serine has been researched along with Anxiety in 15 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After establishing FDL, l-serine treatment: 1) improved spatial learning, memory and cognitive ability in mice, and relieved anxiety for 4 weeks post-FDL induction; 2) reduced abnormally dephosphorylated neurofilament proteins, increased myelin basic protein, and preserved anatomic myelinated axons; 3) inhibited microglia activation and reduced the release of inflammatory factors; 4) promoted recruitment and proliferation of oligodendrocyte progenitor cells, and the efficiency of subsequent remyelination on day twenty-eight post-FDL induction." | 7.91 | Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice. ( Ding, L; Gan, D; Gao, C; Jiang, Z; Luo, Q; Sun, Y; Wang, G; Xu, L; Zhang, N, 2019) |
| "Several compounds that promote activation of the N-methyl-d-aspartate receptor (NMDAR) glycine site have been proposed as treatments for schizophrenia, but the impact of these putative antipsychotics on anxiety remains unclear." | 7.75 | Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors. ( Clapcote, SJ; Labrie, V; Roder, JC, 2009) |
| " After establishing FDL, l-serine treatment: 1) improved spatial learning, memory and cognitive ability in mice, and relieved anxiety for 4 weeks post-FDL induction; 2) reduced abnormally dephosphorylated neurofilament proteins, increased myelin basic protein, and preserved anatomic myelinated axons; 3) inhibited microglia activation and reduced the release of inflammatory factors; 4) promoted recruitment and proliferation of oligodendrocyte progenitor cells, and the efficiency of subsequent remyelination on day twenty-eight post-FDL induction." | 3.91 | Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice. ( Ding, L; Gan, D; Gao, C; Jiang, Z; Luo, Q; Sun, Y; Wang, G; Xu, L; Zhang, N, 2019) |
| "The obtained data suggest that stimulation of the glutamate or glycine recognition site of the NMDA receptor complex significantly decreases the antianxiety properties of antagonists of either site." | 3.79 | NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice. ( Dudka, J; Oniszczuk, T; Poleszak, E; Serefko, A; Szopa, A; Wlaź, P; Wośko, S; Wróbel, A, 2013) |
| "Several compounds that promote activation of the N-methyl-d-aspartate receptor (NMDAR) glycine site have been proposed as treatments for schizophrenia, but the impact of these putative antipsychotics on anxiety remains unclear." | 3.75 | Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors. ( Clapcote, SJ; Labrie, V; Roder, JC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Terrillion, CE | 1 |
| Abazyan, B | 1 |
| Yang, Z | 1 |
| Crawford, J | 1 |
| Shevelkin, AV | 1 |
| Jouroukhin, Y | 1 |
| Yoo, KH | 1 |
| Cho, CH | 1 |
| Roychaudhuri, R | 1 |
| Snyder, SH | 1 |
| Jang, MH | 1 |
| Pletnikov, MV | 1 |
| Leal, RB | 1 |
| Lopes, MW | 1 |
| Formolo, DA | 1 |
| de Carvalho, CR | 1 |
| Hoeller, AA | 1 |
| Latini, A | 1 |
| Sousa, DS | 1 |
| Wolf, P | 1 |
| Prediger, RD | 1 |
| Bortolotto, ZA | 1 |
| Linhares, MN | 1 |
| Lin, K | 1 |
| Walz, R | 1 |
| Wang, G | 1 |
| Ding, L | 1 |
| Gao, C | 1 |
| Zhang, N | 1 |
| Gan, D | 1 |
| Sun, Y | 1 |
| Xu, L | 1 |
| Luo, Q | 1 |
| Jiang, Z | 1 |
| Ben M'Barek, K | 1 |
| Pla, P | 1 |
| Orvoen, S | 1 |
| Benstaali, C | 1 |
| Godin, JD | 1 |
| Gardier, AM | 1 |
| Saudou, F | 1 |
| David, DJ | 1 |
| Humbert, S | 1 |
| Muramatsu, H | 1 |
| Katsuoka, F | 1 |
| Toide, K | 1 |
| Shimizu, Y | 1 |
| Furusako, S | 1 |
| Yamamoto, M | 1 |
| Poleszak, E | 1 |
| Serefko, A | 1 |
| Szopa, A | 1 |
| Wośko, S | 1 |
| Dudka, J | 1 |
| Wróbel, A | 1 |
| Oniszczuk, T | 1 |
| Wlaź, P | 1 |
| Levin, R | 1 |
| Dor-Abarbanel, AE | 1 |
| Edelman, S | 1 |
| Durrant, AR | 1 |
| Hashimoto, K | 1 |
| Javitt, DC | 1 |
| Heresco-Levy, U | 1 |
| Wang, XQ | 1 |
| Zhong, XL | 1 |
| Li, ZB | 1 |
| Wang, HT | 1 |
| Zhang, J | 1 |
| Li, F | 1 |
| Zhang, JY | 1 |
| Dai, RP | 1 |
| Xin-Fu, Z | 1 |
| Li, CQ | 1 |
| Li, ZY | 1 |
| Bi, FF | 1 |
| Labrie, V | 1 |
| Clapcote, SJ | 1 |
| Roder, JC | 1 |
| Kiselycznyk, C | 1 |
| Zhang, X | 1 |
| Huganir, RL | 1 |
| Holmes, A | 1 |
| Svenningsson, P | 1 |
| Kühn, KU | 1 |
| Joe, AY | 1 |
| Meyer, K | 1 |
| Reichmann, K | 1 |
| Maier, W | 1 |
| Rao, ML | 1 |
| Reinhardt, MJ | 1 |
| Biersack, HJ | 1 |
| Quednow, BB | 1 |
| Ren, WH | 1 |
| Guo, JD | 1 |
| Cao, H | 1 |
| Wang, H | 1 |
| Wang, PF | 1 |
| Sha, H | 1 |
| Ji, RR | 1 |
| Zhao, ZQ | 1 |
| Zhang, YQ | 1 |
| Santos, P | 1 |
| Bittencourt, AS | 1 |
| Schenberg, LC | 1 |
| Carobrez, AP | 2 |
| Keays, DA | 1 |
| Tian, G | 1 |
| Poirier, K | 1 |
| Huang, GJ | 1 |
| Siebold, C | 1 |
| Cleak, J | 1 |
| Oliver, PL | 1 |
| Fray, M | 1 |
| Harvey, RJ | 1 |
| Molnár, Z | 1 |
| Piñon, MC | 1 |
| Dear, N | 1 |
| Valdar, W | 1 |
| Brown, SD | 1 |
| Davies, KE | 1 |
| Rawlins, JN | 1 |
| Cowan, NJ | 1 |
| Nolan, P | 1 |
