Page last updated: 2024-11-08

serine and Aging

serine has been researched along with Aging in 141 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Elastin is a protein of the extracellular matrix that forms the major component of elastic fibers from the arterial wall thickness and plays an important role in elastic properties of large blood vessels."5.31Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans. ( Bortolotto, LA; Girerd, X; Hanon, O; Jeunemaitre, X; Luong, V; Mourad, JJ, 2001)
"Mutations in the neuronal protein alpha-synuclein cause familial Parkinson disease."3.75Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. ( Chen, L; Feany, MB; Hyman, BT; McLean, PJ; Negro, A; Periquet, M; Wang, X, 2009)
"Propofol caused an increase in GluA1 phosphorylation in the hippocampus but not in the prefrontal cortex."1.40Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice. ( Fibuch, EE; Hastings, JM; Mao, LM; Wang, JQ, 2014)
"Adenosine is a neuromodulator which inhibits the synaptic release of neurotransmitters."1.35Effects of inhibitory amino acids on adenosine release in the mouse hippocampus. ( Oja, SS; Saransaari, P, 2008)
"The tangles of Alzheimer's disease (AD) are comprised of the tau protein displaying numerous alterations, including phosphorylation at serine 422 (S422) and truncation at aspartic acid 421 (D421)."1.33Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo. ( Berry, RW; Binder, LI; Cahill, ME; Cryns, VL; Guillozet-Bongaarts, AL; Reynolds, MR, 2006)
"Elastin is a protein of the extracellular matrix that forms the major component of elastic fibers from the arterial wall thickness and plays an important role in elastic properties of large blood vessels."1.31Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans. ( Bortolotto, LA; Girerd, X; Hanon, O; Jeunemaitre, X; Luong, V; Mourad, JJ, 2001)
"Inositol incorporation was also measurable, whereas [14C]serine incorporation was low or undetectable."1.27Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism. ( Ancelin, ML; Capron, A; Torpier, G; Vial, HJ, 1985)

Research

Studies (141)

TimeframeStudies, this research(%)All Research%
pre-199037 (26.24)18.7374
1990's19 (13.48)18.2507
2000's45 (31.91)29.6817
2010's32 (22.70)24.3611
2020's8 (5.67)2.80

