJ1
Thompson, N1
Knezevic, V1
Galperin, M1
Ramesh, A1
Dickson, RB1
Cardone, RA1
Bagorda, A1
Bellizzi, A1
Busco, G1
Guerra, L1
Paradiso, A1
Casavola, V1
Zaccolo, M1
Reshkin, SJ1
Chiang, GG1
Abraham, RT1
Wirtenberger, M1
Hemminki, K1
Försti, A1
Klaes, R1
Schmutzler, RK1
Grzybowska, E1
Bermejo, JL1
Wappenschmidt, B1
Bugert, P1
Butkiewicz, D1
Pamula, J1
Pekala, W1
Zientek, H1
Bartram, CR1
Schagdarsurengin, U1
Seidel, C1
Ulbrich, EJ1
Kölbl, H1
Dittmer, J1
Dammann, R1
Ferguson, HA1
Koller, E1
Reyland, ME1
Lee, MS1
Edwards, RA1
Thede, GL1
Glover, JN1
Hui, L1
Rodrik, V1
Pielak, RM1
Knirr, S1
Foster, DA1
Staka, CM1
Nicholson, RI1
Gee, JM1
Joung, YH1
Lim, EJ1
Lee, MY1
Ye, SK1
Park, EU1
Kim, SY1
Zhang, Z1
Lee, KJ1
Park, DK1
Park, T1
Moon, WK1
Yang, YM1
DeAngelis, T1
Chen, J2
Wu, A1
Prisco, M1
Baserga, R1
van Breemen, RB1
Bolton, JL1
Yeh, PY1
Kuo, SH1
Yeh, KH1
Chuang, SE1
Hsu, CH1
Chang, WC1
Lin, HI1
Gao, M1
Cheng, AL1
Tan, XL1
Popanda, O1
Ambrosone, CB1
Kropp, S1
Helmbold, I1
von Fournier, D1
Haase, W1
Sautter-Bihl, ML1
Wenz, F1
Schmezer, P1
Chang-Claude, J1
Yeh, YT1
Ou-Yang, F1
Chen, IF1
Yang, SF1
Wang, YY1
Chuang, HY1
Su, JH1
Hou, MF1
Yuan, SS1
Tharakan, R1
Wang, RA1
Aldaz, CM1
Khan, S1
Aglipay, JA1
Martin, SA1
Tawara, H1
Lee, SW1
Ouchi, T1
Glaros, S1
Atanaskova, N1
Zhao, C1
Skafar, DF1
Reddy, KB1
Jordan, VC1
Casado, P1
Zuazua-Villar, P1
del Valle, E1
Martínez-Campa, C1
Lazo, PS1
Ramos, S1
Shih, A1
Cao, HJ1
Skliris, GP1
Teh, EM1
Peng, B1
Davie, JR1
Niu, YL1
Troup, S1
Tomes, L1
Watson, PH1
Schmitz, ML1
Ranftler, C2
Miller, SL1
Antico, G1
Raghunath, PN1
Tomaszewski, JE1
Jakubowska, A1
Cybulski, C1
Szymańska, A1
Huzarski, T1
Byrski, T1
Gronwald, J1
Debniak, T1
Górski, B1
Kowalska, E1
Narod, SA1
Lubiński, J1
Gueorguieva, M1
Herbacek, I1
Song, L1
Li, D1
Liu, R1
Huang, X1
Venere, M1
Snyder, A1
Zgheib, O1
Halazonetis, TD1
Wong, LL1
Koay, ES1
Piersma, D1
Verhoef-Post, M1
Look, MP1
Uitterlinden, AG1
Pols, HA1
Berns, EM1
Themmen, AP1
Jiang, J1
Peston, D1
Kulinskaya, E1
Shousha, S1
Yang, JY1
Zong, CS1
Xia, W1
Yamaguchi, H1
Ding, Q1
Xie, X1
Lang, JY1
Lai, CC1
Chang, CJ1
Huang, WC1
Huang, H1
Kuo, HP1
Lee, DF1
Li, LY1
Lien, HC1
Cheng, X1
Chang, KJ1
Hsiao, CD1
Tsai, FJ1
Tsai, CH1
Muller, WJ1
Mills, GB1
Yu, D1
Hung, MC1
Plotnikov, A1
Tran, TH1
Tang, W1
Palazzo, JP1
Rui, H1
Fuchs, SY1
McDonald, PC1
Oloumi, A1
Mills, J1
Dobreva, I1
Maidan, M1
Gray, V1
Wederell, ED1
Bally, MB1
Foster, LJ1
Dedhar, S1
Atsriku, C1
Phoenix, F1
Zoubir, M1
Mathieu, MC1
Mazouni, C1
Liedtke, C1
Corley, L1
Geha, S1
Bouaziz, J1
Spielmann, M1
Drusche, F1
Symmans, WF1
Delaloge, S1
Andre, F1
Tampio, M1
Loikkanen, J1
Myllynen, P1
Mertanen, A1
Vähäkangas, KH1
Johnatty, SE1
Beesley, J1
Hopper, JL1
Southey, MC1
Giles, GG1
Goldgar, DE1
Chenevix-Trench, G1
Spurdle, AB1
Arnold, SF1
Obourn, JD1
Jaffe, H1
Notides, AC1
Speckter, H1
Blümich, B1
Just, M1
Trömel, U1
Mitze, M1
Thelen, M1
Plummer, SJ1
Anton-Culver, H1
Webster, L1
Noble, B1
Liao, S1
Kennedy, A1
Belinson, J1
Casey, G1
MacDonald, NJ1
Freije, JM1
Stracke, ML1
Manrow, RE1
Steeg, PS2
Weis, KE1
Ekena, K1
Thomas, JA1
Lazennec, G1
Katzenellenbogen, BS1
Chadwick, MP1
May, FE1
Westley, BR1
Gallegos, A1
Gasdaska, JR1
Taylor, CW1
Paine-Murrieta, GD1
Goodman, D1
Gasdaska, PY1
Berggren, M1
Briehl, MM1
Powis, G1
Wipf, P1
Cunningham, A1
Rice, RL1
Lazo, JS1
Newton, DL1
Rybak, SM1
Srivastava, RK1
Mi, QS1
Hardwick, JM1
Longo, DL1
Sauvé, DM1
Anderson, HJ1
Ray, JM1
James, WM1
Roberge, M1
Lee, GR1
Kim, SN1
Noguchi, K1
Park, SD1
Hong, SH1
Cho-Chung, YS1
O'Brien, KA1
Lemke, SJ1
Cocke, KS1
Rao, RN1
Beckmann, RP1
Craig, AL1
Blaydes, JP1
Burch, LR1
Thompson, AM1
Vadlamudi, R1
Adam, L1
Talukder, A1
Mendelsohn, J1
Forman, AP1
Mathews, MB1
Gunnery, S1
Oda, K1
Arakawa, H1
Matsuda, K1
Tanikawa, C1
Mori, T1
Nishimori, H1
Tamai, K1
Tokino, T1
Taya, Y1
Campbell, RA1
Bhat-Nakshatri, P1
Patel, NM1
Constantinidou, D1
Nakshatri, H1
Matsuoka, M1
Igisu, H1
Fu, TF1
Rife, JP1
Schirch, V1
Mishra, SK1
Mandal, M1
Mazumdar, A1
Takahashi, K1
Shitashige, M1
Toi, M1
Yano, T1
Shibata, M1
Matsuo, Y1
Shibasaki, F1
Hartsough, MT1
Morrison, DK1
Salerno, M1
Palmieri, D1
Ouatas, T1
Mair, M1
Patrick, J1
Schneider, SL1
Dao, TL1
Lippman, M1
Monaco, ME1
Bolan, G1
Nishimura, M1
Nakada, H1
Nakajima, H1
Hori, Y1
Ezaki, M1
Goto, T1
Okuhara, M1
Watanabe, J1
Holinka, CF1
Anzai, Y1
Kuramoto, H1
Gurpide, E1
Schütze, S1
Scheurich, P1
Pfizenmaier, K1
Krönke, M1
Wolberg, WH1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Levels of Phosphorylated AKT in Patients With Node-Positive Breast Cancer: Correlation With Disease-Free and Overall Survival[NCT00965276]2,500 participants (Actual)Observational2004-01-13Completed
A Randomized Trial With Factorial Design Comparing Fulvestrant ± Lapatinib ± Aromatase Inhibitor in Metastatic Breast Cancer Progressing After Aromatase Inhibitor Therapy[NCT02394496]Phase 3396 participants (Anticipated)Interventional2007-11-30Recruiting
A Randomized, Molecular Driven Phase II Trial of Carboplatin-Paclitaxel-Bevacizumab vs Carboplatin-Paclitaxel-Bevacizumab-Rucaparib vs Carboplatin-Paclitaxel-Rucaparib, Selected According to HRD Status, in Patients With Advanced (Stage III B-C-IV) Ovarian[NCT03462212]Phase 1/Phase 2290 participants (Anticipated)Interventional2021-03-17Recruiting
Study of the N680S Polymorphism of the FSHR Gene and Its Relationship With the Type of Gonadotropin Used in Controlled Ovarian Stimulation[NCT04122729]300 participants (Anticipated)Observational2019-09-25Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for serine and Breast Neoplasms

