serine has been researched along with Brain Ischemia in 36 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Excerpt | Relevance | Reference |
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"To investigate the neuroprotective effect of L-serine and its underlying mechanisms, focal cerebral ischemia was induced in rats by occlusion of middle cerebral artery (MCAO) with a suture, and reperfusion was given by filament withdrawal 2 hr later." | 7.76 | Neuroprotective effect of L-serine against temporary cerebral ischemia in rats. ( Chen, ZQ; Jiang, ZL; Li, X; Peng, LL; Wang, GH, 2010) |
"To observe the therapeutic time window of L-serine against focal cerebral ischemia/reperfusion injury in rats, and related mechanisms." | 7.76 | [Experimental study of therapeutic time window of L-serine against focal cerebral ischemia/reperfusion injury in rats]. ( Fan, XJ; Jiang, ZL; Shen, LH; Wang, GH; Zhang, XG, 2010) |
"Recent studies have indicated that cerebral ischemia induces rapid serine phosphorylation of synaptic RAS-GTPase activating protein (SynGAP) by calcium/Camodulin-dependent protein kinase II (CaMKII) in rat hippocampus." | 7.72 | PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus. ( Song, B; Yan, XB; Zhang, GY, 2004) |
"To investigate whether brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase (nNOS) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and the interaction between CaMKII? and nNOS in rat hippocampus." | 7.72 | Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus. ( Meng, FJ; Song, B; Yan, XB; Zhang, GY, 2004) |
"Infarct volume following middle cerebral artery occlusion is dramatically diminished in several regions of the brains of SR mutant mice despite evidence of increased NMDA receptor number and sensitivity." | 5.36 | Serine racemase deletion protects against cerebral ischemia and excitotoxicity. ( Ahmad, AS; Barrow, RK; Coyle, JT; Doré, S; Ehmsen, JT; Gazi, SK; Mustafa, AK; Sikka, G; Snyder, SH; Zeynalov, E, 2010) |
"Brain ischemia was induced by the four-vessel occlusion method on Sprague-Dawley rats." | 5.32 | Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. ( Guo, J; Meng, F; Song, B; Yan, X; Zhang, G, 2003) |
"To investigate the neuroprotective effect of L-serine and its underlying mechanisms, focal cerebral ischemia was induced in rats by occlusion of middle cerebral artery (MCAO) with a suture, and reperfusion was given by filament withdrawal 2 hr later." | 3.76 | Neuroprotective effect of L-serine against temporary cerebral ischemia in rats. ( Chen, ZQ; Jiang, ZL; Li, X; Peng, LL; Wang, GH, 2010) |
"To observe the therapeutic time window of L-serine against focal cerebral ischemia/reperfusion injury in rats, and related mechanisms." | 3.76 | [Experimental study of therapeutic time window of L-serine against focal cerebral ischemia/reperfusion injury in rats]. ( Fan, XJ; Jiang, ZL; Shen, LH; Wang, GH; Zhang, XG, 2010) |
" We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo." | 3.74 | The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. ( Atochin, DN; Ayata, C; Critchlow, JD; Dantas, AP; Huang, PL; Liu, VW; Looft-Wilson, R; Michel, T; Moskowitz, MA; Murata, T; Salomone, S; Sessa, WC; Shin, HK; Wang, A, 2007) |
" This study compared the neuroprotective efficacies of muscimol, a GABA A receptor agonist, and a GABA B receptor agonist baclofen in rat brain ischemia." | 3.74 | Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade. ( Li, C; Xu, J; Yin, XH; Zhang, GY, 2008) |
