Page last updated: 2024-11-08

serine and Body Weight

serine has been researched along with Body Weight in 87 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

ExcerptRelevanceReference
"We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively."7.80Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. ( Cho, HS; Jeong, J; Kim, E; Kim, H; Lee, BI; Lee, SK; Namkoong, K; Park, JY; Park, M, 2014)
" We recently developed a lentivirus (LV) vector that produces an insulin receptor (IR) antisense RNA sequence (IRAS) that when injected into the hypothalamus selectively decreases IR signaling in hypothalamus, resulting in increased body weight, peripheral adiposity and plasma leptin levels."7.77Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction. ( Evans, AN; Grillo, CA; Macht, VA; Mott, DD; Piroli, GG; Reagan, LP; Sakai, RR; Scott, KA; Wilson, SP, 2011)
"A defect of the gene for p94 (calpain 3), a skeletal muscle-specific calpain, is responsible for limb girdle muscular dystrophy type 2A (LGMD2A), or 'calpainopathy', which is an autosomal recessive and progressive neuromuscular disorder."7.70Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A. ( Arahata, K; Fukuda, R; Hata, S; Hayashi, Y; Ishiura, S; Karasuyama, H; Katsui, Y; Nakagawa, M; Nonaka, I; Ono, Y; Seyama, Y; Sorimachi, H; Suzuki, K; Tagawa, K; Taya, C; Toyama-Sorimachi, N; Yonekawa, H, 2000)
"Insulin resistance is a hallmark of late pregnancy both in human and rat."5.34Role of insulin receptor substrate-1 serine 307 phosphorylation and adiponectin in adipose tissue insulin resistance in late pregnancy. ( Bocos, C; de Castro, J; Herrera, E; Ramos, MP; Sevillano, J, 2007)
"We compared body weight and food intake among vehicle-, olanzapine-, and olanzapine plus ALA-treated mice, and measured hypothalamic AMP-activated protein kinase (AMPK) activity by detecting levels of Thr(172) and Ser(485/491) phosphorylation, which indicate activation and inhibition of AMPK, respectively."3.80Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. ( Cho, HS; Jeong, J; Kim, E; Kim, H; Lee, BI; Lee, SK; Namkoong, K; Park, JY; Park, M, 2014)
"05) plasma concentrations of glycine and serine, daily weight gain, and body weight without affecting body composition, while reducing plasma concentrations of ammonia, urea, and glutamine, in a dose-dependent manner."3.80Glycine is a nutritionally essential amino acid for maximal growth of milk-fed young pigs. ( Dahanayaka, S; Dai, Z; Hu, S; Jia, S; Lin, G; Wang, W; Wu, G; Wu, Z, 2014)
" We recently developed a lentivirus (LV) vector that produces an insulin receptor (IR) antisense RNA sequence (IRAS) that when injected into the hypothalamus selectively decreases IR signaling in hypothalamus, resulting in increased body weight, peripheral adiposity and plasma leptin levels."3.77Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction. ( Evans, AN; Grillo, CA; Macht, VA; Mott, DD; Piroli, GG; Reagan, LP; Sakai, RR; Scott, KA; Wilson, SP, 2011)
"In the pulmonary artery isolated from 1-week hypoxia-induced pulmonary hypertensive rats, endothelial NO production stimulated by carbachol was decreased significantly in in situ visualization using diaminofluorescein-2 diacetate and also in cGMP content."3.71Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension. ( Hori, M; Karaki, H; Murata, T; Ozaki, H; Sato, K, 2002)
"A defect of the gene for p94 (calpain 3), a skeletal muscle-specific calpain, is responsible for limb girdle muscular dystrophy type 2A (LGMD2A), or 'calpainopathy', which is an autosomal recessive and progressive neuromuscular disorder."3.70Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A. ( Arahata, K; Fukuda, R; Hata, S; Hayashi, Y; Ishiura, S; Karasuyama, H; Katsui, Y; Nakagawa, M; Nonaka, I; Ono, Y; Seyama, Y; Sorimachi, H; Suzuki, K; Tagawa, K; Taya, C; Toyama-Sorimachi, N; Yonekawa, H, 2000)
"/day for 6-8 days) of L-phenylalanine which did not significantly affect body weight or brain to body weight ratios also did not significantly affect myelin accumulation or synthesis in developing rat brain."3.65Tolerance of protein and lipid synthesis to mild hyperphenylalaninemia in developing rat brain. ( Geison, RL; Siegel, FL, 1975)
"Currently, it is known that cerebral toxoplasmosis increases dopamine levels in the brain and it is related to behavioral changes in animals and humans."1.62Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis. ( Acquarone, M; Barbosa, HS; Gonçalves, PFR; Menezes, JRL; Neves, GA; Panizzutti, R; Perozzo, AF; Poleto, A, 2021)
"Glycine, Ser, or Thr were supplemented on Glyequiv basis to an approximately 3% lower CP diet to achieve the same digestible Gly and Ser level as the SP diet."1.51Supplementing glycine, serine, and threonine in low protein diets for meat type chickens. ( Barekatain, R; Girish, CK; Hilliar, M; Huyen, N; Swick, RA; Wu, S, 2019)
"Treatment with telmisartan reversed the abnormalities of PLB amount, coronary flow rate, and -dP/dt in SHRSP fatty rats."1.39Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction. ( Kagota, S; Kunitomo, M; Maruyama, K; Nakamura, K; Shinozuka, K; Tada, Y; Wakuda, H, 2013)
"ADMS rats dominantly exhibited myokymia, neuromyotonia and generalized tonic-clonic seizures."1.38Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures. ( Baulac, S; Ishida, S; Kaneko, S; Kuwamura, M; Mashimo, T; Nishio, T; Ohno, Y; Sakamoto, Y; Serikawa, T; Takizawa, A, 2012)
" There were no treatment-related adverse effects on urinalysis, hematology, serum biochemistry, organ weights, gross and histopathological examination."1.35A 13-week subchronic oral toxicity study of L-serine in rats. ( Han, L; Hayamizu, K; Kaneko, I; Li, C; Li, J; Liang, A; Liu, T; Yi, Y; Zhao, Y, 2009)
"Insulin resistance is a hallmark of late pregnancy both in human and rat."1.34Role of insulin receptor substrate-1 serine 307 phosphorylation and adiponectin in adipose tissue insulin resistance in late pregnancy. ( Bocos, C; de Castro, J; Herrera, E; Ramos, MP; Sevillano, J, 2007)
" This combination effect was found over wide dosage ranges of AC-7700 (20-80 mg/kg) and CDDP (2."1.32Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo. ( Ehara, S; Harada, K; Morinaga, Y; Nihei, Y; Suga, Y; Suzuki, M, 2003)
"Rats were fed toxic levels of methionine with or without simultaneous dietary supplements of glycine and serine."1.29Methionine toxicity in the rat in relation to hepatic accumulation of S-adenosylmethionine: prevention by dietary stimulation of the hepatic transsulfuration pathway. ( Alakuijala, L; Eloranta, TO; Korhonen, VP; Regina, M; Smith, TK, 1993)
"Glycine was partially effective in alleviating the growth depression caused by excess methionine."1.25Methionine toxicity in the chick: nutritional and metabolic implications. ( Baker, DH; Katz, RS, 1975)

