serine has been researched along with Benign Neoplasms, Brain in 32 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "D-Serine indirectly caused dose- and time-dependent inhibition of neuronal nitric oxide synthase (nNOS) without affecting endothelial nitric oxide synthase (eNOS) in human glioblastoma cell line U87." | 7.73 | Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells. ( Ciampa, AR; Mariotto, S; Shoji, K; Suzuki, H, 2006) |
| "Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days." | 7.66 | Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980) |
| "To investigate the clinical application value of radiomics features based on preoperative magnetic resonance imaging for predicting B-Raf proto-oncogene serine/threonine-protein (BRAF) V600E mutation in pediatric low-grade gliomas." | 5.51 | Radiomics features based on MRI predict BRAF V600E mutation in pediatric low-grade gliomas: A non-invasive method for molecular diagnosis. ( Ai, R; Cai, L; Hu, Q; Lai, M; Li, J; Li, L; Li, S; Shi, C; Xu, J; Ye, K; Zhen, J; Zhou, J, 2022) |
| "Recurrent ependymomas are considered rarely responsive to chemotherapy and often have a dismal prognosis after tumor progression." | 5.37 | mTORC1 activation in childhood ependymoma and response to sirolimus. ( Bowers, DC; Brugarolas, J; Gargan, L; Kucejova, B; Margraf, L, 2011) |
| " Here, we find that serine and glycine levels were higher in low-nutrient regions of tumors in glioblastoma multiforme (GBM) patients than they were in other regions." | 4.02 | Glioma cells require one-carbon metabolism to survive glutamine starvation. ( Bamba, T; Fujita, Y; Hashiguchi, M; Hosoda, K; Irino, Y; Izumi, Y; Kitta, A; Kohmura, E; Kohta, M; Kyotani, K; Nagashima, H; Nakai, T; Sasayama, T; Satoh, N; Shinohara, M; Takahashi, M; Tanaka, K; Uno, T; Uozumi, Y, 2021) |
| "D-Serine indirectly caused dose- and time-dependent inhibition of neuronal nitric oxide synthase (nNOS) without affecting endothelial nitric oxide synthase (eNOS) in human glioblastoma cell line U87." | 3.73 | Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells. ( Ciampa, AR; Mariotto, S; Shoji, K; Suzuki, H, 2006) |
| "In developing iodine-123-labelled amino acid derivatives for imaging cerebral gliomas by single-photon emission tomography (SPET), we compared p-[123I]iodo-L-phenylalanine (IPA), L-[123I]iodo-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid (ITIC) and L-3-[123I]iodo-alpha-methyltyrosine (IMT) with regard to their uptake in human glioblastoma T99 and T3868 cells, and thereafter studied the mechanisms promoting the cellular uptake." | 3.70 | Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats. ( Feiden, W; Heimann, A; Kempski, O; Kirsch, CM; Richter, S; Romeike, BF; Samnick, S, 2000) |
| "Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days." | 3.66 | Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980) |
| "Glioblastoma is the most malignant and lethal subtype brain tumors with high risk of recurrence and therapeutic resistance." | 1.48 | Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma. ( Dong, Z; Du, S; Huang, J; Lei, T; Sun, M; Tong, R; Wang, H; Wang, Y; Yang, J; Yang, Y, 2018) |
