serine has been researched along with Alloxan Diabetes in 44 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Excerpt | Relevance | Reference |
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"We analysed whether administration of an L-serine-enriched diet to mouse models of diabetes, an established method for decreasing the synthesis of 1-deoxysphingolipids in vivo, reduced the severity of acute pancreatitis." | 7.96 | Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice. ( Chen, R; Graf, R; Henstridge, DC; Hills, AP; Hornemann, T; Malagola, E; Reding, T; Schraner, EM; Sonda, S; Štefanić, S; Zuellig, R, 2020) |
" We investigated the effects of O-GlcNAc modification on actin reorganization and morphology of rat insulinoma INS-1 cells after glucosamine (GlcN) treatment." | 7.76 | Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. ( Jung, O; Kang, M; Kim, H; Kim, HJ; Kim, SH; Kwak, TK; Lee, JW; Lee, SA; Park, JM, 2010) |
"We analysed whether administration of an L-serine-enriched diet to mouse models of diabetes, an established method for decreasing the synthesis of 1-deoxysphingolipids in vivo, reduced the severity of acute pancreatitis." | 3.96 | Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice. ( Chen, R; Graf, R; Henstridge, DC; Hills, AP; Hornemann, T; Malagola, E; Reding, T; Schraner, EM; Sonda, S; Štefanić, S; Zuellig, R, 2020) |
"Evodiamine, an alkaloid extracted from the dried unripe fruit of the tree Evodia rutaecarpa Bentham (Rutaceae), reduces obesity and insulin resistance in obese/diabetic mice; however, the mechanism underlying the effect of evodiamine on insulin resistance is unknown." | 3.79 | Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice. ( Kontani, Y; Kusudo, T; Mori, N; Okamatsu, Y; Saito, M; Takeuchi, T; Wang, T; Yamashita, H; Yamashita, Y, 2013) |
" We investigated the effects of O-GlcNAc modification on actin reorganization and morphology of rat insulinoma INS-1 cells after glucosamine (GlcN) treatment." | 3.76 | Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. ( Jung, O; Kang, M; Kim, H; Kim, HJ; Kim, SH; Kwak, TK; Lee, JW; Lee, SA; Park, JM, 2010) |
"In this study, experimental autoimmune diabetes (EAD) mice, which subcutaneous immunization of ins1 or 2B:9-23 induced autoimmune diabetes in F1(B7." | 1.35 | One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide. ( Arai, T; Hara, K; Kameno, M; Kishi, M; Kurohara, M; Moriyama, H; Nagata, M; Okumachi, Y; Yamada, K; Yasuda, H; Yokono, K, 2008) |
"3." | 1.25 | Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses. ( Lopes-Vieira, O; Walker, B; Williamson, DH, 1967) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 13 (29.55) | 18.7374 |
1990's | 3 (6.82) | 18.2507 |
2000's | 10 (22.73) | 29.6817 |
2010's | 12 (27.27) | 24.3611 |
2020's | 6 (13.64) | 2.80 |
Authors | Studies |
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Malhi, NK | 1 |
Allen, CL | 1 |
Stewart, E | 1 |
Horton, KL | 1 |
Riu, F | 1 |
Batson, J | 1 |
Amoaku, W | 1 |
Morris, JC | 1 |
Arkill, KP | 1 |
Bates, DO | 1 |
Rousseau, M | 1 |
Denhez, B | 1 |
Spino, C | 1 |
Lizotte, F | 1 |
Guay, A | 1 |
Côté, AM | 1 |
Burger, D | 1 |
Geraldes, P | 1 |
Li, H | 1 |
Song, D | 1 |
Liu, Q | 1 |
Li, L | 1 |
Sun, X | 1 |
Guo, J | 1 |
Li, D | 1 |
Li, P | 1 |
Alka, K | 1 |
Mohammad, G | 1 |
Kowluru, RA | 1 |
Handzlik, MK | 1 |
Gengatharan, JM | 1 |
Frizzi, KE | 1 |
McGregor, GH | 1 |
Martino, C | 1 |
Rahman, G | 1 |
Gonzalez, A | 1 |
Moreno, AM | 1 |
Green, CR | 1 |
Guernsey, LS | 1 |
Lin, T | 1 |
Tseng, P | 1 |
