serine has been researched along with Aging in 141 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Elastin is a protein of the extracellular matrix that forms the major component of elastic fibers from the arterial wall thickness and plays an important role in elastic properties of large blood vessels." | 5.31 | Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans. ( Bortolotto, LA; Girerd, X; Hanon, O; Jeunemaitre, X; Luong, V; Mourad, JJ, 2001) |
| "Mutations in the neuronal protein alpha-synuclein cause familial Parkinson disease." | 3.75 | Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. ( Chen, L; Feany, MB; Hyman, BT; McLean, PJ; Negro, A; Periquet, M; Wang, X, 2009) |
| "Propofol caused an increase in GluA1 phosphorylation in the hippocampus but not in the prefrontal cortex." | 1.40 | Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice. ( Fibuch, EE; Hastings, JM; Mao, LM; Wang, JQ, 2014) |
| "Adenosine is a neuromodulator which inhibits the synaptic release of neurotransmitters." | 1.35 | Effects of inhibitory amino acids on adenosine release in the mouse hippocampus. ( Oja, SS; Saransaari, P, 2008) |
| "The tangles of Alzheimer's disease (AD) are comprised of the tau protein displaying numerous alterations, including phosphorylation at serine 422 (S422) and truncation at aspartic acid 421 (D421)." | 1.33 | Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo. ( Berry, RW; Binder, LI; Cahill, ME; Cryns, VL; Guillozet-Bongaarts, AL; Reynolds, MR, 2006) |
| "Elastin is a protein of the extracellular matrix that forms the major component of elastic fibers from the arterial wall thickness and plays an important role in elastic properties of large blood vessels." | 1.31 | Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans. ( Bortolotto, LA; Girerd, X; Hanon, O; Jeunemaitre, X; Luong, V; Mourad, JJ, 2001) |
| "Inositol incorporation was also measurable, whereas [14C]serine incorporation was low or undetectable." | 1.27 | Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism. ( Ancelin, ML; Capron, A; Torpier, G; Vial, HJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (26.24) | 18.7374 |
| 1990's | 19 (13.48) | 18.2507 |
| 2000's | 45 (31.91) | 29.6817 |
| 2010's | 32 (22.70) | 24.3611 |
| 2020's | 8 (5.67) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, S | 1 |
| Zhou, J | 1 |
| Zhang, H | 1 |
| Barger, SW | 2 |
| Li, H | 3 |
| Tu, Y | 1 |
| Wan, YG | 1 |
| Mu, GL | 1 |
| Wu, W | 1 |
| Chen, JX | 1 |
| Wang, MZ | 1 |
| Wang, J | 1 |
| Fu, Y | 2 |
| Cai, YF | 1 |
| Wang, Y | 1 |
| Wan, ZY | 1 |
| Wu, Y | 1 |
| Tang, L | 1 |
| Huang, H | 1 |
| Yu, Q | 1 |
| Hu, B | 1 |
| Wang, G | 1 |
| Ge, F | 1 |
| Yin, T | 1 |
| Li, S | 1 |
| Yu, X | 1 |
| Leng, L | 1 |
| Yuan, Z | 1 |
| Su, X | 1 |
| Chen, Z | 2 |
| Yang, S | 2 |
| Chen, M | 1 |
| Zhuang, K | 1 |
| Lin, H | 1 |
| Sun, H | 1 |
| Xue, M | 1 |
| Xu, J | 2 |
| Yan, J | 1 |
| Yuan, T | 1 |
| Zhang, J | 2 |
| Waterworth, WM | 1 |
| Wilson, M | 1 |
| Wang, D | 1 |
| Nuhse, T | 1 |
| Warward, S | 1 |
| Selley, J | 1 |
| West, CE | 1 |
| Wang, W | 1 |
| Tanokashira, D | 1 |
| Fukui, Y | 1 |
| Maruyama, M | 1 |
| Kuroiwa, C | 1 |
| Saito, T | 1 |
| Saido, TC | 1 |
| Taguchi, A | 1 |
| Yang, RL | 1 |
| Huang, HM | 1 |
| Han, CS | 1 |
| Cui, SJ | 1 |
| Zhou, YK | 1 |
| Zhou, YH | 1 |
| Ploux, E | 1 |
| Freret, T | 2 |
| Billard, JM | 7 |
| Torres, AK | 1 |
| Jara, C | 1 |
| Olesen, MA | 1 |
| Tapia-Rojas, C | 1 |
| Clark, AJ | 1 |
| Kugathasan, U | 1 |
| Baskozos, G | 1 |
| Priestman, DA | 1 |
| Fugger, N | 1 |
| Lone, MA | 1 |
| Othman, A | 1 |
| Chu, KH | 1 |
| Blesneac, I | 1 |
| Wilson, ER | 1 |
| Laurà, M | 1 |
| Kalmar, B | 1 |
| Greensmith, L | 1 |
| Hornemann, T | 1 |
| Platt, FM | 1 |
| Reilly, MM | 1 |
| Bennett, DL | 1 |
| Riedlinger, T | 1 |
| Dommerholt, MB | 1 |
| Wijshake, T | 1 |
| Kruit, JK | 1 |
| Huijkman, N | 1 |
| Dekker, D | 1 |
| Koster, M | 1 |
| Kloosterhuis, N | 1 |
| Koonen, DPY | 1 |
| de Bruin, A | 1 |
| Baker, D | 1 |
| Hofker, MH | 1 |
| van Deursen, J | 1 |
| Jonker, JW | 1 |
| Schmitz, ML | 1 |
| van de Sluis, B | 1 |