Research

Studies (87)

TimeframeStudies, this research(%)All Research%
pre-199042 (48.28)18.7374
1990's7 (8.05)18.2507
2000's14 (16.09)29.6817
2010's20 (22.99)24.3611
2020's4 (4.60)2.80

Authors

AuthorsStudies
Chen, Y1
Chen, X1
Li, X1
Liu, Y1
Guo, Y1
Wang, Z1
Dong, Z1
Hilliar, M1
Huyen, N1
Girish, CK1
Barekatain, R1
Wu, S2
Swick, RA1
Wang, CF1
Cai, XR1
Chi, YN1
Miao, XY1
Yang, JY1
Xiao, BK1
Huang, RQ1
Miura, N1
Matsumoto, H1
Cynober, L1
Stover, PJ1
Elango, R1
Kadowaki, M1
Bier, DM1
Smriga, M1
Acquarone, M1
Poleto, A1
Perozzo, AF1
Gonçalves, PFR1
Panizzutti, R1
Menezes, JRL1
Neves, GA1
Barbosa, HS1
Nagamachi, S1
Nishigawa, T1
Takakura, M1
Ikeda, H1
Kodaira, M1
Yamaguchi, T1
Chowdhury, VS1
Yasuo, S1
Furuse, M1
Hernández-Alonso, P1
Giardina, S1
Cañueto, D1
Salas-Salvadó, J1
Cañellas, N1
Bulló, M1
Suwandhi, L1
Hausmann, S1
Braun, A1
Gruber, T1
Heinzmann, SS1
Gálvez, EJC1
Buck, A1
Legutko, B1
Israel, A1
Feuchtinger, A1
Haythorne, E1
Staiger, H1
Heni, M1
Häring, HU1
Schmitt-Kopplin, P1
Walch, A1
Cáceres, CG1
Tschöp, MH1
Rutter, GA1
Strowig, T1
Elsner, M1
Ussar, S1
Okabe, K1
Usui, I1
Yaku, K1
Hirabayashi, Y1
Tobe, K1
Nakagawa, T1
Kobayashi, M1
Matsuda, Y1
Iwai, H1
Hiramitsu, M1
Inoue, T1
Katagiri, T1
Yamashita, Y1
Ashida, H1
Murai, A1
Horio, F1
Kagota, S1
Maruyama, K2
Tada, Y1
Wakuda, H1
Nakamura, K1
Kunitomo, M1
Shinozuka, K1
Savignac, HM1
Corona, G1
Mills, H1
Chen, L1
Spencer, JP1
Tzortzis, G1
Burnet, PW1
Kim, H1
Park, M1
Lee, SK1
Jeong, J1
Namkoong, K1
Cho, HS1
Park, JY1
Lee, BI1
Kim, E1
Wang, W1
Dai, Z1
Wu, Z1
Lin, G1
Jia, S1
Hu, S1
Dahanayaka, S1
Wu, G1
Othman, A1
Bianchi, R1
Alecu, I1
Wei, Y1
Porretta-Serapiglia, C1
Lombardi, R1
Chiorazzi, A1
Meregalli, C1
Oggioni, N1
Cavaletti, G1
Lauria, G1
von Eckardstein, A1
Hornemann, T1
Ericsson, A1
Turner, N1
Hansson, GI1
Wallenius, K1
Oakes, ND1
Wu, Y1
Song, P1
Zhang, W1
Liu, J1
Dai, X1
Liu, Z1
Lu, Q1
Ouyang, C1
Xie, Z1
Zhao, Z1
Zhuo, X1
Viollet, B1
Foretz, M1
Wu, J1
Yuan, Z1
Zou, MH1
Vanella, L1
Canestraro, M1
Lee, CR1
Cao, J1
Zeldin, DC1
Schwartzman, ML1
Abraham, NG1
Kaneko, I1
Han, L1
Liu, T1
Li, J1
Zhao, Y1
Li, C1
Yi, Y1
Liang, A1
Hayamizu, K1
Antflick, JE1
Baker, GB1
Hampson, DR1
Scattoni, ML1
Gasparini, L1
Alleva, E1
Goedert, M1
Calamandrei, G1
Spillantini, MG1
Grillo, CA1
Piroli, GG1
Evans, AN1
Macht, VA1
Wilson, SP1
Scott, KA1
Sakai, RR1
Mott, DD1
Reagan, LP1
Jiang, H1
Fang, J1
Wu, B1
Yin, G1
Sun, L1
Qu, J1
Barger, SW1
Ishida, S1
Sakamoto, Y1
Nishio, T1
Baulac, S1
Kuwamura, M1
Ohno, Y1
Takizawa, A1
Kaneko, S1
Serikawa, T1
Mashimo, T1
Dagon, Y1
Hur, E1
Zheng, B1
Wellenstein, K1
Cantley, LC1
Kahn, BB1
Murata, T1
Sato, K1
Hori, M1
Ozaki, H1
Karaki, H1
Morinaga, Y1
Suga, Y1
Ehara, S1
Harada, K1
Nihei, Y2
Suzuki, M2
Rangwala, SM1
Rhoades, B1
Shapiro, JS1
Rich, AS1
Kim, JK1
Shulman, GI2