Ideguchi, Y | 1 |
Fallon, RJ | 1 |
Chaix, A | 1 |
Panda, S | 1 |
Mali, P | 1 |
Wallace, M | 1 |
Knight, R | 1 |
Gantner, ML | 1 |
Calcutt, NA | 1 |
Metallo, CM | 1 |
Chen, R | 1 |
Hornemann, T | 1 |
Štefanić, S | 1 |
Schraner, EM | 1 |
Zuellig, R | 1 |
Reding, T | 1 |
Malagola, E | 1 |
Henstridge, DC | 1 |
Hills, AP | 1 |
Graf, R | 1 |
Sonda, S | 1 |
Okuyama, S | 1 |
Shinoka, W | 1 |
Nakamura, K | 1 |
Kotani, M | 1 |
Sawamoto, A | 1 |
Sugawara, K | 1 |
Sudo, M | 1 |
Nakajima, M | 1 |
Furukawa, Y | 1 |
Bathina, S | 1 |
Das, UN | 1 |
Kobayashi, M | 1 |
Matsuda, Y | 1 |
Iwai, H | 1 |
Hiramitsu, M | 1 |
Inoue, T | 1 |
Katagiri, T | 1 |
Yamashita, Y | 2 |
Ashida, H | 1 |
Murai, A | 1 |
Horio, F | 1 |
Wang, T | 1 |
Kusudo, T | 1 |
Takeuchi, T | 1 |
Kontani, Y | 1 |
Okamatsu, Y | 1 |
Saito, M | 1 |
Mori, N | 1 |
Yamashita, H | 1 |
Matsumoto, S | 1 |
Shimabukuro, M | 2 |
Fukuda, D | 1 |
Soeki, T | 1 |
Yamakawa, K | 1 |
Masuzaki, H | 1 |
Sata, M | 1 |
Yang, J | 1 |
Song, Y | 1 |
Wang, H | 1 |
Liu, C | 1 |
Li, Z | 1 |
Liu, Y | 2 |
Kong, Y | 1 |
Chu, EP | 1 |
Elso, CM | 1 |
Pollock, AH | 1 |
Alsayb, MA | 1 |
Mackin, L | 1 |
Thomas, HE | 1 |
Kay, TW | 1 |
Silveira, PA | 1 |
Mansell, AS | 1 |
Gaus, K | 1 |
Brodnicki, TC | 1 |
Sung, JH | 1 |
Koh, PO | 1 |
Mack, E | 1 |
Ziv, E | 1 |
Reuveni, H | 1 |
Kalman, R | 1 |
Niv, MY | 1 |
Jörns, A | 1 |
Lenzen, S | 1 |
Shafrir, E | 1 |
Okumachi, Y | 1 |
Moriyama, H | 1 |
Kameno, M | 1 |
Arai, T | 1 |
Kishi, M | 1 |
Kurohara, M | 1 |
Yamada, K | 1 |
Yasuda, H | 1 |
Hara, K | 1 |
Yokono, K | 1 |
Nagata, M | 1 |
Lin, G | 1 |
MacLeod, KM | 1 |
Muñoz, MC | 1 |
Giani, JF | 1 |
Mayer, MA | 1 |
Toblli, JE | 1 |
Turyn, D | 1 |
Dominici, FP | 1 |
Kobayashi, T | 1 |
Taguchi, K | 1 |
Nemoto, S | 1 |
Nogami, T | 1 |
Matsumoto, T | 1 |
Kamata, K | 1 |
Gurevitch, D | 1 |
Boura-Halfon, S | 1 |
Isaac, R | 1 |
Shahaf, G | 1 |
Alberstein, M | 1 |
Ronen, D | 1 |
Lewis, EC | 1 |
Zick, Y | 1 |
Kwak, TK | 1 |
Kim, H | 1 |
Jung, O | 1 |
Lee, SA | 1 |
Kang, M | 1 |
Kim, HJ | 1 |
Park, JM | 1 |
Kim, SH | 1 |
Lee, JW | 1 |
Jiang, H | 1 |
Fang, J | 1 |
Wu, B | 1 |
Yin, G | 1 |
Sun, L | 1 |
Qu, J | 1 |
Barger, SW | 1 |
Wu, S | 1 |
Suzuki, M | 1 |
Sasabe, J | 1 |
Furuya, S | 1 |
Mita, M | 1 |
Hamase, K | 1 |
Aiso, S | 1 |
ISHIKAWA, E | 1 |
NINAGAWA, T | 1 |
SUDA, M | 4 |
RIESER, P | 1 |
Yasukawa, T | 1 |
Tokunaga, E | 1 |
Ota, H | 1 |
Sugita, H | 1 |
Martyn, JA | 1 |
Kaneki, M | 1 |
Christopher, M | 1 |
Rantzau, C | 1 |
Chen, ZP | 1 |
Snow, R | 1 |
Kemp, B | 1 |
Alford, FP | 1 |
Song, P | 1 |
Wu, Y | 1 |
Xu, J | 1 |
Xie, Z | 1 |
Dong, Y | 1 |
Zhang, M | 1 |
Zou, MH | 1 |
Malhotra, A | 1 |
Kang, BP | 1 |
Vashistha, H | 1 |
Yadav, VS | 1 |
Meggs, LG | 1 |
Williamson, DH | 1 |
Lopes-Vieira, O | 1 |
Walker, B | 1 |
Mann, GE | 2 |
Norman, PS | 1 |
Beliveau, GP | 1 |
Freedland, RA | 1 |
Higa, M | 1 |
Zhou, YT | 1 |
Wang, MY | 1 |
Newgard, CB | 1 |
Unger, RH | 1 |
Saxena, AK | 1 |
Saxena, P | 1 |
Wu, X | 1 |
Obrenovich, M | 1 |
Weiss, MF | 1 |
Monnier, VM | 1 |
Nejsum, LN | 1 |
Kwon, TH | 1 |
Marples, D | 1 |
Flyvbjerg, A | 1 |
Knepper, MA | 1 |
Frøkiaer, J | 1 |
Nielsen, S | 1 |
Hayashi, S | 1 |
Tanaka, T | 1 |
Naito, J | 1 |
Kuo, JF | 1 |
Miyazaki, T | 1 |
Uno, M | 1 |
Uehira, M | 1 |
Kikutani, H | 1 |
Kishimoto, T | 1 |
Kimoto, M | 1 |
Nishimoto, H | 1 |
Miyazaki, J | 1 |
Yamamura, K | 1 |
Habara, Y | 1 |
Peran, S | 1 |
Hetenyi, G | 1 |
Anderson, PJ | 1 |
Raman, M | 1 |
Ferrarotto, C | 1 |
Sallach, HJ | 1 |
Sanborn, TA | 1 |
Bruin, WJ | 1 |
Nakagawa, H | 2 |
Miura, S | 1 |
