Page last updated: 2024-11-08

serine and Alloxan Diabetes

serine has been researched along with Alloxan Diabetes in 44 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"We analysed whether administration of an L-serine-enriched diet to mouse models of diabetes, an established method for decreasing the synthesis of 1-deoxysphingolipids in vivo, reduced the severity of acute pancreatitis."7.96Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice. ( Chen, R; Graf, R; Henstridge, DC; Hills, AP; Hornemann, T; Malagola, E; Reding, T; Schraner, EM; Sonda, S; Štefanić, S; Zuellig, R, 2020)
" We investigated the effects of O-GlcNAc modification on actin reorganization and morphology of rat insulinoma INS-1 cells after glucosamine (GlcN) treatment."7.76Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. ( Jung, O; Kang, M; Kim, H; Kim, HJ; Kim, SH; Kwak, TK; Lee, JW; Lee, SA; Park, JM, 2010)
"We analysed whether administration of an L-serine-enriched diet to mouse models of diabetes, an established method for decreasing the synthesis of 1-deoxysphingolipids in vivo, reduced the severity of acute pancreatitis."3.96Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice. ( Chen, R; Graf, R; Henstridge, DC; Hills, AP; Hornemann, T; Malagola, E; Reding, T; Schraner, EM; Sonda, S; Štefanić, S; Zuellig, R, 2020)
"Evodiamine, an alkaloid extracted from the dried unripe fruit of the tree Evodia rutaecarpa Bentham (Rutaceae), reduces obesity and insulin resistance in obese/diabetic mice; however, the mechanism underlying the effect of evodiamine on insulin resistance is unknown."3.79Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice. ( Kontani, Y; Kusudo, T; Mori, N; Okamatsu, Y; Saito, M; Takeuchi, T; Wang, T; Yamashita, H; Yamashita, Y, 2013)
" We investigated the effects of O-GlcNAc modification on actin reorganization and morphology of rat insulinoma INS-1 cells after glucosamine (GlcN) treatment."3.76Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. ( Jung, O; Kang, M; Kim, H; Kim, HJ; Kim, SH; Kwak, TK; Lee, JW; Lee, SA; Park, JM, 2010)
"In this study, experimental autoimmune diabetes (EAD) mice, which subcutaneous immunization of ins1 or 2B:9-23 induced autoimmune diabetes in F1(B7."1.35One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide. ( Arai, T; Hara, K; Kameno, M; Kishi, M; Kurohara, M; Moriyama, H; Nagata, M; Okumachi, Y; Yamada, K; Yasuda, H; Yokono, K, 2008)
"3."1.25Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses. ( Lopes-Vieira, O; Walker, B; Williamson, DH, 1967)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199013 (29.55)18.7374
1990's3 (6.82)18.2507
2000's10 (22.73)29.6817
2010's12 (27.27)24.3611
2020's6 (13.64)2.80