Authors

AuthorsStudies
Wu, S1
Zhou, J1
Zhang, H1
Barger, SW2
Li, H3
Tu, Y1
Wan, YG1
Mu, GL1
Wu, W1
Chen, JX1
Wang, MZ1
Wang, J1
Fu, Y2
Cai, YF1
Wang, Y1
Wan, ZY1
Wu, Y1
Tang, L1
Huang, H1
Yu, Q1
Hu, B1
Wang, G1
Ge, F1
Yin, T1
Li, S1
Yu, X1
Leng, L1
Yuan, Z1
Su, X1
Chen, Z2
Yang, S2
Chen, M1
Zhuang, K1
Lin, H1
Sun, H1
Xue, M1
Xu, J2
Yan, J1
Yuan, T1
Zhang, J2
Waterworth, WM1
Wilson, M1
Wang, D1
Nuhse, T1
Warward, S1
Selley, J1
West, CE1
Wang, W1
Tanokashira, D1
Fukui, Y1
Maruyama, M1
Kuroiwa, C1
Saito, T1
Saido, TC1
Taguchi, A1
Yang, RL1
Huang, HM1
Han, CS1
Cui, SJ1
Zhou, YK1
Zhou, YH1
Ploux, E1
Freret, T2
Billard, JM7
Torres, AK1
Jara, C1
Olesen, MA1
Tapia-Rojas, C1
Clark, AJ1
Kugathasan, U1
Baskozos, G1
Priestman, DA1
Fugger, N1
Lone, MA1
Othman, A1
Chu, KH1
Blesneac, I1
Wilson, ER1
Laurà, M1
Kalmar, B1
Greensmith, L1
Hornemann, T1
Platt, FM1
Reilly, MM1
Bennett, DL1
Riedlinger, T1
Dommerholt, MB1
Wijshake, T1
Kruit, JK1
Huijkman, N1
Dekker, D1
Koster, M1
Kloosterhuis, N1
Koonen, DPY1
de Bruin, A1
Baker, D1
Hofker, MH1
van Deursen, J1
Jonker, JW1
Schmitz, ML1
van de Sluis, B1
Xie, WR1
Jen, HI1
Seymour, ML1
Yeh, SY1
Pereira, FA1
Groves, AK1
Klisch, TJ1
Zoghbi, HY1
Okada, A1
Nangaku, M1
Jao, TM1
Maekawa, H1
Ishimono, Y1
Kawakami, T1
Inagi, R1
Kashiwagi, K1
Ito, S1
Maeda, S1
Kato, G1
Jin, X1
Qiao, A1
Moskophidis, D1
Mivechi, NF1
Beltrán-Castillo, S1
Eugenín, J1
von Bernhardi, R1
Liu, YJ1
Janssens, GE1
McIntyre, RL1
Molenaars, M1
Kamble, R1
Gao, AW1
Jongejan, A1
Weeghel, MV1
MacInnes, AW1
Houtkooper, RH1
Consitt, LA1
Van Meter, J1
Newton, CA1
Collier, DN1
Dar, MS1
Wojtaszewski, JF1
Treebak, JT1
Tanner, CJ1
Houmard, JA1
Panizzutti, R1
Scoriels, L1
Avellar, M1
Mirisola, MG1
Taormina, G1
Fabrizio, P1
Wei, M1
Hu, J1
Longo, VD1
Mao, LM1
Hastings, JM1
Fibuch, EE1
Wang, JQ1
Krześniak, M1
Zajkowicz, A1
Matuszczyk, I1
Rusin, M1
Longo, F1
Russo, I1
Shimshek, DR1
Greggio, E1
Morari, M1
Biemans, EA1
Verhoeven-Duif, NM1
Gerrits, J1
Claassen, JA1
Kuiperij, HB1
Verbeek, MM1
Baruffaldi, F1
Montarras, D1
Basile, V1
De Feo, L1
Badodi, S1
Ganassi, M1
Battini, R1
Nicoletti, C1
Imbriano, C1
Musarò, A1
Molinari, S1
McQuail, JA1
Beas, BS1
Kelly, KB1
Simpson, KL1
Frazier, CJ1
Setlow, B1
Bizon, JL1
Yuan, C1
Sheng, Q1
Tang, H1
Li, Y1
Zeng, R1
Solaro, RJ1
Kawakami, K2
Nakamura, A2
Ishigami, A1
Goto, S2
Takahashi, R1
Shay, KP1
Hagen, TM1
Wai, MS1
Liang, Y1
Shi, C1
Cho, EY1
Kung, HF1
Yew, DT1
Sengoku, R1
Saito, Y1
Ikemura, M1
Hatsuta, H1
Sakiyama, Y1
Kanemaru, K1
Arai, T1
Sawabe, M1
Tanaka, N1
Mochizuki, H1
Inoue, K1
Murayama, S1
Nie, K1
Yu, JC1
Cheng, HY1
Chen, FY1
Qu, Y1
Han, JX1
Schell, H1
Hasegawa, T1
Neumann, M1
Kahle, PJ1
Lebiedzinska, M1
Duszynski, J1
Rizzuto, R1
Pinton, P1
Wieckowski, MR1
Oja, SS2
Saransaari, P2
Nguyen, XV1
Liu, M1
Kim, HC1
Bing, G1
Schaeffer, PJ1
Desantiago, J1
Yang, J1
Flagg, TP1
Kovacs, A1
Weinheimer, CJ1
Courtois, M1
Leone, TC1
Nichols, CG1
Bers, DM1
Kelly, DP1
Chen, L1
Periquet, M1
Wang, X1
Negro, A1
McLean, PJ1
Hyman, BT1
Feany, MB1
Utrera, J1
Junyent, F1
de Lemos, L1
Pallàs, M1
Camins, A1
Romero, R1
Auladell, C1
Darra, E1
Ebner, FH1
Shoji, K1
Suzuki, H1
Mariotto, S1
Pauli, JR1
Ropelle, ER1
Cintra, DE1
De Souza, CT1
da Silva, AS1
Moraes, JC1
Prada, PO1
de Almeida Leme, JA1
Luciano, E1
Velloso, LA1
Carvalheira, JB1
Saad, MJ1
Kabzińska, D1
Sinkiewicz-Darol, E1
Hausmanowa-Petrusewicz, I1
Kochański, A1
Kametani, F1
Nakamoto, H1
Gaugler, M1
Brown, A1
Merrell, E1
DiSanto-Rose, M1
Rathmacher, JA1
Reynolds, TH1
Bian, YH1
Rotllant, P1
Shen, T1
Chu, W1
Schneider, M1
Du, SJ1
Haxaire, C1
Turpin, FR1
Potier, B2
Kervern, M1
Sinet, PM2
Barbanel, G1
Mothet, JP5
Dutar, P2
McCormack, AL1
Mak, SK1
Di Monte, DA1
Florea, S1
Anjak, A1
Cai, WF1
Qian, J1
Vafiadaki, E1
Figueria, S1
Haghighi, K1
Rubinstein, J1
Lorenz, J1
Kranias, EG1
Su, SP1
Lyons, B1
Friedrich, M1
McArthur, JD1
Song, X1
Xavier, D1
Truscott, RJ3
Aquilina, JA1
Miyoshi, Y1
Konno, R1
Sasabe, J1
Ueno, K1
Tojo, Y1
Mita, M1
Aiso, S1
Hamase, K1
Hooi, MY1
Raftery, MJ1
Asghar, M2
Hussain, T1
Lokhandwala, MF1
Kubo, T1
Nishimura, S1
Kumagae, Y1
Kaneko, I1
Hashimoto, A5
WENDER, M1
WALIGORA, Z1
MCMURRAY, WC1
Bialek, P1
Kern, B1
Yang, X1
Schrock, M1
Sosic, D1
Hong, N1
Wu, H1
Yu, K1
Ornitz, DM1
Olson, EN1
Justice, MJ1
Karsenty, G1
Kim, SS1
Cao, L1
Li, C1
Xu, X1
Huber, LJ1
Chodosh, LA1
Deng, CX1
Hagopian, K1
Ramsey, JJ1
Weindruch, R1
Qiao, H1
Wen, L1
Zhou, W1
Zhang, Y1
Dayalan, AH1
Jothi, M1
Keshava, R1
Thomas, R1
Gope, ML1
Doddaballapur, SK1
Somanna, S1
Praharaj, SS1
Ashwathnarayanarao, CB1
Gope, R1
Williams, SM1
Diaz, CM1
Macnab, LT1
Sullivan, RK1
Pow, DV1
Fortin, CF1
Larbi, A1
Lesur, O1
Douziech, N1
Fulop, T1
Wang, GL1
Shi, X1
Salisbury, E1
Sun, Y1
Albrecht, JH1
Smith, RG1
Timchenko, NA1
Guillozet-Bongaarts, AL1
Cahill, ME1
Cryns, VL1
Reynolds, MR1
Berry, RW1
Binder, LI1
Saunders-Pullman, R1
Lipton, RB1
Senthil, G1
Katz, M1
Costan-Toth, C1
Derby, C1
Bressman, S1
Verghese, J1
Ozelius, LJ1
Puyal, J1
Martineau, M1
Nicolas, MT1
Raymond, J1
Fardoun, RZ1
Lokhandwala, M1
Junjaud, G1
Rouaud, E2
Turpin, F1
Jouvenceau, A1
Videau, C1
Epelbaum, J1
Vernet, N1
Dennefeld, C1
Guillou, F1
Chambon, P1
Ghyselinck, NB1
Mark, M1
Lobsiger, CS1
Boillée, S1
Cleveland, DW1
Edwards, AO1
Lisý, V2
Stastný, F2
Murphy, S1
Hájková, B1
Taketomi, T1
Uemura, K1
Yuzawa, M1
Vallebuona, F1
Raiteri, M1
Kumashiro, S2
Nishikawa, T4
Kilby, GW1
Carver, JA1
Zhu, JL1
Sheil, MM1
Arioka, M1
Tsukamoto, M1
Ishiguro, K1
Kato, R1
Sato, K1
Imahori, K1
Uchida, T1
Oka, T3
Takahashi, K2
Goedert, M1
Jakes, R1
Crowther, RA1
Six, J1
Lübke, U1
Vandermeeren, M1
Cras, P1
Trojanowski, JQ1
Lee, VM1
Mito, T1
Takashima, S1
Doi, N1
Mizutani, Y1
Yamazaki, T1
Abe, M1
Iriki, T1
Funaba, M1
Masson, P1
Fortier, PL1
Albaret, C1
Froment, MT1
Bartels, CF1
Lockridge, O1
Huang, Y1
Satoh, K1
Iwata, T1
Fukushima, T1
Santa, T1
Homma, H1
Imai, K1
Nagata, Y1
Uehara, T1
Kitamura, Y1
Nomura, Y1
Horiike, K1
Fountain, WC1
Requena, JR1
Jenkins, AJ1
Lyons, TJ1
Smyth, B1
Baynes, JW1
Thorpe, SR1
Parent, AT1
Wolosker, H1
Brady, RO1
Linden, DJ1
Ferris, CD1
Rogawski, MA1
Snyder, SH1
Ilincheta de Boschero, MG2
Roque, ME2
Salvador, GA1
Giusto, NM2
Pratta, MA1
Tortorella, MD1
Arner, EC1
Thompson, HR1
Jones, GM1
Narkewicz, MR1
Foletti, DL1
Scheller, RH1
Yamasaki, M1
Yamada, K1
Furuya, S1
Mitoma, J1
Hirabayashi, Y1
Watanabe, M1
Hanon, O1
Luong, V1
Mourad, JJ1
Bortolotto, LA1
Jeunemaitre, X1
Girerd, X1
Maurage, CA1
Sergeant, N1
Ruchoux, MM1
Hauw, JJ1
Delacourte, A1
Zhen, X1
Torres, C1
Wang, HY1
Friedman, E1
Kern, HL1
Woodbury, RG1
Neurath, H1
Glimcher, MJ1
Brickley-Parsons, D1
Kossiva, D1
Mays, LL1
Lawrence, AE1
Ho, RW1
Ackley, S1
Bertolini, AM1
Santagostino, A1
Wong, PP1
Kuo, T1
Ryan, CA1
Snell, K1
Jankásková, B1
Whisler, RL1
Liu, BQ1
Newhouse, YG1
Walters, JD1
Breckenridge, MB1
Grants, IS1
Narabayashi, H1
Yokochi, F1
Ogawa, T1
Igakura, T1
Kalbag, SS1
Palekar, AG1
Gaiarsa, JL1
Corradetti, R1
Cherubini, E1
Ben-Ari, Y1
Sanecka-Obacz, M1
Brattström, LE1
Hultberg, BL1
Hardebo, JE1
Vial, HJ1
Torpier, G1
Ancelin, ML1
Capron, A1
Bourdel, G1
Girard, A1
Forestier, M1
Manley, G1
Mullinger, RN1
Lloyd, PH1
Jamdar, SC1
Greengard, O2
Weinhold, PA1
Sanders, RD1
Weiss, B1
Stiller, RL1
Federman, M1
Knox, WE1
Hoshino, J1
Simon, D1
Robert, B1
Kröger, H1
Spadafora, C1
Igo-Kemenes, T1
Zachau, HG1
Jones, JP1
Ramsey, RB1
Aexel, RT1
Nicholas, HJ1
Short, NA1
Sander, EG1
Rennert, OM1
Rowsell, EV1
al-Tai, AH1
Carnie, JA1
De Loecker, W1
Stas, ML1
Slaughter, JC1
Davies, LP1
Johnston, GA1
Schoenmakers, JG1
Gerding, JJ1
Bloemendal, H1
Morell, P1
Costantino-Ceccarini, E1
Witt, I1
Hasler, K1
Den, H1
Kaufman, B1
Roseman, S1
Burton, RM1
Beck, G1
Hentzen, D1
Ebel, JP1
Horrocks, LA1
Cheung, GP1
Cotropia, JP1
Sallach, HJ1
Bygrave, FL1
Kaiser, W1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Amyotrophic Lateral Sclerosis and the Innate Immune System[NCT02869048]375 participants (Anticipated)Observational2016-06-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

