serine has been researched along with Adenocarcinoma in 58 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested the hypothesis that Akt-Ser473 phosphorylation (pAkt) predicts benefit from the sequential addition of paclitaxel to adjuvant doxorubicin plus cyclophosphamide (AC) chemotherapy in patients with node-positive breast cancer participating in the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 trial." | 9.14 | Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer. ( Costantino, JP; Jeong, JH; Kidwell, K; Kim, C; Mamounas, EP; Nguyen, D; Paik, S; Swain, SM; Wolmark, N; Yang, SX, 2010) |
| " We examined the role of ILK in determining pancreatic adenocarcinoma cellular chemoresistance to the nucleoside analogue gemcitabine." | 7.73 | RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. ( Ashley, SW; Benoit, E; Duxbury, MS; Ito, H; Waseem, T; Whang, EE, 2005) |
| "Azaserine was selected because it behaves as a direct-acting mutagen in two bacterial test systems and because tissue distribution studies showed concentration especially in kidney and pancreas." | 5.25 | Adenocarcinoma of the pancreas in azaserine-treated rats. ( Curphey, TJ; Longnecker, DS, 1975) |
| "We tested the hypothesis that Akt-Ser473 phosphorylation (pAkt) predicts benefit from the sequential addition of paclitaxel to adjuvant doxorubicin plus cyclophosphamide (AC) chemotherapy in patients with node-positive breast cancer participating in the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-28 trial." | 5.14 | Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer. ( Costantino, JP; Jeong, JH; Kidwell, K; Kim, C; Mamounas, EP; Nguyen, D; Paik, S; Swain, SM; Wolmark, N; Yang, SX, 2010) |
| " We examined the role of ILK in determining pancreatic adenocarcinoma cellular chemoresistance to the nucleoside analogue gemcitabine." | 3.73 | RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. ( Ashley, SW; Benoit, E; Duxbury, MS; Ito, H; Waseem, T; Whang, EE, 2005) |
| " To address this problem, we have measured the synthetic rate of fibrinogen (perhaps the major acute phase protein) and plasma amino acid profiles in a group of patients with adenocarcinoma of the pancreas and an ongoing inflammatory response (serum C-reactive protein >10 mg/L in the absence of any other obvious infective or inflammatory cause)." | 3.70 | Fibrinogen synthesis is elevated in fasting cancer patients with an acute phase response. ( Falconer, JS; Fearon, KC; McMillan, DC; Preston, T; Shenkin, A; Slater, C, 1998) |
| "In samples of colonic adenocarcinomas, the mean activities of thymidine kinase, glucose-6-phosphate dehydrogenase, phosphoserine phosphatase and pyrroline-5-carboxylate reductase were several fold higher than those of nonneoplastic colon." | 3.66 | Human colon tumors: enzymic and histological characteristics. ( Greengard, O; Herzfeld, A; Legg, MA, 1978) |
| "The study was performed on ovarian cancer cell line (OvBH-1), colon adenocarcinoma metastasis to ovary (SW626) and on cells isolated from ascitic fluids from patients with ovarian cancer: with (p53+) or without (p53-) p53 nuclear protein accumulation." | 1.48 | The association between p53 protein phosphorylation at serine 15, serine 20 and sensitivity of cells isolated from patients with ovarian cancer and cell lines to chemotherapy in in vitro study. ( Bar, JK; Kamińska, I, 2018) |
