serine has been researched along with Autosomal Dominant Juvenile Parkinson Disease in 24 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For those greater than 60 years old, parkinsonism was present in 38." | 1.39 | Greater risk of parkinsonism associated with non-N370S GBA1 mutations. ( Alfonso, P; Barrett, MJ; Capablo, JL; Garcia-Rodriguez, B; Giraldo, P; Irun, P; Pastores, GM; Pocovi, M, 2013) |
| "Parkinsonism is one of the phenotypic features associated also with the W748S mutation." | 1.35 | Parkinsonism associated with the homozygous W748S mutation in the POLG1 gene. ( Hinttala, R; Kärppä, M; Majamaa, K; Remes, AM; Soini, H; Takalo, R; Uusimaa, J, 2008) |
| "The mean age at onset for parkinsonism was 60 years, range 30-79 years; fewer than 20% of the patients had symptoms before the age 50 years, while by 75 years >90% of them had developed symptoms." | 1.35 | Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease. ( Benecke, R; Berg, D; Bonifati, V; Brown, L; Cras, P; De Deyn, PP; Engelborghs, S; Farrer, MJ; Foroud, T; Gaig, C; Gasser, T; Gibson, JM; Goldwurm, S; Guidi, M; Hagenah, J; Haugarvoll, K; Kachergus, JM; Klein, C; Nichols, WC; Nuytemans, K; Pals, P; Pickut, B; Rademakers, R; Riboldazzi, G; Ross, OA; Samii, A; Tan, EK; Theuns, J; Tolosa, E; Uitti, RJ; Van Broeckhoven, C; Walter, U; Wszolek, ZK; Zabetian, CP, 2008) |
| "Frontotemporal dementia with parkinsonism linked to chromosome 17q21-22 (FTDP-17) is an autosomal dominant tauopathy manifested by a variable combination of personality changes, cognitive decline and hypokinetic-rigid movement disorder." | 1.32 | Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family. ( Abramsky, O; Biran, I; Boher, M; Ekstein, D; Gal, A; Gomori, JM; Lossos, A; Meiner, Z; Newman, JP; Reches, A; Rosenmann, H; Soffer, D, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (58.33) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Nakahara, K | 3 |
| Okuda, H | 3 |
| Isonishi, A | 3 |
| Kawabe, Y | 3 |
| Tanaka, T | 3 |
| Tatsumi, K | 3 |
| Wanaka, A | 3 |
| Vieweg, S | 1 |
| Mulholland, K | 1 |
| Bräuning, B | 1 |
| Kachariya, N | 1 |
| Lai, YC | 1 |
| Toth, R | 1 |
| Singh, PK | 1 |
| Volpi, I | 1 |
| Sattler, M | 1 |
| Groll, M | 1 |
| Itzen, A | 1 |
| Muqit, MMK | 1 |
| Salvatore, MF | 1 |
| El Arfani, A | 1 |
| Albertini, G | 1 |
| Bentea, E | 1 |
| Demuyser, T | 1 |
| Van Eeckhaut, A | 1 |
| Smolders, I | 1 |
| Massie, A | 1 |
| Morris, JK | 1 |
| Zhang, H | 1 |
| Gupte, AA | 1 |
| Bomhoff, GL | 1 |
| Stanford, JA | 1 |
| Geiger, PC | 1 |
| Munhoz, RP | 1 |
| Teive, HA | 1 |
| Francisco, AN | 1 |
| Raskin, S | 1 |
| Rogaeva, E | 1 |
| Chalimoniuk, M | 1 |
| Stolecka, A | 1 |
| Ziemińska, E | 1 |
| Stepień, A | 1 |
| Langfort, J | 1 |
| Strosznajder, JB | 1 |
| Nguyen, XV | 1 |
| Liu, M | 1 |
| Kim, HC | 1 |
| Bing, G | 1 |
| Wider, C | 1 |
| Dachsel, JC | 2 |
| Farrer, MJ | 4 |
| Dickson, DW | 2 |
| Tsuboi, Y | 1 |
| Wszolek, ZK | 2 |