| Xie, WR | 1 |
| Jen, HI | 1 |
| Seymour, ML | 1 |
| Yeh, SY | 1 |
| Pereira, FA | 1 |
| Groves, AK | 1 |
| Klisch, TJ | 1 |
| Zoghbi, HY | 1 |
| Okada, A | 1 |
| Nangaku, M | 1 |
| Jao, TM | 1 |
| Maekawa, H | 1 |
| Ishimono, Y | 1 |
| Kawakami, T | 1 |
| Inagi, R | 1 |
| Kashiwagi, K | 1 |
| Ito, S | 1 |
| Maeda, S | 1 |
| Kato, G | 1 |
| Jin, X | 1 |
| Qiao, A | 1 |
| Moskophidis, D | 1 |
| Mivechi, NF | 1 |
| Beltrán-Castillo, S | 1 |
| Eugenín, J | 1 |
| von Bernhardi, R | 1 |
| Liu, YJ | 1 |
| Janssens, GE | 1 |
| McIntyre, RL | 1 |
| Molenaars, M | 1 |
| Kamble, R | 1 |
| Gao, AW | 1 |
| Jongejan, A | 1 |
| Weeghel, MV | 1 |
| MacInnes, AW | 1 |
| Houtkooper, RH | 1 |
| Consitt, LA | 1 |
| Van Meter, J | 1 |
| Newton, CA | 1 |
| Collier, DN | 1 |
| Dar, MS | 1 |
| Wojtaszewski, JF | 1 |
| Treebak, JT | 1 |
| Tanner, CJ | 1 |
| Houmard, JA | 1 |
| Panizzutti, R | 1 |
| Scoriels, L | 1 |
| Avellar, M | 1 |
| Mirisola, MG | 1 |
| Taormina, G | 1 |
| Fabrizio, P | 1 |
| Wei, M | 1 |
| Hu, J | 1 |
| Longo, VD | 1 |
| Mao, LM | 1 |
| Hastings, JM | 1 |
| Fibuch, EE | 1 |
| Wang, JQ | 1 |
| Krześniak, M | 1 |
| Zajkowicz, A | 1 |
| Matuszczyk, I | 1 |
| Rusin, M | 1 |
| Longo, F | 1 |
| Russo, I | 1 |
| Shimshek, DR | 1 |
| Greggio, E | 1 |
| Morari, M | 1 |
| Biemans, EA | 1 |
| Verhoeven-Duif, NM | 1 |
| Gerrits, J | 1 |
| Claassen, JA | 1 |
| Kuiperij, HB | 1 |
| Verbeek, MM | 1 |
| Baruffaldi, F | 1 |
| Montarras, D | 1 |
| Basile, V | 1 |
| De Feo, L | 1 |
| Badodi, S | 1 |
| Ganassi, M | 1 |
| Battini, R | 1 |
| Nicoletti, C | 1 |
| Imbriano, C | 1 |
| Musarò, A | 1 |
| Molinari, S | 1 |
| McQuail, JA | 1 |
| Beas, BS | 1 |
| Kelly, KB | 1 |
| Simpson, KL | 1 |
| Frazier, CJ | 1 |
| Setlow, B | 1 |
| Bizon, JL | 1 |
| Yuan, C | 1 |
| Sheng, Q | 1 |
| Tang, H | 1 |
| Li, Y | 1 |
| Zeng, R | 1 |
| Solaro, RJ | 1 |
| Kawakami, K | 2 |
| Nakamura, A | 2 |
| Ishigami, A | 1 |
| Goto, S | 2 |
| Takahashi, R | 1 |
| Shay, KP | 1 |
| Hagen, TM | 1 |
| Wai, MS | 1 |
| Liang, Y | 1 |
| Shi, C | 1 |
| Cho, EY | 1 |
| Kung, HF | 1 |
| Yew, DT | 1 |
| Sengoku, R | 1 |
| Saito, Y | 1 |
| Ikemura, M | 1 |
| Hatsuta, H | 1 |
| Sakiyama, Y | 1 |
| Kanemaru, K | 1 |
| Arai, T | 1 |
| Sawabe, M | 1 |
| Tanaka, N | 1 |
| Mochizuki, H | 1 |
| Inoue, K | 1 |
| Murayama, S | 1 |
| Nie, K | 1 |
| Yu, JC | 1 |
| Cheng, HY | 1 |
| Chen, FY | 1 |
| Qu, Y | 1 |
| Han, JX | 1 |
| Schell, H | 1 |
| Hasegawa, T | 1 |
| Neumann, M | 1 |
| Kahle, PJ | 1 |
| Lebiedzinska, M | 1 |
| Duszynski, J | 1 |
| Rizzuto, R | 1 |
| Pinton, P | 1 |
| Wieckowski, MR | 1 |
| Oja, SS | 2 |
| Saransaari, P | 2 |
| Nguyen, XV | 1 |
| Liu, M | 1 |
| Kim, HC | 1 |
| Bing, G | 1 |
| Schaeffer, PJ | 1 |
| Desantiago, J | 1 |
| Yang, J | 1 |
| Flagg, TP | 1 |
| Kovacs, A | 1 |
| Weinheimer, CJ | 1 |
| Courtois, M | 1 |
| Leone, TC | 1 |
| Nichols, CG | 1 |
| Bers, DM | 1 |
| Kelly, DP | 1 |
| Chen, L | 1 |
| Periquet, M | 1 |
| Wang, X | 1 |
| Negro, A | 1 |
| McLean, PJ | 1 |
| Hyman, BT | 1 |
| Feany, MB | 1 |
| Utrera, J | 1 |
| Junyent, F | 1 |
| de Lemos, L | 1 |
| Pallàs, M | 1 |
| Camins, A | 1 |
| Romero, R | 1 |
| Auladell, C | 1 |
| Darra, E | 1 |
| Ebner, FH | 1 |
| Shoji, K | 1 |
| Suzuki, H | 1 |
| Mariotto, S | 1 |
| Pauli, JR | 1 |
| Ropelle, ER | 1 |
| Cintra, DE | 1 |
| De Souza, CT | 1 |
| da Silva, AS | 1 |
| Moraes, JC | 1 |
| Prada, PO | 1 |
| de Almeida Leme, JA | 1 |
| Luciano, E | 1 |
| Velloso, LA | 1 |
| Carvalheira, JB | 1 |
| Saad, MJ | 1 |
| Kabzińska, D | 1 |
| Sinkiewicz-Darol, E | 1 |
| Hausmanowa-Petrusewicz, I | 1 |
| Kochański, A | 1 |
| Kametani, F | 1 |
| Nakamoto, H | 1 |
| Gaugler, M | 1 |
| Brown, A | 1 |
| Merrell, E | 1 |
| DiSanto-Rose, M | 1 |
| Rathmacher, JA | 1 |
| Reynolds, TH | 1 |
| Bian, YH | 1 |
| Rotllant, P | 1 |
| Shen, T | 1 |
| Chu, W | 1 |
| Schneider, M | 1 |
| Du, SJ | 1 |
| Haxaire, C | 1 |
| Turpin, FR | 1 |
| Potier, B | 2 |
| Kervern, M | 1 |
| Sinet, PM | 2 |
| Barbanel, G | 1 |
| Mothet, JP | 5 |
| Dutar, P | 2 |
| McCormack, AL | 1 |
| Mak, SK | 1 |
| Di Monte, DA | 1 |
| Florea, S | 1 |