| "Recurrent ependymomas are considered rarely responsive to chemotherapy and often have a dismal prognosis after tumor progression." | 1.37 | mTORC1 activation in childhood ependymoma and response to sirolimus. ( Bowers, DC; Brugarolas, J; Gargan, L; Kucejova, B; Margraf, L, 2011) |
| "Gliomas are the most common type of primary intracranial tumor." | 1.35 | Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis. ( Cheng, C; Shen, A; Sun, L; Wang, Y; Zhao, Y; Zou, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.25) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 13 (40.63) | 29.6817 |
| 2010's | 11 (34.38) | 24.3611 |
| 2020's | 5 (15.63) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, L | 1 |
| Kiang, KM | 1 |
| Cheng, SY | 1 |
| Leung, GK | 1 |
| Dutta, R | 1 |
| Sharma, MC | 1 |
| Suri, V | 2 |
| Sarkar, C | 1 |
| Garg, A | 1 |
| Suri, A | 1 |
| Kale, SS | 1 |
| Xu, J | 1 |
| Lai, M | 1 |
| Li, S | 1 |
| Ye, K | 1 |
| Li, L | 1 |
| Hu, Q | 1 |
| Ai, R | 1 |
| Zhou, J | 1 |
| Li, J | 1 |
| Zhen, J | 1 |
| Cai, L | 1 |
| Shi, C | 1 |
| Ngo, B | 1 |
| Kim, E | 1 |
| Osorio-Vasquez, V | 1 |
| Doll, S | 1 |
| Bustraan, S | 1 |
| Liang, RJ | 1 |
| Luengo, A | 1 |
| Davidson, SM | 1 |
| Ali, A | 1 |
| Ferraro, GB | 1 |
| Fischer, GM | 1 |
| Eskandari, R | 1 |
| Kang, DS | 1 |
| Ni, J | 1 |
| Plasger, A | 1 |
| Rajasekhar, VK | 1 |
| Kastenhuber, ER | 1 |
| Bacha, S | 1 |
| Sriram, RK | 1 |
| Stein, BD | 1 |
| Bakhoum, SF | 1 |
| Snuderl, M | 1 |
| Cotzia, P | 1 |
| Healey, JH | 1 |
| Mainolfi, N | 1 |
| Friedman, A | 1 |
| Manfredi, M | 1 |
| Sabatini, DM | 1 |
| Jones, DR | 1 |
| Yu, M | 1 |
| Zhao, JJ | 1 |
| Jain, RK | 1 |
| Keshari, KR | 1 |
| Davies, MA | 1 |
| Vander Heiden, MG | 1 |
| Hernando, E | 1 |
| Mann, M | 1 |
| Cantley, LC | 1 |
| Pacold, ME | 1 |
| Tanaka, K | 1 |
| Sasayama, T | 1 |
| Nagashima, H | 1 |
| Irino, Y | 1 |
| Takahashi, M | 1 |
| Izumi, Y | 1 |
| Uno, T | 1 |
| Satoh, N | 1 |
| Kitta, A | 1 |
| Kyotani, K | 1 |
| Fujita, Y | 1 |
| Hashiguchi, M | 1 |
| Nakai, T | 1 |
| Kohta, M | 1 |
| Uozumi, Y | 1 |
| Shinohara, M | 1 |
| Hosoda, K | 1 |
| Bamba, T | 1 |
| Kohmura, E | 1 |
| Gu, Y | 1 |
| Albuquerque, CP | 1 |
| Braas, D | 1 |
| Zhang, W | 1 |
| Villa, GR | 1 |
| Bi, J | 1 |
| Ikegami, S | 1 |
| Masui, K | 1 |
| Gini, B | 1 |
| Yang, H | 1 |
| Gahman, TC | 1 |
| Shiau, AK | 1 |
| Cloughesy, TF | 1 |
| Christofk, HR | 1 |
| Zhou, H | 1 |
| Guan, KL | 1 |
| Mischel, PS | 1 |
| Yang, Y | 1 |
| Lei, T | 1 |
| Du, S | 1 |
| Tong, R | 1 |
| Wang, H | 2 |
| Yang, J | 1 |
| Huang, J | 1 |
| Sun, M | 1 |
| Wang, Y | 2 |
| Dong, Z | 1 |
| Mandal, T | 1 |
| Bhowmik, A | 1 |
| Chatterjee, A | 1 |
| Chatterjee, U | 1 |
| Chatterjee, S | 1 |
| Ghosh, MK | 1 |
| Gao, X | 1 |
| Cai, S | 1 |
| Saadatzadeh, MR | 1 |
| Hanenberg, H | 1 |
| Pollok, KE | 1 |
| Cohen-Gadol, AA | 1 |
| Chen, J | 2 |
| Ouédraogo, ZG | 1 |
| Müller-Barthélémy, M | 1 |
| Kemeny, JL | 1 |