Kimura, H | 1 |
Kanatsuna, T | 1 |
Sakuma, M | 1 |
Nakao, K | 1 |
44 other studies available for serine and Alloxan Diabetes
Article | Year |
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Serine-arginine-rich protein kinase-1 inhibition for the treatment of diabetic retinopathy.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Humans; Hyperglycemia; Mac | 2022 |
Reduction of DUSP4 contributes to podocytes oxidative stress, insulin resistance and diabetic nephropathy.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glucose; Insulin; Insul | 2022 |
miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation.
Topics: Animals; Atherosclerosis; Azo Compounds; C-Reactive Protein; Cholesterol, LDL; Diabetes Mellitus, Ex | 2022 |
Regulation of serine palmitoyl-transferase and Rac1-Nox2 signaling in diabetic retinopathy.
Topics: Animals; Ceramides; Cytosine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic R | 2022 |
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.
Topics: Adiposity; Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Dyslipidemias; Glycine; Insulin | 2023 |
Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice.
Topics: Acinar Cells; Animals; Apoptosis; Ceruletide; Diabetes Mellitus, Experimental; Disease Models, Anima | 2020 |
Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice.
Topics: Animals; Blood Glucose; Citrus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hippocam | 2018 |
Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cell Line; Diabetes Mellitus, Experimental; Diabe | 2018 |
Coffee improves insulin-stimulated Akt phosphorylation in liver and skeletal muscle in diabetic KK-A(y) mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Coffee; Diabetes Mellitus, Experimental; Hyperg | 2012 |
Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Diabetes Me | 2013 |
Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser(1177)/Thr(497) of endothelial nitric oxide synthase in diabetic mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Diabetes Mellitus, Experimental; E | 2014 |
Insulin treatment prevents the increase in D-serine in hippocampal CA1 area of diabetic rats.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Diabetes Mellitus, Experimental; Glutamic Acid; | 2015 |
Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility.
Topics: Animals; Autoimmune Diseases; Cell Separation; Diabetes Mellitus, Experimental; Disease Models, Anim | 2017 |
Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.
Topics: Animals; Apoptosis Regulatory Proteins; Brain Ischemia; Diabetes Mellitus, Experimental; Diabetic Ne | 2017 |
Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus.
Topics: Animals; Catalytic Domain; Diabetes Mellitus, Experimental; Female; Gerbillinae; Insulin Receptor Su | 2008 |
One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide.
Topics: Amino Acid Sequence; Animals; CD4 Antigens; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2008 |
Regulation of muscle creatine kinase by phosphorylation in normal and diabetic hearts.
Topics: Adenosine Triphosphate; Animals; Creatine Kinase, MM Form; Diabetes Mellitus, Experimental; Male; Mu | 2009 |
TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance.
Topics: Animals; Diabetes Mellitus, Experimental; Inflammation; Insulin Resistance; Liver; Male; Mice; Mice, | 2009 |
Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Acetylcholine; Animals; Aorta; Blood Glucose; Blood Pr | 2009 |
Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress.