| Anjak, A | 1 |
| Cai, WF | 1 |
| Qian, J | 1 |
| Vafiadaki, E | 1 |
| Figueria, S | 1 |
| Haghighi, K | 1 |
| Rubinstein, J | 1 |
| Lorenz, J | 1 |
| Kranias, EG | 1 |
| Su, SP | 1 |
| Lyons, B | 1 |
| Friedrich, M | 1 |
| McArthur, JD | 1 |
| Song, X | 1 |
| Xavier, D | 1 |
| Truscott, RJ | 3 |
| Aquilina, JA | 1 |
| Miyoshi, Y | 1 |
| Konno, R | 1 |
| Sasabe, J | 1 |
| Ueno, K | 1 |
| Tojo, Y | 1 |
| Mita, M | 1 |
| Aiso, S | 1 |
| Hamase, K | 1 |
| Hooi, MY | 1 |
| Raftery, MJ | 1 |
| Asghar, M | 2 |
| Hussain, T | 1 |
| Lokhandwala, MF | 1 |
| Kubo, T | 1 |
| Nishimura, S | 1 |
| Kumagae, Y | 1 |
| Kaneko, I | 1 |
| Hashimoto, A | 5 |
| WENDER, M | 1 |
| WALIGORA, Z | 1 |
| MCMURRAY, WC | 1 |
| Bialek, P | 1 |
| Kern, B | 1 |
| Yang, X | 1 |
| Schrock, M | 1 |
| Sosic, D | 1 |
| Hong, N | 1 |
| Wu, H | 1 |
| Yu, K | 1 |
| Ornitz, DM | 1 |
| Olson, EN | 1 |
| Justice, MJ | 1 |
| Karsenty, G | 1 |
| Kim, SS | 1 |
| Cao, L | 1 |
| Li, C | 1 |
| Xu, X | 1 |
| Huber, LJ | 1 |
| Chodosh, LA | 1 |
| Deng, CX | 1 |
| Hagopian, K | 1 |
| Ramsey, JJ | 1 |
| Weindruch, R | 1 |
| Qiao, H | 1 |
| Wen, L | 1 |
| Zhou, W | 1 |
| Zhang, Y | 1 |
| Dayalan, AH | 1 |
| Jothi, M | 1 |
| Keshava, R | 1 |
| Thomas, R | 1 |
| Gope, ML | 1 |
| Doddaballapur, SK | 1 |
| Somanna, S | 1 |
| Praharaj, SS | 1 |
| Ashwathnarayanarao, CB | 1 |
| Gope, R | 1 |
| Williams, SM | 1 |
| Diaz, CM | 1 |
| Macnab, LT | 1 |
| Sullivan, RK | 1 |
| Pow, DV | 1 |
| Fortin, CF | 1 |
| Larbi, A | 1 |
| Lesur, O | 1 |
| Douziech, N | 1 |
| Fulop, T | 1 |
| Wang, GL | 1 |
| Shi, X | 1 |
| Salisbury, E | 1 |
| Sun, Y | 1 |
| Albrecht, JH | 1 |
| Smith, RG | 1 |
| Timchenko, NA | 1 |
| Guillozet-Bongaarts, AL | 1 |
| Cahill, ME | 1 |
| Cryns, VL | 1 |
| Reynolds, MR | 1 |
| Berry, RW | 1 |
| Binder, LI | 1 |
| Saunders-Pullman, R | 1 |
| Lipton, RB | 1 |
| Senthil, G | 1 |
| Katz, M | 1 |
| Costan-Toth, C | 1 |
| Derby, C | 1 |
| Bressman, S | 1 |
| Verghese, J | 1 |
| Ozelius, LJ | 1 |
| Puyal, J | 1 |
| Martineau, M | 1 |
| Nicolas, MT | 1 |
| Raymond, J | 1 |
| Fardoun, RZ | 1 |
| Lokhandwala, M | 1 |
| Junjaud, G | 1 |
| Rouaud, E | 2 |
| Turpin, F | 1 |
| Jouvenceau, A | 1 |
| Videau, C | 1 |
| Epelbaum, J | 1 |
| Vernet, N | 1 |
| Dennefeld, C | 1 |
| Guillou, F | 1 |
| Chambon, P | 1 |
| Ghyselinck, NB | 1 |
| Mark, M | 1 |
| Lobsiger, CS | 1 |
| Boillée, S | 1 |
| Cleveland, DW | 1 |
| Edwards, AO | 1 |
| Lisý, V | 2 |
| Stastný, F | 2 |
| Murphy, S | 1 |
| Hájková, B | 1 |
| Taketomi, T | 1 |
| Uemura, K | 1 |
| Yuzawa, M | 1 |
| Vallebuona, F | 1 |
| Raiteri, M | 1 |
| Kumashiro, S | 2 |
| Nishikawa, T | 4 |
| Kilby, GW | 1 |
| Carver, JA | 1 |
| Zhu, JL | 1 |
| Sheil, MM | 1 |
| Arioka, M | 1 |
| Tsukamoto, M | 1 |
| Ishiguro, K | 1 |
| Kato, R | 1 |
| Sato, K | 1 |
| Imahori, K | 1 |
| Uchida, T | 1 |
| Oka, T | 3 |
| Takahashi, K | 2 |
| Goedert, M | 1 |
| Jakes, R | 1 |
| Crowther, RA | 1 |
| Six, J | 1 |
| Lübke, U | 1 |
| Vandermeeren, M | 1 |
| Cras, P | 1 |
| Trojanowski, JQ | 1 |
| Lee, VM | 1 |
| Mito, T | 1 |
| Takashima, S | 1 |
| Doi, N | 1 |
| Mizutani, Y | 1 |
| Yamazaki, T | 1 |
| Abe, M | 1 |
| Iriki, T | 1 |
| Funaba, M | 1 |
| Masson, P | 1 |
| Fortier, PL | 1 |
| Albaret, C | 1 |
| Froment, MT | 1 |
| Bartels, CF | 1 |
| Lockridge, O | 1 |
| Huang, Y | 1 |
| Satoh, K | 1 |
| Iwata, T | 1 |
| Fukushima, T | 1 |
| Santa, T | 1 |
| Homma, H | 1 |
| Imai, K | 1 |
| Nagata, Y | 1 |
| Uehara, T | 1 |
| Kitamura, Y | 1 |
| Nomura, Y | 1 |
| Horiike, K | 1 |
| Fountain, WC | 1 |
| Requena, JR | 1 |
| Jenkins, AJ | 1 |
| Lyons, TJ | 1 |
| Smyth, B | 1 |
| Baynes, JW | 1 |
| Thorpe, SR | 1 |
| Parent, AT | 1 |
| Wolosker, H | 1 |
| Brady, RO | 1 |
| Linden, DJ | 1 |
| Ferris, CD | 1 |
| Rogawski, MA | 1 |
| Snyder, SH | 1 |
| Ilincheta de Boschero, MG | 2 |
| Roque, ME | 2 |
| Salvador, GA | 1 |
| Giusto, NM | 2 |
| Pratta, MA | 1 |
| Tortorella, MD | 1 |
| Arner, EC | 1 |
| Thompson, HR | 1 |
| Jones, GM | 1 |
| Narkewicz, MR | 1 |
| Foletti, DL | 1 |
| Scheller, RH | 1 |
| Yamasaki, M | 1 |
| Yamada, K | 1 |
| Furuya, S | 1 |
| Mitoma, J | 1 |