"Recent studies have indicated that cerebral ischemia induces rapid serine phosphorylation of synaptic RAS-GTPase activating protein (SynGAP) by calcium/Camodulin-dependent protein kinase II (CaMKII) in rat hippocampus." | 3.72 | PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus. ( Song, B; Yan, XB; Zhang, GY, 2004) |
"To investigate whether brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase (nNOS) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and the interaction between CaMKII? and nNOS in rat hippocampus." | 3.72 | Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus. ( Meng, FJ; Song, B; Yan, XB; Zhang, GY, 2004) |
"Nimodipine treatment attenuated CCH induced tau phosphorylation by up-regulating expression of miR-132." | 1.48 | Nimodipine attenuates tau phosphorylation at Ser396 via miR-132/GSK-3β pathway in chronic cerebral hypoperfusion rats. ( Chen, Y; Liu, X; Tan, Z; Xie, W; Zhu, Y, 2018) |
"Infarct volume following middle cerebral artery occlusion is dramatically diminished in several regions of the brains of SR mutant mice despite evidence of increased NMDA receptor number and sensitivity." | 1.36 | Serine racemase deletion protects against cerebral ischemia and excitotoxicity. ( Ahmad, AS; Barrow, RK; Coyle, JT; Doré, S; Ehmsen, JT; Gazi, SK; Mustafa, AK; Sikka, G; Snyder, SH; Zeynalov, E, 2010) |
"Brain ischemia was induced by the four-vessel occlusion method on Sprague-Dawley rats." | 1.32 | Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. ( Guo, J; Meng, F; Song, B; Yan, X; Zhang, G, 2003) |
"Pentobarbital pretreatment may be used to predict biochemical events involved in ischemic brain damage following bilateral carotid artery ligations in the gerbil, since it reduces the subsequent edema and mortality." | 1.28 | Arachidonic acid metabolism in gerbil cerebra: effects of ischemia and pentobarbital. ( Dorman, RV; Hamm, TF, 1990) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (5.56) | 18.2507 |
2000's | 19 (52.78) | 29.6817 |
2010's | 14 (38.89) | 24.3611 |
2020's | 1 (2.78) | 2.80 |
Authors | Studies |
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Cramer, T | 1 |
Gill, R | 1 |
Thirouin, ZS | 1 |
Vaas, M | 1 |
Sampath, S | 1 |
Martineau, F | 1 |
Noya, SB | 1 |
Panzanelli, P | 1 |
Sudharshan, TJJ | 1 |
Colameo, D | 1 |
Chang, PK | 1 |
Wu, PY | 1 |
Shi, R | 1 |
Barker, PA | 1 |
Brown, SA | 1 |
Paolicelli, RC | 1 |
Klohs, J | 1 |
McKinney, RA | 1 |
Tyagarajan, SK | 1 |
McQueen, J | 1 |
Ryan, TJ | 1 |
McKay, S | 1 |
Marwick, K | 1 |
Baxter, P | 1 |
Carpanini, SM | 1 |
Wishart, TM | 1 |
Gillingwater, TH | 1 |
Manson, JC | 1 |
Wyllie, DJA | 1 |
Grant, SGN | 1 |
McColl, BW | 1 |
Komiyama, NH | 1 |
Hardingham, GE | 1 |
Tan, Z | 1 |
Chen, Y | 1 |
Xie, W | 1 |
Liu, X | 1 |
Zhu, Y | 2 |
Lie, ME | 1 |
Gowing, EK | 1 |
Johansen, NB | 1 |
Dalby, NO | 1 |
Thiesen, L | 1 |
Wellendorph, P | 1 |
Clarkson, AN | 1 |
Zhan, L | 1 |
Lu, Z | 1 |
Zhu, X | 1 |
Xu, W | 1 |
Li, L | 1 |
Li, X | 2 |
Chen, S | 1 |
Sun, W | 1 |
Xu, E | 1 |
Kozoriz, MG | 1 |
Lai, S | 1 |
Vega, JL | 1 |
Sáez, JC | 1 |
Sin, WC | 1 |
Bechberger, JF | 1 |
Naus, CC | 1 |
Osuka, K | 1 |
Watanabe, Y | 1 |
Usuda, N | 1 |
Atsuzawa, K | 1 |
Takayasu, M | 1 |
Dhami, KS | 1 |
Churchward, MA | 1 |
Baker, GB | 1 |
Todd, KG | 1 |
Abe, T | 1 |
Suzuki, M | 1 |
Sasabe, J | 1 |
Takahashi, S | 1 |
Unekawa, M | 1 |
Mashima, K | 1 |
Iizumi, T | 1 |
Hamase, K | 1 |