12 reviews available for serine and Aging

ArticleYear
Serine Racemase Expression Differentiates Aging from Alzheimer's Brain.
    Current Alzheimer research, 2022, Volume: 19, Issue:7

    Topics: Aging; Alzheimer Disease; Brain; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine

2022
d-serine in physiological and pathological brain aging.
    Biochimica et biophysica acta. Proteins and proteomics, 2021, Volume: 1869, Issue:1

    Topics: Aging; Alzheimer Disease; Animals; Astrocytes; Cognition; Gene Expression; Glucose; Glutamic Acid; H

2021
Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS.
    Mediators of inflammation, 2018, Volume: 2018

    Topics: Aging; Animals; Central Nervous System; Humans; Microglia; Neurodegenerative Diseases; Serine

2018
The co-agonist site of NMDA-glutamate receptors: a novel therapeutic target for age-related cognitive decline.
    Current pharmaceutical design, 2014, Volume: 20, Issue:32

    Topics: Adult; Age Factors; Aged; Aging; Animals; Binding Sites; Cognition Disorders; Hippocampus; Humans; M

2014
D-Serine in the aging hippocampus.
    Journal of pharmaceutical and biomedical analysis, 2015, Dec-10, Volume: 116

    Topics: Aging; Animals; Hippocampus; Humans; Memory; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Seri

2015
Biological significance of protein modifications in aging and calorie restriction.
    Annals of the New York Academy of Sciences, 2010, Volume: 1197

    Topics: Acetylation; Aging; Animals; Caloric Restriction; Histones; Lysine; Phosphorylation; Protein Process

2010
An unconventional hypothesis of oxidation in Alzheimer's disease: intersections with excitotoxicity.
    Frontiers in bioscience : a journal and virtual library, 2004, Sep-01, Volume: 9

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cystine; Glutamates; Humans; Inflam

2004
Genetics of age-related macular degeneration.
    Advances in experimental medicine and biology, 2008, Volume: 613

    Topics: Aging; Amino Acid Substitution; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 10; Haplotypes;

2008
D-serine signalling as a prominent determinant of neuronal-glial dialogue in the healthy and diseased brain.
    Journal of cellular and molecular medicine, 2008, Volume: 12, Issue:5B

    Topics: Aging; Animals; Brain; Brain Diseases; Humans; Models, Neurological; Neuroglia; Neurons; Serine; Sig

2008
[Endogenous free D-aspartate and D-serine in mammals].
    Seikagaku. The Journal of Japanese Biochemical Society, 1996, Volume: 68, Issue:8

    Topics: Adrenal Glands; Aging; Animals; Aspartic Acid; Brain; Kidney; Liver; Male; Serine; Testis

1996
Transport of organic solutes in the lens.
    Current topics in eye research, 1979, Volume: 1

    Topics: Aging; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Calcium; Carbohydrate Meta

1979
[Protein kinases of the central nervous system in ontogenesis].
    Postepy biochemii, 1989, Volume: 35, Issue:3

    Topics: Aging; Animals; Brain; Calcium; Calmodulin; Humans; Nucleotides, Cyclic; Phospholipids; Protein Kina