ArticleYear
YAP/TAZ-mediated activation of serine metabolism and methylation regulation is critical for LKB1-deficient breast cancer progression.
    Bioscience reports, 2017, Oct-31, Volume: 37, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinase Kinases; Breast Neoplasms; Diseas

2017
Insights into how phosphorylation of estrogen receptor at serine 305 modulates tamoxifen activity in breast cancer.
    Molecular and cellular endocrinology, 2019, 03-01, Volume: 483

    Topics: Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Phosphorylation; Protein Conformation;

2019
Nonessential amino acid metabolism in breast cancer.
    Advances in biological regulation, 2016, Volume: 62

    Topics: Animals; Arginine; Breast Neoplasms; Cysteine; Diet Therapy; Female; Food Deprivation; Glutamic Acid

2016
Potential role of estrogen receptor alpha (ERalpha) phosphorylated at Serine118 in human breast cancer in vivo.
    The Journal of steroid biochemistry and molecular biology, 2006, Volume: 102, Issue:1-5

    Topics: Breast Neoplasms; Estrogen Receptor alpha; Gene Expression Regulation, Neoplastic; Humans; Phosphory

2006
Sliding p21-activated kinase 1 to nucleus impacts tamoxifen sensitivity.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2007, Volume: 61, Issue:7

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Nucleus; Drug Resistance, Neoplasm; Estrogen

2007

Trials

6 trials available for serine and Breast Neoplasms

ArticleYear
Estrogen receptor-alpha phosphorylation at serine-118 and tamoxifen response in breast cancer.
    Journal of the National Cancer Institute, 2009, Dec-16, Volume: 101, Issue:24

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease-Free Survival; Estrogen Receptor alpha; F

2009
Estrogen receptor-alpha phosphorylation at serine 305, nuclear p21-activated kinase 1 expression, and response to tamoxifen in postmenopausal breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Mar-01, Volume: 16, Issue:5

    Topics: Breast Neoplasms; Cell Nucleus; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Exp

2010
PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer.
    Breast cancer research and treatment, 2011, Volume: 125, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Cyclic AMP-Dependent Protein Kinases; Di

2011
Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jun-20, Volume: 28, Issue:18

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adju

2010
Activation of Akt, mTOR, and the estrogen receptor as a signature to predict tamoxifen treatment benefit.
    Breast cancer research and treatment, 2013, Volume: 137, Issue:2

    Topics: Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Middle Aged; P

2013
hOGG1 Ser326Cys polymorphism and breast cancer risk among Asian women.
    Breast cancer research and treatment, 2003, Volume: 79, Issue:1

    Topics: Adult; Aged; Amino Acid Substitution; Asian People; Breast Neoplasms; Case-Control Studies; Cysteine

2003

Other Studies

231 other studies available for serine and Breast Neoplasms

ArticleYear
Investigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells.
    International journal of molecular sciences, 2021, Oct-12, Volume: 22, Issue:20

    Topics: bcl-Associated Death Protein; Breast Neoplasms; Crystallography, X-Ray; Density Functional Theory; F

2021
Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors.
    Cell reports, 2022, 01-18, Volume: 38, Issue:3

    Topics: Breast Neoplasms; Female; Humans; Serine; Transaminases

2022
The clinicopathological and prognostic significances of LATS1 expression in breast cancer.
    Histology and histopathology, 2022, Volume: 37, Issue:7

    Topics: Breast Neoplasms; Carcinogenesis; Female; Gene Expression Regulation, Neoplastic; Humans; Prognosis;

2022
How previous treatment changes the metabolomic profile in patients with metastatic breast cancer.
    Archives of gynecology and obstetrics, 2022, Volume: 306, Issue:6

    Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Methionine; Neoplastic Cells, Circulating; Rece

2022
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis.
    Nature communications, 2022, 05-16, Volume: 13, Issue:1

    Topics: Breast Neoplasms; Carbon Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Folic A

2022
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis.
    Nature, 2022, Volume: 605, Issue:7911

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression;

2022
Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland.
    Matrix biology : journal of the International Society for Matrix Biology, 2022, Volume: 111

    Topics: Animals; Breast Neoplasms; Collagen; Collagen Type I; Eukaryotic Initiation Factor-4E; Female; Human

2022
SDC4-rs1981429 and ATM-rs228590 may provide early biomarkers of breast cancer risk.
    Journal of cancer research and clinical oncology, 2023, Volume: 149, Issue:8

    Topics: Ataxia Telangiectasia Mutated Proteins; Australia; Biomarkers; Breast Neoplasms; Female; Heparan Sul

2023
A functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility.
    Communications biology, 2022, 09-28, Volume: 5, Issue:1

    Topics: Breast Neoplasms; Cell Movement; Female; Holoenzymes; Humans; Protein Phosphatase 2; Serine; Threoni

2022
S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.
    eLife, 2022, 10-03, Volume: 11

    Topics: Breast Neoplasms; CDC2 Protein Kinase; DNA; DNA Repair; DNA-Binding Proteins; Female; G2 Phase Cell

2022
Multi-Omics Analysis Revealed Increased De Novo Synthesis of Serine and Lower Activity of the Methionine Cycle in Breast Cancer Cell Lines.
    Molecules (Basel, Switzerland), 2023, Jun-03, Volume: 28, Issue:11

    Topics: Breast Neoplasms; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Methionine; Multiomics; Racemethion

2023
Oxygen-independent stabilization of HIF-2α in breast cancer through direct interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1.
    Free radical biology & medicine, 2023, Volume: 207

    Topics: Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Female; Humans; NIMA-Interacting Pep

2023
EYA4 promotes breast cancer progression and metastasis through its role in replication stress avoidance.
    Molecular cancer, 2023, 09-30, Volume: 22, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Female; Humans; Phosphoprotein Phosphatases; Protein Tyrosine Ph

2023
An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.
    EMBO reports, 2023, 11-06, Volume: 24, Issue:11

    Topics: Autophagy-Related Protein-1 Homolog; Breast Neoplasms; Cell Movement; Female; Humans; Intracellular

2023
Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth.
    Nature communications, 2023, 10-25, Volume: 14, Issue:1

    Topics: Amino Acids; Amino Acids, Essential; Breast Neoplasms; Female; Glycine; Humans; Large Neutral Amino

2023
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.
    EMBO molecular medicine, 2020, 02-07, Volume: 12, Issue:2

    Topics: Aminopyridines; Animals; Breast Neoplasms; Culture Media, Conditioned; Epithelial Cells; Female; Hum

2020
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
    Molecular cancer research : MCR, 2020, Volume: 18, Issue:4

    Topics: Animals; Breast Neoplasms; Carbon; Female; Humans; Metabolomics; Mice; Mitochondria; Serine

2020
Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression.
    The Journal of clinical investigation, 2020, 06-01, Volume: 130, Issue:6

    Topics: A549 Cells; Animals; Breast Neoplasms; Female; Humans; Lung Neoplasms; MCF-7 Cells; Mice; Mice, Inbr

