serine has been researched along with Behavior Disorders in 20 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Plasma serine levels (PSL) in a group of patients with the diagnosis of major or atypical psychoses were significantly higher than in patients with nonpsychotic diagnoses or nonpatient controls." | 3.67 | Serine metabolism and psychosis. ( Mott, J; Sherman, AD; Waziri, R; Wilcox, J, 1984) |
| "Schizophrenia is a debilitating and complex mental disorder with a prevalence of approximately 1% worldwide." | 2.46 | Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: Ser311Cys polymorphisms of the dopamine D2-receptor gene and schizophrenia. ( Arinami, T; Itokawa, M; Toru, M, 2010) |
| "Currently, it is known that cerebral toxoplasmosis increases dopamine levels in the brain and it is related to behavioral changes in animals and humans." | 1.62 | Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis. ( Acquarone, M; Barbosa, HS; Gonçalves, PFR; Menezes, JRL; Neves, GA; Panizzutti, R; Perozzo, AF; Poleto, A, 2021) |
| "We genotyped patients with alcohol dependence, panic disorder without agoraphobia, generalized anxiety disorder, narcolepsy and normal healthy volunteers for the 5-HT2C Cys23Ser polymorphism." | 1.31 | Sex differences in allelic frequencies of the 5-HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association study. ( Anghelescu, I; Dahmen, N; Fehr, C; Hiemke, C; Klawe, C; Szegedi, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 8 (40.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, W | 1 |
| Liu, D | 1 |
| Traynelis, SF | 1 |
| Yuan, H | 1 |
| Acquarone, M | 1 |
| Poleto, A | 1 |
| Perozzo, AF | 1 |
| Gonçalves, PFR | 1 |
| Panizzutti, R | 1 |
| Menezes, JRL | 1 |
| Neves, GA | 1 |
| Barbosa, HS | 1 |
| Bardaweel, SK | 1 |
| Alzweiri, M | 1 |
| Ishaqat, AA | 1 |
| Nomura, J | 1 |
| Jaaro-Peled, H | 1 |
| Lewis, E | 1 |
| Nuñez-Abades, P | 1 |
| Huppe-Gourgues, F | 1 |
| Cash-Padgett, T | 1 |
| Emiliani, F | 1 |
| Kondo, MA | 1 |
| Furuya, A | 1 |
| Landek-Salgado, MA | 1 |
| Ayhan, Y | 1 |
| Kamiya, A | 1 |
| Takumi, T | 1 |
| Huganir, R | 1 |
| Pletnikov, M | 1 |
| O'Donnell, P | 1 |
| Sawa, A | 1 |
| Nishikawa, T | 4 |
| Fukui, K | 1 |
| Hashimoto, K | 1 |
| Wada, A | 1 |
| Pollegioni, L | 1 |
| Sacchi, S | 1 |
| Itokawa, M | 1 |
| Arinami, T | 1 |
| Toru, M | 1 |
| Burnet, PW | 1 |
| Anderson, PN | 1 |
| Chen, L | 1 |
| Nikiforova, N | 1 |
| Harrison, PJ | 1 |
| Wood, MJ | 1 |
| Kudo, Y | 1 |
| Waziri, R | 2 |
| Wilcox, J | 1 |
| Sherman, AD | 1 |
| Mott, J | 2 |
| Kumashiro, S | 1 |
| Hashimoto, A | 1 |
| Fehr, C | 1 |
| Szegedi, A | 1 |
| Anghelescu, I | 1 |
| Klawe, C | 1 |
| Hiemke, C | 1 |
| Dahmen, N | 1 |
| Snyder, SH | 1 |
| Ferris, CD | 1 |
| Montini, M | 1 |
| Ongaro, A | 1 |
| Simonutti, M | 1 |
10 reviews available for serine and Behavior Disorders
| Article | Year |
|---|---|
D-Serine in neurobiology: CNS neurotransmission and neuromodulation.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Central Nervous System; Epilepsy; Glutami | 2014 |
[Metabolism and functions of brain D-serine in mammals: relevance to neuropsychiatric disorders].