1989

Other Studies

129 other studies available for serine and Aging

ArticleYear
[Effect and mechanism of Dahuang Zhechong Pills against testicular aging in rats by inhibiting necroptosis signaling pathway].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:15

    Topics: Aging; Animals; Drugs, Chinese Herbal; Male; Necroptosis; Protein Kinases; Rats; Reactive Oxygen Spe

2022
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
    Nature communications, 2023, 03-10, Volume: 14, Issue:1

    Topics: Aging; Animals; Cellular Senescence; Endothelial Cells; Glycolysis; Histones; Mice; Phosphoglycerate

2023
Hypothalamic Menin regulates systemic aging and cognitive decline.
    PLoS biology, 2023, Volume: 21, Issue:3

    Topics: Aging; Animals; Cognitive Dysfunction; Hypothalamus; Mice; Serine; Transcription Factors

2023
Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress.
    The Plant journal : for cell and molecular biology, 2019, Volume: 100, Issue:5

    Topics: Aging; Arabidopsis; Arabidopsis Proteins; ATP-Binding Cassette Transporters; Cells, Cultured; DNA Da

2019
Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.
    Nutrients, 2019, Aug-17, Volume: 11, Issue:8

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Dia

2019
Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16.
    Journal of dental research, 2021, Volume: 100, Issue:1

    Topics: Aging; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cellular Senescence; Cyclin-Depend

2021
Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice.
    Scientific reports, 2021, 02-24, Volume: 11, Issue:1

    Topics: Aging; Animals; Cognitive Dysfunction; Hippocampus; Memory Disorders; Mice; Mice, Inbred C57BL; Mito

2021
An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions.
    Cell reports. Medicine, 2021, 07-20, Volume: 2, Issue:7

    Topics: Aging; Axons; Base Sequence; Caspase 3; Cell Line; Gangliosides; Gene Expression Regulation; Heredit

2021
NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.
    Biochimica et biophysica acta. Molecular cell research, 2017, Volume: 1864, Issue:10

    Topics: Aging; Amino Acid Substitution; Animals; Gene Expression Regulation; Gene Knock-In Techniques; Human

2017
An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017, 09-06, Volume: 37, Issue:36

    Topics: Aging; Alleles; Animals; Basic Helix-Loop-Helix Transcription Factors; Female; Gene Knock-In Techniq

2017
D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation.
    Scientific reports, 2017, 09-11, Volume: 7, Issue:1

    Topics: Aging; Apoptosis; Cell Cycle Checkpoints; Cells, Cultured; Epithelial Cells; Humans; Kidney Diseases

2017
A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice.
    Scientific reports, 2017, 12-01, Volume: 7, Issue:1

    Topics: Aging; Amino Acid Substitution; Animals; Apoptosis; Asparagine; Cell Count; Cell Survival; Mice; Mic

2017
Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance.
    Molecular and cellular biology, 2018, 09-15, Volume: 38, Issue:18

    Topics: Aging; Amino Acid Substitution; Animals; Cells, Cultured; Disease Models, Animal; Female; Gene Knock

2018
Asc-1 transporter activation: an alternative to rescue age-related alterations in functional plasticity at rat hippocampal CA3/CA1 synapses.
    Journal of neurochemistry, 2018, Volume: 147, Issue:4

    Topics: Aging; Amino Acid Transport System ASC; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; E

2018
Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion.
    PLoS genetics, 2019, Volume: 15, Issue:3

    Topics: Aging; Animals; Caenorhabditis elegans; Diet; Genes, Helminth; Glycine; Longevity; Metabolic Network

2019
Impairments in site-specific AS160 phosphorylation and effects of exercise training.
    Diabetes, 2013, Volume: 62, Issue:10

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aged, 80 and over; Aging; Blotting, Western; Cros

2013
Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging.
    PLoS genetics, 2014, Volume: 10, Issue:2

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Aging; Animals; Cyclic AMP-Dependent Protein Kinases;

2014
Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice.
    European journal of pharmacology, 2014, Sep-05, Volume: 738

    Topics: Aging; Anesthetics, General; Animals; Mice; Phosphorylation; Prefrontal Cortex; Propofol; Receptors,

2014
Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D.
    Mechanisms of ageing and development, 2014, Volume: 139

    Topics: Aging; Antibiotics, Antineoplastic; Cell Line, Tumor; Dactinomycin; Humans; Lung Neoplasms; Nuclear

2014
Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
    Neurobiology of disease, 2014, Volume: 71

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Analysis of Variance; Animals; Brain; Dose-Res

2014
CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls.
    Neurobiology of aging, 2016, Volume: 42

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid;

2016
Dynamic Phosphorylation of the Myocyte Enhancer Factor 2Cα1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy.
    Stem cells (Dayton, Ohio), 2017, Volume: 35, Issue:3

    Topics: Aging; Alternative Splicing; Amino Acid Sequence; Animals; Cell Differentiation; Cell Proliferation;

2017
NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 12-14, Volume: 36, Issue:50

    Topics: Aging; Animals; Cognitive Dysfunction; Conditioning, Operant; Excitatory Amino Acid Antagonists; Mal

2016
Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:2

    Topics: Age Factors; Aging; Amino Acid Sequence; Animals; Animals, Newborn; Blotting, Western; Cardiac Myosi

2008
Age-related difference of site-specific histone modifications in rat liver.
    Biogerontology, 2009, Volume: 10, Issue:4

    Topics: Acetylation; Age Factors; Aging; Amino Acid Sequence; Animals; Chromatin Assembly and Disassembly; E

2009
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
    Biogerontology, 2009, Volume: 10, Issue:4

    Topics: Age Factors; Aging; Animals; Antioxidants; Cell Survival; Cells, Cultured; Hepatocytes; Insulin; Mal

2009
Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer's disease patients.
    Biogerontology, 2009, Volume: 10, Issue:4

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Apoptosis; Brain Stem; Caspase 3; Ca

2009
Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb.
    Journal of neuropathology and experimental neurology, 2008, Volume: 67, Issue:11

    Topics: Aged; Aged, 80 and over; Aging; alpha-Synuclein; Amyloid beta-Peptides; Brain; Female; Humans; Incid

2008
Age-related decrease in constructive activation of Akt/PKB in SAMP10 hippocampus.
    Biochemical and biophysical research communications, 2009, Jan-02, Volume: 378, Issue:1

    Topics: Age Factors; Aging; Aging, Premature; Alzheimer Disease; Animals; Hippocampus; Male; Maze Learning;