Authors

AuthorsStudies
Malhi, NK1
Allen, CL1
Stewart, E1
Horton, KL1
Riu, F1
Batson, J1
Amoaku, W1
Morris, JC1
Arkill, KP1
Bates, DO1
Rousseau, M1
Denhez, B1
Spino, C1
Lizotte, F1
Guay, A1
Côté, AM1
Burger, D1
Geraldes, P1
Li, H1
Song, D1
Liu, Q1
Li, L1
Sun, X1
Guo, J1
Li, D1
Li, P1
Alka, K1
Mohammad, G1
Kowluru, RA1
Handzlik, MK1
Gengatharan, JM1
Frizzi, KE1
McGregor, GH1
Martino, C1
Rahman, G1
Gonzalez, A1
Moreno, AM1
Green, CR1
Guernsey, LS1
Lin, T1
Tseng, P1
Ideguchi, Y1
Fallon, RJ1
Chaix, A1
Panda, S1
Mali, P1
Wallace, M1
Knight, R1
Gantner, ML1
Calcutt, NA1
Metallo, CM1
Chen, R1
Hornemann, T1
Štefanić, S1
Schraner, EM1
Zuellig, R1
Reding, T1
Malagola, E1
Henstridge, DC1
Hills, AP1
Graf, R1
Sonda, S1
Okuyama, S1
Shinoka, W1
Nakamura, K1
Kotani, M1
Sawamoto, A1
Sugawara, K1
Sudo, M1
Nakajima, M1
Furukawa, Y1
Bathina, S1
Das, UN1
Kobayashi, M1
Matsuda, Y1
Iwai, H1
Hiramitsu, M1
Inoue, T1
Katagiri, T1
Yamashita, Y2
Ashida, H1
Murai, A1
Horio, F1
Wang, T1
Kusudo, T1
Takeuchi, T1
Kontani, Y1
Okamatsu, Y1
Saito, M1
Mori, N1
Yamashita, H1
Matsumoto, S1
Shimabukuro, M2
Fukuda, D1
Soeki, T1
Yamakawa, K1
Masuzaki, H1
Sata, M1
Yang, J1
Song, Y1
Wang, H1
Liu, C1
Li, Z1
Liu, Y2
Kong, Y1
Chu, EP1
Elso, CM1
Pollock, AH1
Alsayb, MA1
Mackin, L1
Thomas, HE1
Kay, TW1
Silveira, PA1
Mansell, AS1
Gaus, K1
Brodnicki, TC1
Sung, JH1
Koh, PO1
Mack, E1
Ziv, E1
Reuveni, H1
Kalman, R1
Niv, MY1
Jörns, A1
Lenzen, S1
Shafrir, E1
Okumachi, Y1
Moriyama, H1
Kameno, M1
Arai, T1
Kishi, M1
Kurohara, M1
Yamada, K1
Yasuda, H1
Hara, K1
Yokono, K1
Nagata, M1
Lin, G1
MacLeod, KM1
Muñoz, MC1
Giani, JF1
Mayer, MA1
Toblli, JE1
Turyn, D1
Dominici, FP1
Kobayashi, T1
Taguchi, K1
Nemoto, S1
Nogami, T1
Matsumoto, T1
Kamata, K1
Gurevitch, D1
Boura-Halfon, S1
Isaac, R1
Shahaf, G1
Alberstein, M1
Ronen, D1
Lewis, EC1
Zick, Y1
Kwak, TK1
Kim, H1
Jung, O1
Lee, SA1
Kang, M1
Kim, HJ1
Park, JM1
Kim, SH1
Lee, JW1
Jiang, H1
Fang, J1
Wu, B1
Yin, G1
Sun, L1
Qu, J1
Barger, SW1
Wu, S1
Suzuki, M1
Sasabe, J1
Furuya, S1
Mita, M1
Hamase, K1
Aiso, S1
ISHIKAWA, E1
NINAGAWA, T1
SUDA, M4
RIESER, P1
Yasukawa, T1
Tokunaga, E1
Ota, H1
Sugita, H1
Martyn, JA1
Kaneki, M1
Christopher, M1
Rantzau, C1
Chen, ZP1
Snow, R1
Kemp, B1
Alford, FP1
Song, P1
Wu, Y1
Xu, J1
Xie, Z1
Dong, Y1
Zhang, M1
Zou, MH1
Malhotra, A1
Kang, BP1
Vashistha, H1
Yadav, VS1
Meggs, LG1
Williamson, DH1
Lopes-Vieira, O1
Walker, B1
Mann, GE2
Norman, PS1
Beliveau, GP1
Freedland, RA1
Higa, M1
Zhou, YT1
Wang, MY1
Newgard, CB1
Unger, RH1
Saxena, AK1
Saxena, P1
Wu, X1
Obrenovich, M1
Weiss, MF1
Monnier, VM1
Nejsum, LN1
Kwon, TH1
Marples, D1
Flyvbjerg, A1
Knepper, MA1
Frøkiaer, J1
Nielsen, S1
Hayashi, S1
Tanaka, T1
Naito, J1
Kuo, JF1
Miyazaki, T1
Uno, M1
Uehira, M1
Kikutani, H1
Kishimoto, T1
Kimoto, M1
Nishimoto, H1
Miyazaki, J1
Yamamura, K1
Habara, Y1
Peran, S1
Hetenyi, G1
Anderson, PJ1
Raman, M1
Ferrarotto, C1
Sallach, HJ1
Sanborn, TA1
Bruin, WJ1
Nakagawa, H2
Miura, S1
Kimura, H1
Kanatsuna, T1
Sakuma, M1
Nakao, K1

Other Studies

44 other studies available for serine and Alloxan Diabetes

ArticleYear
Serine-arginine-rich protein kinase-1 inhibition for the treatment of diabetic retinopathy.
    American journal of physiology. Heart and circulatory physiology, 2022, 06-01, Volume: 322, Issue:6

    Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Humans; Hyperglycemia; Mac

2022
Reduction of DUSP4 contributes to podocytes oxidative stress, insulin resistance and diabetic nephropathy.
    Biochemical and biophysical research communications, 2022, 10-08, Volume: 624

    Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glucose; Insulin; Insul

2022
miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation.
    Molecular medicine (Cambridge, Mass.), 2022, 09-30, Volume: 28, Issue:1

    Topics: Animals; Atherosclerosis; Azo Compounds; C-Reactive Protein; Cholesterol, LDL; Diabetes Mellitus, Ex

2022
Regulation of serine palmitoyl-transferase and Rac1-Nox2 signaling in diabetic retinopathy.
    Scientific reports, 2022, 10-06, Volume: 12, Issue:1

    Topics: Animals; Ceramides; Cytosine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic R