| Hirabayashi, Y | 1 |
| Watanabe, M | 1 |
| Hanon, O | 1 |
| Luong, V | 1 |
| Mourad, JJ | 1 |
| Bortolotto, LA | 1 |
| Jeunemaitre, X | 1 |
| Girerd, X | 1 |
| Maurage, CA | 1 |
| Sergeant, N | 1 |
| Ruchoux, MM | 1 |
| Hauw, JJ | 1 |
| Delacourte, A | 1 |
| Zhen, X | 1 |
| Torres, C | 1 |
| Wang, HY | 1 |
| Friedman, E | 1 |
| Kern, HL | 1 |
| Woodbury, RG | 1 |
| Neurath, H | 1 |
| Glimcher, MJ | 1 |
| Brickley-Parsons, D | 1 |
| Kossiva, D | 1 |
| Mays, LL | 1 |
| Lawrence, AE | 1 |
| Ho, RW | 1 |
| Ackley, S | 1 |
| Bertolini, AM | 1 |
| Santagostino, A | 1 |
| Wong, PP | 1 |
| Kuo, T | 1 |
| Ryan, CA | 1 |
| Snell, K | 1 |
| Jankásková, B | 1 |
| Whisler, RL | 1 |
| Liu, BQ | 1 |
| Newhouse, YG | 1 |
| Walters, JD | 1 |
| Breckenridge, MB | 1 |
| Grants, IS | 1 |
| Narabayashi, H | 1 |
| Yokochi, F | 1 |
| Ogawa, T | 1 |
| Igakura, T | 1 |
| Kalbag, SS | 1 |
| Palekar, AG | 1 |
| Gaiarsa, JL | 1 |
| Corradetti, R | 1 |
| Cherubini, E | 1 |
| Ben-Ari, Y | 1 |
| Sanecka-Obacz, M | 1 |
| Brattström, LE | 1 |
| Hultberg, BL | 1 |
| Hardebo, JE | 1 |
| Vial, HJ | 1 |
| Torpier, G | 1 |
| Ancelin, ML | 1 |
| Capron, A | 1 |
| Bourdel, G | 1 |
| Girard, A | 1 |
| Forestier, M | 1 |
| Manley, G | 1 |
| Mullinger, RN | 1 |
| Lloyd, PH | 1 |
| Jamdar, SC | 1 |
| Greengard, O | 2 |
| Weinhold, PA | 1 |
| Sanders, RD | 1 |
| Weiss, B | 1 |
| Stiller, RL | 1 |
| Federman, M | 1 |
| Knox, WE | 1 |
| Hoshino, J | 1 |
| Simon, D | 1 |
| Robert, B | 1 |
| Kröger, H | 1 |
| Spadafora, C | 1 |
| Igo-Kemenes, T | 1 |
| Zachau, HG | 1 |
| Jones, JP | 1 |
| Ramsey, RB | 1 |
| Aexel, RT | 1 |
| Nicholas, HJ | 1 |
| Short, NA | 1 |
| Sander, EG | 1 |
| Rennert, OM | 1 |
| Rowsell, EV | 1 |
| al-Tai, AH | 1 |
| Carnie, JA | 1 |
| De Loecker, W | 1 |
| Stas, ML | 1 |
| Slaughter, JC | 1 |
| Davies, LP | 1 |
| Johnston, GA | 1 |
| Schoenmakers, JG | 1 |
| Gerding, JJ | 1 |
| Bloemendal, H | 1 |
| Morell, P | 1 |
| Costantino-Ceccarini, E | 1 |
| Witt, I | 1 |
| Hasler, K | 1 |
| Den, H | 1 |
| Kaufman, B | 1 |
| Roseman, S | 1 |
| Burton, RM | 1 |
| Beck, G | 1 |
| Hentzen, D | 1 |
| Ebel, JP | 1 |
| Horrocks, LA | 1 |
| Cheung, GP | 1 |
| Cotropia, JP | 1 |
| Sallach, HJ | 1 |
| Bygrave, FL | 1 |
| Kaiser, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Amyotrophic Lateral Sclerosis and the Innate Immune System[NCT02869048] | 375 participants (Anticipated) | Observational | 2016-06-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for serine and Aging
| Article | Year |
|---|---|
Serine Racemase Expression Differentiates Aging from Alzheimer's Brain.
Topics: Aging; Alzheimer Disease; Brain; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine | 2022 |
d-serine in physiological and pathological brain aging.
Topics: Aging; Alzheimer Disease; Animals; Astrocytes; Cognition; Gene Expression; Glucose; Glutamic Acid; H | 2021 |
Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS.
Topics: Aging; Animals; Central Nervous System; Humans; Microglia; Neurodegenerative Diseases; Serine | 2018 |
The co-agonist site of NMDA-glutamate receptors: a novel therapeutic target for age-related cognitive decline.
Topics: Adult; Age Factors; Aged; Aging; Animals; Binding Sites; Cognition Disorders; Hippocampus; Humans; M | 2014 |
D-Serine in the aging hippocampus.
Topics: Aging; Animals; Hippocampus; Humans; Memory; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Seri | 2015 |
Biological significance of protein modifications in aging and calorie restriction.
Topics: Acetylation; Aging; Animals; Caloric Restriction; Histones; Lysine; Phosphorylation; Protein Process | 2010 |
An unconventional hypothesis of oxidation in Alzheimer's disease: intersections with excitotoxicity.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cystine; Glutamates; Humans; Inflam | 2004 |
Genetics of age-related macular degeneration.
Topics: Aging; Amino Acid Substitution; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 10; Haplotypes; | 2008 |
D-serine signalling as a prominent determinant of neuronal-glial dialogue in the healthy and diseased brain.