2020
The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism.
    EMBO reports, 2020, 09-03, Volume: 21, Issue:9

    Topics: Breast Neoplasms; Female; Humans; I-kappa B Kinase; Mitochondria; Oncogenes; Serine

2020
p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability.
    Nature communications, 2020, 10-06, Volume: 11, Issue:1

    Topics: Animals; Binding Sites; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Female; Fibroblasts; Genomic

2020
Serine synthesis influences tamoxifen response in ER+ human breast carcinoma.
    Endocrine-related cancer, 2021, Volume: 28, Issue:1

    Topics: Breast Neoplasms; Female; Humans; Serine; Tamoxifen; Transfection

2021
"Serine and One-Carbon Metabolism in Breast Cancer Metastasis"-Letter.
    Molecular cancer research : MCR, 2020, Volume: 18, Issue:11

    Topics: Breast Neoplasms; Carbon; Humans; Metabolomics; Mitochondria; Serine

2020
O-GlcNAc stabilizes SMAD4 by inhibiting GSK-3β-mediated proteasomal degradation.
    Scientific reports, 2020, 11-16, Volume: 10, Issue:1

    Topics: Acetylglucosamine; Breast Neoplasms; Female; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms

2020
Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis-Addicted Breast Tumor Growth.
    Molecular cancer therapeutics, 2021, Volume: 20, Issue:1

    Topics: Animals; Antidepressive Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ce

2021
p-CREB-1 at Ser 133 is a potential marker for breast cancer.
    European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:22

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Cell Line; Cyclic AMP Response

2020
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition.
    Molecular cell, 2021, 01-21, Volume: 81, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Prolif

2021
Food for Growth: Distinct Nutrient Preferences between Primary Tumors and Metastases.
    Molecular cell, 2021, 01-21, Volume: 81, Issue:2

    Topics: Breast Neoplasms; Humans; Lung Neoplasms; Mechanistic Target of Rapamycin Complex 1; Nutrients; Seri

2021
L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness.
    Cell communication and signaling : CCS, 2021, 02-22, Volume: 19, Issue:1

    Topics: Breast Neoplasms; Cell Line; Cell Movement; Female; Humans; Membrane Glycoproteins; Microfilament Pr

2021
Prognostic significance of phosphoglycerate dehydrogenase in breast cancer.
    Breast cancer research and treatment, 2021, Volume: 186, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Phosphoglycerate Dehydrogena

2021
Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer.
    Scientific reports, 2021, 06-29, Volume: 11, Issue:1

    Topics: Breast Neoplasms; Carcinogenesis; Female; Humans; MCF-7 Cells; Neoplasm Proteins; Phosphorylation; P

2021
Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs.
    Journal of hematology & oncology, 2017, 04-17, Volume: 10, Issue:1

    Topics: Antiporters; Breast Neoplasms; Cell Line, Tumor; Core Binding Factor Alpha 1 Subunit; Female; Gene E

2017
Investigation of the Filamin A-Dependent Mechanisms of Tissue Factor Incorporation into Microvesicles.
    Thrombosis and haemostasis, 2017, Volume: 117, Issue:11

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell-Derived Microparticles; Endothelial Cells; Female; Filamins

2017
ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway.
    Journal of experimental & clinical cancer research : CR, 2017, Nov-28, Volume: 36, Issue:1

    Topics: beta Catenin; Breast Neoplasms; Disease Progression; DNA-Binding Proteins; Down-Regulation; Epigenes

2017
Deoxycytidine kinase participates in the regulation of radiation-induced autophagy and apoptosis in breast cancer cells.
    International journal of oncology, 2018, Volume: 52, Issue:3

    Topics: Apoptosis; Autophagy; Beclin-1; Breast Neoplasms; Cell Line, Tumor; Deoxycytidine Kinase; Female; G2

2018
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.
    Molecular cell, 2018, 02-15, Volume: 69, Issue:4

    Topics: Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; CRISPR-Cas Systems; Cytosol; Female; Glyci

2018
Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways.
    BMC cancer, 2018, Jun-26, Volume: 18, Issue:1

    Topics: Amino Acids; Benzyl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Citric Acid C

2018
The NAD
    Cell reports, 2018, 08-28, Volume: 24, Issue:9

    Topics: Breast Neoplasms; Cell Line, Tumor; Cytokines; Female; Humans; MCF-7 Cells; NAD; Nicotinamide Phosph

2018
ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response.
    Nucleic acids research, 2019, 01-25, Volume: 47, Issue:2

    Topics: Active Transport, Cell Nucleus; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; DNA Damag

2019
Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion.
    Oncogene, 2019, Volume: 38, Issue:17

    Topics: Breast Neoplasms; CCCTC-Binding Factor; Cell Line, Tumor; Female; Humans; Kruppel-Like Transcription

2019
Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1.
    Oncogene, 2019, Volume: 38, Issue:19

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Enzyme Activation; Female; Humans; MAP K

2019
Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors.
    European journal of medicinal chemistry, 2019, Jul-15, Volume: 174

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Coumarins; Drug Disco

2019
Relationship between a point mutation S97C in CK1δ protein and its affect on ATP-binding affinity.
    Journal of biomolecular structure & dynamics, 2014, Volume: 32, Issue:3

    Topics: Adenosine Triphosphate; Breast Neoplasms; Carcinoma, Ductal, Breast; Casein Kinase Idelta; Computer

2014
PTPα-mediated Src activation by EGF in human breast cancer cells.
    Acta biochimica et biophysica Sinica, 2013, Volume: 45, Issue:4

    Topics: Acetophenones; Benzopyrans; Biocatalysis; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Epi

2013
17β-estradiol activates glucose uptake via GLUT4 translocation and PI3K/Akt signaling pathway in MCF-7 cells.
    Endocrinology, 2013, Volume: 154, Issue:6

    Topics: 4-Chloro-7-nitrobenzofurazan; Blotting, Western; Breast Neoplasms; Cell Membrane; Deoxyglucose; Estr

2013
The nuclear import of oncoprotein hepatitis B X-interacting protein depends on interacting with c-Fos and phosphorylation of both proteins in breast cancer cells.
    The Journal of biological chemistry, 2013, Jun-28, Volume: 288, Issue:26

    Topics: Active Transport, Cell Nucleus; Amino Acid Motifs; Breast Neoplasms; Cell Line, Tumor; Cell Movement

2013
Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W.
    Biochimica et biophysica acta, 2013, Volume: 1833, Issue:10

    Topics: 14-3-3 Proteins; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell Proliferation; Flow Cyt

2013
Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Anilides; Benzoates; Breast Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Survival; Epithelial

2013
Phosphorylation of P-Rex1 at serine 1169 participates in IGF-1R signaling in breast cancer cells.
    Cellular signalling, 2013, Volume: 25, Issue:11

    Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gene

2013
A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cells.
    Nucleic acids research, 2013, Volume: 41, Issue:19

    Topics: Breast Neoplasms; Casein Kinase II; Cell Line, Tumor; Cell Proliferation; Dual Specificity Phosphata

2013
Slug/β-catenin-dependent proinflammatory phenotype in hypoxic breast cancer stem cells.
    The American journal of pathology, 2013, Volume: 183, Issue:5

    Topics: Autocrine Communication; beta Catenin; Breast Neoplasms; Cell Hypoxia; Cytokines; DNA Damage; Female

2013
Loss of glucocorticoid receptor activation is a hallmark of BRCA1-mutated breast tissue.
    Breast cancer research and treatment, 2013, Volume: 142, Issue:2

    Topics: Adult; Apoptosis; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cells, Cult

2013
Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Disease-Free Survival; Female; Glycine; Glyco

2014
Expression of serine and glycine-related enzymes in phyllodes tumor.
    Neoplasma, 2014, Volume: 61, Issue:5

    Topics: Adult; Breast Neoplasms; Female; Glycine; Humans; Middle Aged; Phyllodes Tumor; Serine

2014
Simultaneous quantification of protein phosphorylation sites using liquid chromatography-tandem mass spectrometry-based targeted proteomics: a linear algebra approach for isobaric phosphopeptides.
    Journal of proteome research, 2014, Dec-05, Volume: 13, Issue:12