Kaestner, KH1
Lazar, MA1
Levine, S1
Saltzman, A1
Araújo, EP1
De Souza, CT1
Gasparetti, AL1
Ueno, M1
Boschero, AC1
Saad, MJ1
Velloso, LA1
Morino, K1
Petersen, KF1
Dufour, S1
Befroy, D1
Frattini, J1
Shatzkes, N1
Neschen, S1
White, MF1
Bilz, S1
Sono, S1
Pypaert, M1
Schenck, EJ1
Brooks, CL1
Takasaki, C1
Miura, E1
Watanabe, M1
Sevillano, J1
de Castro, J1
Bocos, C1
Herrera, E1
Ramos, MP1
Tsai, GE1
Lane, HY1
Vandenberg, CM1
Liu, YC1
Tsai, P1
Jann, MW1
Vinayagamoorthi, R1
Bobby, Z1
Sridhar, MG1
Benevenga, NJ2
Harper, AE5
de Moraes, GH1
Rogler, JC1
Featherston, WR2
Betzin, B1
Bergner, H1
Simon, O1
Hiasa, Y1
Enoki, N1
Kitahori, Y1
Konishi, N1
Shimoyama, T1
Davis, AT1
Austic, RE1
Regina, M1
Korhonen, VP1
Smith, TK1
Alakuijala, L1
Eloranta, TO1
Sleet, RB1
Ross, WP1
Qu, S1
Perlaky, SE1
Organ, EL1
Crawford, D1
Cavener, DR1
Hori, K1
Saito, S1
Sato, Y1
Tagawa, K1
Taya, C1
Hayashi, Y1
Nakagawa, M1
Ono, Y1
Fukuda, R1
Karasuyama, H1
Toyama-Sorimachi, N1
Katsui, Y1
Hata, S1
Ishiura, S1
Nonaka, I1
Seyama, Y1
Arahata, K1
Yonekawa, H1
Sorimachi, H1
Suzuki, K1
Hamada, M1
Yamamoto, S1
Moriguchi, S1
Kishino, Y1
Combe, E1
Pesti, GM1
Sunde, ML2
Ngo, A1
Coon, C1
Holcenberg, JS1
Tang, E1
Dolowy, WC1
Katz, RS1
Baker, DH2
Geison, RL1
Siegel, FL1
Pathirana, C1
Grimble, RF1
Chen, XZ1
Shafer, AW1
Yun, JS1
Li, YS1
Wagner, TE1
Kopchick, JJ1
Gonçalves, CA1
Salbego, C1
Wofchuk, S1
Rocha, E1
Souza, DO1
Rathbun, WE1
Druse, MJ1
de Boer, JE1
Oostenbroek, RJ1
van Dongen, JJ1
Janssen, MA1
Soeters, PB1
Stöckl, W1
Jöchle, W1
Aoyama, Y1
Yasui, H1
Ashida, K1
Toya, RE1
Kretchmar, AL1
Price, EJ1
Girard-Globa, A1
Robin, P1
Forestier, M1
Coon, CN1
Grossie, VB1
Couch, JR1
Kruger, BJ1
Snell, EE1
Salem, SI1
Hegazi, SM1
Morcos, SR1
Boomgaardt, J1
Kurtz, DJ1
Kanfer, JN1
Adibi, SA1
Modesto, TA1
Morse, EL1
Amin, PM1
Rabbani, A1
Akrabawi, S1
Daghir, NJ2
Gaitonde, MK1
Nixey, RW1
Sharman, IM1
Cross, DL1
Ludwick, RL1
Boling, JA1
Bradley, NW1
Sifri, M1
Asmar, JA1
Tasaki, I1
Ono, T1
Baumgartner, R1
Ando, T1
Nyhan, WL1
Lakhanpal, RK1
Harrill, I1
Bowman, F1
Rogers, QR1
Chen, DM1
Katz, SI1
Edwards, CH1
Booker, LK1
Rumph, CH1
Wright, WG1
Ganapathy, SN1
Akrabawi, SS1
Kratzer, FH1
Gershoff, SN1
Gill, TJ1
Simonian, SJ1
Steinberg, AI1
Oltjen, RR1
Lehmann, RP1
Womack, M1
Sonenberg, M1
Money, WL1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Gut Microbial Remodeling With Resistant Maltodextrin for Motor and Non-motor Symptoms in Parkinson's Disease: Safety and Tolerability Study[NCT03667404]Phase 230 participants (Anticipated)Interventional2018-11-06Active, not recruiting
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in Pulmonary Arterial Hypertension[NCT03979482]30 participants (Actual)Observational2019-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for serine and Body Weight

