serine has been researched along with Bipolar Disorder in 21 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Increased plasma levels of glutamate as well as higher glutamine+glutamate levels in the brain have been demonstrated in patients with bipolar disorder as compared to healthy controls." | 3.81 | Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls. ( Ågren, H; Ekman, CJ; Fujita, Y; Hashimoto, K; Jakobsson, J; Landén, M; Pålsson, E; Sellgren, C; Södersten, K, 2015) |
| " This finding in human bipolar disorder is in agreement with preclinical data suggesting that inhibition of GSK3 by increasing serine phosphorylation is a response of GSK3 to psychotropics used in bipolar disorder, supporting the notion that GSK3 is a promising molecular target in the pharmacological treatment of bipolar disorder." | 3.76 | Regulation of glycogen synthase kinase-3 during bipolar mania treatment. ( Cai, Z; Li, X; Liu, M; Wang, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Murtas, G | 1 |
| Pollegioni, L | 1 |
| Molla, G | 1 |
| Sacchi, S | 1 |
| Li, C | 1 |
| Wang, A | 1 |
| Wang, C | 1 |
| Ramamurthy, J | 1 |
| Zhang, E | 1 |
| Guadagno, E | 1 |
| Trakadis, Y | 1 |
| Pandey, GN | 1 |
| Rizavi, HS | 1 |
| Tripathi, M | 1 |
| Ren, X | 1 |
| Pålsson, E | 1 |
| Jakobsson, J | 1 |
| Södersten, K | 1 |
| Fujita, Y | 1 |
| Sellgren, C | 1 |
| Ekman, CJ | 1 |
| Ågren, H | 1 |
| Hashimoto, K | 2 |
| Landén, M | 1 |
| Yasseen, B | 1 |
| Kennedy, JL | 2 |
| Zawertailo, LA | 1 |
| Busto, UE | 1 |
| Lin, CI | 1 |
| Lee, SY | 1 |
| Chang, YH | 1 |
| Wu, JY | 1 |
| Wu, YS | 1 |
| Wu, PL | 1 |
| Chen, HC | 1 |
| Chen, SL | 1 |
| Lee, IH | 1 |
| Yeh, TL | 1 |
| Yang, YK | 1 |
| Ko, HC | 1 |
| Lu, RB | 1 |
| Li, X | 2 |
| Liu, M | 1 |
| Cai, Z | 1 |
| Wang, G | 1 |
| Kristensen, LV | 1 |
| Sandager-Nielsen, K | 1 |
| Hansen, HH | 1 |
| Massat, I | 2 |
| Lerer, B | 2 |
| Souery, D | 2 |
| Blackwood, D | 2 |
| Muir, W | 2 |
| Kaneva, R | 2 |
| Nöthen, MM | 2 |
| Oruc, L | 2 |
| Papadimitriou, GN | 2 |
| Dikeos, D | 1 |
| Serretti, A | 3 |
| Bellivier, F | 1 |
| Golmard, JL | 1 |
| Milanova, V | 2 |
| Del-Favero, J | 1 |
| Van Broeckhoven, C | 2 |
| Mendlewicz, J | 2 |
| Masui, T | 1 |
| Hashimoto, R | 1 |
| Kusumi, I | 1 |
| Suzuki, K | 1 |
| Tanaka, T | 1 |
| Nakagawa, S | 1 |
| Suzuki, T | 1 |
| Iwata, N | 1 |
| Ozaki, N | 1 |
| Kato, T | 1 |
| Takeda, M | 1 |
| Kunugi, H | 1 |
| Koyama, T | 1 |
| Dracheva, S | 1 |
| Patel, N | 1 |
| Woo, DA | 1 |
| Marcus, SM | 1 |
| Siever, LJ | 1 |
| Haroutunian, V | 1 |
| Reiners, J | 1 |
| Schmidt, M | 1 |
| Packer, J | 1 |
| Unger, L | 1 |
| Wernet, W | 1 |
| Heckenlively, J | 1 |
| Fekkes, D | 2 |
| Pepplinkhuizen, L | 2 |
| Verheij, R | 1 |
| Bruinvels, J | 2 |
| Rietschel, M | 2 |
| Lannfelt, L | 1 |
| Sokoloff, P | 1 |
| Schwartz, JC | 1 |
| Lanczik, M | 1 |
| Fritze, J | 1 |
| Cichon, S | 1 |
| Fimmers, R | 1 |
| Körner, J | 1 |
| Sasaki, T | 1 |
| Macciardi, FM | 1 |
| Badri, F | 1 |
| Verga, M | 1 |
| Meltzer, HY | 1 |
| Lieberman, J | 1 |
| Howard, A | 1 |
| Bean, G | 1 |
| Joffe, RT | 1 |
| Hudson, CJ | 1 |
| Lattuada, E | 1 |
| Lorenzi, C | 1 |
| Lilli, R | 2 |
| Smeraldi, E | 1 |
| Macciardi, F | 1 |
| Segman, RH | 1 |
| Adolfsson, R | 1 |
| Blairy, S | 1 |
| Del Favero, J | 1 |
| Dikeos, DG | 1 |
| Noethen, M | 1 |
| Petrova, T | 1 |
| Van Gestel, S | 1 |
| Rees, JR | 1 |
| Allsopp, MN | 1 |
| Hullin, RP | 1 |
2 reviews available for serine and Bipolar Disorder
| Article | Year |
|---|---|
Biochemical Properties and Physiological Functions of pLG72: Twenty Years of Investigations.