| Morissette, M | 1 |
| Samadi, P | 1 |
| Hadj Tahar, A | 1 |
| Bélanger, N | 1 |
| Di Paolo, T | 1 |
| Malagelada, C | 1 |
| Jin, ZH | 1 |
| Jackson-Lewis, V | 1 |
| Przedborski, S | 1 |
| Greene, LA | 1 |
| Valldeoriola, F | 2 |
| Gaig, C | 3 |
| Muxí, A | 1 |
| Navales, I | 1 |
| Paredes, P | 1 |
| Lomeña, F | 1 |
| De la Cerda, A | 1 |
| Buongiorno, M | 1 |
| Ezquerra, M | 2 |
| Santacruz, P | 1 |
| Martí, MJ | 2 |
| Tolosa, E | 3 |
| Barrett, MJ | 1 |
| Giraldo, P | 1 |
| Capablo, JL | 1 |
| Alfonso, P | 1 |
| Irun, P | 1 |
| Garcia-Rodriguez, B | 1 |
| Pocovi, M | 1 |
| Pastores, GM | 1 |
| van Nuenen, BF | 1 |
| Helmich, RC | 1 |
| Ferraye, M | 1 |
| Thaler, A | 1 |
| Hendler, T | 1 |
| Orr-Urtreger, A | 1 |
| Mirelman, A | 1 |
| Bressman, S | 1 |
| Marder, KS | 1 |
| Giladi, N | 1 |
| van de Warrenburg, BP | 1 |
| Bloem, BR | 1 |
| Toni, I | 1 |
| Lossos, A | 1 |
| Reches, A | 1 |
| Gal, A | 1 |
| Newman, JP | 1 |
| Soffer, D | 1 |
| Gomori, JM | 1 |
| Boher, M | 1 |
| Ekstein, D | 1 |
| Biran, I | 1 |
| Meiner, Z | 1 |
| Abramsky, O | 1 |
| Rosenmann, H | 1 |
| Kobayashi, K | 2 |
| Kidani, T | 2 |
| Ujike, H | 2 |
| Hayashi, M | 2 |
| Ishihara, T | 2 |
| Miyazu, K | 1 |
| Kuroda, S | 2 |
| Koshino, Y | 2 |
| Iijima, M | 1 |
| Nakano, H | 1 |
| Sugimori, K | 1 |
| Shimazaki, M | 1 |
| Rajput, A | 1 |
| Robinson, CA | 1 |
| Ross, OA | 3 |
| Lincoln, SJ | 1 |
| Cobb, SA | 1 |
| Rajput, ML | 1 |
| Schüpbach, M | 1 |
| Lohmann, E | 1 |
| Anheim, M | 1 |
| Lesage, S | 1 |
| Czernecki, V | 1 |
| Yaici, S | 1 |
| Worbe, Y | 1 |
| Charles, P | 1 |
| Welter, ML | 1 |
| Pollak, P | 1 |
| Dürr, A | 1 |
| Agid, Y | 1 |
| Brice, A | 1 |
| González-Fernández, MC | 1 |
| Lezcano, E | 1 |
| Gómez-Esteban, JC | 1 |
| Gómez-Busto, F | 1 |
| Velasco, F | 1 |
| Alvarez-Alvarez, M | 1 |
| Rodríguez-Martínez, MB | 1 |
| Ciordia, R | 1 |
| Zarranz, JJ | 1 |
| Mata, IF | 1 |
| de Pancorbo, MM | 1 |
| Remes, AM | 1 |
| Hinttala, R | 1 |
| Kärppä, M | 1 |
| Soini, H | 1 |
| Takalo, R | 1 |
| Uusimaa, J | 1 |
| Majamaa, K | 1 |
| Haugarvoll, K | 1 |
| Rademakers, R | 1 |
| Kachergus, JM | 1 |
| Nuytemans, K | 1 |
| Gibson, JM | 1 |
| Tan, EK | 1 |
| Goldwurm, S | 1 |
| Guidi, M | 1 |
| Riboldazzi, G | 1 |
| Brown, L | 1 |
| Walter, U | 1 |
| Benecke, R | 1 |
| Berg, D | 1 |
| Gasser, T | 1 |
| Theuns, J | 1 |
| Pals, P | 1 |
| Cras, P | 1 |
| De Deyn, PP | 1 |
| Engelborghs, S | 1 |
| Pickut, B | 1 |
| Uitti, RJ | 1 |
| Foroud, T | 1 |
| Nichols, WC | 1 |
| Hagenah, J | 1 |
| Klein, C | 1 |
| Samii, A | 1 |
| Zabetian, CP | 1 |
| Bonifati, V | 1 |
| Van Broeckhoven, C | 1 |
| Muñoz, E | 1 |
| Lladó, A | 1 |
| Rey, MJ | 1 |
| Cardozo, A | 1 |
| Molinuevo, JL | 1 |
| Lavedan, C | 1 |
| Buchholtz, S | 1 |
| Nussbaum, RL | 1 |
| Albin, RL | 1 |
| Polymeropoulos, MH | 1 |
1 trial available for serine and Autosomal Dominant Juvenile Parkinson Disease
| Article | Year |
|---|---|
Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations.