ArticleYear
Relation of chemical structure to metabolic activity of vitamin B 6 .
    Advances in biochemical psychopharmacology, 1972, Volume: 4

    Topics: Animals; Apoproteins; Aspartate Aminotransferases; Body Weight; Catalysis; Chemical Phenomena; Chemi

1972

Trials

3 trials available for serine and Body Weight

ArticleYear
Subchronic Tolerance Trials of Graded Oral Supplementation with Phenylalanine or Serine in Healthy Adults.
    Nutrients, 2021, Jun-08, Volume: 13, Issue:6

    Topics: Administration, Oral; Adult; Body Weight; Dietary Supplements; Energy Intake; Female; Health; Humans

2021
Changes in Plasma Metabolite Concentrations after a Low-Glycemic Index Diet Intervention.
    Molecular nutrition & food research, 2019, Volume: 63, Issue:1

    Topics: Adult; Biomarkers; Blood Glucose; Body Weight; Diet; Diet, Fat-Restricted; Female; Glycemic Index; H

2019
Utilization of wheat by adult man: nitrogen metabolism, plasma amino acids and lipids.
    The American journal of clinical nutrition, 1971, Volume: 24, Issue:2

    Topics: Adult; Amino Acids; Aminobutyrates; Blood Pressure; Blood Urea Nitrogen; Body Weight; Cholesterol; D

1971

Other Studies

83 other studies available for serine and Body Weight

ArticleYear
Effects of bisphenol AF on growth, behavior, histology and gene expression in marine medaka (Oryzias melastigma).
    Chemosphere, 2022, Volume: 308, Issue:Pt 3

    Topics: Animals; Antioxidants; Aromatase; Benzhydryl Compounds; Body Weight; Catalase; Complement C5; Diacyl

2022
Supplementing glycine, serine, and threonine in low protein diets for meat type chickens.
    Poultry science, 2019, Dec-01, Volume: 98, Issue:12

    Topics: Animal Feed; Animals; Body Weight; Chickens; Diet, Protein-Restricted; Dietary Supplements; Glycine;

2019
Analgesic Activity of Jin Ling Zi Powder and Its Single Herbs: A Serum Metabonomics Study.
    Chinese journal of integrative medicine, 2022, Volume: 28, Issue:11

    Topics: Analgesics; Animals; Aspirin; Biomarkers; Body Weight; Drugs, Chinese Herbal; Glycine; Glyoxylates;

2022
Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis.
    Scientific reports, 2021, 07-07, Volume: 11, Issue:1

    Topics: Animals; Behavior, Animal; Body Weight; Brain; Glutamic Acid; Hippocampus; Mental Disorders; Mice; N

2021
Dietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice.
    The Journal of veterinary medical science, 2018, Feb-09, Volume: 80, Issue:2

    Topics: Amino Acids; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Diet; Female; Lactation; Male

2018
Chronic d-serine supplementation impairs insulin secretion.
    Molecular metabolism, 2018, Volume: 16

    Topics: Animals; Blood Glucose; Body Weight; Diet, High-Fat; Dietary Supplements; Energy Metabolism; Glucose