2009
Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.
    Neuroscience, 2009, Jun-02, Volume: 160, Issue:4

    Topics: Aging; alpha-Synuclein; Amygdala; Animals; Brain; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Co

2009
Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues.
    Archives of biochemistry and biophysics, 2009, Jun-01, Volume: 486, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Antioxidants; Cells, Cultured; Female; Free Radicals; Liver; Mice;

2009
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
    Neurochemical research, 2009, Volume: 34, Issue:9

    Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid;

2009
Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP.
    Experimental neurology, 2009, Volume: 219, Issue:1

    Topics: Aging; Amino Acid Sequence; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Enkephalins;

2009
Effects of inhibitory amino acids on adenosine release in the mouse hippocampus.
    Proceedings of the Western Pharmacology Society, 2008, Volume: 51

    Topics: Adenosine; Aging; Animals; Animals, Newborn; beta-Alanine; Excitatory Amino Acid Antagonists; Female

2008
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:4

    Topics: Aging; Animals; Calcineurin; Calcium Signaling; Calcium-Binding Proteins; Cardiomyopathies; Cardioto

2009
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
    The Journal of clinical investigation, 2009, Volume: 119, Issue:11

    Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila m

2009
Tau hyperphosphorylation and axonal damage induced by N,N-diethyldithiocarbamate (DEDTC) treatment along late postnatal development is followed by a rescue during adulthood.
    Journal of neuroscience research, 2010, Volume: 88, Issue:5

    Topics: Age Factors; Aging; Amino Acid Sequence; Animals; Animals, Newborn; Axons; Blotting, Western; Brain;

2010
Dual cross-talk between nitric oxide and D-serine in astrocytes and neurons in the brain.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Brain Neoplasms; Cells, Cultured; Cytokines; Gl

2009
Acute exercise reverses aged-induced impairments in insulin signaling in rodent skeletal muscle.
    Mechanisms of ageing and development, 2010, Volume: 131, Issue:5

    Topics: Aging; Animals; I-kappa B Proteins; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance

2010
Charcot-Marie-Tooth type 1A disease caused by a novel Ser112Arg mutation in the PMP22 gene, coexisting with a slowly progressive hearing impairment.
    Journal of applied genetics, 2010, Volume: 51, Issue:2

    Topics: Adolescent; Adult; Age of Onset; Aging; Amino Acid Sequence; Amino Acid Substitution; Arginine; Audi

2010
PKB signaling and atrogene expression in skeletal muscle of aged mice.
    Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 111, Issue:1

    Topics: Age Factors; Aging; Animals; Apoptosis Regulatory Proteins; Autophagy; Cytoskeletal Proteins; Forkhe

2011
Smyd1b_tv1, a key regulator of sarcomere assembly, is localized on the M-line of skeletal muscle fibers.
    PloS one, 2011, Volume: 6, Issue:12

    Topics: Aging; Alternative Splicing; Amino Acid Sequence; Animals; Cell Differentiation; Embryo, Nonmammalia

2011
Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting D-serine-dependent NMDA receptor activation.
    Aging cell, 2012, Volume: 11, Issue:2

    Topics: Acetylcysteine; Aging; Animals; Hippocampus; Lysine; Male; Neuronal Plasticity; Oxidative Stress; Ra

2012
Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra.
    Cell death & disease, 2012, May-31, Volume: 3

    Topics: Aging; alpha-Synuclein; Animals; Humans; Neurons; Nitro Compounds; Phosphorylation; Protein Processi

2012
Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging.
    Basic research in cardiology, 2012, Volume: 107, Issue:5

    Topics: Aging; Animals; Calcium; Carrier Proteins; Mice; Mice, Transgenic; Myocardial Contraction; Myocardia

2012
Molecular signatures of long-lived proteins: autolytic cleavage adjacent to serine residues.
    Aging cell, 2012, Volume: 11, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Crystallins; Hot Temperature; Humans; Lens, Cryst

2012
Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase.
    Amino acids, 2012, Volume: 43, Issue:5

    Topics: Aging; Animals; Cerebellum; Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Mice; Mice,

2012
Age-dependent racemization of serine residues in a human chaperone protein.
    Protein science : a publication of the Protein Society, 2013, Volume: 22, Issue:1

    Topics: Aging; alpha-Crystallin A Chain; Humans; Lens, Crystalline; Models, Molecular; Serine; Stereoisomeri

2013
Higher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats.
    American journal of physiology. Renal physiology, 2002, Volume: 283, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Aging; Animals; Benzazepine

2002
In vivo conversion of racemized beta-amyloid ([D-Ser 26]A beta 1-40) to truncated and toxic fragments ([D-Ser 26]A beta 25-35/40) and fragment presence in the brains of Alzheimer's patients.
    Journal of neuroscience research, 2002, Nov-01, Volume: 70, Issue:3

    Topics: Aged; Aging; Alzheimer Disease; Amino Acid Isomerases; Amyloid beta-Peptides; Animals; Astrocytes; B

2002
Effect of the intracerebroventricular and systemic administration of L-serine on the concentrations of D- and L-serine in several brain areas and periphery of rat.
    Brain research, 2002, Nov-15, Volume: 955, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Brain; Injections, Intraventricular; Male; Rats; Rats, Wistar; Ser

2002
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG. III. SPINAL CORD.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Cystine; Fetus; Glutamates;

1964
METABOLISM OF PHOSPHATIDES IN DEVELOPING RAT BRAIN--I. INCORPORATION OF RADIOACTIVE PRECURSORS.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Aging; Animals; Animals, Newborn; Brain; Choline; Lecithins; Lipid Metabolism; Phosphates; Phosphati

1964
A twist code determines the onset of osteoblast differentiation.
    Developmental cell, 2004, Volume: 6, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Cell Differentiation; Cells

2004
Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.
    Molecular and cellular biology, 2004, Volume: 24, Issue:21

    Topics: Aging; Animals; BRCA1 Protein; Carcinogens; Cell Cycle; Cell Transformation, Neoplastic; Checkpoint

2004
Serine utilization in mouse liver: influence of caloric restriction and aging.
    FEBS letters, 2005, Mar-28, Volume: 579, Issue:9

    Topics: Aging; Animals; Caloric Restriction; Gluconeogenesis; L-Serine Dehydratase; Liver; Male; Mice; Mice,

2005
D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8.
    Neuroscience letters, 2005, Apr-29, Volume: 379, Issue:1

    Topics: Age Factors; Aging; Analysis of Variance; Animals; D-Amino-Acid Oxidase; Drug Interactions; Electric