Topics: Aging; Animals; Brain; Brain Diseases; Humans; Models, Neurological; Neuroglia; Neurons; Serine; Sig | 2008 |
[Endogenous free D-aspartate and D-serine in mammals].
Topics: Adrenal Glands; Aging; Animals; Aspartic Acid; Brain; Kidney; Liver; Male; Serine; Testis | 1996 |
Transport of organic solutes in the lens.
Topics: Aging; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Calcium; Carbohydrate Meta | 1979 |
[Protein kinases of the central nervous system in ontogenesis].
Topics: Aging; Animals; Brain; Calcium; Calmodulin; Humans; Nucleotides, Cyclic; Phospholipids; Protein Kina | 1989 |
129 other studies available for serine and Aging
| Article | Year |
|---|---|
[Effect and mechanism of Dahuang Zhechong Pills against testicular aging in rats by inhibiting necroptosis signaling pathway].
Topics: Aging; Animals; Drugs, Chinese Herbal; Male; Necroptosis; Protein Kinases; Rats; Reactive Oxygen Spe | 2022 |
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Topics: Aging; Animals; Cellular Senescence; Endothelial Cells; Glycolysis; Histones; Mice; Phosphoglycerate | 2023 |
Hypothalamic Menin regulates systemic aging and cognitive decline.
Topics: Aging; Animals; Cognitive Dysfunction; Hypothalamus; Mice; Serine; Transcription Factors | 2023 |
Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress.
Topics: Aging; Arabidopsis; Arabidopsis Proteins; ATP-Binding Cassette Transporters; Cells, Cultured; DNA Da | 2019 |
Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Dia | 2019 |
Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16.
Topics: Aging; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cellular Senescence; Cyclin-Depend | 2021 |
Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice.
Topics: Aging; Animals; Cognitive Dysfunction; Hippocampus; Memory Disorders; Mice; Mice, Inbred C57BL; Mito | 2021 |
An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions.
Topics: Aging; Axons; Base Sequence; Caspase 3; Cell Line; Gangliosides; Gene Expression Regulation; Heredit | 2021 |
NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.
Topics: Aging; Amino Acid Substitution; Animals; Gene Expression Regulation; Gene Knock-In Techniques; Human | 2017 |
An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment.
Topics: Aging; Alleles; Animals; Basic Helix-Loop-Helix Transcription Factors; Female; Gene Knock-In Techniq | 2017 |
D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation.
Topics: Aging; Apoptosis; Cell Cycle Checkpoints; Cells, Cultured; Epithelial Cells; Humans; Kidney Diseases | 2017 |
A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice.
Topics: Aging; Amino Acid Substitution; Animals; Apoptosis; Asparagine; Cell Count; Cell Survival; Mice; Mic | 2017 |
Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance.
Topics: Aging; Amino Acid Substitution; Animals; Cells, Cultured; Disease Models, Animal; Female; Gene Knock | 2018 |
Asc-1 transporter activation: an alternative to rescue age-related alterations in functional plasticity at rat hippocampal CA3/CA1 synapses.
Topics: Aging; Amino Acid Transport System ASC; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; E | 2018 |
Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion.
Topics: Aging; Animals; Caenorhabditis elegans; Diet; Genes, Helminth; Glycine; Longevity; Metabolic Network | 2019 |
Impairments in site-specific AS160 phosphorylation and effects of exercise training.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aged, 80 and over; Aging; Blotting, Western; Cros | 2013 |
Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Aging; Animals; Cyclic AMP-Dependent Protein Kinases; | 2014 |
Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice.
Topics: Aging; Anesthetics, General; Animals; Mice; Phosphorylation; Prefrontal Cortex; Propofol; Receptors, | 2014 |
Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D.
Topics: Aging; Antibiotics, Antineoplastic; Cell Line, Tumor; Dactinomycin; Humans; Lung Neoplasms; Nuclear | 2014 |
Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Analysis of Variance; Animals; Brain; Dose-Res | 2014 |
CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; | 2016 |
Dynamic Phosphorylation of the Myocyte Enhancer Factor 2Cα1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy.
Topics: Aging; Alternative Splicing; Amino Acid Sequence; Animals; Cell Differentiation; Cell Proliferation; | 2017 |
NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline.
Topics: Aging; Animals; Cognitive Dysfunction; Conditioning, Operant; Excitatory Amino Acid Antagonists; Mal | 2016 |
Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts.
Topics: Age Factors; Aging; Amino Acid Sequence; Animals; Animals, Newborn; Blotting, Western; Cardiac Myosi | 2008 |
Age-related difference of site-specific histone modifications in rat liver.
Topics: Acetylation; Age Factors; Aging; Amino Acid Sequence; Animals; Chromatin Assembly and Disassembly; E | 2009 |
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
Topics: Age Factors; Aging; Animals; Antioxidants; Cell Survival; Cells, Cultured; Hepatocytes; Insulin; Mal | 2009 |
Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer's disease patients.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Apoptosis; Brain Stem; Caspase 3; Ca | 2009 |
Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb.
Topics: Aged; Aged, 80 and over; Aging; alpha-Synuclein; Amyloid beta-Peptides; Brain; Female; Humans; Incid | 2008 |
Age-related decrease in constructive activation of Akt/PKB in SAMP10 hippocampus.
Topics: Age Factors; Aging; Aging, Premature; Alzheimer Disease; Animals; Hippocampus; Male; Maze Learning; | 2009 |
Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.
Topics: Aging; alpha-Synuclein; Amygdala; Animals; Brain; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Co | 2009 |
Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues.
Topics: Aging; Animals; Animals, Newborn; Antioxidants; Cells, Cultured; Female; Free Radicals; Liver; Mice; | 2009 |
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid; | 2009 |
Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP.
Topics: Aging; Amino Acid Sequence; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Enkephalins; | 2009 |
Effects of inhibitory amino acids on adenosine release in the mouse hippocampus.
Topics: Adenosine; Aging; Animals; Animals, Newborn; beta-Alanine; Excitatory Amino Acid Antagonists; Female | 2008 |
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.
Topics: Aging; Animals; Calcineurin; Calcium Signaling; Calcium-Binding Proteins; Cardiomyopathies; Cardioto | 2009 |
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila m | 2009 |
Tau hyperphosphorylation and axonal damage induced by N,N-diethyldithiocarbamate (DEDTC) treatment along late postnatal development is followed by a rescue during adulthood.