2018
Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice.
    Biochemical and biophysical research communications, 2018, 09-26, Volume: 504, Issue:1

    Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Body Weight; Diet; Female; Gene D

2018
Coffee improves insulin-stimulated Akt phosphorylation in liver and skeletal muscle in diabetic KK-A(y) mice.
    Journal of nutritional science and vitaminology, 2012, Volume: 58, Issue:6

    Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Coffee; Diabetes Mellitus, Experimental; Hyperg

2012
Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:2

    Topics: Animals; Benzimidazoles; Benzoates; Blood Glucose; Body Weight; Calcium; Calcium-Binding Proteins; C

2013
Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine.
    Neurochemistry international, 2013, Volume: 63, Issue:8

    Topics: Amino Acids; Animals; Bifidobacterium; Body Weight; Brain-Derived Neurotrophic Factor; Cell Line, Tu

2013
Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine.
    Psychopharmacology, 2014, Volume: 231, Issue:20

    Topics: AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Antipsychotic Agents; Benzodiazepines;

2014
Glycine is a nutritionally essential amino acid for maximal growth of milk-fed young pigs.
    Amino acids, 2014, Volume: 46, Issue:8

    Topics: Adenosine Triphosphatases; Amino Acid Transport Systems; Ammonia; Animal Feed; Animal Nutritional Ph

2014
Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats.
    Diabetes, 2015, Volume: 64, Issue:3

    Topics: Animals; Body Weight; Diabetic Neuropathies; Eating; Electrophysiology; Hereditary Sensory and Auton

2015
Pharmacological PPARα activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: Animals; Arginase; Arginine; Body Weight; Calorimetry, Indirect; Glycine; Liver; Male; Nitrogen; PPA

2014
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.
    Nature medicine, 2015, Volume: 21, Issue:4

    Topics: Adipocytes; Adiposity; AMP-Activated Protein Kinases; Animals; Body Composition; Body Weight; Dual S

2015
Soluble epoxide hydrolase null mice exhibit female and male differences in regulation of vascular homeostasis.
    Prostaglandins & other lipid mediators, 2015, Volume: 120

    Topics: Animals; Blood Vessels; Body Weight; Cytokines; Eicosanoids; Epoxide Hydrolases; Female; Gene Expres

2015
A 13-week subchronic oral toxicity study of L-serine in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009, Volume: 47, Issue:9

    Topics: Administration, Oral; Animals; Blood Chemical Analysis; Body Weight; Eating; Female; Food Additives;

2009
The effects of a low protein diet on amino acids and enzymes in the serine synthesis pathway in mice.
    Amino acids, 2010, Volume: 39, Issue:1

    Topics: Amino Acids; Animals; Body Weight; Diet; Dietary Proteins; L-Serine Dehydratase; Male; Mice; Mice, I

2010
Early behavioural markers of disease in P301S tau transgenic mice.
    Behavioural brain research, 2010, Mar-17, Volume: 208, Issue:1

    Topics: Age Factors; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain; Cues; Disease Mode

2010
Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction.
    Physiology & behavior, 2011, Aug-03, Volume: 104, Issue:2

    Topics: Adiposity; Animals; Area Under Curve; Autoradiography; Body Weight; Corticosterone; Disease Models,

2011
Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy.
    Journal of neuroinflammation, 2011, Sep-22, Volume: 8

    Topics: Animals; Aqueous Humor; Blood Glucose; Body Weight; Cell Death; Diabetes Mellitus, Experimental; Dia

2011
Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
    Brain research, 2012, Jan-30, Volume: 1435

    Topics: Animals; Antiemetics; Biophysical Phenomena; Biotinylation; Body Weight; Carbamazepine; Cells, Cultu

2012
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.
    Cell metabolism, 2012, Jul-03, Volume: 16, Issue:1

    Topics: Adenylate Kinase; Agouti-Related Protein; Animals; Body Weight; Cell Line; Eating; Hypothalamus; Lep

2012
Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension.
    The Journal of biological chemistry, 2002, Nov-15, Volume: 277, Issue:46

    Topics: Animals; Blotting, Western; Body Weight; Calcium; Carbachol; Cell Membrane; Cyclic GMP; Electrophore

2002
Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo.
    Cancer science, 2003, Volume: 94, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Col

2003
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity.
    Developmental cell, 2003, Volume: 5, Issue:4

    Topics: Adiponectin; Adipose Tissue; Adipose Tissue, Brown; Alanine; Amino Acid Substitution; Animals; Blood

2003
Hydropic degeneration of the anterior pituitary gland (adenohypophysis) in uremic rats.
    Toxicology letters, 2004, Mar-01, Volume: 147, Issue:2

    Topics: Animals; Body Water; Body Weight; Diet; Hyponatremia; Kidney Tubular Necrosis, Acute; Male; Mercuric

2004
Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity.
    Endocrinology, 2005, Volume: 146, Issue:3

    Topics: Adipose Tissue; Animals; Body Weight; Epididymis; Glucose; Glucose Clamp Technique; Glucose Toleranc

2005
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
    The Journal of clinical investigation, 2005, Volume: 115, Issue:12