Topics: Adult; Aged; Deep Brain Stimulation; Female; Glycine; Humans; Leucine-Rich Repeat Serine-Threonine P | 2007 |
23 other studies available for serine and Autosomal Dominant Juvenile Parkinson Disease
| Article | Year |
|---|---|
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System y+; Animals; Basal Ganglia; Dopamine; D | 2023 |
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
Topics: HEK293 Cells; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mitochondria; Parkinson | 2020 |
ser31 Tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-OHDA lesion.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Male; O | 2014 |
Alterations in the motor cortical and striatal glutamatergic system and D-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Glutamic Acid; Male; Motor Cortex; Oxidopamine; Pa | 2015 |
Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Basal Ganglia; Blotting, Western; Chromatography, High Pressure Liquid; | 2008 |
Unilateral pallidotomy in a patient with parkinsonism and G2019S LRRK2 mutation.
Topics: Female; Functional Laterality; Glycine; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase- | 2009 |
Involvement of multiple protein kinases in cPLA2 phosphorylation, arachidonic acid release, and cell death in in vivo and in vitro models of 1-methyl-4-phenylpyridinium-induced parkinsonism--the possible key role of PKG.
Topics: Animals; Arachidonic Acid; Calcium; Catalytic Domain; Cell Death; Cyclic GMP; Cyclic GMP-Dependent P | 2009 |
Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP.
Topics: Aging; Amino Acid Sequence; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Enkephalins; | 2009 |
Elucidating the genetics and pathology of Perry syndrome.
Topics: Adult; Age of Onset; Aged; Animals; Brain; Chlorocebus aethiops; COS Cells; Depression; DNA-Binding | 2010 |
Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys.
Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cabergoline; Corpus Striatum; Disease Models, Animal; D | 2010 |
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Cell Death; Cycloheximi | 2010 |
123I-MIBG cardiac uptake and smell identification in parkinsonian patients with LRRK2 mutations.
Topics: 3-Iodobenzylguanidine; Adult; Aged; Aged, 80 and over; Female; Glycine; Heart; Humans; Leucine-Rich | 2011 |
Greater risk of parkinsonism associated with non-N370S GBA1 mutations.
Topics: Adult; Aged; Amino Acid Substitution; beta-Glucosidase; Female; Genetic Association Studies; Genetic | 2013 |
Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism.
Topics: Adult; Analysis of Variance; Biomechanical Phenomena; Brain; Cerebral Cortex; DNA Mutational Analysi | 2012 |
Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family.
Topics: Adult; Algeria; Cerebral Cortex; Dementia; DNA Mutational Analysis; Family Health; Female; Humans; I | 2003 |
Another phenotype of frontotemporal dementia and parkinsonism linked to chromosome-17 (FTDP-17) with a missense mutation of S305N closely resembling Pick's disease.
Topics: Asparagine; Chromosomes, Human, Pair 17; Dementia; Dentate Gyrus; Genetic Linkage; Humans; Immunohis | 2003 |
Pick's disease pathology of a missense mutation of S305N of frontotemporal dementia and parkinsonism linked to chromosome 17: another phenotype of S305N.
Topics: Asparagine; Base Sequence; Brain; Dementia; DNA Mutational Analysis; Genetic Linkage; Heterozygote; | 2004 |
Parkinsonism, Lrrk2 G2019S, and tau neuropathology.
Topics: Aged; alpha-Synuclein; Brain; Cell Line; Disability Evaluation; Disease Progression; Female; Glycine | 2006 |
Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain.
Topics: Adult; Aged; Arginine; DNA Mutational Analysis; Family Health; Female; Genetic Predisposition to Dis | 2007 |
Parkinsonism associated with the homozygous W748S mutation in the POLG1 gene.
Topics: Aged; Cocaine; DNA Polymerase gamma; DNA-Directed DNA Polymerase; Humans; Male; Mutation; Parkinsoni | 2008 |
Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Cysteine; DNA Mutational Analysis | 2008 |
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Topics: Dementia; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Genetic Testing; Glyci | 2008 |
A mutation in the human neurofilament M gene in Parkinson's disease that suggests a role for the cytoskeleton in neuronal degeneration.
Topics: Adult; Age of Onset; Brain; Cytoskeleton; DNA Mutational Analysis; Female; Genetic Testing; Glycine; | 2002 |