serine has been researched along with Astrocytoma, Grade IV in 40 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Besides STAT3 tyrosine 705 phosphorylation (pTyr705-STAT3), phosphorylation of STAT3 at serine 727 (pSer727-STAT3) is shown to contribute to tumorigenesis and be closely related with resistance to radiotherapy and chemotherapy in glioma, but there is currently no study regarding its relevance to prognosis in glioblastoma (GBM)." | 7.80 | STAT3 serine 727 phosphorylation influences clinical outcome in glioblastoma. ( Chen, L; Chen, YP; Lin, GS; Lin, ZX; Wang, XF; Zheng, ZQ, 2014) |
| "3) has been proposed to play a main role in the degradation of D-serine, an allosteric activator of the N-methyl-D-aspartate-type glutamate receptor in the human brain, and to be associated with the onset of schizophrenia." | 7.77 | Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase. ( Frattini, LF; Molla, G; Piubelli, L; Pollegioni, L; Sacchi, S, 2011) |
| "In the human glioblastoma cell line U87, the activity of serine racemase (SR), catalyzing the isomerisation of serine, was inversely regulated by D-serine and nitric oxide (NO), a neuromodulator and a neurotransmitter, respectively." | 7.73 | Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells. ( Ciampa, AR; Mariotto, S; Shoji, K; Suzuki, H, 2006) |
| "D-Serine indirectly caused dose- and time-dependent inhibition of neuronal nitric oxide synthase (nNOS) without affecting endothelial nitric oxide synthase (eNOS) in human glioblastoma cell line U87." | 7.73 | Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells. ( Ciampa, AR; Mariotto, S; Shoji, K; Suzuki, H, 2006) |
| "Glioblastoma is the most common brain tumor with dismal outcomes in adults." | 5.72 | Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma. ( Amano, T; Fujiwara, M; Hirose, H; Matsuo, S; Miyamatsu, Y; Nakamizo, A; Shimamura, T; Yoshimoto, K, 2022) |
| " Here, we find that serine and glycine levels were higher in low-nutrient regions of tumors in glioblastoma multiforme (GBM) patients than they were in other regions." | 4.02 | Glioma cells require one-carbon metabolism to survive glutamine starvation. ( Bamba, T; Fujita, Y; Hashiguchi, M; Hosoda, K; Irino, Y; Izumi, Y; Kitta, A; Kohmura, E; Kohta, M; Kyotani, K; Nagashima, H; Nakai, T; Sasayama, T; Satoh, N; Shinohara, M; Takahashi, M; Tanaka, K; Uno, T; Uozumi, Y, 2021) |
| "Besides STAT3 tyrosine 705 phosphorylation (pTyr705-STAT3), phosphorylation of STAT3 at serine 727 (pSer727-STAT3) is shown to contribute to tumorigenesis and be closely related with resistance to radiotherapy and chemotherapy in glioma, but there is currently no study regarding its relevance to prognosis in glioblastoma (GBM)." | 3.80 | STAT3 serine 727 phosphorylation influences clinical outcome in glioblastoma. ( Chen, L; Chen, YP; Lin, GS; Lin, ZX; Wang, XF; Zheng, ZQ, 2014) |
| "3) has been proposed to play a main role in the degradation of D-serine, an allosteric activator of the N-methyl-D-aspartate-type glutamate receptor in the human brain, and to be associated with the onset of schizophrenia." | 3.77 | Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase. ( Frattini, LF; Molla, G; Piubelli, L; Pollegioni, L; Sacchi, S, 2011) |
