serine has been researched along with Brain Neoplasms in 32 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "D-Serine indirectly caused dose- and time-dependent inhibition of neuronal nitric oxide synthase (nNOS) without affecting endothelial nitric oxide synthase (eNOS) in human glioblastoma cell line U87." | 7.73 | Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells. ( Ciampa, AR; Mariotto, S; Shoji, K; Suzuki, H, 2006) |
| "Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days." | 7.66 | Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980) |
| "To investigate the clinical application value of radiomics features based on preoperative magnetic resonance imaging for predicting B-Raf proto-oncogene serine/threonine-protein (BRAF) V600E mutation in pediatric low-grade gliomas." | 5.51 | Radiomics features based on MRI predict BRAF V600E mutation in pediatric low-grade gliomas: A non-invasive method for molecular diagnosis. ( Ai, R; Cai, L; Hu, Q; Lai, M; Li, J; Li, L; Li, S; Shi, C; Xu, J; Ye, K; Zhen, J; Zhou, J, 2022) |
| "Recurrent ependymomas are considered rarely responsive to chemotherapy and often have a dismal prognosis after tumor progression." | 5.37 | mTORC1 activation in childhood ependymoma and response to sirolimus. ( Bowers, DC; Brugarolas, J; Gargan, L; Kucejova, B; Margraf, L, 2011) |
| " Here, we find that serine and glycine levels were higher in low-nutrient regions of tumors in glioblastoma multiforme (GBM) patients than they were in other regions." | 4.02 | Glioma cells require one-carbon metabolism to survive glutamine starvation. ( Bamba, T; Fujita, Y; Hashiguchi, M; Hosoda, K; Irino, Y; Izumi, Y; Kitta, A; Kohmura, E; Kohta, M; Kyotani, K; Nagashima, H; Nakai, T; Sasayama, T; Satoh, N; Shinohara, M; Takahashi, M; Tanaka, K; Uno, T; Uozumi, Y, 2021) |
| "D-Serine indirectly caused dose- and time-dependent inhibition of neuronal nitric oxide synthase (nNOS) without affecting endothelial nitric oxide synthase (eNOS) in human glioblastoma cell line U87." | 3.73 | Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells. ( Ciampa, AR; Mariotto, S; Shoji, K; Suzuki, H, 2006) |
| "In developing iodine-123-labelled amino acid derivatives for imaging cerebral gliomas by single-photon emission tomography (SPET), we compared p-[123I]iodo-L-phenylalanine (IPA), L-[123I]iodo-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid (ITIC) and L-3-[123I]iodo-alpha-methyltyrosine (IMT) with regard to their uptake in human glioblastoma T99 and T3868 cells, and thereafter studied the mechanisms promoting the cellular uptake." | 3.70 | Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats. ( Feiden, W; Heimann, A; Kempski, O; Kirsch, CM; Richter, S; Romeike, BF; Samnick, S, 2000) |
| "Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days." | 3.66 | Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980) |
| "Glioblastoma is the most malignant and lethal subtype brain tumors with high risk of recurrence and therapeutic resistance." | 1.48 | Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma. ( Dong, Z; Du, S; Huang, J; Lei, T; Sun, M; Tong, R; Wang, H; Wang, Y; Yang, J; Yang, Y, 2018) |
