serine and Ataxia
serine has been researched along with Ataxia in 9 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "D-Serine, a selective agonist at the strychnine-insensitive glycine binding site, antagonized PCP-induction of stereotyped behavior and ataxia in a dose-dependent manner." | 7.68 | D-serine antagonized phencyclidine- and MK-801-induced stereotyped behavior and ataxia. ( Contreras, PC, 1990) |
| "Effects of systemic injection of the glycine(B) agonist, d-serine, the GlyT-1 glycine transporter inhibitor, ALX-5407, and the glycine(B) antagonist, L-701,324, were tested for the effects on EtOH-induced ataxia, hypothermia, and loss of righting reflex (LORR) duration in C57BL/6J (B6) and 129S1/SvImJ (S1) inbred mice." | 3.79 | Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site. ( Camp, M; Debrouse, L; Grant, SG; Gunduz-Cinar, O; Holmes, A; Hurd, B; Kiselycznyk, C; Mishina, M; Plitt, A; Todaro, A, 2013) |
| "D-Serine, a selective agonist at the strychnine-insensitive glycine binding site, antagonized PCP-induction of stereotyped behavior and ataxia in a dose-dependent manner." | 3.68 | D-serine antagonized phencyclidine- and MK-801-induced stereotyped behavior and ataxia. ( Contreras, PC, 1990) |
| "Familial hemiplegic migraine is an episodic neurological disorder characterized by transient sensory and motor symptoms and signs." | 1.56 | Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway. ( Bice, AR; Bonni, A; Brier, LM; Bumstead, JR; Chen, X; Crowley, JR; Culver, JP; Dikranian, K; Haigis, MC; Ippolito, JE; Oldenborg, A; Papouin, T; Rensing, NR; Ringel, AE; Shin, H; Smith, SE; Wong, M; Zhao, G, 2020) |
| "Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje cells." | 1.48 | Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model. ( Adamski, CJ; Duvick, L; Friedrich, J; Hawkinson, JE; Henzler, C; Lagalwar, S; Mollema, N; O'Callaghan, B; Orr, HT; Pérez Ortiz, JM; Strasser, J; Toker, N; Walters, MA; Zoghbi, HY, 2018) |
Research
Studies (9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Smith, SE | 1 |
| Chen, X | 1 |
| Brier, LM | 1 |
| Bumstead, JR | 1 |
| Rensing, NR | 1 |
| Ringel, AE | 1 |
| Shin, H | 1 |
| Oldenborg, A | 1 |
| Crowley, JR | 1 |
| Bice, AR | 1 |
| Dikranian, K | 1 |
| Ippolito, JE | 1 |
| Haigis, MC | 1 |
| Papouin, T | 1 |
| Zhao, G | 1 |
| Wong, M | 1 |
| Culver, JP | 1 |
| Bonni, A | 1 |
| Pérez Ortiz, JM | 1 |
| Mollema, N | 1 |
| Toker, N | 1 |
| Adamski, CJ | 1 |
| O'Callaghan, B | 1 |
| Duvick, L | 1 |
| Friedrich, J | 1 |
| Walters, MA | 1 |
| Strasser, J | 1 |
| Hawkinson, JE | 1 |
| Zoghbi, HY | 1 |
| Henzler, C | 1 |
| Orr, HT | 1 |
| Lagalwar, S | 1 |
| Pelayo-Negro, AL | 1 |
| Sánchez-Quintana, C | 1 |
| Rodríguez-Oroz, MC | 1 |
| Volpini, V | 1 |
| Zeviani, M | 1 |
| Tola-Arribas, MA | 1 |
| Berciano, J | 1 |
| Infante, J | 1 |
| Debrouse, L | 1 |
| Hurd, B | 1 |
| Kiselycznyk, C | 1 |
| Plitt, A | 1 |
| Todaro, A | 1 |
| Mishina, M | 1 |
| Grant, SG | 1 |
| Camp, M | 1 |
| Gunduz-Cinar, O | 1 |
| Holmes, A | 1 |
| Sawada, K | 1 |
| Ando, M | 1 |
| Sakata-Haga, H | 1 |
| Sun, XZ | 1 |
| Jeong, YG | 1 |
| Hisano, S | 1 |
| Takeda, N | 1 |
| Fukui, Y | 1 |
| Tanii, Y | 1 |
| Nishikawa, T | 1 |
| Hashimoto, A | 1 |
| Takahashi, K | 1 |
| Bank, WJ | 1 |
| Pizer, L | 1 |
| Pfendner, W | 1 |
| Sorrels, TL | 1 |
| Bostock, E | 1 |
| Contreras, PC | 1 |
Other Studies
9 other studies available for serine and Ataxia
| Article | Year |
|---|---|
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway.
Topics: Animals; Astrocytes; Ataxia; Brain; Disease Models, Animal; Electroencephalography; Female; Function | 2020 |
Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.
Topics: Animals; Ataxia; Ataxin-1; Cyclic AMP-Dependent Protein Kinases; Female; Humans; Male; Mice; Mice, T | 2018 |
Screening for POLG W748S and A467T mutations in ataxia patients from Spain.
Topics: Adult; Age of Onset; Aged; Alanine; Ataxia; DNA Polymerase gamma; DNA-Directed DNA Polymerase; Femal | 2012 |
Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
Topics: Alcoholic Intoxication; Animals; Ataxia; Cycloserine; Disease Models, Animal; Disks Large Homolog 4 | 2013 |
Abnormal expression of tyrosine hydroxylase not accompanied by phosphorylation at serine 40 in cerebellar Purkinje cells of ataxic mutant mice, rolling mouse Nagoya and dilute-lethal.
Topics: Animals; Ataxia; Cerebellum; Female; Immunohistochemistry; Male; Mice; Phosphorylation; Purkinje Cel | 2004 |
Stereoselective antagonism by enantiomers of alanine and serine of phencyclidine-induced hyperactivity, stereotypy and ataxia in the rat.
Topics: Alanine; Animals; Ataxia; Injections, Intraventricular; Male; Motor Activity; Phencyclidine; Rats; R | 1994 |
Glycine metabolism and spinal cord disorders.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Animals; Ataxia; Cats; Cells, Cultured; Chi | 1978 |
Induction of feeding by 7-chlorokynurenic acid, a strychnine-insensitive glycine binding site antagonist.
Topics: Analysis of Variance; Animals; Ataxia; Dose-Response Relationship, Drug; Feeding Behavior; Glycine; | 1992 |
D-serine antagonized phencyclidine- and MK-801-induced stereotyped behavior and ataxia.
Topics: Animals; Ataxia; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Inject | 1990 |