serine has been researched along with Akinetic-Rigid Variant of Huntington Disease in 15 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that S421 phosphorylation mitigates neurodegeneration by increasing proteasome-dependent turnover of mHTT and reducing the presence of a toxic mHTT conformer." | 1.43 | Serine 421 regulates mutant huntingtin toxicity and clearance in mice. ( Daub, AC; Finkbeiner, S; Gu, X; Humbert, S; Kratter, IH; Lau, A; Masliah, E; Osmand, A; Saudou, F; Steffan, JS; Tsvetkov, AS; Weiberth, KF; Yang, XW; Zahed, H, 2016) |
| " These data predict that the ability of cdk5 phosphorylation to protect against htt cleavage, aggregation, and toxicity is compromised in cells expressing toxic fragments of htt." | 1.33 | Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity. ( Davies, JE; Luo, S; Rubinsztein, DC; Vacher, C, 2005) |
| "Here we demonstrate in precise genetic Huntington's disease mouse and striatal cell models that these early phenotypes are associated with activation of the Akt pro-survival signaling pathway." | 1.32 | Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. ( Gines, S; Ivanova, E; MacDonald, ME; Saura, CA; Seong, IS, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (60.00) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cariulo, C | 1 |
| Martufi, P | 1 |
| Verani, M | 1 |
| Toledo-Sherman, L | 1 |
| Lee, R | 1 |
| Dominguez, C | 1 |
| Petricca, L | 1 |
| Caricasole, A | 1 |
| Petrozziello, T | 1 |
| Huntress, SS | 1 |
| Castillo-Torres, AL | 1 |
| Quinn, JP | 1 |
| Connors, TR | 1 |
| Auger, CA | 1 |
| Mills, AN | 1 |
| Kim, SE | 1 |
| Liu, S | 1 |
| Mahmood, F | 1 |
| Boudi, A | 1 |
| Wu, M | 1 |
| Sapp, E | 1 |
| Kivisäkk, P | 1 |
| Sunderesh, SR | 1 |
| Pouladi, MA | 1 |
| Arnold, SE | 1 |
| Hyman, BT | 1 |
| Rosas, HD | 1 |
| DiFiglia, M | 1 |
| Mouro Pinto, R | 1 |
| Kegel-Gleason, K | 1 |
| Sadri-Vakili, G | 1 |
| Watkin, EE | 1 |
| Arbez, N | 1 |
| Waldron-Roby, E | 1 |
| O'Meally, R | 1 |
| Ratovitski, T | 1 |
| Cole, RN | 1 |
| Ross, CA | 2 |
| Kratter, IH | 1 |
| Zahed, H | 1 |
| Lau, A | 1 |
| Tsvetkov, AS | 1 |
| Daub, AC | 1 |
| Weiberth, KF | 1 |
| Gu, X | 2 |
| Saudou, F | 5 |
| Humbert, S | 5 |
| Yang, XW | 2 |
| Osmand, A | 2 |
| Steffan, JS | 2 |
| Masliah, E | 1 |
| Finkbeiner, S | 2 |
| Zala, D | 1 |
| Colin, E | 3 |
| Rangone, H | 3 |
| Liot, G | 1 |
| Perrin, V | 1 |
| Dufour, N | 1 |
| Raoul, C | 1 |
| Hassig, R | 1 |
| Brouillet, E | 1 |
| Aebischer, P | 2 |
| Luthi-Carter, R | 1 |
| Déglon, N | 2 |
| Xu, EH | 1 |
| Tang, Y | 1 |
| Li, D | 1 |
| Jia, JP | 1 |
| Greiner, ER | 1 |
| Mishra, R | 1 |
| Kodali, R | 1 |
| Thompson, LM | 1 |
| Wetzel, R | 1 |
| Atwal, RS | 1 |
| Desmond, CR | 1 |
| Caron, N | 1 |
| Maiuri, T | 1 |
| Xia, J | 1 |
| Sipione, S | 1 |
| Truant, R | 1 |
| Gines, S | 1 |
| Ivanova, E | 1 |
| Seong, IS | 1 |
| Saura, CA | 1 |
| MacDonald, ME | 2 |
| Poizat, G | 1 |
| Troncoso, J | 1 |
| Pardo, R | 2 |
| Girault, JA | 1 |
| Luo, S | 1 |
| Vacher, C | 1 |
| Davies, JE | 1 |
| Rubinsztein, DC | 1 |
| Régulier, E | 1 |
| Bonilla, E | 1 |
| Prasad, AL | 1 |
| Arrieta, A | 1 |
15 other studies available for serine and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway.
Topics: Humans; Huntington Disease; I-kappa B Kinase; Phosphorylation; Serine | 2023 |
Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington's Disease Prefrontal Cortex.
Topics: Animals; Disease Models, Animal; Humans; Huntington Disease; Mice; Mice, Transgenic; Phosphorylation | 2023 |
Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.
Topics: Amino Acid Sequence; Animals; Cell Death; Cells, Cultured; HEK293 Cells; Humans; Huntingtin Protein; | 2014 |
Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Topics: Alanine; Animals; Aspartic Acid; Behavior, Animal; Chromosomes, Artificial, Bacterial; Disease Model | 2016 |
Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.
Topics: Animals; Axonal Transport; Brain-Derived Neurotrophic Factor; Cell Line; Cells, Cultured; Genetic Ve | 2008 |
Implication of the JNK pathway in a rat model of Huntington's disease.
Topics: Analysis of Variance; Animals; Cell Line, Transformed; CREB-Binding Protein; Disease Models, Animal; | 2009 |
Polymorphism of HD and UCHL-1 genes in Huntington's disease.
Topics: Adult; Age of Onset; Aged; Alleles; Chi-Square Distribution; Family Health; Female; Gene Frequency; | 2009 |
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Aspartic Acid; Disease Mode | 2009 |
Kinase inhibitors modulate huntingtin cell localization and toxicity.
Topics: Animals; Blotting, Western; Casein Kinase II; Cell Line; Cell Nucleus; Cell Survival; Disease Models | 2011 |
Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells.
Topics: Alleles; Animals; beta Catenin; Cell Membrane; Cells, Cultured; Chromones; Corpus Striatum; Cyclin D | 2003 |
The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.
Topics: Animals; Brain; Cell Line; Cells, Cultured; Female; Humans; Huntingtin Protein; Huntington Disease; | 2004 |
Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cell Line; COS Cells; Electropho | 2005 |
Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.
Topics: Amino Acid Sequence; Animals; Brain; Caspases; Cell Death; Cell Membrane; Cyclin-Dependent Kinase 5; | 2005 |
Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.
Topics: Animals; Brain; Calcineurin; Calcineurin Inhibitors; Female; Humans; Huntingtin Protein; Huntington | 2006 |
Huntington's disease: studies on brain free amino acids.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; | 1988 |