serine has been researched along with Brain Injuries in 15 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " During long-term administration of thiopental and midazolam, pathologically elevated ventricular CSF glutamate levels were associated with significantly increased glutamine and alanine levels up to 14 days after trauma." | 2.69 | Thiopental and midazolam do not seem to impede metabolism of glutamate in brain-injured patients. ( Kempski, OS; Kossmann, T; Morganti-Kossmann, MC; Pleines, UE; Stocker, R; Stover, JF, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Tapanes, SA | 2 |
| Arizanovska, D | 1 |
| Díaz, MM | 1 |
| Folorunso, OO | 1 |
| Harvey, T | 1 |
| Brown, SE | 1 |
| Radzishevsky, I | 1 |
| Close, LN | 1 |
| Jagid, JR | 1 |
| Graciolli Cordeiro, J | 1 |
| Wolosker, H | 1 |
| Balu, DT | 2 |
| Liebl, DJ | 2 |
| He, Z | 1 |
| Tao, D | 1 |
| Xiong, J | 1 |
| Lou, F | 1 |
| Zhang, J | 1 |
| Chen, J | 1 |
| Dai, W | 1 |
| Sun, J | 1 |
| Wang, Y | 1 |
| Perez, EJ | 1 |
| Loris, ZB | 1 |
| Sick, TJ | 1 |
| Coyle, JT | 1 |
| Cohen-Yeshurun, A | 2 |
| Willner, D | 1 |
| Trembovler, V | 3 |
| Alexandrovich, A | 3 |
| Mechoulam, R | 3 |
| Shohami, E | 3 |
| Leker, RR | 2 |
| Mann, A | 1 |
| Smoum, R | 1 |
| Breuer, A | 1 |
| Zhai, PP | 1 |
| Xu, LH | 1 |
| Yang, JJ | 1 |
| Jiang, ZL | 1 |
| Zhao, GW | 1 |
| Sun, L | 1 |
| Wang, GH | 1 |
| Li, X | 1 |
| Xu, L | 1 |
| Ryu, J | 1 |
| Nguyen, JV | 1 |
| Arena, J | 1 |
| Rha, E | 1 |
| Vranis, P | 1 |
| Hitt, D | 1 |
| Marsh-Armstrong, N | 1 |
| Koliatsos, VE | 1 |
| Lee, HT | 1 |
| Chang, YC | 1 |
| Tu, YF | 1 |
| Huang, CC | 1 |
| Ryberg, E | 1 |
| Greasley, PJ | 1 |
| Brecht, S | 1 |
| Kirchhof, R | 1 |
| Chromik, A | 1 |
| Willesen, M | 1 |
| Nicolaus, T | 1 |
| Raivich, G | 1 |
| Wessig, J | 1 |
| Waetzig, V | 1 |
| Goetz, M | 1 |
| Claussen, M | 1 |
| Pearse, D | 1 |
| Kuan, CY | 1 |
| Vaudano, E | 1 |
| Behrens, A | 1 |
| Wagner, E | 1 |
| Flavell, RA | 1 |
| Davis, RJ | 1 |
| Herdegen, T | 1 |
| Neary, JT | 1 |
| Kang, Y | 1 |
| Tran, M | 1 |
| Feld, J | 1 |
| Palmer, AM | 1 |
| Marion, DW | 1 |
| Botscheller, ML | 1 |
| Swedlow, PE | 1 |
| Styren, SD | 1 |
| DeKosky, ST | 1 |
| Kuchiwaki, H | 1 |
| Inao, S | 1 |
| Yamamoto, M | 1 |
| Yoshida, K | 1 |
| Sugita, K | 1 |
| Stover, JF | 1 |
| Pleines, UE | 1 |
| Morganti-Kossmann, MC | 1 |
| Stocker, R | 1 |
| Kempski, OS | 1 |
| Kossmann, T | 1 |
| Gründig, E | 1 |
| Gerstenbrand, F | 1 |
1 review available for serine and Brain Injuries
| Article | Year |
|---|---|
Phosphorylation of 5-LOX: The Potential Set-point of Inflammation.
Topics: Animals; Arachidonate 5-Lipoxygenase; Brain; Brain Injuries; Humans; Inflammation; Lipoxygenase Inhi | 2020 |
1 trial available for serine and Brain Injuries
| Article | Year |
|---|---|
Thiopental and midazolam do not seem to impede metabolism of glutamate in brain-injured patients.
Topics: Adolescent; Adult; Aged; Alanine; Brain Injuries; Cerebral Ventricles; Glutamic Acid; Glutamine; Hum | 1999 |
13 other studies available for serine and Brain Injuries
| Article | Year |
|---|---|
Inhibition of glial D-serine release rescues synaptic damage after brain injury.
Topics: Amino Acid Transport System ASC; Animals; Astrocytes; Brain Injuries; Humans; Mice; Neuroglia; Neuro | 2022 |
Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury.
Topics: Animals; Astrocytes; Brain; Brain Injuries; Brain Injuries, Traumatic; Cells, Cultured; Gliosis; Glu | 2017 |
N-arachidonoyl-L-serine (AraS) possesses proneurogenic properties in vitro and in vivo after traumatic brain injury.
Topics: Animals; Arachidonic Acids; Astrocytes; Behavior, Animal; Blotting, Western; Brain; Brain Injuries; | 2013 |
Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury.
Topics: Animals; Arachidonic Acids; Brain Injuries; Dose-Response Relationship, Drug; Endocannabinoids; Glyc | 2015 |
Reduction of inflammatory responses by L-serine treatment leads to neuroprotection in mice after traumatic brain injury.
Topics: Animals; Apoptosis; Astrocytes; Brain; Brain Edema; Brain Injuries; Cytokines; Disease Models, Anima | 2015 |
Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Count; Cerebral Cortex; Disease Models, Animal; | 2015 |
CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells.
Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding P | 2010 |
N-arachidonoyl-L-serine is neuroprotective after traumatic brain injury by reducing apoptosis.
Topics: Animals; Apoptosis; Arachidonic Acids; Brain Injuries; Male; Mice; Mitogen-Activated Protein Kinase | 2011 |
Specific pathophysiological functions of JNK isoforms in the brain.
Topics: Animals; Autonomic Denervation; Behavior, Animal; Blotting, Western; Brain; Brain Injuries; Cell Cou | 2005 |
Traumatic injury activates protein kinase B/Akt in cultured astrocytes: role of extracellular ATP and P2 purinergic receptors.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Brain Injuries; Calcium Channels; Cel | 2005 |
Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Brain | 1993 |
An assessment of progression of brain edema with amino acid levels in cerebrospinal fluid and changes in electroencephalogram in an adult cat model of cold brain injury.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cats | 1994 |
[Correlation between Parkinsonism symptoms and a disorder in the amino acid metabolism in CNS].
Topics: Amino Acids; Animals; Brain Injuries; Central Nervous System Diseases; Cerebrospinal Fluid; Cysteine | 1970 |