Konno, R | 1 |
Aiso, S | 1 |
Suzuki, N | 1 |
Sung, JH | 1 |
Koh, PO | 1 |
Oja, SS | 1 |
Saransaari, P | 1 |
Miyamoto, N | 1 |
Tanaka, R | 1 |
Zhang, N | 1 |
Shimura, H | 1 |
Onodera, M | 1 |
Mochizuki, H | 1 |
Hattori, N | 1 |
Urabe, T | 1 |
Stanton, PK | 1 |
Potter, PE | 1 |
Aguilar, J | 1 |
Decandia, M | 1 |
Moskal, JR | 1 |
Yao, LY | 1 |
Lin, Q | 1 |
Niu, YY | 1 |
Deng, KM | 1 |
Zhang, JH | 1 |
Lu, Y | 2 |
Mustafa, AK | 1 |
Ahmad, AS | 1 |
Zeynalov, E | 1 |
Gazi, SK | 1 |
Sikka, G | 1 |
Ehmsen, JT | 1 |
Barrow, RK | 1 |
Coyle, JT | 1 |
Snyder, SH | 1 |
Doré, S | 1 |
Wang, GH | 2 |
Jiang, ZL | 2 |
Chen, ZQ | 1 |
Peng, LL | 1 |
Wang, WW | 1 |
Hu, SQ | 1 |
Li, C | 2 |
Zhou, C | 1 |
Qi, SH | 1 |
Zhang, GY | 5 |
Zhang, XG | 1 |
Shen, LH | 1 |
Fan, XJ | 1 |
Stetler, RA | 1 |
Gao, Y | 1 |
Zhang, L | 1 |
Weng, Z | 1 |
Zhang, F | 1 |
Hu, X | 1 |
Wang, S | 1 |
Vosler, P | 1 |
Cao, G | 1 |
Sun, D | 1 |
Graham, SH | 1 |
Chen, J | 1 |
Song, B | 4 |
Meng, F | 1 |
Yan, X | 1 |
Guo, J | 1 |
Zhang, G | 1 |
Wang, J | 1 |
Liu, S | 1 |
Fu, Y | 1 |
Wang, JH | 1 |
Uchihara, T | 1 |
Nakamura, A | 1 |
Arai, T | 1 |
Ikeda, K | 1 |
Tsuchiya, K | 1 |
Yan, XB | 3 |
Buratta, S | 1 |
Mambrini, R | 1 |
Miniaci, MC | 1 |
Tempia, F | 1 |
Mozzi, R | 1 |
Meng, FJ | 1 |
Morioka, M | 2 |
Kawano, T | 2 |
Yano, S | 2 |
Kai, Y | 2 |
Tsuiki, H | 1 |
Yoshinaga, Y | 1 |
Matsumoto, J | 1 |
Maeda, T | 1 |
Hamada, J | 1 |
Yamamoto, H | 1 |
Fukunaga, K | 4 |
Kuratsu, J | 1 |
Sasaki, T | 1 |
Han, F | 2 |
Shioda, N | 2 |
Moriguchi, S | 2 |
Kasahara, J | 1 |
Ishiguro, K | 1 |
Atochin, DN | 1 |
Wang, A | 1 |
Liu, VW | 1 |
Critchlow, JD | 1 |
Dantas, AP | 1 |
Looft-Wilson, R | 1 |
Murata, T | 1 |
Salomone, S | 1 |
Shin, HK | 1 |
Ayata, C | 1 |
Moskowitz, MA | 2 |
Michel, T | 1 |
Sessa, WC | 1 |
Huang, PL | 2 |
Xu, J | 1 |
Yin, XH | 1 |
Shimizu-Sasamata, M | 1 |
Bosque-Hamilton, P | 1 |
Lo, EH | 1 |
Li, PA | 1 |
Shuaib, A | 1 |
Miyashita, H | 1 |
He, QP | 1 |
Siesjö, BK | 1 |
Warner, DS | 1 |
Hara, T | 1 |
Hamada , J | 1 |
Miyamoto, E | 1 |
Ushio, Y | 1 |
Friguls, B | 1 |
Justicia, C | 1 |
Pallàs, M | 1 |
Planas, AM | 1 |
Hamm, TF | 1 |
Dorman, RV | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
FLOW Trial: Fluoxetine to Open the Critical Period Time Window to Improve Motor Recovery After Stroke[NCT03448159] | Phase 2 | 52 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
36 other studies available for serine and Brain Ischemia
Article | Year |
---|---|
Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Infarction; Mice; Microglia; Receptor, t | 2022 |
Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.
Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Cerebral Cortex; Death-Associated Protein Kina | 2017 |
Nimodipine attenuates tau phosphorylation at Ser396 via miR-132/GSK-3β pathway in chronic cerebral hypoperfusion rats.
Topics: Animals; Apoptosis; Brain Ischemia; Cerebral Cortex; Chronic Disease; Gene Expression Regulation, En | 2018 |
GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; | 2019 |
Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats.
Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Ki | 2019 |
Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia.
Topics: Animals; Astrocytes; Brain Infarction; Brain Ischemia; Cell Death; Cells, Cultured; Connexin 43; Cra | 2013 |
Phosphorylation of neuronal nitric oxide synthase at Ser1412 in the dentate gyrus of rat brain after transient forebrain ischemia.