| "In the human glioblastoma cell line U87, the activity of serine racemase (SR), catalyzing the isomerisation of serine, was inversely regulated by D-serine and nitric oxide (NO), a neuromodulator and a neurotransmitter, respectively." | 3.73 | Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells. ( Ciampa, AR; Mariotto, S; Shoji, K; Suzuki, H, 2006) |
| "D-Serine indirectly caused dose- and time-dependent inhibition of neuronal nitric oxide synthase (nNOS) without affecting endothelial nitric oxide synthase (eNOS) in human glioblastoma cell line U87." | 3.73 | Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells. ( Ciampa, AR; Mariotto, S; Shoji, K; Suzuki, H, 2006) |
| "In developing iodine-123-labelled amino acid derivatives for imaging cerebral gliomas by single-photon emission tomography (SPET), we compared p-[123I]iodo-L-phenylalanine (IPA), L-[123I]iodo-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid (ITIC) and L-3-[123I]iodo-alpha-methyltyrosine (IMT) with regard to their uptake in human glioblastoma T99 and T3868 cells, and thereafter studied the mechanisms promoting the cellular uptake." | 3.70 | Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats. ( Feiden, W; Heimann, A; Kempski, O; Kirsch, CM; Richter, S; Romeike, BF; Samnick, S, 2000) |
| "Glioblastoma is the most common brain tumor with dismal outcomes in adults." | 1.72 | Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma. ( Amano, T; Fujiwara, M; Hirose, H; Matsuo, S; Miyamatsu, Y; Nakamizo, A; Shimamura, T; Yoshimoto, K, 2022) |
| "Glioblastoma is the most malignant and lethal subtype brain tumors with high risk of recurrence and therapeutic resistance." | 1.48 | Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma. ( Dong, Z; Du, S; Huang, J; Lei, T; Sun, M; Tong, R; Wang, H; Wang, Y; Yang, J; Yang, Y, 2018) |
| "Treatment with wortmannin or calphostin C or the expression of dominant negative Akt inhibited phosphorylation of GSK-3beta at Ser-9 following the KCl-induced depolarization of SH-SY5Y cells." | 1.33 | Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells. ( Juhnn, YS; Kang, UG; Kim, SY; Kim, Y; Kim, YS; Lee, YI; Seo, M, 2005) |
| " First, we evaluated the response of human cells to microwave exposure at a specific absorption rate (SAR) of 80 mW/kg, which corresponds to the limit of the average whole-body SAR for general public exposure defined as a basic restriction by the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines." | 1.33 | Phosphorylation and gene expression of p53 are not affected in human cells exposed to 2.1425 GHz band CW or W-CDMA modulated radiation allocated to mobile radio base stations. ( Hirose, H; Kaji, N; Miyakoshi, J; Nojima, T; Sakuma, N; Sekijima, M; Suhara, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.50) | 18.2507 |
| 2000's | 18 (45.00) | 29.6817 |
| 2010's | 13 (32.50) | 24.3611 |
| 2020's | 8 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, L | 1 |
| Kiang, KM | 1 |
| Cheng, SY | 1 |
| Leung, GK | 1 |
| Dutta, R | 1 |
| Sharma, MC | 1 |
| Suri, V | 1 |
| Sarkar, C | 1 |
| Garg, A | 1 |
| Suri, A | 1 |
| Kale, SS | 1 |
| Morjen, M | 1 |
| Moslah, W | 1 |
| Touihri-Baraketi, I | 1 |
| Srairi-Abid, N | 1 |
| Luis, J | 1 |
| Marrakchi, N | 1 |
| Jebali, J | 1 |
| Bhattacharya, S | 1 |
| Yin, J | 1 |
| Yang, C | 1 |
| Wang, Y | 2 |
| Sims, M | 1 |
| Pfeffer, LM | 1 |