    Topics: Adult; Algorithms; Amino Acid Sequence; Binding Sites; Blotting, Western; Breast Neoplasms; Chromato

2014
TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1.
    Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:15

    Topics: Breast Neoplasms; Cell Line, Tumor; Female; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP

2014
Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1.
    The Journal of biological chemistry, 2015, Apr-03, Volume: 290, Issue:14

    Topics: Breast Neoplasms; Cell Line, Tumor; Genes, Tumor Suppressor; Humans; Phosphorylation; Profilins; Ser

2015
Pro-Tumorigenic Phosphorylation of p120 Catenin in Renal and Breast Cancer.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Blotting, Western; Breast Neoplasms; Carcinoma, Renal Cell; Catenins; Cell Transformation, Neoplasti

2015
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.
    Nature communications, 2015, Jul-09, Volume: 6

    Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Catalysis; Cell Line, Tumor; Cell Movement; Cytoki

2015
Sonic hedgehog stimulates glycolysis and proliferation of breast cancer cells: Modulation of PFKFB3 activation.
    Biochemical and biophysical research communications, 2015, Aug-28, Volume: 464, Issue:3

    Topics: Adult; Breast Neoplasms; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Enzyme Activati

2015
A novel BRCA2 in frame deletion in a Tunisian woman with early onset sporadic breast cancer.
    Pathologie-biologie, 2015, Volume: 63, Issue:4-5

    Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Amino Acid Sequence; BRCA2 Protein; Breast Neoplasms;

2015
The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma.
    Oncotarget, 2015, Oct-06, Volume: 6, Issue:30

    Topics: Breast Neoplasms; Carcinoma, Ductal; Cell Adhesion Molecules; Cell Line; Cell Line, Tumor; Cell Move

2015
SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Jan-15, Volume: 22, Issue:2

    Topics: Animals; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; CHO

2016
Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer.
    Molecular oncology, 2016, Volume: 10, Issue:2

    Topics: Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Checkpoint Kinase 1; Cohort Studies; DNA R

2016
mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation.
    Oncogene, 2016, 07-07, Volume: 35, Issue:27

    Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Breast Neoplasms; Cell Line, T

2016
L-plastin Ser5 phosphorylation in breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016, Volume: 30, Issue:3

    Topics: Actins; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Humans; MAP Kinase Signaling Syst

2016
The Small C-terminal Domain Phosphatase 1 Inhibits Cancer Cell Migration and Invasion by Dephosphorylating Ser(P)68-Twist1 to Accelerate Twist1 Protein Degradation.
    The Journal of biological chemistry, 2016, May-27, Volume: 291, Issue:22

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Humans; Mitoge

2016
CLDN6-induced apoptosis via regulating ASK1-p38/JNK signaling in breast cancer MCF-7 cells.
    International journal of oncology, 2016, Volume: 48, Issue:6

    Topics: Apoptosis; Breast Neoplasms; Caspase 3; Claudins; Female; Humans; MAP Kinase Kinase Kinase 5; MAP Ki

2016
The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis.
    Cancer letters, 2016, 07-10, Volume: 377, Issue:1

    Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Decision Support Tech

2016
Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.
    Oncotarget, 2016, Jul-12, Volume: 7, Issue:28

    Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Movement; Chick Embryo; Female; Humans; Male; MCF-7

2016
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth.
    Oncogene, 2016, 11-17, Volume: 35, Issue:46

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Mode

2016
12(S)-HETE increases intracellular Ca(2+) in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply.
    Cancer letters, 2016, 09-28, Volume: 380, Issue:1

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Breast Neoplasms; Calcium; Calcium Channel Blockers; Cal

2016
Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer.
    Breast cancer research and treatment, 2016, Volume: 159, Issue:3

    Topics: Animals; Antigens, CD; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferat

2016
Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance.
    Cancer letters, 2016, 12-28, Volume: 383, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Colonic Neoplasms; Dose-Response Relati

2016
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer.
    Oncogene, 2017, 04-20, Volume: 36, Issue:16

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; CRISPR-Cas Systems; Cyclin-Dependent Ki

2017
Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.
    Biochimica et biophysica acta. Molecular basis of disease, 2017, Volume: 1863, Issue:2

    Topics: Acetyl Coenzyme A; Aspartic Acid; Biosynthetic Pathways; Breast Neoplasms; Cell Line, Tumor; Cell Pr

2017
2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor.
    Journal of cellular physiology, 2017, Volume: 232, Issue:11

    Topics: 2-Methoxyestradiol; Antineoplastic Agents; Binding Sites; Bone Neoplasms; Breast Neoplasms; Cell Mov

2017
Serine 28 phosphorylation of NRIF3 confers its co-activator function for estrogen receptor-alpha transactivation.
    Oncogene, 2008, Sep-04, Volume: 27, Issue:39

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Estrogen Receptor alpha; Humans; Nuclear Pro

2008
Low phosphorylation of estrogen receptor alpha (ERalpha) serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast cancer.
    Endocrine-related cancer, 2008, Volume: 15, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms

2008
Filamin A is a novel caveolin-1-dependent target in IGF-I-stimulated cancer cell migration.
    Experimental cell research, 2008, Sep-10, Volume: 314, Issue:15

    Topics: Amino Acid Sequence; Breast Neoplasms; Caveolae; Caveolin 1; Cell Line, Tumor; Cell Membrane; Cell M

2008
The phospholipidosis-lnducing potential of the chemopotentiating drug, N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene) correlates with its stimulation of phosphatidylserine synthesis and exposure on the plasma membrane in MCF-7 breas
    Proceedings of the Western Pharmacology Society, 2007, Volume: 50

    Topics: Antineoplastic Agents; Arachidonic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Drug Syn

2007
Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha.
    Breast cancer research and treatment, 2009, Volume: 118, Issue:2

    Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Estrogen Receptor alpha; Ext

2009
Phosphorylation of the oestrogen receptor alpha at serine 305 and prediction of tamoxifen resistance in breast cancer.
    The Journal of pathology, 2009, Volume: 217, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Carcinoma;

2009
Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.
    Breast cancer research : BCR, 2008, Volume: 10, Issue:6

    Topics: Animals; Benzopyrans; Blotting, Western; Breast Neoplasms; Cell Proliferation; Cells, Cultured; Chro

2008
Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells.
    The Journal of biological chemistry, 2009, Apr-17, Volume: 284, Issue:16

    Topics: beta Catenin; Breast; Breast Neoplasms; Cadherins; Casein Kinase Ialpha; Cell Adhesion; Cell Line, T

2009
Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.
    The Journal of biological chemistry, 2009, May-29, Volume: 284, Issue:22

    Topics: Alleles; Amino Acid Substitution; Base Sequence; Breast Neoplasms; Cell Line, Tumor; DNA Mutational

2009
CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.
    Nucleic acids research, 2009, Volume: 37, Issue:9

    Topics: Animals; Breast Neoplasms; Casein Kinase Idelta; Cell Line; Cell Line, Tumor; Estradiol; Estrogen Re

2009
Prolactin and estradiol utilize distinct mechanisms to increase serine-118 phosphorylation and decrease levels of estrogen receptor alpha in T47D breast cancer cells.
    Breast cancer research and treatment, 2010, Volume: 120, Issue:2

    Topics: Blotting, Western; Breast Neoplasms; Cell Count; Cell Line, Tumor; Cell Proliferation; Estradiol; Es

2010
AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern.
    Cellular signalling, 2009, Volume: 21, Issue:9

    Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Breast Neoplasms; Cell Adhesion; Crk-Asso

2009
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.
    Molecular cell, 2009, May-14, Volume: 34, Issue:4

    Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Line; Cell Transformation, Neoplastic; Deubiqui

2009
NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors.
    Pharmacogenetics and genomics, 2009, Volume: 19, Issue:7

    Topics: Breast Neoplasms; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans;

2009
Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells.
    International journal of oncology, 2009, Volume: 35, Issue:4

    Topics: Blotting, Northern; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Pr

2009
mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor alpha serine 167 phosphorylation.
    FEBS letters, 2010, Jan-04, Volume: 584, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; Female; Humans; Mitogen-Activated Prote