| Dedieu, V | 1 |
| Biau, J | 1 |
| Khalil, T | 1 |
| Raoelfils, LI | 1 |
| Granzotto, A | 1 |
| Pereira, B | 1 |
| Beaudoin, C | 1 |
| Guissou, IP | 1 |
| Berger, M | 1 |
| Morel, L | 1 |
| Chautard, E | 1 |
| Verrelle, P | 1 |
| Amano, T | 1 |
| Nakamizo, A | 1 |
| Mishra, SK | 1 |
| Gumin, J | 1 |
| Shinojima, N | 1 |
| Sawaya, R | 1 |
| Lang, FF | 1 |
| Shen, A | 2 |
| Zhao, Y | 1 |
| Zou, L | 1 |
| Sun, L | 1 |
| Cheng, C | 1 |
| McBride, SM | 1 |
| Perez, DA | 1 |
| Polley, MY | 1 |
| Vandenberg, SR | 1 |
| Smith, JS | 1 |
| Zheng, S | 1 |
| Lamborn, KR | 1 |
| Wiencke, JK | 1 |
| Chang, SM | 1 |
| Prados, MD | 1 |
| Berger, MS | 1 |
| Stokoe, D | 1 |
| Haas-Kogan, DA | 1 |
| Darra, E | 1 |
| Ebner, FH | 1 |
| Shoji, K | 2 |
| Suzuki, H | 2 |
| Mariotto, S | 2 |
| Wang, D | 1 |
| He, F | 1 |
| Zhang, L | 2 |
| Zhang, F | 1 |
| Wang, Q | 1 |
| Qian, X | 1 |
| Pan, X | 1 |
| Meng, J | 1 |
| Peng, C | 1 |
| Bowers, DC | 1 |
| Kucejova, B | 1 |
| Margraf, L | 1 |
| Gargan, L | 1 |
| Brugarolas, J | 1 |
| Filippova, N | 1 |
| Yang, X | 1 |
| King, P | 1 |
| Nabors, LB | 1 |
| Yang, W | 1 |
| Xia, Y | 1 |
| Cao, Y | 1 |
| Zheng, Y | 1 |
| Bu, W | 1 |
| You, MJ | 1 |
| Koh, MY | 1 |
| Cote, G | 1 |
| Aldape, K | 1 |
| Li, Y | 1 |
| Verma, IM | 1 |
| Chiao, PJ | 1 |
| Lu, Z | 1 |
| Alam, R | 1 |
| Schultz, CR | 1 |
| Golembieski, WA | 1 |
| Poisson, LM | 1 |
| Rempel, SA | 1 |
| Jeng, YM | 1 |
| Hsu, HC | 1 |
| Bijur, GN | 1 |
| Jope, RS | 1 |
| Fujita, M | 1 |
| Mizuno, M | 1 |
| Nagasaka, T | 1 |
| Wakabayashi, T | 1 |
| Maeda, K | 1 |
| Ishii, D | 1 |
| Arima, T | 1 |
| Kawajiri, A | 1 |
| Inagaki, M | 1 |
| Yoshida, J | 1 |
| Ciampa, AR | 1 |
| Woerner, BM | 1 |
| Warrington, NM | 1 |
| Kung, AL | 1 |
| Perry, A | 1 |
| Rubin, JB | 1 |
| Claudio, PP | 1 |
| Cui, J | 1 |
| Ghafouri, M | 1 |
| Mariano, C | 1 |
| White, MK | 1 |
| Safak, M | 1 |
| Sheffield, JB | 1 |
| Giordano, A | 1 |
| Khalili, K | 1 |
| Amini, S | 1 |
| Sawaya, BE | 1 |
| Vernez, M | 1 |
| Hutter, P | 1 |
| Monnerat, C | 1 |
| Halkic, N | 1 |
| Gugerli, O | 1 |
| Bouzourene, H | 1 |
| Demir, O | 1 |
| Kurnaz, IA | 1 |
| Yue, XF | 1 |
| Wu, FG | 1 |
| Xu, B | 1 |
| Kohl, RL | 1 |
| Perez-Polo, JR | 1 |
| Quay, WB | 1 |
| Garcia, MC | 1 |
| Ward, G | 1 |
| Ma, YC | 1 |
| Salem, N | 1 |
| Kim, HY | 1 |
| Mullapudi, SR | 1 |
| Ali-Osman, F | 1 |
| Shou, J | 1 |
| Srivenugopal, KS | 1 |
| Samnick, S | 1 |
| Richter, S | 1 |
| Romeike, BF | 1 |
| Heimann, A | 1 |
| Feiden, W | 1 |
| Kempski, O | 1 |
| Kirsch, CM | 1 |
1 trial available for serine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Radiomics features based on MRI predict BRAF V600E mutation in pediatric low-grade gliomas: A non-invasive method for molecular diagnosis.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Female; Glioma; Humans; Magnetic Resonance Ima | 2022 |
31 other studies available for serine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Survival; DNA Da | 2022 |
TTF-1: A Well-Favored Addition to the Immunohistochemistry Armamentarium as a Diagnostic Marker of SEGA.