2005
Age dependent phosphorylation and deregulation of p53 in human vestibular schwannomas.
    Molecular carcinogenesis, 2006, Volume: 45, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Blotting, Western; Cell Line; Female; Humans; Loss of Heterozygosity

2006
Immunocytochemical analysis of D-serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neurons.
    Glia, 2006, Volume: 53, Issue:4

    Topics: Aging; Animals; Biomarkers; Brain; Brain Chemistry; Fixatives; Formaldehyde; gamma-Aminobutyric Acid

2006
Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions.
    Journal of leukocyte biology, 2006, Volume: 79, Issue:5

    Topics: Adult; Age Factors; Aged; Aging; Apoptosis; Chemotaxis, Leukocyte; Down-Regulation; Enzyme Inhibitor

2006
Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes.
    Molecular and cellular biology, 2006, Volume: 26, Issue:7

    Topics: 3T3-L1 Cells; Aging; Animals; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cyclin D3;

2006
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.
    Journal of neurochemistry, 2006, Volume: 97, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Antibodies; Apoptosis; Aspar

2006
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.
    Neuroscience letters, 2006, Jul-10, Volume: 402, Issue:1-2

    Topics: Aged, 80 and over; Aging; Dementia; DNA Mutational Analysis; Female; Glycine; Humans; Jews; Leucine-

2006
Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei.
    The Journal of comparative neurology, 2006, Aug-01, Volume: 497, Issue:4

    Topics: Afferent Pathways; Aging; Animals; Animals, Newborn; Biomarkers; Cell Communication; Cell Differenti

2006
Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats.
    American journal of physiology. Renal physiology, 2006, Volume: 291, Issue:5

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Antioxidants; beta-Adren

2006
Age-related effects of the neuromodulator D-serine on neurotransmission and synaptic potentiation in the CA1 hippocampal area of the rat.
    Journal of neurochemistry, 2006, Volume: 98, Issue:4

    Topics: Aging; Animals; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Glycine; Hippoca

2006
A critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memory.
    Aging cell, 2006, Volume: 5, Issue:3

    Topics: Aging; Animals; Binding Sites; Hippocampus; Learning; Long-Term Potentiation; Male; Memory; Neurogli

2006
Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.
    The EMBO journal, 2006, Dec-13, Volume: 25, Issue:24

    Topics: Aging; Animals; Cell Count; Cell Cycle; Cell Polarity; Epithelium; Gene Expression; Male; Mice; Phen

2006
Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, May-01, Volume: 104, Issue:18

    Topics: Aging; Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Cell Separation; Enzym

2007
Glutamate uptake into cerebral cortex slices is reduced in the presence of a gamma-glutamyl transpeptidase inhibitor.
    Experientia, 1983, Jan-15, Volume: 39, Issue:1

    Topics: Aging; Animals; Biological Transport, Active; Borates; Cerebral Cortex; gamma-Glutamyltransferase; G

1983
Metabolic studies of N-bases of phospholipids and long chain bases of sphingolipids in two-weeks-old mouse brain tissue in comparison with one-month-old mouse visceral tissues.
    The Japanese journal of experimental medicine, 1980, Volume: 50, Issue:4

    Topics: Aging; Animals; Brain; Choline; Decarboxylation; Ethanolamines; Mice; Phospholipids; Serine; Sphingo

1980
Age-related changes in the NMDA receptor/nitric oxide/cGMP pathway in the hippocampus and cerebellum of freely moving rats subjected to transcerebral microdialysis.
    The European journal of neuroscience, 1995, Apr-01, Volume: 7, Issue:4

    Topics: Aging; Amino Acid Oxidoreductases; Animals; Behavior, Animal; Cerebellum; Cyclic GMP; Extracellular

1995
Free D-serine in post-mortem brains and spinal cords of individuals with and without neuropsychiatric diseases.
    Brain research, 1995, May-29, Volume: 681, Issue:1-2

    Topics: Aging; Amino Acids; Animals; Brain Chemistry; Humans; Mental Disorders; Nervous System Diseases; Par

1995
Loss of the C-terminal serine residue from bovine beta B2-crystallin.
    Experimental eye research, 1995, Volume: 60, Issue:5

    Topics: Aging; Animals; Cattle; Chromatography, High Pressure Liquid; Crystallins; Humans; Lens, Crystalline

1995
Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein.
    Journal of neurochemistry, 1993, Volume: 60, Issue:2

    Topics: Aging; Amino Acid Sequence; Animals; Brain; Cattle; Cyclin-Dependent Kinase 5; Electrophoresis, Gel,

1993
Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging.
    Journal of neurochemistry, 1993, Volume: 60, Issue:2

    Topics: Aging; Animals; Brain; Glycine; Kidney; Liver; Male; Organ Specificity; Rats; Rats, Wistar; Receptor

1993
The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Jun-01, Volume: 90, Issue:11

    Topics: Adult; Aging; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cerebral Cortex; Fetus; Humans

1993
Embryonic development and postnatal changes in free D-aspartate and D-serine in the human prefrontal cortex.
    Journal of neurochemistry, 1993, Volume: 61, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Child, Preschool; Chromatog

1993
Lysine deficiency in postweaned calves fed corn and corn gluten meal diets.
    Journal of animal science, 1997, Volume: 75, Issue:7

    Topics: Aging; Analysis of Variance; Animals; Arginine; Caseins; Cattle; Cattle Diseases; Cysteine; Deficien

1997
Aging of di-isopropyl-phosphorylated human butyrylcholinesterase.
    The Biochemical journal, 1997, Oct-15, Volume: 327 ( Pt 2)

    Topics: Aging; Animals; Binding Sites; Butyrylcholinesterase; CHO Cells; Cholinesterase Inhibitors; Cricetin

1997
Urinary excretion of D-serine in human: comparison of different ages and species.
    Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:2

    Topics: Adult; Aging; Alanine; Animal Feed; Animals; Child; Chromatography, High Pressure Liquid; Colostrum;

1998
D-serine content and D-[3H]serine binding in the brain regions of the senescence-accelerated mouse.
    Mechanisms of ageing and development, 1998, Aug-14, Volume: 104, Issue:2

    Topics: Aging; Animals; Autoradiography; Brain; Brain Mapping; Cerebellum; Female; Frontal Lobe; Hippocampus

1998
Quantification of N-(glucitol)ethanolamine and N-(carboxymethyl)serine: two products of nonenzymatic modification of aminophospholipids formed in vivo.
    Analytical biochemistry, 1999, Jul-15, Volume: 272, Issue:1