    Topics: Biopsy; Blood Glucose; Blotting, Western; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; D

2005
Effects of an S84E mutation of bovine growth hormone in transgenic mice.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:3

    Topics: Acetic Acid; Animals; Blotting, Southern; Body Weight; Female; Glutamic Acid; Growth Hormone; Insuli

2006
Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney.
    Biomedical research (Tokyo, Japan), 2007, Volume: 28, Issue:2

    Topics: Amino Acid Transport System ASC; Animals; Body Weight; Brain; Gene Expression Regulation; Gene Expre

2007
Role of insulin receptor substrate-1 serine 307 phosphorylation and adiponectin in adipose tissue insulin resistance in late pregnancy.
    Endocrinology, 2007, Volume: 148, Issue:12

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adaptor Proteins, Signal Transducing; Adiponectin; Adi

2007
Disposition of D-serine in healthy adults.
    Journal of clinical pharmacology, 2008, Volume: 48, Issue:4

    Topics: Adult; Area Under Curve; Biotransformation; Body Weight; Female; Half-Life; Humans; Male; Models, St

2008
Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance.
    The Journal of endocrinology, 2008, Volume: 197, Issue:2

    Topics: Animals; Antioxidants; Body Weight; Cells, Cultured; Dietary Fats; Hydrogen Peroxide; Insulin; Insul

2008
Alleviation of methionine and homocystine toxicity in the rat.
    The Journal of nutrition, 1967, Volume: 93, Issue:1

    Topics: Amino Acids; Animals; Body Weight; Diet; Glycine; Growth; Homocystine; Male; Methionine; Rats; Serin

1967
Effects of a nonspecific nitrogen deficiency on growth rate and leg problems in chicks.
    Poultry science, 1984, Volume: 63, Issue:2

    Topics: Amino Acids, Essential; Animals; Body Weight; Bone Diseases, Metabolic; Chickens; Glutamates; Glutam

1984
[Investigation of the feed value of straw].
    Archiv fur Tierernahrung, 1980, Volume: 30, Issue:6

    Topics: Animal Feed; Animals; Arginine; Body Weight; Dietary Fiber; Digestion; Edible Grain; Glutamates; Iso

1980
DL-Serine: promoting activity on renal tumorigenesis by N-ethyl-N-hydroxyethylnitrosamine in rats.
    Journal of the National Cancer Institute, 1984, Volume: 73, Issue:1

    Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Drug Synergism; Kidney; Kidney Neoplasms; Mal

1984
Threonine imbalance and the threonine requirement of the chicken.
    The Journal of nutrition, 1982, Volume: 112, Issue:11

    Topics: Amino Acids; Animals; Body Weight; Chickens; Diet; Dose-Response Relationship, Drug; Female; Male; N

1982
Methionine toxicity in the rat in relation to hepatic accumulation of S-adenosylmethionine: prevention by dietary stimulation of the hepatic transsulfuration pathway.
    Archives of biochemistry and biophysics, 1993, Feb-01, Volume: 300, Issue:2

    Topics: Amino Acids; Animals; Body Weight; Diet; Feeding Behavior; Glycine; Kidney; Liver; Male; Methionine;

1993
Serine-enhanced restoration of 2-methoxyethanol-induced dysmorphogenesis in the rat embryo and near-term fetus.
    Toxicology and applied pharmacology, 1997, Volume: 145, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Drug Combinations; Embryonic and Fetal Developmen

1997
Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster.
    Gene expression, 1997, Volume: 6, Issue:6

    Topics: Alanine; Amino Acid Substitution; Animals; Animals, Genetically Modified; Aspartic Acid; Body Weight

1997
Antitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700.
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:9

    Topics: Animals; Antineoplastic Agents; Blood Pressure; Body Weight; Disease Models, Animal; Drug Screening

1999
Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A.
    Human molecular genetics, 2000, May-22, Volume: 9, Issue:9

    Topics: Animals; Binding Sites; Body Weight; Calpain; Connectin; Cysteine; Female; Immunohistochemistry; Mic

2000
Phagocytosis of alveolar macrophages after conagenin injection to rats.
    The Journal of antibiotics, 2001, Volume: 54, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Body Weight; Dose-Response Relationship, Drug; Erythrocytes; Inject

2001
[Influence of intestinal microflora on the amino acid composition of lamb feces].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1976, Volume: 170, Issue:4

    Topics: Amino Acids; Animals; Bacterial Proteins; Body Weight; Feces; Germ-Free Life; Lysine; Male; Nitrogen

1976
Sulfur amino acid and methyl donor status of corn-soy diets fed to starting broiler chicks and turkey poults.
    Poultry science, 1979, Volume: 58, Issue:6

    Topics: Amino Acids, Sulfur; Animal Feed; Animals; Arginine; Betaine; Body Weight; Chickens; Choline; Cystin

1979
The effect of feeding various levels of dietary glycine in a pre-experimental diet to one-day old chicks on their subsequent glycine plus serine requirement.
    Poultry science, 1976, Volume: 55, Issue:5