| Chaum, E | 1 |
| Nakamizo, A | 1 |
| Miyamatsu, Y | 1 |
| Hirose, H | 2 |
| Amano, T | 1 |
| Matsuo, S | 1 |
| Fujiwara, M | 1 |
| Shimamura, T | 1 |
| Yoshimoto, K | 1 |
| Sliusar, MY | 1 |
| Minchenko, DO | 1 |
| Khita, OO | 1 |
| Tsymbal, DO | 1 |
| Viletska, YM | 1 |
| Luzina, OY | 1 |
| Danilovskyi, SV | 1 |
| Ratushna, OO | 1 |
| Minchenko, OH | 1 |
| Engel, AL | 1 |
| Lorenz, NI | 1 |
| Klann, K | 1 |
| Münch, C | 1 |
| Depner, C | 1 |
| Steinbach, JP | 1 |
| Ronellenfitsch, MW | 1 |
| Luger, AL | 1 |
| Tanaka, K | 1 |
| Sasayama, T | 1 |
| Nagashima, H | 1 |
| Irino, Y | 1 |
| Takahashi, M | 1 |
| Izumi, Y | 1 |
| Uno, T | 1 |
| Satoh, N | 1 |
| Kitta, A | 1 |
| Kyotani, K | 1 |
| Fujita, Y | 1 |
| Hashiguchi, M | 1 |
| Nakai, T | 1 |
| Kohta, M | 1 |
| Uozumi, Y | 1 |
| Shinohara, M | 1 |
| Hosoda, K | 1 |
| Bamba, T | 1 |
| Kohmura, E | 1 |
| Gu, Y | 1 |
| Albuquerque, CP | 1 |
| Braas, D | 1 |
| Zhang, W | 1 |
| Villa, GR | 1 |
| Bi, J | 1 |
| Ikegami, S | 1 |
| Masui, K | 1 |
| Gini, B | 1 |
| Yang, H | 1 |
| Gahman, TC | 1 |
| Shiau, AK | 1 |
| Cloughesy, TF | 1 |
| Christofk, HR | 1 |
| Zhou, H | 1 |
| Guan, KL | 1 |
| Mischel, PS | 1 |
| Yang, Y | 1 |
| Lei, T | 1 |
| Du, S | 1 |
| Tong, R | 1 |
| Wang, H | 2 |
| Yang, J | 1 |
| Huang, J | 1 |
| Sun, M | 1 |
| Dong, Z | 1 |
| Teramoto, K | 1 |
| Katoh, H | 1 |
| Lin, GS | 1 |
| Chen, YP | 1 |
| Lin, ZX | 1 |
| Wang, XF | 1 |
| Zheng, ZQ | 1 |
| Chen, L | 1 |
| Ouédraogo, ZG | 1 |
| Müller-Barthélémy, M | 1 |
| Kemeny, JL | 1 |
| Dedieu, V | 1 |
| Biau, J | 1 |
| Khalil, T | 1 |
| Raoelfils, LI | 1 |
| Granzotto, A | 1 |
| Pereira, B | 1 |
| Beaudoin, C | 1 |
| Guissou, IP | 1 |
| Berger, M | 1 |
| Morel, L | 1 |
| Chautard, E | 1 |
| Verrelle, P | 1 |
| Kim, RK | 1 |
| Suh, Y | 1 |
| Hwang, E | 1 |
| Yoo, KC | 1 |
| Choi, KS | 1 |
| An, S | 1 |
| Hwang, SG | 1 |
| Kim, IG | 1 |
| Kim, MJ | 1 |
| Lee, HJ | 1 |
| Lee, SJ | 1 |
| Joy, A | 1 |
| Kapoor, M | 1 |
| Georges, J | 1 |
| Butler, L | 1 |
| Chang, Y | 1 |
| Li, C | 1 |
| Crouch, A | 1 |
| Smirnov, I | 1 |
| Nakada, M | 1 |
| Hepler, J | 1 |
| Marty, M | 1 |
| Feuerstein, BG | 1 |
| Chiasserini, D | 1 |
| Davidescu, M | 1 |
| Orvietani, PL | 1 |
| Susta, F | 1 |
| Macchioni, L | 1 |
| Petricciuolo, M | 1 |
| Castigli, E | 1 |
| Roberti, R | 1 |
| Binaglia, L | 1 |
| Corazzi, L | 1 |
| Brantley, EC | 1 |
| Nabors, LB | 1 |
| Gillespie, GY | 1 |
| Choi, YH | 1 |
| Palmer, CA | 1 |
| Harrison, K | 1 |
| Roarty, K | 1 |
| Benveniste, EN | 1 |
| Mandell, JW | 1 |
| Glass, G | 1 |
| Gianchandani, EP | 1 |
| Locke, CN | 1 |
| Amos, S | 2 |
| Bourne, TD | 1 |
| Schiff, D | 1 |
| Papin, JA | 1 |
| Gulati, N | 1 |
| Karsy, M | 1 |
| Albert, L | 1 |
| Murali, R | 1 |
| Jhanwar-Uniyal, M | 1 |
| Mut, M | 1 |
| Hussaini, IM | 1 |
| Chen, H | 1 |
| Mei, L | 1 |
| Zhou, L | 1 |
| Zhang, X | 1 |
| Guo, C | 1 |
| Li, J | 1 |
| Zhu, Y | 1 |
| Zheng, Y | 2 |
| Huang, L | 1 |
| Frattini, LF | 1 |
| Piubelli, L | 1 |
| Sacchi, S | 1 |
| Molla, G | 1 |
| Pollegioni, L | 1 |
| Caracciolo, V | 1 |
| Laurenti, G | 1 |
| Romano, G | 1 |
| Carnevale, V | 1 |
| Cimini, AM | 1 |
| Crozier-Fitzgerald, C | 1 |
| Gentile Warschauer, E | 1 |
| Russo, G | 1 |
| Giordano, A | 2 |
| Yang, W | 1 |
| Xia, Y | 1 |
| Cao, Y | 1 |
| Bu, W | 1 |
| Zhang, L | 1 |
| You, MJ | 1 |