Topics: Age Factors; Aging; Amino Acid Sequence; Animals; Animals, Newborn; Axons; Blotting, Western; Brain; | 2010 |
Dual cross-talk between nitric oxide and D-serine in astrocytes and neurons in the brain.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Brain Neoplasms; Cells, Cultured; Cytokines; Gl | 2009 |
Acute exercise reverses aged-induced impairments in insulin signaling in rodent skeletal muscle.
Topics: Aging; Animals; I-kappa B Proteins; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance | 2010 |
Charcot-Marie-Tooth type 1A disease caused by a novel Ser112Arg mutation in the PMP22 gene, coexisting with a slowly progressive hearing impairment.
Topics: Adolescent; Adult; Age of Onset; Aging; Amino Acid Sequence; Amino Acid Substitution; Arginine; Audi | 2010 |
PKB signaling and atrogene expression in skeletal muscle of aged mice.
Topics: Age Factors; Aging; Animals; Apoptosis Regulatory Proteins; Autophagy; Cytoskeletal Proteins; Forkhe | 2011 |
Smyd1b_tv1, a key regulator of sarcomere assembly, is localized on the M-line of skeletal muscle fibers.
Topics: Aging; Alternative Splicing; Amino Acid Sequence; Animals; Cell Differentiation; Embryo, Nonmammalia | 2011 |
Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting D-serine-dependent NMDA receptor activation.
Topics: Acetylcysteine; Aging; Animals; Hippocampus; Lysine; Male; Neuronal Plasticity; Oxidative Stress; Ra | 2012 |
Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra.
Topics: Aging; alpha-Synuclein; Animals; Humans; Neurons; Nitro Compounds; Phosphorylation; Protein Processi | 2012 |
Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging.
Topics: Aging; Animals; Calcium; Carrier Proteins; Mice; Mice, Transgenic; Myocardial Contraction; Myocardia | 2012 |
Molecular signatures of long-lived proteins: autolytic cleavage adjacent to serine residues.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Crystallins; Hot Temperature; Humans; Lens, Cryst | 2012 |
Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase.
Topics: Aging; Animals; Cerebellum; Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Mice; Mice, | 2012 |
Age-dependent racemization of serine residues in a human chaperone protein.
Topics: Aging; alpha-Crystallin A Chain; Humans; Lens, Crystalline; Models, Molecular; Serine; Stereoisomeri | 2013 |
Higher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Aging; Animals; Benzazepine | 2002 |
In vivo conversion of racemized beta-amyloid ([D-Ser 26]A beta 1-40) to truncated and toxic fragments ([D-Ser 26]A beta 25-35/40) and fragment presence in the brains of Alzheimer's patients.
Topics: Aged; Aging; Alzheimer Disease; Amino Acid Isomerases; Amyloid beta-Peptides; Animals; Astrocytes; B | 2002 |
Effect of the intracerebroventricular and systemic administration of L-serine on the concentrations of D- and L-serine in several brain areas and periphery of rat.
Topics: Aging; Animals; Animals, Newborn; Brain; Injections, Intraventricular; Male; Rats; Rats, Wistar; Ser | 2002 |
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG. III. SPINAL CORD.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Cystine; Fetus; Glutamates; | 1964 |
METABOLISM OF PHOSPHATIDES IN DEVELOPING RAT BRAIN--I. INCORPORATION OF RADIOACTIVE PRECURSORS.
Topics: Aging; Animals; Animals, Newborn; Brain; Choline; Lecithins; Lipid Metabolism; Phosphates; Phosphati | 1964 |
A twist code determines the onset of osteoblast differentiation.
Topics: Aging; Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Cell Differentiation; Cells | 2004 |
Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.
Topics: Aging; Animals; BRCA1 Protein; Carcinogens; Cell Cycle; Cell Transformation, Neoplastic; Checkpoint | 2004 |
Serine utilization in mouse liver: influence of caloric restriction and aging.
Topics: Aging; Animals; Caloric Restriction; Gluconeogenesis; L-Serine Dehydratase; Liver; Male; Mice; Mice, | 2005 |
D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8.
Topics: Age Factors; Aging; Analysis of Variance; Animals; D-Amino-Acid Oxidase; Drug Interactions; Electric | 2005 |
Age dependent phosphorylation and deregulation of p53 in human vestibular schwannomas.
Topics: Adolescent; Adult; Aged; Aging; Blotting, Western; Cell Line; Female; Humans; Loss of Heterozygosity | 2006 |
Immunocytochemical analysis of D-serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neurons.
Topics: Aging; Animals; Biomarkers; Brain; Brain Chemistry; Fixatives; Formaldehyde; gamma-Aminobutyric Acid | 2006 |
Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions.
Topics: Adult; Age Factors; Aged; Aging; Apoptosis; Chemotaxis, Leukocyte; Down-Regulation; Enzyme Inhibitor | 2006 |
Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes.
Topics: 3T3-L1 Cells; Aging; Animals; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cyclin D3; | 2006 |
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Antibodies; Apoptosis; Aspar | 2006 |
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.
Topics: Aged, 80 and over; Aging; Dementia; DNA Mutational Analysis; Female; Glycine; Humans; Jews; Leucine- | 2006 |
Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei.
Topics: Afferent Pathways; Aging; Animals; Animals, Newborn; Biomarkers; Cell Communication; Cell Differenti | 2006 |
Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Antioxidants; beta-Adren | 2006 |
Age-related effects of the neuromodulator D-serine on neurotransmission and synaptic potentiation in the CA1 hippocampal area of the rat.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Glycine; Hippoca | 2006 |
A critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memory.
Topics: Aging; Animals; Binding Sites; Hippocampus; Learning; Long-Term Potentiation; Male; Memory; Neurogli | 2006 |
Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.
Topics: Aging; Animals; Cell Count; Cell Cycle; Cell Polarity; Epithelium; Gene Expression; Male; Mice; Phen | 2006 |
Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons.
Topics: Aging; Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Cell Separation; Enzym | 2007 |
Glutamate uptake into cerebral cortex slices is reduced in the presence of a gamma-glutamyl transpeptidase inhibitor.
Topics: Aging; Animals; Biological Transport, Active; Borates; Cerebral Cortex; gamma-Glutamyltransferase; G | 1983 |
Metabolic studies of N-bases of phospholipids and long chain bases of sphingolipids in two-weeks-old mouse brain tissue in comparison with one-month-old mouse visceral tissues.