Topics: Animals; Brain; Drug Design; Glycine; Humans; Isomerism; Mental Disorders; Nervous System Diseases; | 2008 |
[Disease-oriented enzymology in D-amino acid metabolism].
Topics: Amino Acids; Animals; Antipsychotic Agents; Astrocytes; Cloning, Molecular; Crystallization; D-Amino | 2008 |
GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics.
Topics: Chromaffin Cells; Glycogen Synthase Kinase 3; Humans; Lithium Compounds; Mental Disorders; Phosphory | 2009 |
Metabolism of the neuromodulator D-serine.
Topics: Brain; D-Amino-Acid Oxidase; Gene Expression Regulation, Enzymologic; Humans; Mental Disorders; Neur | 2010 |
Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: Ser311Cys polymorphisms of the dopamine D2-receptor gene and schizophrenia.
Topics: Alleles; Animals; Cysteine; Dopamine; Drug Discovery; Humans; Mental Disorders; Polymorphism, Geneti | 2010 |
Analysis of free D-serine in mammals and its biological relevance.
Topics: Animals; Brain; Brain Chemistry; Glutamic Acid; Humans; Mental Disorders; Receptors, N-Methyl-D-Aspa | 2011 |
Metabolism and functional roles of endogenous D-serine in mammalian brains.
Topics: Animals; Brain; Brain Chemistry; Humans; Mental Disorders; Nervous System Diseases; Receptors, N-Met | 2005 |
[New development in glial cell research].
Topics: Adenosine Triphosphate; Animals; Astrocytes; Brain; Glutamates; Humans; Mental Disorders; Neuroglia; | 2007 |
Novel neurotransmitters and their neuropsychiatric relevance.
Topics: Carbon Monoxide; Humans; Mental Disorders; Neurotransmitter Agents; Nitric Oxide; Receptors, N-Methy | 2000 |
1 trial available for serine and Behavior Disorders
| Article | Year |
|---|---|
[Controlled clinical study and clinico-psychological evaluation of a preparation with neurotrophic effects].
Topics: Aged; Arginine; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Glutamine; Hum | 1977 |
9 other studies available for serine and Behavior Disorders
| Article | Year |
|---|---|
Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders.
Topics: Allosteric Regulation; Animals; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Gen | 2020 |
Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Glutamic Acid; Hippocampus; Mental Disorders; Mice; N | 2021 |
Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Age Factors; Animals; | 2016 |
CSF serine enantiomers and glycine in the study of neurologic and psychiatric disorders.
Topics: Animals; Cerebrospinal Fluid; Glycine; Humans; Mental Disorders; Nervous System Diseases; Serine; St | 2008 |
D-amino acid oxidase knockdown in the mouse cerebellum reduces NR2A mRNA.
Topics: Animals; Cell Line; Cerebellum; D-Amino-Acid Oxidase; Gene Knockdown Techniques; Genetic Vectors; Gr | 2011 |
Serine metabolism and psychosis.
Topics: Adult; Antipsychotic Agents; Brief Psychiatric Rating Scale; Diet; Glycine; Glycine Hydroxymethyltra | 1984 |
Free D-serine in post-mortem brains and spinal cords of individuals with and without neuropsychiatric diseases.
Topics: Aging; Amino Acids; Animals; Brain Chemistry; Humans; Mental Disorders; Nervous System Diseases; Par | 1995 |
Sex differences in allelic frequencies of the 5-HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association study.
Topics: Adult; Alcoholism; Alleles; Amino Acid Substitution; Anxiety Disorders; Cysteine; Female; Gene Frequ | 2000 |
Drug effects on serine metabolism in psychiatric patients.
Topics: Antipsychotic Agents; Glycine Hydroxymethyltransferase; Humans; Mental Disorders; Psychotic Disorder | 1986 |