serine has been researched along with Ataxia Telangiectasia in 22 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Ataxia Telangiectasia: An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with lactacystin (an inhibitor of the proteasome) or heat shock leads to similar levels of p53 accumulation in normal and AT fibroblasts, but the p53 protein lacks a phosphorylated serine 15." | 1.30 | Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks. ( Nakagawa, K; Tamai, K; Taya, Y; Yamaizumi, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 17 (77.27) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| von Morgen, P | 1 |
| Burdova, K | 1 |
| Flower, TG | 1 |
| O'Reilly, NJ | 1 |
| Boulton, SJ | 1 |
| Smerdon, SJ | 1 |
| Macurek, L | 1 |
| Hořejší, Z | 1 |
| Gatei, M | 2 |
| Kijas, AW | 1 |
| Biard, D | 1 |
| Dörk, T | 1 |
| Lavin, MF | 2 |
| Das, BB | 1 |
| Antony, S | 1 |
| Gupta, S | 1 |
| Dexheimer, TS | 1 |
| Redon, CE | 1 |
| Garfield, S | 1 |
| Shiloh, Y | 3 |
| Pommier, Y | 1 |
| Sutton, IJ | 1 |
| Last, JI | 2 |
| Ritchie, SJ | 1 |
| Harrington, HJ | 1 |
| Byrd, PJ | 2 |
| Taylor, AM | 2 |
| Goodarzi, AA | 2 |
| Lees-Miller, SP | 2 |
| Jonnalagadda, JC | 1 |
| Douglas, P | 1 |
| Young, D | 1 |
| Ye, R | 1 |
| Moorhead, GB | 1 |
| Khanna, KK | 2 |
| Erker, L | 1 |
| Schubert, R | 1 |
| Yakushiji, H | 1 |
| Barlow, C | 1 |
| Larson, D | 1 |
| Mitchell, JB | 1 |
| Wynshaw-Boris, A | 1 |
| Suzuki, K | 1 |
| Kodama, S | 1 |
| Watanabe, M | 1 |
| Siliciano, JD | 1 |
| Canman, CE | 1 |
| Taya, Y | 4 |
| Sakaguchi, K | 1 |
| Appella, E | 1 |
| Kastan, MB | 4 |
| Nakagawa, K | 2 |
| Tamai, K | 1 |
| Yamaizumi, M | 1 |
| Lakin, ND | 1 |
| Hann, BC | 1 |
| Jackson, SP | 1 |
| Pandita, TK | 1 |
| Lieberman, HB | 1 |
| Lim, DS | 2 |
| Dhar, S | 1 |
| Zheng, W | 1 |
| Kim, ST | 1 |
| Xu, B | 1 |
| Maser, RS | 1 |
| Lin, J | 1 |
| Petrini, JH | 1 |
| Zhao, S | 1 |
| Weng, YC | 1 |
| Yuan, SS | 1 |
| Lin, YT | 1 |
| Hsu, HC | 1 |
| Lin, SC | 1 |
| Gerbino, E | 1 |
| Song, MH | 1 |
| Zdzienicka, MZ | 1 |
| Gatti, RA | 1 |
| Shay, JW | 1 |
| Ziv, Y | 2 |
| Lee, EY | 1 |
| Wu, X | 1 |
| Ranganathan, V | 1 |
| Weisman, DS | 1 |
| Heine, WF | 1 |
| Ciccone, DN | 1 |
| O'Neill, TB | 1 |
| Crick, KE | 1 |
| Pierce, KA | 1 |
| Lane, WS | 1 |
| Rathbun, G | 1 |
| Livingston, DM | 1 |
| Weaver, DT | 1 |
| Delia, D | 1 |
| Mizutani, S | 1 |
| Panigone, S | 1 |
| Tagliabue, E | 1 |
| Fontanella, E | 1 |
| Asada, M | 1 |
| Yamada, T | 1 |
| Prudente, S | 1 |
| Saviozzi, S | 1 |
| Frati, L | 1 |
| Pierotti, MA | 1 |
| Chessa, L | 1 |
| Scott, SP | 1 |
| Filippovitch, I | 1 |
| Soronika, N | 1 |
| Weber, B | 1 |
| Yang, DQ | 1 |
| Stewart, ZA | 1 |
| Tang, LJ | 1 |
| Pietenpol, JA | 1 |
| Kishi, S | 1 |
| Zhou, XZ | 1 |
| Khoo, C | 1 |
| Hill, DE | 1 |
| Lu, KP | 1 |
| Stewart, GS | 1 |
| Stankovic, T | 1 |
| Haites, N | 1 |
| Kidd, AM | 1 |
| Yoshida, M | 1 |
| Hosoi, Y | 1 |
| Miyachi, H | 1 |
| Ishii, N | 1 |
| Matsumoto, Y | 1 |
| Enomoto, A | 1 |
| Yamada, S | 1 |
| Suzuki, N | 1 |
| Ono, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Status of the Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis in Relation to Growth Failure, Body Weight and Neuroprotection in Children With Ataxia Telangiectasia[NCT01052623] | Phase 4 | 24 participants (Anticipated) | Interventional | 2010-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for serine and Ataxia Telangiectasia
| Article | Year |
|---|---|
[Low-dose radiation effects and intracellular signaling pathways].
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; DNA Damage; DNA- | 2006 |
21 other studies available for serine and Ataxia Telangiectasia
| Article | Year |
|---|---|
MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.
Topics: Animals; Apoptosis Regulatory Proteins; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Protein | 2017 |
RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.
Topics: Acid Anhydride Hydrolases; Ataxia Telangiectasia; Cell Line; Checkpoint Kinase 1; DNA Breaks, Double | 2014 |
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Carnitine O-Palmitoyltransferase; Cel | 2009 |
Adult-onset ataxia telangiectasia due to ATM 5762ins137 mutation homozygosity.
Topics: Adult; Alanine; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Blood Cells; Blotting | 2004 |
Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells.
Topics: Amino Acid Sequence; Androstadienes; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; | 2004 |
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Catalytic Domain; Cell Cycle Proteins | 2004 |
Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.
Topics: Animals; Antioxidants; Apoptosis; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cel | 2005 |
DNA damage induces phosphorylation of the amino terminus of p53.
Topics: Ataxia Telangiectasia; Binding Sites; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin | 1997 |
Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks.
Topics: Acetylcysteine; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; | 1999 |
The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Catalysis; Cell Cycle Proteins; DNA; | 1999 |
Ionizing radiation activates the ATM kinase throughout the cell cycle.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Cell | 2000 |
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; DNA; | 2000 |
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Chrom | 2000 |
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Catalysis; Cell Cycle Proteins; Cell | 2000 |
ATM protein and p53-serine 15 phosphorylation in ataxia-telangiectasia (AT) patients and at heterozygotes.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Cell | 2000 |
Role for ATM in DNA damage-induced phosphorylation of BRCA1.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Cell Cycle; Cell Cycle | 2000 |
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Ataxia Telangiectasia; Ataxia Telangiectas | 2000 |
Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner.
Topics: Antineoplastic Agents; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Pro | 2001 |
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Ataxia Telangiectasia; Ataxia Telangiectasia | 2001 |
Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cells | 2001 |
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.
Topics: Androstadienes; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycl | 2002 |