Topics: Aging; Animals; Brain; Choline; Decarboxylation; Ethanolamines; Mice; Phospholipids; Serine; Sphingo | 1980 |
Age-related changes in the NMDA receptor/nitric oxide/cGMP pathway in the hippocampus and cerebellum of freely moving rats subjected to transcerebral microdialysis.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Behavior, Animal; Cerebellum; Cyclic GMP; Extracellular | 1995 |
Free D-serine in post-mortem brains and spinal cords of individuals with and without neuropsychiatric diseases.
Topics: Aging; Amino Acids; Animals; Brain Chemistry; Humans; Mental Disorders; Nervous System Diseases; Par | 1995 |
Loss of the C-terminal serine residue from bovine beta B2-crystallin.
Topics: Aging; Animals; Cattle; Chromatography, High Pressure Liquid; Crystallins; Humans; Lens, Crystalline | 1995 |
Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein.
Topics: Aging; Amino Acid Sequence; Animals; Brain; Cattle; Cyclin-Dependent Kinase 5; Electrophoresis, Gel, | 1993 |
Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging.
Topics: Aging; Animals; Brain; Glycine; Kidney; Liver; Male; Organ Specificity; Rats; Rats, Wistar; Receptor | 1993 |
The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.
Topics: Adult; Aging; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cerebral Cortex; Fetus; Humans | 1993 |
Embryonic development and postnatal changes in free D-aspartate and D-serine in the human prefrontal cortex.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Child, Preschool; Chromatog | 1993 |
Lysine deficiency in postweaned calves fed corn and corn gluten meal diets.
Topics: Aging; Analysis of Variance; Animals; Arginine; Caseins; Cattle; Cattle Diseases; Cysteine; Deficien | 1997 |
Aging of di-isopropyl-phosphorylated human butyrylcholinesterase.
Topics: Aging; Animals; Binding Sites; Butyrylcholinesterase; CHO Cells; Cholinesterase Inhibitors; Cricetin | 1997 |
Urinary excretion of D-serine in human: comparison of different ages and species.
Topics: Adult; Aging; Alanine; Animal Feed; Animals; Child; Chromatography, High Pressure Liquid; Colostrum; | 1998 |
D-serine content and D-[3H]serine binding in the brain regions of the senescence-accelerated mouse.
Topics: Aging; Animals; Autoradiography; Brain; Brain Mapping; Cerebellum; Female; Frontal Lobe; Hippocampus | 1998 |
Quantification of N-(glucitol)ethanolamine and N-(carboxymethyl)serine: two products of nonenzymatic modification of aminophospholipids formed in vivo.
Topics: Aging; Amines; Diabetes Mellitus, Type 1; Erythrocyte Membrane; Gas Chromatography-Mass Spectrometry | 1999 |
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
Topics: Aging; Animals; Astrocytes; Cells, Cultured; Cerebellum; D-Amino-Acid Oxidase; Embryo, Mammalian; Gl | 2000 |
Alternative pathways for phospholipid synthesis in different brain areas during aging.
Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Male; Methyltransferases; Phosphatidylethanolami | 2000 |
Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase.
Topics: Age Factors; Aggrecans; Aging; Alanine; Animals; beta-Galactosidase; Blotting, Western; Cattle; Chon | 2000 |
Ontogeny of hepatic enzymes involved in serine- and folate-dependent one-carbon metabolism in rabbits.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aging; Amino Acid Oxidoreductases; Animal | 2001 |
Developmental regulation and specific brain distribution of phosphorabphilin.
Topics: Adaptor Proteins, Signal Transducing; Aging; Animals; Antibodies; Antibody Specificity; Blotting, We | 2001 |
3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain.
Topics: Aging; Animals; Antibody Specificity; Astrocytes; Brain; Carbohydrate Dehydrogenases; Cell Different | 2001 |
Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans.
Topics: Aging; Carotid Arteries; Cohort Studies; Compliance; Elastin; Female; Genotype; Glycine; Humans; Mal | 2001 |
Paradoxical phosphorylation of the serine 199 on tau proteins from young individuals.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Child; Fe | 2001 |
Prenatal exposure to cocaine disrupts D1A dopamine receptor function via selective inhibition of protein phosphatase 1 pathway in rabbit frontal cortex.
Topics: Aging; Animals; Cocaine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Activation; Female; F | 2001 |
Purification of an atypical mast cell protease and its levels in developing rats.
Topics: Aging; Amino Acids; Animals; Female; Immunodiffusion; Intestinal Mucosa; Intestine, Small; Mast Cell | 1978 |
Phosphopeptides and gamma-carboxyglutamic acid-containing peptides in calcified turkey tendon: their absence in uncalcified tendon.
Topics: 1-Carboxyglutamic Acid; Aging; Animals; Female; Glutamates; Organophosphorus Compounds; Peptides; Ph | 1979 |
Age-related changes in function of transfer ribonucleic acid of rat livers.
Topics: Acylation; Aging; Animals; Liver; Lysine; Protein Biosynthesis; Rats; Ribosomes; RNA, Transfer; Seri | 1979 |
[Senile liver and its repercussions on cerebral activity].
Topics: Aged; Aging; Amino Acids; Brain; Cystine; Glutamates; Histidine; Humans; Liver; Serine; Threonine; T | 1979 |
Growth-dependent accumulation and utilization of proteinase inhibitor I in tobacco callus tissues.
Topics: Aging; Cells, Cultured; Enzyme Inhibitors; Nicotiana; Plant Development; Plant Physiological Phenome | 1975 |
Mitochondrial-cytosolic interrelationships involved in gluconeogenesis from serine in rat liver.
Topics: Aging; Animals; Animals, Newborn; Cytosol; Gluconeogenesis; Glutamate Dehydrogenase; L-Serine Dehydr | 1975 |
Effect of gamma-glutamyl transpeptidase inhibitors on the transport of glutamate into neuronal and glial primary cultures.
Topics: Aging; Animals; Biological Transport; Borates; Brain; Cells, Cultured; Chickens; Diazooxonorleucine; | 1992 |
Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system.
Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Choline; Fatty Acids; Medulla Oblongata; Palmiti | 1992 |
Signal transduction in human B cells during aging: alterations in stimulus-induced phosphorylations of tyrosine and serine/threonine substrates and in cytosolic calcium responsiveness.
Topics: Aging; Amino Acids; B-Lymphocytes; Calcium; Cell Division; Cells, Cultured; Cytosol; Humans; Phospho | 1991 |
[Analysis of L-threo-3, 4-dihydroxyphenylserine effect on motor and psychological symptoms in Parkinson's disease].