2010
IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer.
    The Journal of biological chemistry, 2010, Feb-05, Volume: 285, Issue:6

    Topics: Amino Acid Substitution; Antineoplastic Agents, Hormonal; Apoptosis; Breast Neoplasms; Cell Line; Ce

2010
Serine 2481-autophosphorylation of mammalian target of rapamycin (mTOR) couples with chromosome condensation and segregation during mitosis: confocal microscopy characterization and immunohistochemical validation of PP-mTOR(Ser2481) as a novel high-contra
    International journal of oncology, 2010, Volume: 36, Issue:1

    Topics: Biopsy; Breast Neoplasms; Carcinoma; Cell Nucleus; Chromosomes; Cytoplasm; Genetic Markers; HeLa Cel

2010
Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.
    Molecular cancer, 2009, Dec-31, Volume: 8

    Topics: Breast Neoplasms; Cell Division; Cell Line, Tumor; Choline Kinase; Enzyme Inhibitors; Gene Silencing

2009
Phosphorylation of the mutant K303R estrogen receptor alpha at serine 305 affects aromatase inhibitor sensitivity.
    Oncogene, 2010, Apr-22, Volume: 29, Issue:16

    Topics: Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Estrogen Recept

2010
FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy.
    Cancer research, 2010, Feb-01, Volume: 70, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cathepsin D; Cell Line, Tumor; Cell Proliferation

2010
Syndecan-4 promotes cytokinesis in a phosphorylation-dependent manner.
    Cellular and molecular life sciences : CMLS, 2010, Volume: 67, Issue:11

    Topics: Adenocarcinoma; Amino Acid Substitution; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cytokinesis

2010
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis.
    Breast cancer research and treatment, 2011, Volume: 125, Issue:2

    Topics: Animals; Blotting, Western; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cell Differentiation;

2011
The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.
    Molecular cell, 2010, May-14, Volume: 38, Issue:3

    Topics: Actins; Breast Neoplasms; Cell Movement; Cell Shape; Cytoskeletal Proteins; Cytoskeleton; Enzyme Act

2010
A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling.
    The Journal of biological chemistry, 2010, Sep-03, Volume: 285, Issue:36

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferat

2010
Phosphorylation of estrogen receptor beta at serine 105 is associated with good prognosis in breast cancer.
    The American journal of pathology, 2010, Volume: 177, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Chi-Square Distribution; Estrogen Receptor beta; Female; Flow Cy

2010
The expression of activated Y-box binding protein-1 serine 102 mediates trastuzumab resistance in breast cancer cells by increasing CD44+ cells.
    Oncogene, 2010, Nov-25, Volume: 29, Issue:47

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Cell Line, Tumor; Cell

2010
Phosphorylation of eEF1A1 at Ser300 by TβR-I results in inhibition of mRNA translation.
    Current biology : CB, 2010, Sep-28, Volume: 20, Issue:18

    Topics: Amino Acid Sequence; Base Sequence; Breast Neoplasms; Cell Line; Cell Proliferation; Female; Humans;

2010
Serine 59 phosphorylation of {alpha}B-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells.
    The Journal of biological chemistry, 2010, Nov-26, Volume: 285, Issue:48

    Topics: alpha-Crystallin B Chain; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Female; Hu

2010
Silencing kinase-interacting stathmin gene enhances erlotinib sensitivity by inhibiting Ser¹⁰ p27 phosphorylation in epidermal growth factor receptor-expressing breast cancer.
    Molecular cancer therapeutics, 2010, Volume: 9, Issue:11

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cyclin-Dependent Kina

2010
Expression of estrogen receptor beta and phosphorylation of estrogen receptor alpha serine 167 correlate with progression-free survival in patients with metastatic breast cancer treated with aromatase inhibitors.
    Oncology, 2010, Volume: 79, Issue:1-2

    Topics: Adult; Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bre

2010
Interference with ER-α enhances the therapeutic efficacy of the selective CDK inhibitor roscovitine towards ER-positive breast cancer cells.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:4

    Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cycli

2011
IkappaB kinase beta promotes cell survival by antagonizing p53 functions through DeltaNp73alpha phosphorylation and stabilization.
    Molecular and cellular biology, 2011, Volume: 31, Issue:11

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA-Binding Proteins; G

2011
Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.
    Molecular cell, 2011, Apr-22, Volume: 42, Issue:2

    Topics: Active Transport, Cell Nucleus; Animals; Apoptosis Regulatory Proteins; Breast Neoplasms; Calcium-Ca

2011
Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness.
    Cancer research, 2011, Jun-01, Volume: 71, Issue:11

    Topics: Breast Neoplasms; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; HEK293 Cells; Humans;

2011
ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells.
    Molecular and cellular biology, 2011, Volume: 31, Issue:12

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Baculoviral IAP Repeat-Containing 3 Protein; B

2011
Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation.
    International journal of cancer, 2011, Dec-01, Volume: 129, Issue:11

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Differentiation; Cell Line

2011
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
    Nature, 2011, Aug-18, Volume: 476, Issue:7360

    Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycl

2011
3,3'-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation.
    Molecular and cellular biochemistry, 2011, Volume: 358, Issue:1-2

    Topics: Animals; Base Sequence; Breast Neoplasms; cdc25 Phosphatases; Cell Cycle Checkpoints; Cell Cycle Pro

2011
Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Aug-02, Volume: 108, Issue:31

    Topics: Animals; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Calcium-Calmodulin-Depe

2011
Delayed cell cycle progression from SEPW1 depletion is p53- and p21-dependent in MCF-7 breast cancer cells.
    Biochemical and biophysical research communications, 2011, Sep-16, Volume: 413, Issue:1

    Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulati

2011
Elevated p-CREB-2 (ser 245) expression is potentially associated with carcinogenesis and development of breast carcinoma.
    Molecular medicine reports, 2012, Volume: 5, Issue:2

    Topics: Activating Transcription Factor 4; Adolescent; Adult; Aged; Breast Neoplasms; Cell Line, Tumor; Fema

2012
Cancer's sweet tooth for serine.
    Breast cancer research : BCR, 2011, Volume: 13, Issue:6

    Topics: Breast Neoplasms; Female; Humans; Phosphoglycerate Dehydrogenase; Serine

2011
PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation.
    Experimental cell research, 2012, Apr-15, Volume: 318, Issue:7

    Topics: Adenocarcinoma; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; F

2012
Serine-305 phosphorylation modulates estrogen receptor alpha binding to a coregulator peptide array, with potential application in predicting responses to tamoxifen.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:4

    Topics: Antineoplastic Agents, Hormonal; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Estrogen Recept

2012
The p85α regulatory subunit of PI3K mediates cAMP-PKA and retinoic acid biological effects on MCF7 cell growth and migration.
    International journal of oncology, 2012, Volume: 40, Issue:5

    Topics: Alanine; Animals; Antineoplastic Agents; Aspartic Acid; Breast Neoplasms; Cattle; Cell Cycle Checkpo

2012
Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, May-22, Volume: 109, Issue:21

    Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Catalysis; Cell Cycle; Cell Nucleus; Cell Transfor

2012
Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305.
    Molecular cancer research : MCR, 2012, Volume: 10, Issue:8

    Topics: Breast Neoplasms; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Estradiol; Es

2012
The DNA binding and accumulation of p53 from breast cancer cell lines and the link with serine 15 phosphorylation.
    Cancer biology & therapy, 2012, Volume: 13, Issue:10

    Topics: Breast Neoplasms; Cell Line, Tumor; DNA; DNA-Binding Proteins; Female; Humans; Mutation; Phosphoryla

2012
Piperine, a dietary phytochemical, inhibits angiogenesis.
    The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:1

    Topics: Alkaloids; Angiogenesis Inhibitors; Animals; Aorta; Benzodioxoles; Breast Neoplasms; Cell Movement;

2013
Interactions between MAP kinase and oestrogen receptor in human breast cancer.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:6

    Topics: Breast Neoplasms; Cell Nucleus; Cytoplasm; Estradiol; Estrogen Receptor alpha; Female; Fluorescent A