Topics: Animals; Blotting, Western; Brain Ischemia; Cyclic AMP-Dependent Protein Kinases; Dentate Gyrus; Nit | 2013 |
Fluoxetine and citalopram decrease microglial release of glutamate and D-serine to promote cortical neuronal viability following ischemic insult.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Citalopram; | 2013 |
Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Ischemia; Disease Models, Animal; Female; Humans; Infar | 2014 |
Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.
Topics: Animals; Apoptosis Regulatory Proteins; Brain Ischemia; Diabetes Mellitus, Experimental; Diabetic Ne | 2017 |
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid; | 2009 |
Crucial role for Ser133-phosphorylated form of cyclic AMP-responsive element binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion.
Topics: Animals; Apoptosis; Brain Ischemia; Carotid Stenosis; Cerebral Ventricles; Cerebrovascular Circulati | 2009 |
Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13.
Topics: Animals; Brain Ischemia; Carotid Artery Diseases; Cell Death; Cell Hypoxia; Female; Gerbillinae; Glu | 2009 |
Synthesis of Lipoamino acids and their activity against cerebral ischemic injury.
Topics: Anaerobiosis; Animals; Brain; Brain Ischemia; Hydrogen Peroxide; Neuroprotective Agents; Rats; Serin | 2009 |
Serine racemase deletion protects against cerebral ischemia and excitotoxicity.
Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Cells, Cultured; Cytoprotection; Disease Models, A | 2010 |
Neuroprotective effect of L-serine against temporary cerebral ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, Drug; Glu | 2010 |
Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia.
Topics: Amino Acid Sequence; Animals; Brain Ischemia; Catalytic Domain; Cytoprotection; Disks Large Homolog | 2010 |
[Experimental study of therapeutic time window of L-serine against focal cerebral ischemia/reperfusion injury in rats].
Topics: Animals; Brain Ischemia; Interleukin-6; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats, | 2010 |
Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cognition Disorders; Disease Models, Anim | 2012 |
Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent | 2003 |
Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors.
Topics: Amino Acid Sequence; Animals; Brain Ischemia; Cell Death; Cyclin-Dependent Kinase 5; Cyclin-Dependen | 2003 |
Microglial tau undergoes phosphorylation-independent modification after ischemia.
Topics: Aged; Aged, 80 and over; Antibodies; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Epitopes; | 2004 |
Postsynaptic density protein 95 mediates Ca2+/calmodulin-dependent protein kinase II-activated serine phosphorylation of neuronal nitric oxide synthase during brain ischemia in rat hippocampus.
Topics: Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Depe | 2004 |
PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus.
Topics: Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Depe | 2004 |
Group I metabotropic glutamate receptors mediate the inhibition of phosphatidylserine synthesis in rat cerebellar slices: a possible role in physiology and pathology.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Cerebellum; Electric Stimulation; Excitatory Amino Acid Agoni | 2004 |
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent | 2004 |
Hyperphosphorylation at serine 199/202 of tau factor in the gerbil hippocampus after transient forebrain ischemia.
Topics: Animals; Apoptosis; Binding Sites; Brain Ischemia; Gerbillinae; Hippocampus; Male; Phosphorylation; | 2006 |
Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
Topics: Animals; Antimanic Agents; Brain Infarction; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Ki | 2006 |
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo.
Topics: Alanine; Animals; Aspartic Acid; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; Gene Exp | 2007 |
Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia.
Topics: Analysis of Variance; Animals; Brain Ischemia; Calcineurin; Cell Death; Electrophoretic Mobility Shi | 2007 |
Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade.
Topics: Analysis of Variance; Animals; Baclofen; Brain Ischemia; Disease Models, Animal; Dose-Response Relat | 2008 |
Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene.
Topics: Alanine; Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cortical | 1998 |
Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Glutamic Acid; Glutamine; Glycine; Hyperglycemia; Male; Prosenceph | 2000 |
Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus.
Topics: Androstadienes; Animals; Apoptosis; Brain Ischemia; Enzyme Activation; Enzyme Inhibitors; Gerbillina | 2001 |
Focal cerebral ischemia causes two temporal waves of Akt activation.
Topics: Amino Acid Sequence; Animals; Apoptosis; bcl-Associated Death Protein; Brain Ischemia; Carrier Prote | 2001 |
Arachidonic acid metabolism in gerbil cerebra: effects of ischemia and pentobarbital.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Ischemia; Cerebral Cortex; Choline; Ethanolamine | 1990 |