Topics: Aged; Aging; Droxidopa; Female; Humans; Male; Middle Aged; Parkinson Disease; Psychomotor Performanc | 1991 |
Postnatal development of the glycine cleavage system in rat liver.
Topics: Aging; Amino Acids; Aminomethyltransferase; Animals; Animals, Newborn; Female; Glycine; Glycine Hydr | 1990 |
The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.
Topics: Aging; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Aspartic Acid; Electric Co | 1990 |
Folic acid responsive postmenopausal homocysteinemia.
Topics: Adult; Aging; Cystine; Dipeptides; Fasting; Female; Folic Acid; Glycine; Homocysteine; Humans; Male; | 1985 |
Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism.
Topics: Aging; Animals; Biomphalaria; Carbon Radioisotopes; Choline; Ethanolamine; Ethanolamines; Female; Gl | 1985 |
[Effects of dietary surcharges of DL-methionine and DL-serine adminisitered alone or in combination on the development of mono and binucleated rat pancreas cells].
Topics: Aging; Animals; Diet; DNA; Methionine; Pancreas; Rats; Serine; Staining and Labeling | 1969 |
Properties of heparan sulphate and chondroitin sulphate from young and old human aortae.
Topics: Adolescent; Adult; Aged; Aging; Amino Acids; Aorta, Thoracic; Aspartic Acid; Chondroitin; Chromatogr | 1969 |
Phosphoserine phosphatase: development formation and hormonal regulation in rat tissues.
Topics: Aging; Animals; Animals, Newborn; Brain; Estradiol; Female; Fetus; Glucagon; Hydrocortisone; Kidney; | 1969 |
Phospholipid metabolism during the development of the liver. The incorporation of [1,2-14C]ethanolamine, [2-3H]myo-inositol and L-[U-14C]serine into phospholipids by liver slices.
Topics: Aging; Amino Alcohols; Animals; Carbon Isotopes; Cholesterol; Fatty Acids; Female; Glycerides; Glyce | 1971 |
Dibutyryl cyclic adenosine 3',5-monophosphate and brain lipid metabolism.
Topics: Acetates; Aging; Animals; Brain; Bucladesine; Carbon Radioisotopes; Cerebrosides; Cesium; Cholestero | 1974 |
Cytomorphometry of developing rat liver and its application to enzymic differentiation.
Topics: Aging; Animals; Aspartic Acid; Cell Count; Female; Glucagon; Glucokinase; Glucosyltransferases; Glyc | 1972 |
Dietary and cortisone regulation of cytosol serine and phosphoserine aminotransferases in rat liver.
Topics: Adrenal Glands; Adrenalectomy; Aging; Animals; Cortisone; Cytosol; Dactinomycin; Diet; Dietary Prote | 1974 |
Changes in transfer RNAs and aminoacyl-tRNA synthetases during sea urchin development.
Topics: Aging; Amino Acyl-tRNA Synthetases; Animals; Arginine; Carbon Isotopes; Chromatography, DEAE-Cellulo | 1973 |
Lipid biosynthesis in neuron-enriched and glial-enriched fractions of rat brain: ganglioside biosynthesis.
Topics: Acetates; Aging; Animals; Brain; Carbon Isotopes; Gangliosides; Glycolipids; Lipids; Mevalonic Acid; | 1972 |
Isoprenylation of transfer ribonucleic acid.
Topics: Adenosine; Aging; Alkenes; Animals; Carbon Isotopes; Cattle; Chromatography, DEAE-Cellulose; Chromat | 1973 |
Increased liver L-serine-pyruvate aminotransferase activity under gluconeogenic conditions.
Topics: Aging; Alloxan; Animals; Animals, Newborn; Female; Fetus; Glucagon; Gluconeogenesis; L-Serine Dehydr | 1973 |
Effect of cortisol treatment on free amino acid levels in rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Glycine; Hydrocortisone; Liver; Male; Muscle Pr | 1973 |
Inhibition of 3-phosphoglycerate dehydrogenase from Pisum sativum by purine nucleotides.
Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Aging; Alcohol Oxidoreductases; Binding | 1973 |
Postnatal changes in the levels of glycine and the activities of serine hydroxymethyltransferase and glycine:2-oxoglutarate aminotransferase in the rat central nervous system.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Antimetabolites; Brain; Carbon Radioisotopes; Cerebel | 1974 |
The subunit structure of alpha-crystallin. Isolation and characterization of the S-carboxymethylated acidic subunits from adult and embryonic origin.
Topics: Aging; Alkylation; Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Cattle; Chromatography, Ion | 1969 |
Jimpy mouse: in vitro studies of brain sphingolipid biosynthesis.
Topics: Aging; Animals; Brain; Carbon Isotopes; Ceramides; Coenzyme A; Galactose; Glucose; Glucosyltransfera | 1972 |
Influence of organically bound phosphorus in foetal and adult fibrinogen on the kinetics of the interaction between thrombin and fibrinogen.
Topics: Aging; Alkaline Phosphatase; Animals; Blood; Blood Coagulation Tests; Cattle; Fetus; Fibrinogen; Hum | 1972 |
Properties of some glycosyltransferases in embryonic chicken brain.
Topics: Aging; Albumins; Amniotic Fluid; Animals; Brain; Carbon Isotopes; Chick Embryo; Cytosine Nucleotides | 1970 |
Factors affecting incorporation of precursors into body constituents: a review of common sense considerations with glycolipids as examples.
Topics: Aging; Animals; Aspartic Acid; Brain; Carbon Isotopes; Cerebrosides; Galactose; Gangliosides; Glucos | 1970 |
[Hormonal regulation at the level of transfer RNA. I. Comparative study of transfer RNA from the liver of immature hens and laying hens].
Topics: Aging; Alanine; Animals; Carbon Isotopes; Chickens; Chromatography, Ion Exchange; Estradiol; Female; | 1970 |
Composition of mouse brain myelin during development.
Topics: Aging; Amino Alcohols; Animals; Brain; Brain Chemistry; Cholesterol; Galactose; Glycerylphosphorylch | 1968 |
Comparative studies of enzymes related to serine metabolis in fetal and adult liver.
Topics: Aged; Aging; Alcohol Oxidoreductases; Animals; Cats; Cattle; Cesarean Section; Chick Embryo; Dogs; F | 1968 |
The magnesium-dependent incorporation of serine into the phospholipids of mitochondria isolated from the developing flight muscle of the african locust Locusta migratoria.
Topics: Adenosine Triphosphate; Aging; Animals; Carbon Isotopes; Cytosine Nucleotides; Hydrogen-Ion Concentr | 1969 |