    Topics: Aging; Amines; Diabetes Mellitus, Type 1; Erythrocyte Membrane; Gas Chromatography-Mass Spectrometry

1999
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Apr-25, Volume: 97, Issue:9

    Topics: Aging; Animals; Astrocytes; Cells, Cultured; Cerebellum; D-Amino-Acid Oxidase; Embryo, Mammalian; Gl

2000
Alternative pathways for phospholipid synthesis in different brain areas during aging.
    Experimental gerontology, 2000, Volume: 35, Issue:5

    Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Male; Methyltransferases; Phosphatidylethanolami

2000
Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase.
    The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50

    Topics: Age Factors; Aggrecans; Aging; Alanine; Animals; beta-Galactosidase; Blotting, Western; Cattle; Chon

2000
Ontogeny of hepatic enzymes involved in serine- and folate-dependent one-carbon metabolism in rabbits.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 280, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aging; Amino Acid Oxidoreductases; Animal

2001
Developmental regulation and specific brain distribution of phosphorabphilin.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Aug-01, Volume: 21, Issue:15

    Topics: Adaptor Proteins, Signal Transducing; Aging; Animals; Antibodies; Antibody Specificity; Blotting, We

2001
3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Oct-01, Volume: 21, Issue:19

    Topics: Aging; Animals; Antibody Specificity; Astrocytes; Brain; Carbohydrate Dehydrogenases; Cell Different

2001
Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5

    Topics: Aging; Carotid Arteries; Cohort Studies; Compliance; Elastin; Female; Genotype; Glycine; Humans; Mal

2001
Paradoxical phosphorylation of the serine 199 on tau proteins from young individuals.
    Neuroreport, 2001, Oct-29, Volume: 12, Issue:15

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Child; Fe

2001
Prenatal exposure to cocaine disrupts D1A dopamine receptor function via selective inhibition of protein phosphatase 1 pathway in rabbit frontal cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Dec-01, Volume: 21, Issue:23

    Topics: Aging; Animals; Cocaine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Activation; Female; F

2001
Purification of an atypical mast cell protease and its levels in developing rats.
    Biochemistry, 1978, Oct-03, Volume: 17, Issue:20

    Topics: Aging; Amino Acids; Animals; Female; Immunodiffusion; Intestinal Mucosa; Intestine, Small; Mast Cell

1978
Phosphopeptides and gamma-carboxyglutamic acid-containing peptides in calcified turkey tendon: their absence in uncalcified tendon.
    Calcified tissue international, 1979, Jul-03, Volume: 27, Issue:3

    Topics: 1-Carboxyglutamic Acid; Aging; Animals; Female; Glutamates; Organophosphorus Compounds; Peptides; Ph

1979
Age-related changes in function of transfer ribonucleic acid of rat livers.
    Federation proceedings, 1979, Volume: 38, Issue:6

    Topics: Acylation; Aging; Animals; Liver; Lysine; Protein Biosynthesis; Rats; Ribosomes; RNA, Transfer; Seri

1979
[Senile liver and its repercussions on cerebral activity].
    Minerva medica, 1979, Sep-22, Volume: 70, Issue:40

    Topics: Aged; Aging; Amino Acids; Brain; Cystine; Glutamates; Histidine; Humans; Liver; Serine; Threonine; T

1979
Growth-dependent accumulation and utilization of proteinase inhibitor I in tobacco callus tissues.
    Biochemical and biophysical research communications, 1975, Mar-03, Volume: 63, Issue:1

    Topics: Aging; Cells, Cultured; Enzyme Inhibitors; Nicotiana; Plant Development; Plant Physiological Phenome

1975
Mitochondrial-cytosolic interrelationships involved in gluconeogenesis from serine in rat liver.
    FEBS letters, 1975, Jul-15, Volume: 55, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Cytosol; Gluconeogenesis; Glutamate Dehydrogenase; L-Serine Dehydr

1975
Effect of gamma-glutamyl transpeptidase inhibitors on the transport of glutamate into neuronal and glial primary cultures.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1992, Volume: 10, Issue:3

    Topics: Aging; Animals; Biological Transport; Borates; Brain; Cells, Cultured; Chickens; Diazooxonorleucine;

1992
Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system.
    Lipids, 1992, Volume: 27, Issue:11

    Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Choline; Fatty Acids; Medulla Oblongata; Palmiti

1992
Signal transduction in human B cells during aging: alterations in stimulus-induced phosphorylations of tyrosine and serine/threonine substrates and in cytosolic calcium responsiveness.
    Lymphokine and cytokine research, 1991, Volume: 10, Issue:6

    Topics: Aging; Amino Acids; B-Lymphocytes; Calcium; Cell Division; Cells, Cultured; Cytosol; Humans; Phospho

1991
[Analysis of L-threo-3, 4-dihydroxyphenylserine effect on motor and psychological symptoms in Parkinson's disease].
    No to shinkei = Brain and nerve, 1991, Volume: 43, Issue:3

    Topics: Aged; Aging; Droxidopa; Female; Humans; Male; Middle Aged; Parkinson Disease; Psychomotor Performanc

1991
Postnatal development of the glycine cleavage system in rat liver.
    Biochemical medicine and metabolic biology, 1990, Volume: 43, Issue:2

    Topics: Aging; Amino Acids; Aminomethyltransferase; Animals; Animals, Newborn; Female; Glycine; Glycine Hydr

1990
The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:1

    Topics: Aging; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Aspartic Acid; Electric Co

1990
Folic acid responsive postmenopausal homocysteinemia.
    Metabolism: clinical and experimental, 1985, Volume: 34, Issue:11

    Topics: Adult; Aging; Cystine; Dipeptides; Fasting; Female; Folic Acid; Glycine; Homocysteine; Humans; Male;

1985
Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism.
    Molecular and biochemical parasitology, 1985, Volume: 17, Issue:2

    Topics: Aging; Animals; Biomphalaria; Carbon Radioisotopes; Choline; Ethanolamine; Ethanolamines; Female; Gl

1985
[Effects of dietary surcharges of DL-methionine and DL-serine adminisitered alone or in combination on the development of mono and binucleated rat pancreas cells].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1969, Aug-25, Volume: 269, Issue:8

    Topics: Aging; Animals; Diet; DNA; Methionine; Pancreas; Rats; Serine; Staining and Labeling

1969
Properties of heparan sulphate and chondroitin sulphate from young and old human aortae.
    The Biochemical journal, 1969, Volume: 114, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Amino Acids; Aorta, Thoracic; Aspartic Acid; Chondroitin; Chromatogr