    Topics: Animal Feed; Animals; Body Weight; Caseins; Chickens; Glycine; Male; Nutritional Requirements; Serin

1976
Effect of Acinetobacter glutaminase-asparaginase treatment on free amino acids in mouse tissues.
    Cancer research, 1975, Volume: 35, Issue:5

    Topics: Acetyltransferases; Acinetobacter; Amino Acids; Ammonia; Animals; Asparaginase; Asparagine; Aspartic

1975
Methionine toxicity in the chick: nutritional and metabolic implications.
    The Journal of nutrition, 1975, Volume: 105, Issue:9

    Topics: Adenine; Amino Acids; Animals; Arginine; Blood Glucose; Body Weight; Chickens; Glycine; Hypoglycemia

1975
Relative utilization of serine and glycine by chicks.
    Poultry science, 1975, Volume: 54, Issue:1

    Topics: Animal Feed; Animals; Body Weight; Chickens; Cystine; Feces; Glutamine; Glycine; Glycine max; Male;

1975
Tolerance of protein and lipid synthesis to mild hyperphenylalaninemia in developing rat brain.
    Brain research, 1975, Jul-18, Volume: 92, Issue:3

    Topics: Acetates; Animals; Body Weight; Brain; Brain Stem; Cerebellum; Glycolipids; Leucine; Lipids; Mesence

1975
Taurine and serine supplementation modulates the metabolic response to tumor necrosis factor alpha in rats fed a low protein diet.
    The Journal of nutrition, 1992, Volume: 122, Issue:7

    Topics: Acute-Phase Proteins; Animals; Body Weight; Caseins; Ceruloplasmin; Dietary Proteins; Glutathione; K

1992
Conversion of bovine growth hormone cysteine residues to serine affects secretion by cultured cells and growth rates in transgenic mice.
    Molecular endocrinology (Baltimore, Md.), 1992, Volume: 6, Issue:4

    Topics: Amino Acid Sequence; Animals; Blotting, Western; Body Weight; Cattle; Cells, Cultured; Cysteine; Dis

1992
Effects of undernutrition during suckling on phosphoryl serine levels in nuclear and synaptosomal proteins from cerebral cortex of rats.
    The Journal of nutrition, 1990, Volume: 120, Issue:6

    Topics: Animals; Animals, Suckling; Body Weight; Cerebral Cortex; Deficiency Diseases; Dietary Proteins; DNA

1990
Maternal undernutrition during lactation: effect on amino acids in brain regions of offspring.
    Journal of neurochemistry, 1985, Volume: 45, Issue:6

    Topics: Amino Acids; Animals; Aspartic Acid; Body Weight; Brain Chemistry; Corpus Striatum; Female; gamma-Am

1985
Sequential metabolic characteristics following portacaval shunt in rats.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1986, Volume: 18, Issue:2

    Topics: Amino Acids; Animals; Body Weight; Glucagon; Insulin; Isoleucine; Leucine; Male; Phenylalanine; Port

1986
Corticosteroid induced changes in plasma amino acids and thyroid activity in dairy cows treated early or late during lactation.
    Journal of dairy science, 1971, Volume: 54, Issue:2

    Topics: Adrenal Cortex Hormones; Amino Acids; Animals; Body Weight; Cattle; Dexamethasone; Female; Flumethas

1971
Effect of dietary protein and amino acids in a choline-deficient diet on lipid accumulation in rat liver.
    The Journal of nutrition, 1971, Volume: 101, Issue:6

    Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Body Composition; Body Weight; Cas

1971
Altered lipid and serine metabolism in graft-versus-host disease.
    Radiation research, 1971, Volume: 46, Issue:3

    Topics: Animals; Body Weight; Carbon Dioxide; Chromatography, Thin Layer; Formates; Graft vs Host Disease; G

1971
Long-term adaptation of weanling rats to high dietary levels of methionine and serine.
    The Journal of nutrition, 1972, Volume: 102, Issue:2

    Topics: Adaptation, Biological; Adrenal Cortex Hormones; Amino Acids; Animal Nutritional Physiological Pheno

1972
Glycine-serine requirement for chicks.
    Poultry science, 1974, Volume: 53, Issue:5

    Topics: Age Factors; Amino Acids; Animal Feed; Animals; Body Weight; Chickens; Female; Glucose; Glycine; Mal

1974
Utilization of ( 3 H)-serine by ameloblasts of rats receiving sub-mottling doses of fluoride.
    Archives of oral biology, 1972, Volume: 17, Issue:10

    Topics: Ameloblasts; Animals; Autoradiography; Body Weight; Dental Enamel; Fluorides; Fluorosis, Dental; Inj

1972
Experimental protein-energy deficiency in rats. Ratio of serine+glycine to threonine as an index of deficiency.
    The British journal of nutrition, 1973, Volume: 29, Issue:1

    Topics: Amino Acids; Animals; Blood Proteins; Body Weight; Chromatography; Diarrhea; Dietary Proteins; Edema

1973
Sequence of limiting amino acids in gelatin for the growing chick.
    Poultry science, 1972, Volume: 51, Issue:5

    Topics: Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Arginine; Body Weight