| Chelly, J | 1 |
| Flint, J | 1 |
| Schmitt, ML | 1 |
| Coelho, W | 1 |
| Lopes-de-Souza, AS | 1 |
| Guimarães, FS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Behavioral and Cognitive Effects of the N-methyl-D-aspartate Receptor (NMDAR) Co-agonist D-serine in Healthy Humans[NCT02051426] | 35 participants (Actual) | Interventional | 2007-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The d-prime score is a score given to each participant on a scale of 0.0 - 1.0 in which discrimination sensitivity is measured. A score of 0 equates to no sensitivity whereas a score of 1.0 equates to perfect sensitivity." (NCT02051426)
Timeframe: Baseline, 2 hours post intervention
| Intervention | units on a scale (Mean) |
|---|---|
| D-serine | .5 |
| Placebo | 0 |
RAVLT measures short term verbal memory, verbal learning, susceptibility to (proactive and retroactive) interference, retention of information after a certain period of time during which other activities are performed and recognition memory. The test consists of a list of 15 common nouns, which are read to the subject in five consecutive trials (trials 1 through 5); each reading is followed by a free-recall task. In trial 6, an interface list of 15 new common nouns is presented, followed by free recall of these new nouns. In trial 7, without additional reading, subjects are again asked to recall the first list. Twenty minutes later, without an additional reading, subjects are asked to recall once more the first list (trial 8). The RAVLT score range from 0-90 correctly recalled words. For trial 7 the score ranges from 0 to 15 correctly recalled words. (NCT02051426)
Timeframe: Baseline, 2 hours post intervention
| Intervention | units on a scale (Mean) |
|---|---|
| D-serine | 2 |
| Placebo | .3 |
The subject was asked to point on the VAS scale according to his anxiety level. VAS anxiety scale 0 to 10 ( 0 [no anxiety] to 10 [maximum anxiety] ). (NCT02051426)
Timeframe: Baseline, 2 hours post intervention
| Intervention | units on a scale (Mean) |
|---|---|
| D-serine | 0.5 |
| Placebo | 0.0 |
2 trials available for serine and Anxiety
| Article | Year |
|---|---|
Behavioral and cognitive effects of the N-methyl-D-aspartate receptor co-agonist D-serine in healthy humans: initial findings.
Topics: Adult; Affect; Anxiety; Cognition; Cross-Over Studies; Female; Glutamic Acid; Glycine; Humans; Male; | 2015 |
Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor.
Topics: Adult; Anxiety; Brain; Brain Mapping; Cerebrovascular Circulation; Cysteine; Demography; Double-Blin | 2004 |
13 other studies available for serine and Anxiety
| Article | Year |
|---|---|
DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice.
Topics: Animals; Animals, Newborn; Anxiety; Astrocytes; Behavior, Animal; Cell Proliferation; Disease Models | 2017 |
Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.
Topics: Adult; Amygdala; Anxiety; Anxiety Disorders; Biomarkers; Fear; Female; Glutamic Acid; Hippocampus; H | 2020 |
Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice.
Topics: Animals; Anxiety; Axons; Calcium-Binding Proteins; Corpus Callosum; Demyelinating Diseases; Explorat | 2019 |
Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.
Topics: Analysis of Variance; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Depres | 2013 |
Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice.
Topics: Amino Acids; Animals; Anxiety; Behavior, Animal; Brain; Dopamine Agents; Locomotion; Male; Mice; Mic | 2013 |
NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Binding Sites; | 2013 |
Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats.
Topics: Anhedonia; Animals; Anti-Anxiety Agents; Anxiety; Dietary Sucrose; Disease Models, Animal; Hippocamp | 2015 |
Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors.
Topics: Animals; Antipsychotic Agents; Anxiety; Carrier Proteins; D-Amino-Acid Oxidase; Female; Glycine; Mal | 2009 |
Reduced phosphorylation of GluA1 subunits relates to anxiety-like behaviours in mice.
Topics: Animals; Anxiety; Female; Gene Knock-In Techniques; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL | 2013 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cing | 2006 |
Elevated T-maze evaluation of anxiety and memory effects of NMDA/glycine-B site ligands injected into the dorsal periaqueductal gray matter and the superior colliculus of rats.
Topics: Animals; Anxiety; Glycine; Kynurenic Acid; Ligands; Male; Maze Learning; Memory; Microinjections; Pe | 2006 |
Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.
Topics: Amino Acid Sequence; Animals; Anxiety; Behavior, Animal; Cell Movement; Cerebral Cortex; Chromosome | 2007 |
Anxiogenic-like effect of glycine and D-serine microinjected into dorsal periaqueductal gray matter of rats.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Glycine; Male; Maze Learning; Microinjections; P | 1995 |