2022
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.
    Nature, 2023, Volume: 614, Issue:7946

    Topics: Adiposity; Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Dyslipidemias; Glycine; Insulin

2023
Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice.
    Diabetologia, 2020, Volume: 63, Issue:9

    Topics: Acinar Cells; Animals; Apoptosis; Ceruletide; Diabetes Mellitus, Experimental; Disease Models, Anima

2020
Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice.
    Bioscience, biotechnology, and biochemistry, 2018, Volume: 82, Issue:8

    Topics: Animals; Blood Glucose; Citrus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hippocam

2018
Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats.
    Lipids in health and disease, 2018, Jul-24, Volume: 17, Issue:1

    Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cell Line; Diabetes Mellitus, Experimental; Diabe

2018
Coffee improves insulin-stimulated Akt phosphorylation in liver and skeletal muscle in diabetic KK-A(y) mice.
    Journal of nutritional science and vitaminology, 2012, Volume: 58, Issue:6

    Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Coffee; Diabetes Mellitus, Experimental; Hyperg

2012
Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Diabetes Me

2013
Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser(1177)/Thr(497) of endothelial nitric oxide synthase in diabetic mice.
    Cardiovascular diabetology, 2014, Jan-31, Volume: 13

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Diabetes Mellitus, Experimental; E

2014
Insulin treatment prevents the increase in D-serine in hippocampal CA1 area of diabetic rats.
    American journal of Alzheimer's disease and other dementias, 2015, Volume: 30, Issue:2

    Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Diabetes Mellitus, Experimental; Glutamic Acid;

2015
Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility.
    Molecular immunology, 2017, Volume: 82

    Topics: Animals; Autoimmune Diseases; Cell Separation; Diabetes Mellitus, Experimental; Disease Models, Anim

2017
Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.
    The Journal of veterinary medical science, 2017, Mar-28, Volume: 79, Issue:3

    Topics: Animals; Apoptosis Regulatory Proteins; Brain Ischemia; Diabetes Mellitus, Experimental; Diabetic Ne

2017
Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus.
    Diabetes/metabolism research and reviews, 2008, Volume: 24, Issue:7

    Topics: Animals; Catalytic Domain; Diabetes Mellitus, Experimental; Female; Gerbillinae; Insulin Receptor Su

2008
One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide.
    Biochemical and biophysical research communications, 2008, Sep-26, Volume: 374, Issue:3

    Topics: Amino Acid Sequence; Animals; CD4 Antigens; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type

2008
Regulation of muscle creatine kinase by phosphorylation in normal and diabetic hearts.
    Cellular and molecular life sciences : CMLS, 2009, Volume: 66, Issue:1

    Topics: Adenosine Triphosphate; Animals; Creatine Kinase, MM Form; Diabetes Mellitus, Experimental; Male; Mu

2009
TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance.
    The Journal of endocrinology, 2009, Volume: 201, Issue:2

    Topics: Animals; Diabetes Mellitus, Experimental; Inflammation; Insulin Resistance; Liver; Male; Mice; Mice,

2009
Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Acetylcholine; Animals; Aorta; Blood Glucose; Blood Pr

2009
Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress.
    Diabetes, 2010, Volume: 59, Issue:9

    Topics: Animals; Apoptosis; Blood Glucose; Caspases; CHO Cells; Cricetinae; Cricetulus; Cytokines; Diabetes

2010
Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells.
    The Journal of biological chemistry, 2010, Nov-12, Volume: 285, Issue:46

    Topics: Acetylglucosamine; Actins; Animals; Blotting, Western; Cell Adhesion; Cell Line, Tumor; Diabetes Mel

2010
Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy.
    Journal of neuroinflammation, 2011, Sep-22, Volume: 8

    Topics: Animals; Aqueous Humor; Blood Glucose; Body Weight; Cell Death; Diabetes Mellitus, Experimental; Dia

2011
Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection.
    Brain research, 2012, Jul-23, Volume: 1466

    Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hippocampus; M

2012
HORMONAL AND DIETARY CONTROL OF SERINE DEHYDRATASE IN RAT LIVER.
    Journal of biochemistry, 1965, Volume: 57

    Topics: Adrenalectomy; Amino Acids; Animals; Carbohydrate Metabolism; Dactinomycin; Diabetes Mellitus, Exper

1965
ENZYMATIC HYPOGLYCEMIA IN ALLOXAN DIABETIC RATS.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 119

    Topics: Alloxan; Animals; Chymotrypsin; Diabetes Mellitus, Experimental; Histidine; Hypoglycemia; Pharmacolo

1965
S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.
    The Journal of biological chemistry, 2005, Mar-04, Volume: 280, Issue:9

    Topics: 3T3 Cells; Adipocytes; Animals; Cell Line, Tumor; Cells, Cultured; COS Cells; Cysteine; Diabetes Mel