1972
Effect of D-alanine and D-aspartic acid on the chick.
    The Journal of nutrition, 1972, Volume: 102, Issue:11

    Topics: Alanine; Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Asparagine; Aspartic Acid

1972
Composition of myelin lipids and synthesis of 3-ketodihydrosphingosine in the vitamin B 6 -deficient developing rat.
    Journal of neurochemistry, 1973, Volume: 20, Issue:4

    Topics: Animals; Animals, Newborn; Body Weight; Brain; Carbon Isotopes; Cerebrosides; Chromatography, Gas; C

1973
Amino acid levels in plasma, liver, and skeletal muscle during protein deprivation.
    The American journal of physiology, 1973, Volume: 225, Issue:2

    Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Body Weight; Glutamates; Glutamine; Glycin

1973
Effect of dietary folic acid deficiency on serine-glycine interconversion and the activity of liver serine hydroxymethyl transferase in the chick.
    Poultry science, 1973, Volume: 52, Issue:5

    Topics: Animal Feed; Animals; Body Weight; Chickens; Diet; Folic Acid; Folic Acid Deficiency; Glycine; In Vi

1973
The effect of deficiency of thiamine on the metabolism of (U-14C)glucose and (U-14C)ribose and the levels of amino acids in rat brain.
    Journal of neurochemistry, 1974, Volume: 22, Issue:1

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Body Weight; Brain; Carbon Radioisotop

1974
Plasma and rumen fluid components of steers fed two sources and levels of nitrogen.
    Journal of animal science, 1974, Volume: 38, Issue:2

    Topics: Administration, Oral; Amino Acids; Amino Acids, Essential; Ammonia; Animal Feed; Animals; Arginine;

1974
Serum aminotransferase activities and plasma free amino acid concentration as criteria for pyridoxine nutritional status of chicks.
    The British journal of nutrition, 1972, Volume: 28, Issue:2

    Topics: Alanine Transaminase; Amino Acids; Aminobutyrates; Ammonia; Animal Nutritional Physiological Phenome

1972
Effect of dietary protein level on plasma free amino acids in the chicken.
    The Journal of nutrition, 1971, Volume: 101, Issue:9

    Topics: Alanine; Amino Acids; Animals; Blood; Body Weight; Caseins; Chickens; Depression, Chemical; Dietary

1971
Nonketotic hyperglycinemia.
    The Journal of pediatrics, 1969, Volume: 75, Issue:6

    Topics: Agranulocytosis; Amino Acid Metabolism, Inborn Errors; Benzoates; Body Weight; Carbon Isotopes; Diet

1969
Effect of protein and riboflavin on plasma amino acids and hepatic riboflavin-coenzymes in the rat.
    The Journal of nutrition, 1969, Volume: 99, Issue:4

    Topics: Amino Acids; Analysis of Variance; Animals; Body Weight; Caseins; Depression, Chemical; Diet; Dietar

1969
The importance of dispensable amino acids for maximal growth in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1970, Volume: 134, Issue:2

    Topics: Alanine; Amino Acids; Animals; Arginine; Asparagine; Aspartic Acid; Body Weight; Citrates; Diet; Glu

1970
Effect of glycine and serine on methionine metabolism in rats fed diets high in methionine.
    The Journal of nutrition, 1970, Volume: 100, Issue:10

    Topics: Adaptation, Physiological; Animal Feed; Animals; Body Weight; Carbon Isotopes; Glycine; Intestinal A

1970
The amino acid ratio and hydroxyproline creatinine index in marginal protein-calorie malnutrition.
    Tropical and geographical medicine, 1970, Volume: 22, Issue:4

    Topics: Amino Acids; Animals; Body Weight; Child, Preschool; Chromatography, Paper; Creatinine; Diet; Female

1970
Effects of arginine or serine on the requirement for glycine by the chick.
    The Journal of nutrition, 1968, Volume: 95, Issue:1

    Topics: Animals; Arginine; Body Weight; Chickens; Glycine; Serine

1968
Some effects of amino acid deficiencies on antibody formation in the rat.
    The Journal of nutrition, 1968, Volume: 95, Issue:2

    Topics: Amino Acids; Animals; Antibody Formation; Antigens; Antimetabolites; Body Weight; Deficiency Disease

1968
Effect of diethylstilbestrol on the blood plasma amino acid patterns of beef steers fed finishing diets.
    The Journal of nutrition, 1968, Volume: 95, Issue:3

    Topics: Amino Acids; Animals; Autoanalysis; Body Weight; Cattle; Chromatography, Ion Exchange; Depression, C

1968
Amino acid feeding studies: effects of various nonessential nitrogen sources and of added water.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1969, Volume: 131, Issue:3

    Topics: Alanine; Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Aspartic Acid; Body Weigh

1969
Inhibition of bovine growth hormone activity by acetyl proteins.
    The Journal of endocrinology, 1966, Volume: 35, Issue:1

    Topics: Acetates; Albumins; Animals; Antimetabolites; Body Weight; Caseins; Cattle; Growth Hormone; Hypophys

1966