2013
Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2.
    Cancer letters, 2013, Jun-10, Volume: 333, Issue:2

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Antineoplastic Agents, Hormonal; Base Sequence; Breast

2013
The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Drug Resistance, Neopl

2013
Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera.
    Oncogene, 2002, Jul-25, Volume: 21, Issue:32

    Topics: Amino Acid Sequence; Animals; Antibodies; Breast Neoplasms; COS Cells; Cyclin-Dependent Kinase-Activ

2002
Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.
    Cancer research, 2002, Aug-15, Volume: 62, Issue:16

    Topics: Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Breast Neoplasms; Cell Cycle Proteins; DNA Da

2002
Synthesis and growth inhibitory activity of chiral 5-hydroxy-2-N-acyl-(3E)-sphingenines: ceramides with an unusual sphingoid backbone.
    The Journal of organic chemistry, 2003, Jan-24, Volume: 68, Issue:2

    Topics: Antineoplastic Agents; Brain Chemistry; Breast Neoplasms; Catalysis; Ceramides; Chemistry, Organic;

2003
Estradiol rapidly activates Akt via the ErbB2 signaling pathway.
    Molecular endocrinology (Baltimore, Md.), 2003, Volume: 17, Issue:5

    Topics: Androstadienes; Breast Neoplasms; Chromones; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha;

2003
Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.
    Molecular endocrinology (Baltimore, Md.), 2003, Volume: 17, Issue:4

    Topics: Acetylcysteine; Active Transport, Cell Nucleus; Breast Neoplasms; Butadienes; Cell Nucleus; Cysteine

2003
An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer.
    Oncogene, 2003, Jan-30, Volume: 22, Issue:4

    Topics: Base Sequence; Blotting, Western; Breast Neoplasms; Cell Division; Cell Survival; DNA Primers; Human

2003
Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation.
    The Journal of biological chemistry, 2003, Aug-15, Volume: 278, Issue:33

    Topics: Adaptation, Physiological; Breast Neoplasms; Cell Division; Culture Media; ErbB Receptors; Estradiol

2003
Mutagenesis of a Gly-Ser cleavage site in MUC1 inhibits ectodomain shedding.
    Biochemical and biophysical research communications, 2003, Aug-01, Volume: 307, Issue:3

    Topics: Amino Acid Sequence; Animals; Breast Neoplasms; COS Cells; Glycine; Humans; Lung Neoplasms; Mice; Mu

2003
[Effects of p-phenylenediphosphoric acid tetraethyleneimid, ethyleneiminoacetyl serine and their analogs on various strains of transplanted mammary cancers of mice].
    Gan, 1956, Volume: 47, Issue:3-4

    Topics: Amines; Animals; Breast Neoplasms; Humans; Inorganic Chemicals; Mice; Neoplasms, Experimental; Phosp

1956
Effects of combinations of azaserine and of 6-diazo-5-oxo-L-norleucine with purine analogs and other antimetabolites on the growth of two mouse mammary carcinomas.
    Cancer research, 1957, Volume: 17, Issue:10

    Topics: Animals; Antimetabolites; Antineoplastic Agents; Azaserine; Breast; Breast Neoplasms; Diazooxonorleu

1957
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
    The Nebraska state medical journal, 1964, Volume: 49

    Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Gl

1964
Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation.
    The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52

    Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Nucleus; DNA

2003
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.
    Molecular and cellular biology, 2004, Volume: 24, Issue:2

    Topics: Ataxia Telangiectasia Mutated Proteins; Binding Sites; BRCA1 Protein; Breast Neoplasms; Cell Cycle P

2004
Increases in estrogen receptor-alpha concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:1

    Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Line, Tumor; Cell Nucleus; Estradiol; Estrogen Anta

2004
Phospho-serine-118 estrogen receptor-alpha detection in human breast tumors in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Feb-15, Volume: 10, Issue:4

    Topics: Biomarkers, Tumor; Biopsy; Blotting, Western; Breast Neoplasms; Cell Differentiation; Cell Line, Tum

2004
Thyroid hormone causes mitogen-activated protein kinase-dependent phosphorylation of the nuclear estrogen receptor.
    Endocrinology, 2004, Volume: 145, Issue:7

    Topics: Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Nucleus; Enzyme Inhibitors; Estradiol; Estro

2004
Inactivated tumor suppressor Rb by nitric oxide promotes mitosis in human breast cancer cells.
    Journal of cellular biochemistry, 2004, May-01, Volume: 92, Issue:1

    Topics: Arginine; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Female; Humans; Mitosis; Nitric Oxide; omeg

2004
Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation.
    Genes, chromosomes & cancer, 2004, Volume: 40, Issue:3

    Topics: Adult; Alanine; Alleles; Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Breas

2004
Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells.
    Biochemistry, 2004, May-25, Volume: 43, Issue:20

    Topics: Amino Acid Sequence; Breast Neoplasms; Cell Line, Tumor; Female; HMGN1 Protein; Humans; Molecular Se

2004
Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells.
    FEBS letters, 2004, Jun-04, Volume: 567, Issue:2-3

    Topics: Amino Acid Substitution; Breast Neoplasms; Cell Line, Tumor; Cyclin D1; Estrogen Receptor alpha; Est

2004
Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.
    Cancer cell, 2004, Volume: 5, Issue:6

    Topics: Alanine; Apoptosis; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell Cycle; Cell Division

2004
Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.
    Cancer cell, 2004, Volume: 5, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Binding Sites; Blotting, Western; Breast Neoplasms; Cell Division;

2004
Apoptosis of human breast carcinoma cells in the presence of disialosyl gangliosides: II. Treatment of SKBR3 cells with GD3 and GD1b gangliosides.
    Glycoconjugate journal, 2004, Volume: 20, Issue:5

    Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Caspase 3; Caspases; Cattle; Cell Line, Tum

2004
Ser392 phosphorylation regulates the oncogenic function of mutant p53.
    Cancer research, 2004, Jul-15, Volume: 64, Issue:14

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor;

2004
Mutation screening of the BARD1 gene: evidence for involvement of the Cys557Ser allele in hereditary susceptibility to breast cancer.
    Journal of medical genetics, 2004, Volume: 41, Issue:9

    Topics: Alleles; Amino Acid Sequence; Breast Neoplasms; Cysteine; DNA Mutational Analysis; Female; Finland;

2004
Phospho-serine-118 estrogen receptor-alpha expression is associated with better disease outcome in women treated with tamoxifen.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Sep-01, Volume: 10, Issue:17

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease-Free Survival; Estrogen Receptor alpha; F

2004
Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2.
    Molecular and cellular biology, 2004, Volume: 24, Issue:24

    Topics: Alanine; Amino Acid Substitution; Animals; Blotting, Western; Breast Neoplasms; CDC2-CDC28 Kinases;

2004
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
    Molecular and cellular biology, 2004, Volume: 24, Issue:24

    Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Amino Acid Substitution; Animals; Anticar

2004
Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity.
    International journal of cancer, 2005, May-20, Volume: 115, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cyt

2005
AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner.
    Molecular cancer research : MCR, 2005, Volume: 3, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromo

2005
IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner.
    The Journal of biological chemistry, 2005, Apr-08, Volume: 280, Issue:14

    Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Line, Tumor; Epithelial Cells; Female; Humans;

2005
Lack of PTEN sequesters CHK1 and initiates genetic instability.
    Cancer cell, 2005, Volume: 7, Issue:2

    Topics: Animals; Breast Neoplasms; Cell Line; Cell Line, Tumor; Checkpoint Kinase 1; Cytoplasm; DNA Damage;

2005
Pentameric procyanidin from Theobroma cacao selectively inhibits growth of human breast cancer cells.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:4

    Topics: Antioxidants; Benzo(a)pyrene; Biflavonoids; Breast; Breast Neoplasms; Catechin; Cell Line, Tumor; Ce

2005
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.
    Molecular biology of the cell, 2005, Volume: 16, Issue:7

    Topics: Breast Neoplasms; Cation Transport Proteins; Cell Line, Tumor; Collagen; Culture Media, Serum-Free;