Topics: Animals; Bipolar Disorder; Intracellular Signaling Peptides and Proteins; Receptors, N-Methyl-D-Aspa | 2022 |
Metabolomics in patients with psychosis: A systematic review.
Topics: 3-Hydroxybutyric Acid; Aspartic Acid; Biomarkers; Bipolar Disorder; Creatine; Female; Glutamic Acid; | 2018 |
1 trial available for serine and Bipolar Disorder
| Article | Year |
|---|---|
A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder.
Topics: Adult; Analysis of Variance; Antimanic Agents; Asparagine; Bipolar Disorder; Brief Psychiatric Ratin | 2008 |
18 other studies available for serine and Bipolar Disorder
| Article | Year |
|---|---|
Region-specific dysregulation of glycogen synthase kinase-3β and β-catenin in the postmortem brains of subjects with bipolar disorder and schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Base Sequence; beta Catenin; Bipolar Disorder; Brain; Case-Control S | 2015 |
Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.
Topics: Adult; Bipolar Disorder; Female; Glutamic Acid; Glutamine; Glycine; Humans; Male; Middle Aged; Psych | 2015 |
Serine enantiomers as diagnostic biomarkers for schizophrenia and bipolar disorder.
Topics: Biomarkers; Bipolar Disorder; Excitatory Amino Acid Antagonists; Female; Humans; Ketamine; Male; Sch | 2016 |
Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms.
Topics: Adult; Alcohol-Related Disorders; Bipolar Disorder; Chi-Square Distribution; Comorbidity; Cysteine; | 2010 |
Temperamentsxgenes in bipolar I and bipolar II disorder patients.
Topics: Bipolar Disorder; DNA Mutational Analysis; Exploratory Behavior; Female; Genotype; Glycine; Humans; | 2010 |
Regulation of glycogen synthase kinase-3 during bipolar mania treatment.
Topics: Adult; Aged; Analysis of Variance; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Electros | 2010 |
K(v) 7 (KCNQ) channel openers normalize central 2-deoxyglucose uptake in a mouse model of mania and increase prefrontal cortical and hippocampal serine-9 phosphorylation levels of GSK3β.
Topics: Animals; Antimanic Agents; Autoradiography; Benzamides; Bipolar Disorder; Carbamates; Central Nervou | 2012 |
HTR2C (cys23ser) polymorphism influences early onset in bipolar patients in a large European multicenter association study.
Topics: Bipolar Disorder; Cysteine; Europe; Gene Frequency; Genotype; Humans; Polymorphism, Genetic; Psychia | 2007 |
Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide.
Topics: Adult; Bipolar Disorder; Female; Gene Expression; Humans; Male; Middle Aged; Models, Molecular; Pref | 2008 |
A polymorphism linked to bipolar affective disorder does not alter the CRE activity of constitutively activated trace amine receptor 4.
Topics: Bipolar Disorder; Cell Cycle Proteins; Cell Line, Transformed; Colforsin; CREB-Binding Protein; Gene | 2007 |
Possible syndrome of high myopia with retinal degeneration, cataract, manic depression, and elevated plasma amino acids.
Topics: Aged; Amino Acids; Bipolar Disorder; Cataract; Female; Humans; Lysine; Male; Middle Aged; Myopia; Or | 1980 |
Abnormal plasma levels of serine, methionine, and taurine in transient acute polymorphic psychosis.
Topics: Adult; Bipolar Disorder; Diagnosis, Differential; Female; Humans; Male; Methionine; Middle Aged; Psy | 1994 |
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder.
Topics: Alleles; Amino Acid Sequence; Bipolar Disorder; Female; Gene Frequency; Genotype; Glycine; Humans; M | 1993 |
No evidence for association of dopamine D2 receptor variant (Ser311/Cys311) with major psychosis.
Topics: Adult; Age of Onset; Amino Acid Sequence; Bipolar Disorder; Cysteine; Delusions; Female; Genetic Var | 1996 |
Dopamine receptor D2 Ser/Cys 311 variant is associated with delusion and disorganization symptomatology in major psychoses.
Topics: Adult; Amino Acid Substitution; Bipolar Disorder; Cysteine; Depressive Disorder; Female; Genetic Var | 2000 |
Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder.
Topics: Amino Acid Substitution; Bipolar Disorder; Cysteine; Depressive Disorder; Ethnicity; Europe; Female; | 2001 |
Derangement of one-carbon metabolism in episodic schizoaffective psychoses.
Topics: Bipolar Disorder; Carbolines; Carbon; Glycine; Humans; Schizophrenia; Serine; Taurine | 1988 |
Plasma concentrations of tryptophan and other amino acids in manic-depressive patients.
Topics: Alanine; Arginine; Aspartic Acid; Bipolar Disorder; Emotions; Glutamates; Glycine; Humans; Isoleucin | 1974 |