1969
Phosphoserine phosphatase: development formation and hormonal regulation in rat tissues.
    Archives of biochemistry and biophysics, 1969, Volume: 134, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Brain; Estradiol; Female; Fetus; Glucagon; Hydrocortisone; Kidney;

1969
Phospholipid metabolism during the development of the liver. The incorporation of [1,2-14C]ethanolamine, [2-3H]myo-inositol and L-[U-14C]serine into phospholipids by liver slices.
    Biochemistry, 1971, Mar-16, Volume: 10, Issue:6

    Topics: Aging; Amino Alcohols; Animals; Carbon Isotopes; Cholesterol; Fatty Acids; Female; Glycerides; Glyce

1971
Dibutyryl cyclic adenosine 3',5-monophosphate and brain lipid metabolism.
    Lipids, 1974, Volume: 9, Issue:8

    Topics: Acetates; Aging; Animals; Brain; Bucladesine; Carbon Radioisotopes; Cerebrosides; Cesium; Cholestero

1974
Cytomorphometry of developing rat liver and its application to enzymic differentiation.
    The Journal of cell biology, 1972, Volume: 52, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Cell Count; Female; Glucagon; Glucokinase; Glucosyltransferases; Glyc

1972
Dietary and cortisone regulation of cytosol serine and phosphoserine aminotransferases in rat liver.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1974, Volume: 355, Issue:1

    Topics: Adrenal Glands; Adrenalectomy; Aging; Animals; Cortisone; Cytosol; Dactinomycin; Diet; Dietary Prote

1974
Changes in transfer RNAs and aminoacyl-tRNA synthetases during sea urchin development.
    Biochimica et biophysica acta, 1973, Jul-27, Volume: 312, Issue:4

    Topics: Aging; Amino Acyl-tRNA Synthetases; Animals; Arginine; Carbon Isotopes; Chromatography, DEAE-Cellulo

1973
Lipid biosynthesis in neuron-enriched and glial-enriched fractions of rat brain: ganglioside biosynthesis.
    Life sciences. Pt. 1: Physiology and pharmacology, 1972, Mar-15, Volume: 11, Issue:6

    Topics: Acetates; Aging; Animals; Brain; Carbon Isotopes; Gangliosides; Glycolipids; Lipids; Mevalonic Acid;

1972
Isoprenylation of transfer ribonucleic acid.
    Biochemical and biophysical research communications, 1973, May-01, Volume: 52, Issue:1

    Topics: Adenosine; Aging; Alkenes; Animals; Carbon Isotopes; Cattle; Chromatography, DEAE-Cellulose; Chromat

1973
Increased liver L-serine-pyruvate aminotransferase activity under gluconeogenic conditions.
    The Biochemical journal, 1973, Volume: 134, Issue:1

    Topics: Aging; Alloxan; Animals; Animals, Newborn; Female; Fetus; Glucagon; Gluconeogenesis; L-Serine Dehydr

1973
Effect of cortisol treatment on free amino acid levels in rats.
    The Journal of endocrinology, 1973, Volume: 59, Issue:1

    Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Glycine; Hydrocortisone; Liver; Male; Muscle Pr

1973
Inhibition of 3-phosphoglycerate dehydrogenase from Pisum sativum by purine nucleotides.
    The Biochemical journal, 1973, Volume: 135, Issue:3

    Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Aging; Alcohol Oxidoreductases; Binding

1973
Postnatal changes in the levels of glycine and the activities of serine hydroxymethyltransferase and glycine:2-oxoglutarate aminotransferase in the rat central nervous system.
    Journal of neurochemistry, 1974, Volume: 22, Issue:1

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Antimetabolites; Brain; Carbon Radioisotopes; Cerebel

1974
The subunit structure of alpha-crystallin. Isolation and characterization of the S-carboxymethylated acidic subunits from adult and embryonic origin.
    European journal of biochemistry, 1969, Volume: 11, Issue:3

    Topics: Aging; Alkylation; Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Cattle; Chromatography, Ion

1969
Jimpy mouse: in vitro studies of brain sphingolipid biosynthesis.
    Lipids, 1972, Volume: 7, Issue:4

    Topics: Aging; Animals; Brain; Carbon Isotopes; Ceramides; Coenzyme A; Galactose; Glucose; Glucosyltransfera

1972
Influence of organically bound phosphorus in foetal and adult fibrinogen on the kinetics of the interaction between thrombin and fibrinogen.
    Biochimica et biophysica acta, 1972, Jul-21, Volume: 271, Issue:2

    Topics: Aging; Alkaline Phosphatase; Animals; Blood; Blood Coagulation Tests; Cattle; Fetus; Fibrinogen; Hum

1972
Properties of some glycosyltransferases in embryonic chicken brain.
    The Journal of biological chemistry, 1970, Dec-25, Volume: 245, Issue:24

    Topics: Aging; Albumins; Amniotic Fluid; Animals; Brain; Carbon Isotopes; Chick Embryo; Cytosine Nucleotides

1970
Factors affecting incorporation of precursors into body constituents: a review of common sense considerations with glycolipids as examples.
    Lipids, 1970, Volume: 5, Issue:5

    Topics: Aging; Animals; Aspartic Acid; Brain; Carbon Isotopes; Cerebrosides; Galactose; Gangliosides; Glucos

1970
[Hormonal regulation at the level of transfer RNA. I. Comparative study of transfer RNA from the liver of immature hens and laying hens].
    Biochimica et biophysica acta, 1970, Jul-16, Volume: 213, Issue:1

    Topics: Aging; Alanine; Animals; Carbon Isotopes; Chickens; Chromatography, Ion Exchange; Estradiol; Female;

1970
Composition of mouse brain myelin during development.
    Journal of neurochemistry, 1968, Volume: 15, Issue:6

    Topics: Aging; Amino Alcohols; Animals; Brain; Brain Chemistry; Cholesterol; Galactose; Glycerylphosphorylch

1968
Comparative studies of enzymes related to serine metabolis in fetal and adult liver.
    Biochimica et biophysica acta, 1968, Dec-23, Volume: 170, Issue:2

    Topics: Aged; Aging; Alcohol Oxidoreductases; Animals; Cats; Cattle; Cesarean Section; Chick Embryo; Dogs; F

1968
The magnesium-dependent incorporation of serine into the phospholipids of mitochondria isolated from the developing flight muscle of the african locust Locusta migratoria.
    European journal of biochemistry, 1969, Volume: 8, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Carbon Isotopes; Cytosine Nucleotides; Hydrogen-Ion Concentr

1969