2005
Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.
    The Journal of biological chemistry, 2005, Jul-08, Volume: 280, Issue:27

    Topics: Anti-Bacterial Agents; Blood Proteins; Breast Neoplasms; Drug Resistance; HeLa Cells; Humans; In Vit

2005
c-MYC Asn11Ser is associated with increased risk for familial breast cancer.
    International journal of cancer, 2005, Nov-20, Volume: 117, Issue:4

    Topics: Amino Acid Sequence; Asparagine; Breast Neoplasms; Female; Genetic Predisposition to Disease; Humans

2005
A polymorphism at codon 133 of the tumor suppressor RASSF1A is associated with tumorous alteration of the breast.
    International journal of oncology, 2005, Volume: 27, Issue:1

    Topics: Adult; Aged; Alleles; Breast; Breast Neoplasms; Codon; Cohort Studies; DNA Primers; Exons; Female; F

2005
PKCdelta and mTOR interact to regulate stress and IGF-I induced IRS-1 Ser312 phosphorylation in breast cancer cells.
    Breast cancer research and treatment, 2005, Volume: 91, Issue:3

    Topics: Anisomycin; Breast Neoplasms; Enzyme Activation; Female; Humans; Insulin Receptor Substrate Proteins

2005
Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail.
    The Journal of biological chemistry, 2005, Sep-16, Volume: 280, Issue:37

    Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Breast Neoplasms; Calorimetry; Cell Cycle

2005
mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells.
    The Journal of biological chemistry, 2005, Oct-28, Volume: 280, Issue:43

    Topics: Adaptor Proteins, Signal Transducing; Antigens, Polyomavirus Transforming; Apoptosis; Blotting, West

2005
Elevated ERK1/ERK2/estrogen receptor cross-talk enhances estrogen-mediated signaling during long-term estrogen deprivation.
    Endocrine-related cancer, 2005, Volume: 12 Suppl 1

    Topics: Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Estrogen Antagonists; Estrogen Receptor alph

2005
Acquired resistance to oestrogen deprivation: role for growth factor signalling kinases/oestrogen receptor cross-talk revealed in new MCF-7X model.
    Endocrine-related cancer, 2005, Volume: 12 Suppl 1

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Estr

2005
Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells.
    Experimental & molecular medicine, 2005, Aug-31, Volume: 37, Issue:4

    Topics: Anaerobiosis; Animals; Breast Neoplasms; Cell Hypoxia; Chlorocebus aethiops; COS Cells; Cyclin D1; D

2005
Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling.
    Oncogene, 2006, Jan-05, Volume: 25, Issue:1

    Topics: Agar; Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Binding Sites; Blotting,

2006
Characterization of two new variants of human catechol O-methyltransferase in vitro.
    Cancer letters, 2005, Dec-08, Volume: 230, Issue:1

    Topics: Alanine; Breast Neoplasms; Catechol O-Methyltransferase; DNA Methylation; Equilenin; Escherichia col

2005
A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus.
    The Journal of biological chemistry, 2006, Jan-06, Volume: 281, Issue:1

    Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; B-Cell CLL-Lymphoma 10 Protein

2006
Association between TP53 and p21 genetic polymorphisms and acute side effects of radiotherapy in breast cancer patients.
    Breast cancer research and treatment, 2006, Volume: 97, Issue:3

    Topics: Arginine; Body Mass Index; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Female; Gene Fre

2006
STAT3 ser727 phosphorylation and its association with negative estrogen receptor status in breast infiltrating ductal carcinoma.
    International journal of cancer, 2006, Jun-15, Volume: 118, Issue:12

    Topics: Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Gene Expression Regulation,

2006
P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation.
    Cancer research, 2006, Feb-01, Volume: 66, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; HeLa Cells; Humans; p21-Activated Kinas

2006
ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
    The Journal of biological chemistry, 2006, Apr-07, Volume: 281, Issue:14

    Topics: Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Breast Neoplasms; Carcinogens; Cell Cycle Pro

2006
Activation function-1 domain of estrogen receptor regulates the agonistic and antagonistic actions of tamoxifen.
    Molecular endocrinology (Baltimore, Md.), 2006, Volume: 20, Issue:5

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Estr

2006
Pak up your breast tumor--and grow!
    Journal of the National Cancer Institute, 2006, May-17, Volume: 98, Issue:10

    Topics: Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Clinical Trials as Topic; Drug

2006
Vincristine regulates the phosphorylation of the antiapoptotic protein HSP27 in breast cancer cells.
    Cancer letters, 2007, Mar-18, Volume: 247, Issue:2

    Topics: Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Base Sequence; Breast Neoplasms; Cell Line,

2007
Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Nucleus; Cyclooxygenase 2; E1A-

2006
Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells.
    Journal of cellular biochemistry, 2007, Mar-01, Volume: 100, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent K

2007
Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells.
    Oncogene, 2007, Jul-12, Volume: 26, Issue:32

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; CHO Cells; Cricetinae; Cricetulus; Cytos

2007
BARD1 and breast cancer in Poland.
    Breast cancer research and treatment, 2008, Volume: 107, Issue:1

    Topics: Alleles; BRCA1 Protein; Breast Neoplasms; Case-Control Studies; Cell Cycle Proteins; Checkpoint Kina

2008
Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells.
    Annals of the New York Academy of Sciences, 2007, Volume: 1095

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line, Tumor;

2007
Mass spectrometric analysis of high-mobility group proteins and their post-translational modifications in normal and cancerous human breast tissues.
    Journal of proteome research, 2007, Volume: 6, Issue:6

    Topics: Amino Acid Sequence; Breast; Breast Neoplasms; Female; HMGA1a Protein; HMGA1b Protein; Humans; Lysin

2007
Ser-10 phosphorylated histone H3 is involved in cytokinesis as a chromosomal passenger.
    Cell biology international, 2007, Volume: 31, Issue:10

    Topics: Aurora Kinase B; Aurora Kinases; Blotting, Western; Breast Neoplasms; Chromosomes, Human; Cytokinesi

2007
Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.
    Cancer research, 2007, Jul-01, Volume: 67, Issue:13

    Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Ataxia Telangiectasia Mutated Proteins; B

2007
Phosphorylation of Ser78 of Hsp27 correlated with HER-2/neu status and lymph node positivity in breast cancer.
    Molecular cancer, 2007, Aug-14, Volume: 6

    Topics: Breast Neoplasms; Cell Line, Tumor; Genes, erbB-2; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; H

2007
Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer.
    Molecular and cellular endocrinology, 2007, Sep-30, Volume: 276, Issue:1-2

    Topics: Adult; Aged; Aged, 80 and over; Alleles; Asparagine; Breast Neoplasms; Case-Control Studies; Cell Li

2007
Phosphorylation of estrogen receptor-alpha at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Oct-01, Volume: 13, Issue:19

    Topics: Breast Neoplasms; Cell Line, Tumor; Disease Progression; Disease-Free Survival; Estrogen Receptor al

2007
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
    Nature cell biology, 2008, Volume: 10, Issue:2

    Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cel

2008
Oncogene-mediated inhibition of glycogen synthase kinase 3 beta impairs degradation of prolactin receptor.
    Cancer research, 2008, Mar-01, Volume: 68, Issue:5

    Topics: beta-Transducin Repeat-Containing Proteins; Breast Neoplasms; Cell Line, Tumor; Gene Expression Regu

2008
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival.
    Cancer research, 2008, Mar-15, Volume: 68, Issue:6

    Topics: Breast Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Survival; Chromatography, Liquid; Cytoske

2008
A novel serine phosphorylation site detected in the N-terminal domain of estrogen receptor isolated from human breast cancer cells.
    Journal of the American Society for Mass Spectrometry, 2008, Volume: 19, Issue:5

    Topics: Binding Sites; Breast Neoplasms; Chromatography, High Pressure Liquid; Estrogen Receptor alpha; Fema

2008
Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity.
    Journal of molecular endocrinology, 2008, Volume: 40, Issue:4

    Topics: Animals; Breast Neoplasms; Butadienes; Chlorocebus aethiops; COS Cells; Estradiol; Estrogen Receptor

2008
Modulation of ER phosphorylation on serine 118 by endocrine therapy: a new surrogate marker for efficacy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:8