| "Recurrent ependymomas are considered rarely responsive to chemotherapy and often have a dismal prognosis after tumor progression." | 1.37 | mTORC1 activation in childhood ependymoma and response to sirolimus. ( Bowers, DC; Brugarolas, J; Gargan, L; Kucejova, B; Margraf, L, 2011) |
| "Gliomas are the most common type of primary intracranial tumor." | 1.35 | Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis. ( Cheng, C; Shen, A; Sun, L; Wang, Y; Zhao, Y; Zou, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.25) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 13 (40.63) | 29.6817 |
| 2010's | 11 (34.38) | 24.3611 |
| 2020's | 5 (15.63) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, L | 1 |
| Kiang, KM | 1 |
| Cheng, SY | 1 |
| Leung, GK | 1 |
| Dutta, R | 1 |
| Sharma, MC | 1 |
| Suri, V | 2 |
| Sarkar, C | 1 |
| Garg, A | 1 |
| Suri, A | 1 |
| Kale, SS | 1 |
| Xu, J | 1 |
| Lai, M | 1 |
| Li, S | 1 |
| Ye, K | 1 |
| Li, L | 1 |
| Hu, Q | 1 |
| Ai, R | 1 |
| Zhou, J | 1 |
| Li, J | 1 |
| Zhen, J | 1 |
| Cai, L | 1 |
| Shi, C | 1 |
| Ngo, B | 1 |
| Kim, E | 1 |
| Osorio-Vasquez, V | 1 |
| Doll, S | 1 |
| Bustraan, S | 1 |
| Liang, RJ | 1 |
| Luengo, A | 1 |
| Davidson, SM | 1 |
| Ali, A | 1 |
| Ferraro, GB | 1 |
| Fischer, GM | 1 |
| Eskandari, R | 1 |
| Kang, DS | 1 |
| Ni, J | 1 |
| Plasger, A | 1 |
| Rajasekhar, VK | 1 |
| Kastenhuber, ER | 1 |
| Bacha, S | 1 |
| Sriram, RK | 1 |
| Stein, BD | 1 |
| Bakhoum, SF | 1 |
| Snuderl, M | 1 |
| Cotzia, P | 1 |
| Healey, JH | 1 |
| Mainolfi, N | 1 |
| Friedman, A | 1 |
| Manfredi, M | 1 |
| Sabatini, DM | 1 |
| Jones, DR | 1 |
| Yu, M | 1 |
| Zhao, JJ | 1 |
| Jain, RK | 1 |
| Keshari, KR | 1 |
| Davies, MA | 1 |
| Vander Heiden, MG | 1 |
| Hernando, E | 1 |
| Mann, M | 1 |
| Cantley, LC | 1 |
| Pacold, ME | 1 |
| Tanaka, K | 1 |
| Sasayama, T | 1 |
| Nagashima, H | 1 |
| Irino, Y | 1 |
| Takahashi, M | 1 |
| Izumi, Y | 1 |
| Uno, T | 1 |
| Satoh, N | 1 |
| Kitta, A | 1 |
| Kyotani, K | 1 |
| Fujita, Y | 1 |
| Hashiguchi, M | 1 |
| Nakai, T | 1 |
| Kohta, M | 1 |
| Uozumi, Y | 1 |
| Shinohara, M | 1 |
| Hosoda, K | 1 |
| Bamba, T | 1 |
| Kohmura, E | 1 |
| Gu, Y | 1 |
| Albuquerque, CP | 1 |
| Braas, D | 1 |
| Zhang, W | 1 |
| Villa, GR | 1 |
| Bi, J | 1 |
| Ikegami, S | 1 |
| Masui, K | 1 |
| Gini, B | 1 |
| Yang, H | 1 |
| Gahman, TC | 1 |
| Shiau, AK | 1 |
| Cloughesy, TF | 1 |
| Christofk, HR | 1 |
| Zhou, H | 1 |
| Guan, KL | 1 |
| Mischel, PS | 1 |
| Yang, Y | 1 |
| Lei, T | 1 |
| Du, S | 1 |
| Tong, R | 1 |
| Wang, H | 2 |
| Yang, J | 1 |
| Huang, J | 1 |
| Sun, M | 1 |
| Wang, Y | 2 |
| Dong, Z | 1 |
| Mandal, T | 1 |
| Bhowmik, A | 1 |
| Chatterjee, A | 1 |
| Chatterjee, U | 1 |
| Chatterjee, S | 1 |
| Ghosh, MK | 1 |
| Gao, X | 1 |
| Cai, S | 1 |
| Saadatzadeh, MR | 1 |
| Hanenberg, H | 1 |
| Pollok, KE | 1 |
| Cohen-Gadol, AA | 1 |
| Chen, J | 2 |
| Ouédraogo, ZG | 1 |
| Müller-Barthélémy, M | 1 |
| Kemeny, JL | 1 |
| Dedieu, V | 1 |
| Biau, J | 1 |