Topics: Astrocytoma; Brain Neoplasms; Child; Ependymoma; Glioblastoma; Humans; Immunohistochemistry; Neurocy | 2022 |
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Cell Line, Tumor; Datasets as Topic; Drug Re | 2020 |
Glioma cells require one-carbon metabolism to survive glutamine starvation.
Topics: Aminohydrolases; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Ge | 2021 |
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.
Topics: A549 Cells; Amino Acid Transport System y+; Brain Neoplasms; Cysteine; Glioblastoma; Glutamine; Glut | 2017 |
Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; DNA Breaks, | 2018 |
Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells.
Topics: Animals; bcl-X Protein; Brain Neoplasms; Casein Kinase II; Cell Line, Tumor; Cell Movement; Cell Tra | 2014 |
Phosphorylation of NMDA 2B at S1303 in human glioma peritumoral tissue: implications for glioma epileptogenesis.
Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; DNA-Activated Protein Kin | 2014 |
STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma.
Topics: Brain Neoplasms; Carbazoles; Cell Line, Tumor; Cell Proliferation; Colony-Forming Units Assay; Dose- | 2016 |
Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes.
Topics: Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Flow Cytometry; Gene Ex | 2009 |
Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis.
Topics: Adult; Aged; Brain Neoplasms; Cyclin-Dependent Kinase Inhibitor p27; Exportin 1 Protein; Female; Gen | 2009 |
Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival.
Topics: Adult; Brain Neoplasms; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Intracellula | 2010 |
Dual cross-talk between nitric oxide and D-serine in astrocytes and neurons in the brain.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Brain Neoplasms; Cells, Cultured; Cytokines; Gl | 2009 |
The role of p27(Kip1) phosphorylation at serine 10 in the migration of malignant glioma cells in vitro.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase Inhibi | 2011 |
mTORC1 activation in childhood ependymoma and response to sirolimus.
Topics: Brain Neoplasms; Child, Preschool; Ependymoma; Humans; Immunosuppressive Agents; Magnetic Resonance | 2011 |
Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function.
Topics: Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Centrosome; Cyclin A; Cyclin-Dependent Kinase 5; Cyto | 2012 |
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Topics: Animals; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzym | 2012 |
PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma.
Topics: Blotting, Western; Brain Neoplasms; Glioma; HSP27 Heat-Shock Proteins; Humans; Intracellular Signali | 2013 |
KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas.
Topics: Adult; Aged; Alleles; Amino Acid Substitution; Astrocytoma; Brain Neoplasms; Chromosomes, Human, Pai | 2003 |
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation.
Topics: Androstadienes; Brain Neoplasms; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Fractionation; Cell | 2003 |
Aurora-B dysfunction of multinucleated giant cells in glioma detected by site-specific phosphorylated antibodies.
Topics: Antibodies, Monoclonal; Aurora Kinase B; Aurora Kinases; Brain Neoplasms; Cell Line, Tumor; Fluoresc | 2004 |
Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells.
Topics: Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Flu | 2006 |
Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies.
Topics: Animals; Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Chemokine CXCL12; Chemokines, CXC; En | 2005 |
Cdk9 phosphorylates p53 on serine 392 independently of CKII.
Topics: Brain Neoplasms; Casein Kinase II; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Glioblastoma; HIV-1; | 2006 |
A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene.
Topics: Adenocarcinoma, Mucinous; Adenoma; Adult; Brain Neoplasms; Carcinoma; Cholangiocarcinoma; Colorectal | 2007 |
Wildtype Elk-1, but not a SUMOylation mutant, represses egr-1 expression in SH-SY5Y neuroblastomas.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Early Growth Response Protein 1; ets-Domain Protein El | 2008 |
[The anticancer and pharmacologic study of oxalysine (author's transl)].
Topics: Amino Acids, Dicarboxylic; Animals; Antibiotics, Antineoplastic; Brain Neoplasms; Dogs; Haplorhini; | 1980 |
Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells.
Topics: Animals; Brain Neoplasms; Cell Line; Enzyme Activation; Glioma; Glycine; Glycine Hydroxymethyltransf | 1980 |
Effect of docosahexaenoic acid on the synthesis of phosphatidylserine in rat brain in microsomes and C6 glioma cells.
Topics: Animals; Brain; Brain Neoplasms; Docosahexaenoic Acids; Female; Glioma; Microsomes; Phosphatidylseri | 1998 |
DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Brain Neoplasms; Calcium-Calmodulin-Dependent | 2000 |
Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; beta-Alanine; Binding, Competitive; Blood-Brain | 2000 |