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Brea

2008
Benzo(a)pyrene increases phosphorylation of p53 at serine 392 in relation to p53 induction and cell death in MCF-7 cells.
    Toxicology letters, 2008, May-30, Volume: 178, Issue:3

    Topics: Adenocarcinoma; Apoptosis; Benzo(a)pyrene; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cell Pro

2008
The BARD1 Cys557Ser polymorphism and breast cancer risk: an Australian case-control and family analysis.
    Breast cancer research and treatment, 2009, Volume: 115, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Australia; Breast Neoplasms; Case-Control Studies; Cysteine; Family

2009
Phosphorylation of the human estrogen receptor by mitogen-activated protein kinase and casein kinase II: consequence on DNA binding.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 55, Issue:2

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Breast Neoplasms; Calcium-Calmodulin-Dependent

1995
[In vitro NMR spectroscopy of healthy, pathologically changed and carcinomatous breast tissue samples correlated with histological findings].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1994, Volume: 161, Issue:2

    Topics: Breast; Breast Diseases; Breast Neoplasms; Diagnosis, Differential; Fatty Acids; Female; Glucose; Gl

1994
Detection of BRCA1 mutations by the protein truncation test.
    Human molecular genetics, 1995, Volume: 4, Issue:10

    Topics: Adult; Age of Onset; Base Sequence; BRCA1 Protein; Breast Neoplasms; Chromosome Mapping; Chromosomes

1995
Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells.
    The Journal of biological chemistry, 1996, Oct-11, Volume: 271, Issue:41

    Topics: Alanine; Amino Acid Sequence; Animals; Breast Neoplasms; Cell Division; Chemotaxis; Drosophila; Fema

1996
Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.
    Molecular endocrinology (Baltimore, Md.), 1996, Volume: 10, Issue:11

    Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Breast Neoplasms; CHO Cells; Cric

1996
Production and comparison of mature single-domain 'trefoil' peptides pNR-2/pS2 Cys58 and pNR-2/pS2 Ser58.
    The Biochemical journal, 1995, Jun-15, Volume: 308 ( Pt 3)

    Topics: Amino Acid Sequence; Blotting, Western; Breast Neoplasms; Chromatography, Gel; Chromatography, Ion E

1995
Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells.
    Cancer research, 1996, Dec-15, Volume: 56, Issue:24

    Topics: 3T3 Cells; Animals; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cysteine; Gene

1996
Combinatorial synthesis and biological evaluation of library of small-molecule Ser/Thr-protein phosphatase inhibitors.
    Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:1

    Topics: Breast Neoplasms; Cell Cycle; Cell Division; Drug Design; Enzyme Inhibitors; Humans; Magnetic Resona

1997
Unique recombinant human ribonuclease and inhibition of Kaposi's sarcoma cell growth.
    Journal of the National Cancer Institute, 1998, Dec-02, Volume: 90, Issue:23

    Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; DNA, Complementary; Eosinophil-Derived N

1998
Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Mar-30, Volume: 96, Issue:7

    Topics: Alanine; Amino Acid Substitution; Apoptosis; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein

1999
Phosphorylation-induced rearrangement of the histone H3 NH2-terminal domain during mitotic chromosome condensation.
    The Journal of cell biology, 1999, Apr-19, Volume: 145, Issue:2

    Topics: Anaphase; Antibodies, Monoclonal; Breast Neoplasms; Cell Cycle; Chromosomes, Human; Female; Histones

1999
Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth.
    Molecular and cellular biochemistry, 1999, Volume: 195, Issue:1-2

    Topics: Alanine; Amino Acid Substitution; Apoptosis; Breast Neoplasms; Cell Division; Cyclic AMP; Cyclic AMP

1999
Casein kinase 2 binds to and phosphorylates BRCA1.
    Biochemical and biophysical research communications, 1999, Jul-14, Volume: 260, Issue:3

    Topics: Alkaline Phosphatase; Amino Acid Substitution; Animals; BRCA1 Protein; Breast; Breast Neoplasms; Cas

1999
Dephosphorylation of p53 at Ser20 after cellular exposure to low levels of non-ionizing radiation.
    Oncogene, 1999, Nov-04, Volume: 18, Issue:46

    Topics: Antibodies, Monoclonal; Breast Neoplasms; Epitopes; Female; Humans; Nuclear Proteins; Phosphorylatio

1999
Serine phosphorylation of paxillin by heregulin-beta1: role of p38 mitogen activated protein kinase.
    Oncogene, 1999, Dec-02, Volume: 18, Issue:51

    Topics: Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; Female; Humans; Mit

1999
Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.
    Oncogene, 2000, Jun-22, Volume: 19, Issue:27

    Topics: Blotting, Western; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Transformed; eIF-

2000
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.
    Cell, 2000, Sep-15, Volume: 102, Issue:6

    Topics: Adenocarcinoma; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoma, Non-

2000
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
    The Journal of biological chemistry, 2001, Mar-30, Volume: 276, Issue:13

    Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Divis

2001
Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells.
    Biochemical and biophysical research communications, 2001, Apr-20, Volume: 282, Issue:5

    Topics: Androstadienes; Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Cadmium Chloride; Caffeine

2001
The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in MCF-7 cells as determined by (13)C NMR.
    Archives of biochemistry and biophysics, 2001, Sep-01, Volume: 393, Issue:1

    Topics: Breast Neoplasms; Carbon Isotopes; Cytosol; Female; Formates; Glycine; Glycine Hydroxymethyltransfer

2001
Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells.
    FEBS letters, 2001, Oct-19, Volume: 507, Issue:1

    Topics: Acetylation; Base Sequence; Breast Neoplasms; Chromatin; DNA Primers; Female; Gene Expression Regula

2001
The linkage between beta1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of beta1 integrin in normal and cancerous human breast cells.
    BMC cell biology, 2001, Volume: 2

    Topics: Actin Cytoskeleton; Actinin; Actins; Amino Acid Sequence; Breast; Breast Neoplasms; Calcium-Calmodul

2001
Dissociation of Bax from a Bcl-2/Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2.
    Journal of biochemistry, 2001, Volume: 130, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms;

2001
Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway.
    The Journal of biological chemistry, 2002, Aug-30, Volume: 277, Issue:35

    Topics: Alanine; Amino Acid Substitution; Antigens, Neoplasm; Base Sequence; Breast Neoplasms; Cell Line; DN

2002
Effect of Ca2+ and salt on forms of estradiol cytoplasmic receptor in human neoplastic breast tissue.
    Cancer research, 1977, Volume: 37, Issue:2

    Topics: Breast Neoplasms; Calcium; Centrifugation, Density Gradient; Cytosol; Estradiol; Female; Humans; In

1977
Effects of estrone, estradiol, and estriol on hormone-responsive human breast cancer in long-term tissue culture.
    Cancer research, 1977, Volume: 37, Issue:6

    Topics: Binding, Competitive; Breast Neoplasms; Cell Nucleus; Culture Techniques; Cytoplasm; Drug Interactio

1977
A new antitumor antibiotic, FR900840. I. Discovery, identification, isolation and characterization.
    The Journal of antibiotics, 1989, Volume: 42, Issue:4

    Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Female; Fermentation; Humans

1989
Effects of serine and glycine on proliferation of an Ishikawa cell variant.
    Journal of steroid biochemistry, 1989, Volume: 34, Issue:1-6

    Topics: Adenocarcinoma; Adult; Breast Neoplasms; Cell Division; Cell Line; DNA Replication; DNA, Neoplasm; F

1989
Tumor necrosis factor signal transduction. Tissue-specific serine phosphorylation of a 26-kDa cytosolic protein.
    The Journal of biological chemistry, 1989, Feb-25, Volume: 264, Issue:6

    Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cytosol; Electrophoresis, Polyacrylamide Gel;

1989
Response of DNA thymine synthesis in human tumor and normal tissue to 5-fluorouracil.
    Cancer research, 1972, Volume: 32, Issue:1

    Topics: Breast Neoplasms; Carbon Isotopes; Chromatography, Paper; Colon; Colonic Neoplasms; Depression, Chem

1972