| Khalil, T | 1 |
| Raoelfils, LI | 1 |
| Granzotto, A | 1 |
| Pereira, B | 1 |
| Beaudoin, C | 1 |
| Guissou, IP | 1 |
| Berger, M | 1 |
| Morel, L | 1 |
| Chautard, E | 1 |
| Verrelle, P | 1 |
| Amano, T | 1 |
| Nakamizo, A | 1 |
| Mishra, SK | 1 |
| Gumin, J | 1 |
| Shinojima, N | 1 |
| Sawaya, R | 1 |
| Lang, FF | 1 |
| Shen, A | 2 |
| Zhao, Y | 1 |
| Zou, L | 1 |
| Sun, L | 1 |
| Cheng, C | 1 |
| McBride, SM | 1 |
| Perez, DA | 1 |
| Polley, MY | 1 |
| Vandenberg, SR | 1 |
| Smith, JS | 1 |
| Zheng, S | 1 |
| Lamborn, KR | 1 |
| Wiencke, JK | 1 |
| Chang, SM | 1 |
| Prados, MD | 1 |
| Berger, MS | 1 |
| Stokoe, D | 1 |
| Haas-Kogan, DA | 1 |
| Darra, E | 1 |
| Ebner, FH | 1 |
| Shoji, K | 2 |
| Suzuki, H | 2 |
| Mariotto, S | 2 |
| Wang, D | 1 |
| He, F | 1 |
| Zhang, L | 2 |
| Zhang, F | 1 |
| Wang, Q | 1 |
| Qian, X | 1 |
| Pan, X | 1 |
| Meng, J | 1 |
| Peng, C | 1 |
| Bowers, DC | 1 |
| Kucejova, B | 1 |
| Margraf, L | 1 |
| Gargan, L | 1 |
| Brugarolas, J | 1 |
| Filippova, N | 1 |
| Yang, X | 1 |
| King, P | 1 |
| Nabors, LB | 1 |
| Yang, W | 1 |
| Xia, Y | 1 |
| Cao, Y | 1 |
| Zheng, Y | 1 |
| Bu, W | 1 |
| You, MJ | 1 |
| Koh, MY | 1 |
| Cote, G | 1 |
| Aldape, K | 1 |
| Li, Y | 1 |
| Verma, IM | 1 |
| Chiao, PJ | 1 |
| Lu, Z | 1 |
| Alam, R | 1 |
| Schultz, CR | 1 |
| Golembieski, WA | 1 |
| Poisson, LM | 1 |
| Rempel, SA | 1 |
| Jeng, YM | 1 |
| Hsu, HC | 1 |
| Bijur, GN | 1 |
| Jope, RS | 1 |
| Fujita, M | 1 |
| Mizuno, M | 1 |
| Nagasaka, T | 1 |
| Wakabayashi, T | 1 |
| Maeda, K | 1 |
| Ishii, D | 1 |
| Arima, T | 1 |
| Kawajiri, A | 1 |
| Inagaki, M | 1 |
| Yoshida, J | 1 |
| Ciampa, AR | 1 |
| Woerner, BM | 1 |
| Warrington, NM | 1 |
| Kung, AL | 1 |
| Perry, A | 1 |
| Rubin, JB | 1 |
| Claudio, PP | 1 |
| Cui, J | 1 |
| Ghafouri, M | 1 |
| Mariano, C | 1 |
| White, MK | 1 |
| Safak, M | 1 |
| Sheffield, JB | 1 |
| Giordano, A | 1 |
| Khalili, K | 1 |
| Amini, S | 1 |
| Sawaya, BE | 1 |
| Vernez, M | 1 |
| Hutter, P | 1 |
| Monnerat, C | 1 |
| Halkic, N | 1 |
| Gugerli, O | 1 |
| Bouzourene, H | 1 |
| Demir, O | 1 |
| Kurnaz, IA | 1 |
| Yue, XF | 1 |
| Wu, FG | 1 |
| Xu, B | 1 |
| Kohl, RL | 1 |
| Perez-Polo, JR | 1 |
| Quay, WB | 1 |
| Garcia, MC | 1 |
| Ward, G | 1 |
| Ma, YC | 1 |
| Salem, N | 1 |
| Kim, HY | 1 |
| Mullapudi, SR | 1 |
| Ali-Osman, F | 1 |
| Shou, J | 1 |
| Srivenugopal, KS | 1 |
| Samnick, S | 1 |
| Richter, S | 1 |
| Romeike, BF | 1 |
| Heimann, A | 1 |
| Feiden, W | 1 |
| Kempski, O | 1 |
| Kirsch, CM | 1 |
1 trial available for serine and Brain Neoplasms
| Article | Year |
|---|---|
Radiomics features based on MRI predict BRAF V600E mutation in pediatric low-grade gliomas: A non-invasive method for molecular diagnosis.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Female; Glioma; Humans; Magnetic Resonance Ima | 2022 |
31 other studies available for serine and Brain Neoplasms
| Article | Year |
|---|---|
Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Survival; DNA Da | 2022 |
TTF-1: A Well-Favored Addition to the Immunohistochemistry Armamentarium as a Diagnostic Marker of SEGA.