2005
Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:5

    Topics: Acetyl-CoA Carboxylase; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide;

2006
Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner.
    Circulation, 2007, Oct-02, Volume: 116, Issue:14

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Experi

2007
Overexpression of Gsalpha compensates for myocyte loss in diabetic cardiomyopathy.
    Canadian journal of physiology and pharmacology, 2008, Volume: 86, Issue:3

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Calcium-Binding Prote

2008
Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses.
    The Biochemical journal, 1967, Volume: 104, Issue:2

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Diabetes Mellitus, Experimental; Gluconeogenesis; Glut

1967
Regulatory effects of insulin and experimental diabetes on neutral amino acid transport in the perfused rat exocrine pancreas. Kinetics of unidirectional L-serine influx and efflux at the basolateral plasma membrane.
    Biochimica et biophysica acta, 1984, Dec-19, Volume: 778, Issue:3

    Topics: Amino Acids; Animals; Basement Membrane; Biological Transport, Active; Diabetes Mellitus, Experiment

1984
Effects of in vivo hormonal treatment on serine metabolism in isolated rat hepatocytes.
    Endocrinology, 1982, Volume: 111, Issue:2

    Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Hydrocortisone; L-Serine Dehydratase; Liver; Pic

1982
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression.
    The Journal of biological chemistry, 1998, Dec-04, Volume: 273, Issue:49

    Topics: Acyltransferases; Animals; Apoptosis; Ceramides; Diabetes Mellitus, Experimental; Fatty Acids; Gene

1998
Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: relevance to diseases of glycoxidative stress.
    Biochemical and biophysical research communications, 1999, Jul-05, Volume: 260, Issue:2

    Topics: Animals; Ascorbic Acid; Binding Sites; Biopolymers; Catalysis; Cations, Divalent; Collagen; Copper;

1999
Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus.
    American journal of physiology. Renal physiology, 2001, Volume: 280, Issue:4

    Topics: Animals; Aquaporin 1; Aquaporin 2; Aquaporin 3; Aquaporin 4; Aquaporin 6; Aquaporins; Carrier Protei

2001
Dietary and hormonal regulation of serine synthesis in the rat.
    Journal of biochemistry, 1975, Jan-01, Volume: 77, Issue:1?

    Topics: Animals; Carbohydrate Dehydrogenases; Diabetes Mellitus, Experimental; Dietary Proteins; Glucose; Gl

1975
Changes in activities of modulatiors of cyclic AMP-dependent and cyclic GMP-dependent protein kinases in pancreas and adipose tissue from alloxan-induced diabetic rats.
    Biochemical and biophysical research communications, 1975, Aug-18, Volume: 65, Issue:4

    Topics: Adipose Tissue; Animals; Carrier Proteins; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Experimental;

1975
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice.
    Nature, 1990, Jun-21, Volume: 345, Issue:6277

    Topics: Animals; Aspartic Acid; Base Sequence; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; F

1990
Characteristics of L-glutamine transport in the perfused rat exocrine pancreas: lack of sensitivity to insulin and streptozotocin-induced experimental diabetes.
    Pancreas, 1986, Volume: 1, Issue:3

    Topics: Amino Acids; Animals; Biological Transport; Diabetes Mellitus, Experimental; Glutamine; In Vitro Tec

1986
Gluconeogenesis from glycine and serine in fasted normal and diabetic rats.
    The Biochemical journal, 1988, Jul-01, Volume: 253, Issue:1

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fasting; Gluconeogenesis; Glycine; Male; Ra

1988
Dietary and hormonal regulation of hepatic biosynthetic and catabolic enzymes of serine metabolism in rats.
    Endocrinology, 1972, Volume: 91, Issue:4

    Topics: Adrenal Glands; Alcohol Oxidoreductases; Animals; Butyrates; Cortisone; Cyclic AMP; Diabetes Mellitu

1972
Studies on substrate induction of serine dehydratase of rat liver.
    Journal of biochemistry, 1969, Volume: 66, Issue:4

    Topics: Adrenalectomy; Alanine; Amino Acids; Ammonia; Animals; Antibodies; Blood Glucose; Carbon Isotopes; D

1969
[Regulation of metabolism by hormones--reciprocal action in the synthesis and decomposition systems].
    Nihon Naibunpi Gakkai zasshi, 1967, Aug-20, Volume: 43, Issue:5

    Topics: Amino Acids; Animals; Caseins; Diabetes Mellitus, Experimental; Glucokinase; Growth Hormone; Hormone

1967
Effect of bovine growth hormone on serine dehydratase in rat liver.
    Endocrinology, 1968, Volume: 83, Issue:2

    Topics: Animals; Blood Glucose; Cattle; Depression, Chemical; Diabetes Mellitus, Experimental; Growth Hormon

1968