| Koh, MY | 1 |
| Cote, G | 1 |
| Aldape, K | 1 |
| Li, Y | 1 |
| Verma, IM | 1 |
| Chiao, PJ | 1 |
| Lu, Z | 1 |
| Jeng, YM | 1 |
| Hsu, HC | 1 |
| Feng, J | 1 |
| Park, J | 1 |
| Cron, P | 1 |
| Hess, D | 1 |
| Hemmings, BA | 1 |
| Fujita, M | 1 |
| Mizuno, M | 1 |
| Nagasaka, T | 1 |
| Wakabayashi, T | 1 |
| Maeda, K | 1 |
| Ishii, D | 1 |
| Arima, T | 1 |
| Kawajiri, A | 1 |
| Inagaki, M | 1 |
| Yoshida, J | 1 |
| Lee, YI | 1 |
| Seo, M | 1 |
| Kim, Y | 1 |
| Kim, SY | 1 |
| Kang, UG | 1 |
| Kim, YS | 1 |
| Juhnn, YS | 1 |
| Curran, NM | 1 |
| Griffin, BD | 1 |
| O'Toole, D | 1 |
| Brady, KJ | 1 |
| Fitzgerald, SN | 1 |
| Moynagh, PN | 1 |
| Shoji, K | 2 |
| Mariotto, S | 2 |
| Ciampa, AR | 2 |
| Suzuki, H | 2 |
| Koul, D | 2 |
| Shen, R | 2 |
| Bergh, S | 2 |
| Lu, Y | 2 |
| de Groot, JF | 2 |
| Liu, TJ | 1 |
| Mills, GB | 2 |
| Yung, WK | 2 |
| Sheng, X | 1 |
| Shishodia, S | 1 |
| Lafortune, TA | 1 |
| Sakuma, N | 1 |
| Kaji, N | 1 |
| Suhara, T | 1 |
| Sekijima, M | 1 |
| Nojima, T | 1 |
| Miyakoshi, J | 1 |
| Claudio, PP | 1 |
| Cui, J | 1 |
| Ghafouri, M | 1 |
| Mariano, C | 1 |
| White, MK | 1 |
| Safak, M | 1 |
| Sheffield, JB | 1 |
| Khalili, K | 1 |
| Amini, S | 1 |
| Sawaya, BE | 1 |
| Maccario, H | 1 |
| Perera, NM | 1 |
| Davidson, L | 1 |
| Downes, CP | 1 |
| Leslie, NR | 1 |
| Szado, T | 1 |
| Vanderheyden, V | 1 |
| Parys, JB | 1 |
| De Smedt, H | 1 |
| Rietdorf, K | 1 |
| Kotelevets, L | 1 |
| Chastre, E | 1 |
| Khan, F | 1 |
| Landegren, U | 1 |
| Söderberg, O | 1 |
| Bootman, MD | 1 |
| Roderick, HL | 1 |
| Liu, R | 1 |
| Tian, B | 1 |
| Gearing, M | 1 |
| Hunter, S | 1 |
| Ye, K | 1 |
| Mao, Z | 1 |
| Sonoda, Y | 1 |
| Watanabe, S | 1 |
| Matsumoto, Y | 1 |
| Aizu-Yokota, E | 1 |
| Kasahara, T | 1 |
| Samnick, S | 1 |
| Richter, S | 1 |
| Romeike, BF | 1 |
| Heimann, A | 1 |
| Feiden, W | 1 |
| Kempski, O | 1 |
| Kirsch, CM | 1 |
40 other studies available for serine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Survival; DNA Da | 2022 |
TTF-1: A Well-Favored Addition to the Immunohistochemistry Armamentarium as a Diagnostic Marker of SEGA.
Topics: Astrocytoma; Brain Neoplasms; Child; Ependymoma; Glioblastoma; Humans; Immunohistochemistry; Neurocy | 2022 |
Expression of the First Recombinant Anti-Tumoral Snake Venom Kunitz-Type Serine Protease Inhibitor.
Topics: Antivenins; Glioblastoma; Humans; Serine; Serine Proteinase Inhibitors; Snake Venoms | 2022 |
STAT3 suppresses the AMPKα/ULK1-dependent induction of autophagy in glioblastoma cells.
Topics: AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Protein-1 Homolog; Glioblastoma; Humans; | 2022 |
Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma.
Topics: Adult; Biosynthetic Pathways; Glioblastoma; Humans; Nucleotides; Pyrimidines; Serine | 2022 |
Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner.
Topics: Cell Hypoxia; Cell Line, Tumor; Endoribonucleases; Gene Expression Regulation, Neoplastic; Glioblast | 2023 |
Serine-dependent redox homeostasis regulates glioblastoma cell survival.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulati | 2020 |
Glioma cells require one-carbon metabolism to survive glutamine starvation.
Topics: Aminohydrolases; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Ge | 2021 |
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.