Topics: Astrocytoma; Brain Neoplasms; Child; Ependymoma; Glioblastoma; Humans; Immunohistochemistry; Neurocy | 2022 |
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Cell Line, Tumor; Datasets as Topic; Drug Re | 2020 |
Glioma cells require one-carbon metabolism to survive glutamine starvation.
Topics: Aminohydrolases; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Ge | 2021 |
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.
Topics: A549 Cells; Amino Acid Transport System y+; Brain Neoplasms; Cysteine; Glioblastoma; Glutamine; Glut | 2017 |
Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; DNA Breaks, | 2018 |
Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells.
Topics: Animals; bcl-X Protein; Brain Neoplasms; Casein Kinase II; Cell Line, Tumor; Cell Movement; Cell Tra | 2014 |
Phosphorylation of NMDA 2B at S1303 in human glioma peritumoral tissue: implications for glioma epileptogenesis.
Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; DNA-Activated Protein Kin | 2014 |
STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma.
Topics: Brain Neoplasms; Carbazoles; Cell Line, Tumor; Cell Proliferation; Colony-Forming Units Assay; Dose- | 2016 |
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes.
Topics: Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Flow Cytometry; Gene Ex | 2009 |
Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis.
Topics: Adult; Aged; Brain Neoplasms; Cyclin-Dependent Kinase Inhibitor p27; Exportin 1 Protein; Female; Gen | 2009 |
Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival.
Topics: Adult; Brain Neoplasms; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Intracellula | 2010 |
Dual cross-talk between nitric oxide and D-serine in astrocytes and neurons in the brain.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Brain Neoplasms; Cells, Cultured; Cytokines; Gl | 2009 |
The role of p27(Kip1) phosphorylation at serine 10 in the migration of malignant glioma cells in vitro.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase Inhibi | 2011 |
mTORC1 activation in childhood ependymoma and response to sirolimus.
Topics: Brain Neoplasms; Child, Preschool; Ependymoma; Humans; Immunosuppressive Agents; Magnetic Resonance | 2011 |
Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function.
Topics: Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Centrosome; Cyclin A; Cyclin-Dependent Kinase 5; Cyto | 2012 |
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Topics: Animals; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzym | 2012 |
PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma.
Topics: Blotting, Western; Brain Neoplasms; Glioma; HSP27 Heat-Shock Proteins; Humans; Intracellular Signali | 2013 |
KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas.
Topics: Adult; Aged; Alleles; Amino Acid Substitution; Astrocytoma; Brain Neoplasms; Chromosomes, Human, Pai | 2003 |
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation.
Topics: Androstadienes; Brain Neoplasms; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Fractionation; Cell | 2003 |
Aurora-B dysfunction of multinucleated giant cells in glioma detected by site-specific phosphorylated antibodies.
Topics: Antibodies, Monoclonal; Aurora Kinase B; Aurora Kinases; Brain Neoplasms; Cell Line, Tumor; Fluoresc | 2004 |
Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells.
Topics: Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Flu | 2006 |
Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies.
Topics: Animals; Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Chemokine CXCL12; Chemokines, CXC; En | 2005 |
Cdk9 phosphorylates p53 on serine 392 independently of CKII.
Topics: Brain Neoplasms; Casein Kinase II; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Glioblastoma; HIV-1; | 2006 |
A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene.
Topics: Adenocarcinoma, Mucinous; Adenoma; Adult; Brain Neoplasms; Carcinoma; Cholangiocarcinoma; Colorectal | 2007 |
Wildtype Elk-1, but not a SUMOylation mutant, represses egr-1 expression in SH-SY5Y neuroblastomas.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Early Growth Response Protein 1; ets-Domain Protein El | 2008 |
[The anticancer and pharmacologic study of oxalysine (author's transl)].
Topics: Amino Acids, Dicarboxylic; Animals; Antibiotics, Antineoplastic; Brain Neoplasms; Dogs; Haplorhini; | 1980 |
Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells.
Topics: Animals; Brain Neoplasms; Cell Line; Enzyme Activation; Glioma; Glycine; Glycine Hydroxymethyltransf | 1980 |
Effect of docosahexaenoic acid on the synthesis of phosphatidylserine in rat brain in microsomes and C6 glioma cells.
Topics: Animals; Brain; Brain Neoplasms; Docosahexaenoic Acids; Female; Glioma; Microsomes; Phosphatidylseri | 1998 |
DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Brain Neoplasms; Calcium-Calmodulin-Dependent | 2000 |
Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; beta-Alanine; Binding, Competitive; Blood-Brain | 2000 |