Page last updated: 2024-11-08

serine and Adipocere

serine has been researched along with Adipocere in 14 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disease characterized by behavioral abnormalities, personality changes, language dysfunction, and can co-occur with the development of motor neuron disease."1.36Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration. ( Duong, DM; Gearing, M; Herskowitz, JH; Lah, JJ; Levey, AI; Peng, J; Rees, HD; Seyfried, NT; Xia, Q, 2010)
"Glycine was distributed fairly uniformly with large concentrations in certain lower brainstem nuclei."1.27Concentrations of GABA and glycine in discrete brain nuclei. Stress-induced changes in the levels of inhibitory amino acids. ( Elekes, I; Láng, T; Palkovits, M; Patthy, A, 1986)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19902 (14.29)18.7374
1990's2 (14.29)18.2507
2000's5 (35.71)29.6817
2010's5 (35.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Keller, S1
Punzo, D1
Cuomo, M1
Affinito, O1
Coretti, L1
Sacchi, S1
Florio, E1
Lembo, F1
Carella, M1
Copetti, M1
Cocozza, S1
Balu, DT1
Errico, F1
Usiello, A1
Chiariotti, L1
Mamais, A1
Raja, M1
Manzoni, C1
Dihanich, S1
Lees, A1
Moore, D1
Lewis, PA1
Bandopadhyay, R1
Jin, N1
Wu, Y1
Xu, W1
Gong, CX2
Iqbal, K2
Liu, F2
Ma, QL1
Yang, F1
Rosario, ER1
Ubeda, OJ1
Beech, W1
Gant, DJ1
Chen, PP1
Hudspeth, B1
Chen, C1
Zhao, Y1
Vinters, HV1
Frautschy, SA1
Cole, GM1
Herskowitz, JH1
Seyfried, NT1
Duong, DM1
Xia, Q1
Rees, HD1
Gearing, M1
Peng, J1
Lah, JJ1
Levey, AI1
Muntané, G1
Ferrer, I1
Martinez-Vicente, M1
Webber, KM1
Smith, MA1
Lee, HG1
Harris, PL1
Moreira, P1
Perry, G1
Zhu, X1
Li, X1
Friedman, AB1
Roh, MS1
Jope, RS1
Griffin, RJ1
Moloney, A1
Kelliher, M1
Johnston, JA1
Ravid, R1
Dockery, P1
O'Connor, R1
O'Neill, C1
Grundke-Iqbal, I1
Kumashiro, S2
Hashimoto, A1
Nishikawa, T1
Kurumaji, A1
Watanabe, A1
Semba, J1
Toru, M1
Elekes, I1
Patthy, A1
Láng, T1
Palkovits, M1
Shank, RP1
Aprison, MH1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Curcumin and Yoga Exercise Effects in Veterans at Risk for Alzheimer's Disease[NCT01811381]Phase 280 participants (Anticipated)Interventional2014-01-20Active, not recruiting
A Trial of the Effects of Glycine Loading on Clinical Symptoms and Logical Memory in Patients With Schizophrenia[NCT00575848]Phase 116 participants (Anticipated)Interventional2007-12-31Terminated (stopped due to Slow enrollment and due to personnel change there was no viable way to quantify glycine levels through imaging)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

14 other studies available for serine and Adipocere

ArticleYear
DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia.
    Scientific reports, 2018, 07-05, Volume: 8, Issue:1

    Topics: Alleles; Brain; Case-Control Studies; D-Amino-Acid Oxidase; D-Aspartate Oxidase; D-Aspartic Acid; DN

2018
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.
    Neurobiology of disease, 2013, Volume: 58

    Topics: Aged; Aged, 80 and over; alpha-Synuclein; Brain; Female; Gene Expression Regulation; Glycine; Humans

2013
C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.
    FEBS letters, 2017, Volume: 591, Issue:7

    Topics: Active Transport, Cell Nucleus; Aged, 80 and over; Alzheimer Disease; Animals; Autopsy; Blotting, We

2017
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jul-15, Volume: 29, Issue:28

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A

2009
Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration.
    Journal of proteome research, 2010, Dec-03, Volume: 9, Issue:12

    Topics: Aged; Amino Acid Sequence; Binding Sites; Brain; Chromatography, Affinity; Chromatography, Liquid; D

2010
α-synuclein phosphorylation and truncation are normal events in the adult human brain.
    Neuroscience, 2012, Jan-03, Volume: 200

    Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Animals; Brain; Cell Line, Tumor; Female; Humans; L

2012
Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
    Journal of neuroscience research, 2005, Feb-15, Volume: 79, Issue:4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Female; Hippocampus; Histones; Hum

2005
Anesthesia and post-mortem interval profoundly influence the regulatory serine phosphorylation of glycogen synthase kinase-3 in mouse brain.
    Journal of neurochemistry, 2005, Volume: 92, Issue:3

    Topics: Anesthesia; Anesthetics; Animals; Brain; Chloral Hydrate; Glycogen Synthase Kinase 3; Halothane; Iso

2005
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.
    Journal of neurochemistry, 2005, Volume: 93, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antibodies, Monoclonal; Blotting, Western; Cerebral Cort

2005
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.
    The European journal of neuroscience, 2005, Volume: 22, Issue:8

    Topics: Aged, 80 and over; Alzheimer Disease; Catalytic Domain; Dose-Response Relationship, Drug; Enzyme Act

2005
Free D-serine in post-mortem brains and spinal cords of individuals with and without neuropsychiatric diseases.
    Brain research, 1995, May-29, Volume: 681, Issue:1-2

    Topics: Aging; Amino Acids; Animals; Brain Chemistry; Humans; Mental Disorders; Nervous System Diseases; Par

1995
A postmortem study of glycine and its potential precursors in chronic schizophrenics.
    Neurochemistry international, 1996, Volume: 29, Issue:3

    Topics: Adult; Aged; Brain Chemistry; Chromatography, High Pressure Liquid; Chronic Disease; Female; Glycine

1996
Concentrations of GABA and glycine in discrete brain nuclei. Stress-induced changes in the levels of inhibitory amino acids.
    Neuropharmacology, 1986, Volume: 25, Issue:7

    Topics: Animals; Brain Chemistry; gamma-Aminobutyric Acid; Glycine; Male; Postmortem Changes; Rats; Rats, In

1986
Post mortem changes in the content and specific radioactivity of several amino acids in four areas of the rat brain.
    Journal of neurobiology, 1971, Volume: 2, Issue:2

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Carbon Isotopes; Cerebellum; Ce

1971