Topics: A549 Cells; Amino Acid Transport System y+; Brain Neoplasms; Cysteine; Glioblastoma; Glutamine; Glut | 2017 |
Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; DNA Breaks, | 2018 |
The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions.
Topics: Amino Acid Transport System y+; Antiporters; Cell Line, Tumor; Cell Movement; Cell Survival; Cystine | 2019 |
STAT3 serine 727 phosphorylation influences clinical outcome in glioblastoma.
Topics: Adult; Aged; Biomarkers, Tumor; Disease-Free Survival; Female; Glioblastoma; Humans; Immunohistochem | 2014 |
STAT3 Serine 727 Phosphorylation: A Relevant Target to Radiosensitize Human Glioblastoma.
Topics: Brain Neoplasms; Carbazoles; Cell Line, Tumor; Cell Proliferation; Colony-Forming Units Assay; Dose- | 2016 |
PKCδ maintains phenotypes of tumor initiating cells through cytokine-mediated autocrine loop with positive feedback.
Topics: Animals; Autocrine Communication; Cell Line, Tumor; Glioblastoma; Humans; Mice; Neoplastic Stem Cell | 2015 |
The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression.
Topics: Cell Cycle; Cell Line, Tumor; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Gliobla | 2016 |
3-Bromopyruvate treatment induces alterations of metabolic and stress-related pathways in glioblastoma cells.
Topics: Amino Acids; Carbohydrate Metabolism; Cell Line, Tumor; Glioblastoma; Glycolysis; Heat-Shock Protein | 2017 |
Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glioblastoma; | 2008 |
Dephosphorylation of beta-arrestin 1 in glioblastomas.
Topics: Arrestins; beta-Arrestin 1; beta-Arrestins; Cell Line, Tumor; Follow-Up Studies; Glioblastoma; Green | 2009 |
Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; C | 2009 |
PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells.
Topics: Cell Line, Tumor; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Glioblastoma; Humans; Indoles; Maleimi | 2010 |
Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Cell Line; Cell Nucleus; Cell Proliferation; Cyc | 2011 |
Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase.
Topics: Animals; Carrier Proteins; D-Amino-Acid Oxidase; Disease Models, Animal; Enzyme Inhibitors; Flavin-A | 2011 |
Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development.
Topics: Blotting, Western; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase- | 2012 |
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Topics: Animals; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzym | 2012 |
KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas.
Topics: Adult; Aged; Alleles; Amino Acid Substitution; Astrocytoma; Brain Neoplasms; Chromosomes, Human, Pai | 2003 |
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase.
Topics: 3T3-L1 Cells; Amino Acid Motifs; Animals; Cell Line; Cell Line, Tumor; Cell Membrane; Chromatography | 2004 |
Aurora-B dysfunction of multinucleated giant cells in glioma detected by site-specific phosphorylated antibodies.
Topics: Antibodies, Monoclonal; Aurora Kinase B; Aurora Kinases; Brain Neoplasms; Cell Line, Tumor; Fluoresc | 2004 |
Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells.
Topics: Androstadienes; Animals; Calcineurin; Calcium; Cell Line; Cell Line, Tumor; Cell Membrane; Enzyme In | 2005 |
The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner.
Topics: Active Transport, Cell Nucleus; Astrocytes; Astrocytoma; Benzoxazines; Blotting, Western; Calcium Ch | 2005 |
Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells.
Topics: Analysis of Variance; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Enzyme | 2006 |
Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma.
Topics: Blotting, Western; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Movement; Cell Proliferation; C | 2005 |
Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells.
Topics: Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Flu | 2006 |
Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.
Topics: Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Central Nervous System Neoplasm | 2006 |
Phosphorylation and gene expression of p53 are not affected in human cells exposed to 2.1425 GHz band CW or W-CDMA modulated radiation allocated to mobile radio base stations.
Topics: Amino Acid Sequence; Apoptosis; Cell Line; Cell Line, Tumor; Fibroblasts; Gene Expression; Glioblast | 2006 |
Cdk9 phosphorylates p53 on serine 392 independently of CKII.
Topics: Brain Neoplasms; Casein Kinase II; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Glioblastoma; HIV-1; | 2006 |
PTEN is destabilized by phosphorylation on Thr366.
Topics: Animals; Casein Kinase II; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glioblastoma; G | 2007 |
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.
Topics: Animals; Apoptosis; Calcium; Cell Line; Chlorocebus aethiops; Glioblastoma; Humans; Inositol 1,4,5-T | 2008 |
Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion.
Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Movement; Central Nervous System Neoplasms; C | 2008 |
FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line.
Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Adhesion Molecules; | 1999 |
Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; beta-Alanine; Binding, Competitive; Blood-Brain | 2000 |