Topics: Animals; Apoptosis; Blood Glucose; Caspases; CHO Cells; Cricetinae; Cricetulus; Cytokines; Diabetes | 2010 |
Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells.
Topics: Acetylglucosamine; Actins; Animals; Blotting, Western; Cell Adhesion; Cell Line, Tumor; Diabetes Mel | 2010 |
Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy.
Topics: Animals; Aqueous Humor; Blood Glucose; Body Weight; Cell Death; Diabetes Mellitus, Experimental; Dia | 2011 |
Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hippocampus; M | 2012 |
HORMONAL AND DIETARY CONTROL OF SERINE DEHYDRATASE IN RAT LIVER.
Topics: Adrenalectomy; Amino Acids; Animals; Carbohydrate Metabolism; Dactinomycin; Diabetes Mellitus, Exper | 1965 |
ENZYMATIC HYPOGLYCEMIA IN ALLOXAN DIABETIC RATS.
Topics: Alloxan; Animals; Chymotrypsin; Diabetes Mellitus, Experimental; Histidine; Hypoglycemia; Pharmacolo | 1965 |
S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Line, Tumor; Cells, Cultured; COS Cells; Cysteine; Diabetes Mel | 2005 |
Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.
Topics: Acetyl-CoA Carboxylase; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; | 2006 |
Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Experi | 2007 |
Overexpression of Gsalpha compensates for myocyte loss in diabetic cardiomyopathy.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Calcium-Binding Prote | 2008 |
Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Diabetes Mellitus, Experimental; Gluconeogenesis; Glut | 1967 |
Regulatory effects of insulin and experimental diabetes on neutral amino acid transport in the perfused rat exocrine pancreas. Kinetics of unidirectional L-serine influx and efflux at the basolateral plasma membrane.
Topics: Amino Acids; Animals; Basement Membrane; Biological Transport, Active; Diabetes Mellitus, Experiment | 1984 |
Effects of in vivo hormonal treatment on serine metabolism in isolated rat hepatocytes.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Hydrocortisone; L-Serine Dehydratase; Liver; Pic | 1982 |
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression.
Topics: Acyltransferases; Animals; Apoptosis; Ceramides; Diabetes Mellitus, Experimental; Fatty Acids; Gene | 1998 |
Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: relevance to diseases of glycoxidative stress.
Topics: Animals; Ascorbic Acid; Binding Sites; Biopolymers; Catalysis; Cations, Divalent; Collagen; Copper; | 1999 |
Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus.
Topics: Animals; Aquaporin 1; Aquaporin 2; Aquaporin 3; Aquaporin 4; Aquaporin 6; Aquaporins; Carrier Protei | 2001 |
Dietary and hormonal regulation of serine synthesis in the rat.
Topics: Animals; Carbohydrate Dehydrogenases; Diabetes Mellitus, Experimental; Dietary Proteins; Glucose; Gl | 1975 |
Changes in activities of modulatiors of cyclic AMP-dependent and cyclic GMP-dependent protein kinases in pancreas and adipose tissue from alloxan-induced diabetic rats.
Topics: Adipose Tissue; Animals; Carrier Proteins; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Experimental; | 1975 |
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice.
Topics: Animals; Aspartic Acid; Base Sequence; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; F | 1990 |
Characteristics of L-glutamine transport in the perfused rat exocrine pancreas: lack of sensitivity to insulin and streptozotocin-induced experimental diabetes.
Topics: Amino Acids; Animals; Biological Transport; Diabetes Mellitus, Experimental; Glutamine; In Vitro Tec | 1986 |
Gluconeogenesis from glycine and serine in fasted normal and diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fasting; Gluconeogenesis; Glycine; Male; Ra | 1988 |
Dietary and hormonal regulation of hepatic biosynthetic and catabolic enzymes of serine metabolism in rats.
Topics: Adrenal Glands; Alcohol Oxidoreductases; Animals; Butyrates; Cortisone; Cyclic AMP; Diabetes Mellitu | 1972 |
Studies on substrate induction of serine dehydratase of rat liver.
Topics: Adrenalectomy; Alanine; Amino Acids; Ammonia; Animals; Antibodies; Blood Glucose; Carbon Isotopes; D | 1969 |
[Regulation of metabolism by hormones--reciprocal action in the synthesis and decomposition systems].
Topics: Amino Acids; Animals; Caseins; Diabetes Mellitus, Experimental; Glucokinase; Growth Hormone; Hormone | 1967 |
Effect of bovine growth hormone on serine dehydratase in rat liver.
Topics: Animals; Blood Glucose; Cattle; Depression, Chemical; Diabetes Mellitus, Experimental; Growth Hormon | 1968 |