serine and Adipocere
serine has been researched along with Adipocere in 14 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disease characterized by behavioral abnormalities, personality changes, language dysfunction, and can co-occur with the development of motor neuron disease." | 1.36 | Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration. ( Duong, DM; Gearing, M; Herskowitz, JH; Lah, JJ; Levey, AI; Peng, J; Rees, HD; Seyfried, NT; Xia, Q, 2010) |
| "Glycine was distributed fairly uniformly with large concentrations in certain lower brainstem nuclei." | 1.27 | Concentrations of GABA and glycine in discrete brain nuclei. Stress-induced changes in the levels of inhibitory amino acids. ( Elekes, I; Láng, T; Palkovits, M; Patthy, A, 1986) |
Research
Studies (14)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Keller, S | 1 |
| Punzo, D | 1 |
| Cuomo, M | 1 |
| Affinito, O | 1 |
| Coretti, L | 1 |
| Sacchi, S | 1 |
| Florio, E | 1 |
| Lembo, F | 1 |
| Carella, M | 1 |
| Copetti, M | 1 |
| Cocozza, S | 1 |
| Balu, DT | 1 |
| Errico, F | 1 |
| Usiello, A | 1 |
| Chiariotti, L | 1 |
| Mamais, A | 1 |
| Raja, M | 1 |
| Manzoni, C | 1 |
| Dihanich, S | 1 |
| Lees, A | 1 |
| Moore, D | 1 |
| Lewis, PA | 1 |
| Bandopadhyay, R | 1 |
| Jin, N | 1 |
| Wu, Y | 1 |
| Xu, W | 1 |
| Gong, CX | 2 |
| Iqbal, K | 2 |
| Liu, F | 2 |
| Ma, QL | 1 |
| Yang, F | 1 |
| Rosario, ER | 1 |
| Ubeda, OJ | 1 |
| Beech, W | 1 |
| Gant, DJ | 1 |
| Chen, PP | 1 |
| Hudspeth, B | 1 |
| Chen, C | 1 |
| Zhao, Y | 1 |
| Vinters, HV | 1 |
| Frautschy, SA | 1 |
| Cole, GM | 1 |
| Herskowitz, JH | 1 |
| Seyfried, NT | 1 |
| Duong, DM | 1 |
| Xia, Q | 1 |
| Rees, HD | 1 |
| Gearing, M | 1 |
| Peng, J | 1 |
| Lah, JJ | 1 |
| Levey, AI | 1 |
| Muntané, G | 1 |
| Ferrer, I | 1 |
| Martinez-Vicente, M | 1 |
| Webber, KM | 1 |
| Smith, MA | 1 |
| Lee, HG | 1 |
| Harris, PL | 1 |
| Moreira, P | 1 |
| Perry, G | 1 |
| Zhu, X | 1 |
| Li, X | 1 |
| Friedman, AB | 1 |
| Roh, MS | 1 |
| Jope, RS | 1 |
| Griffin, RJ | 1 |
| Moloney, A | 1 |
| Kelliher, M | 1 |
| Johnston, JA | 1 |
| Ravid, R | 1 |
| Dockery, P | 1 |
| O'Connor, R | 1 |
| O'Neill, C | 1 |
| Grundke-Iqbal, I | 1 |
| Kumashiro, S | 2 |
| Hashimoto, A | 1 |
| Nishikawa, T | 1 |
| Kurumaji, A | 1 |
| Watanabe, A | 1 |
| Semba, J | 1 |
| Toru, M | 1 |
| Elekes, I | 1 |
| Patthy, A | 1 |
| Láng, T | 1 |
| Palkovits, M | 1 |
| Shank, RP | 1 |
| Aprison, MH | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Curcumin and Yoga Exercise Effects in Veterans at Risk for Alzheimer's Disease[NCT01811381] | Phase 2 | 80 participants (Anticipated) | Interventional | 2014-01-20 | Active, not recruiting | ||
| A Trial of the Effects of Glycine Loading on Clinical Symptoms and Logical Memory in Patients With Schizophrenia[NCT00575848] | Phase 1 | 16 participants (Anticipated) | Interventional | 2007-12-31 | Terminated (stopped due to Slow enrollment and due to personnel change there was no viable way to quantify glycine levels through imaging) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Other Studies
14 other studies available for serine and Adipocere
| Article | Year |
|---|---|
DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia.
Topics: Alleles; Brain; Case-Control Studies; D-Amino-Acid Oxidase; D-Aspartate Oxidase; D-Aspartic Acid; DN | 2018 |
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Brain; Female; Gene Expression Regulation; Glycine; Humans | 2013 |
C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.
Topics: Active Transport, Cell Nucleus; Aged, 80 and over; Alzheimer Disease; Animals; Autopsy; Blotting, We | 2017 |
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A | 2009 |
Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration.
Topics: Aged; Amino Acid Sequence; Binding Sites; Brain; Chromatography, Affinity; Chromatography, Liquid; D | 2010 |
α-synuclein phosphorylation and truncation are normal events in the adult human brain.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Animals; Brain; Cell Line, Tumor; Female; Humans; L | 2012 |
Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Female; Hippocampus; Histones; Hum | 2005 |
Anesthesia and post-mortem interval profoundly influence the regulatory serine phosphorylation of glycogen synthase kinase-3 in mouse brain.
Topics: Anesthesia; Anesthetics; Animals; Brain; Chloral Hydrate; Glycogen Synthase Kinase 3; Halothane; Iso | 2005 |
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antibodies, Monoclonal; Blotting, Western; Cerebral Cort | 2005 |
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.
Topics: Aged, 80 and over; Alzheimer Disease; Catalytic Domain; Dose-Response Relationship, Drug; Enzyme Act | 2005 |
Free D-serine in post-mortem brains and spinal cords of individuals with and without neuropsychiatric diseases.
Topics: Aging; Amino Acids; Animals; Brain Chemistry; Humans; Mental Disorders; Nervous System Diseases; Par | 1995 |
A postmortem study of glycine and its potential precursors in chronic schizophrenics.
Topics: Adult; Aged; Brain Chemistry; Chromatography, High Pressure Liquid; Chronic Disease; Female; Glycine | 1996 |
Concentrations of GABA and glycine in discrete brain nuclei. Stress-induced changes in the levels of inhibitory amino acids.
Topics: Animals; Brain Chemistry; gamma-Aminobutyric Acid; Glycine; Male; Postmortem Changes; Rats; Rats, In | 1986 |
Post mortem changes in the content and specific radioactivity of several amino acids in four areas of the rat brain.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Carbon Isotopes; Cerebellum; Ce | 1971 |