| "Cowden's syndrome is a rare autosomal dominant disorder that has been linked to germline mutations in the phosphatase and TENsin homolog (PTEN) gene." | 1.39 | Primary lung adenocarcinoma occurring in a PTEN related syndrome (Cowden's disease): routine EGFR sequencing also highlights two rare somatic mutations S768I and V769L. ( Boespflug, A; Bringuier, PP; Couraud, S; Durieu, I; Edery, P; Gérinière, L; Isaac, S; Perrot, E; Souquet, PJ, 2013) |
| "We studied Akt-FAK interaction in colon cancer cells under 15 mmHg increased extracellular pressure." | 1.37 | Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis. ( Basson, MD; Wang, S, 2011) |
| "Although hyperoxia is known to cause DNA base modifications and strand breaks, the DNA damage response has not been adequately investigated." | 1.35 | Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation. ( Das, KC; Kulkarni, A, 2008) |
| " This combination effect was found over wide dosage ranges of AC-7700 (20-80 mg/kg) and CDDP (2." | 1.32 | Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo. ( Ehara, S; Harada, K; Morinaga, Y; Nihei, Y; Suga, Y; Suzuki, M, 2003) |
| "Hyperoxia has been shown to cause DNA damage resulting in growth arrest of cells in p53-dependent, as well as p53-independent, pathways." | 1.32 | Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites. ( Das, KC; Dashnamoorthy, R, 2004) |
| "Azaserine was selected because it behaves as a direct-acting mutagen in two bacterial test systems and because tissue distribution studies showed concentration especially in kidney and pancreas." | 1.25 | Adenocarcinoma of the pancreas in azaserine-treated rats. ( Curphey, TJ; Longnecker, DS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (15.52) | 18.7374 |
| 1990's | 4 (6.90) | 18.2507 |
| 2000's | 24 (41.38) | 29.6817 |
| 2010's | 18 (31.03) | 24.3611 |
| 2020's | 3 (5.17) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L | 1 |
| Kang, Y | 1 |
| Jiang, Y | 1 |
| You, J | 1 |
| Huang, C | 1 |
| Xu, X | 1 |
| Chen, F | 1 |
| Zamaraev, AV | 1 |
| Volik, PI | 1 |
| Nilov, DK | 1 |
| Turkina, MV | 1 |
| Egorshina, AY | 1 |
| Gorbunova, AS | 1 |
| Iarovenko, SI | 1 |
| Zhivotovsky, B | 1 |
| Kopeina, GS | 1 |
| Banh, RS | 1 |
| Biancur, DE | 1 |
| Yamamoto, K | 1 |
| Sohn, ASW | 1 |
| Walters, B | 1 |
| Kuljanin, M | 1 |
| Gikandi, A | 1 |
| Wang, H | 1 |
| Mancias, JD | 1 |
| Schneider, RJ | 1 |
| Pacold, ME | 1 |
| Kimmelman, AC | 1 |
| Zhang, B | 1 |
| Zheng, A | 1 |
| Hydbring, P | 1 |
| Ambroise, G | 1 |
| Ouchida, AT | 1 |
| Goiny, M | 1 |
| Vakifahmetoglu-Norberg, H | 1 |
| Norberg, E | 1 |
| Kamińska, I | 1 |
| Bar, JK | 1 |
| Li, Z | 2 |
| Park, HR | 1 |
| Shi, Z | 1 |
| Pham, CD | 1 |
| Du, Y | 1 |
| Khuri, FR | 1 |
| Zhang, Y | 1 |
| Han, Q | 1 |
| Fu, H | 1 |
| Song, L | 1 |
| Smith, MA | 1 |
| Doshi, P | 1 |
| Sasser, K | 1 |
| Fulp, W | 1 |
| Altiok, S | 1 |
| Haura, EB | 1 |
| Paone, A | 1 |
| Marani, M | 1 |
| Fiascarelli, A | 1 |
| Rinaldo, S | 1 |
| Giardina, G | 1 |
| Contestabile, R | 1 |
| Paiardini, A | 1 |
| Cutruzzolà, F | 1 |
| Davelaar, AL | 1 |
| Straub, D | 1 |
| Parikh, KB | 1 |
| Lau, L | 1 |
| Fockens, P | 1 |
| Krishnadath, KK | 1 |
| Yoon, S | 1 |
| Kim, JG | 1 |
| Seo, AN | 1 |
| Park, SY | 1 |
| Kim, HJ | 1 |
| Park, JS | 1 |
| Choi, GS | 1 |
| Jeong, JY | 1 |
| Jun, do Y | 1 |
| Yoon, GS | 1 |
| Kang, BW | 1 |
| DeNicola, GM | 1 |
| Chen, PH | 1 |
| Mullarky, E | 1 |
| Sudderth, JA | 1 |
| Hu, Z | 1 |
| Wu, D | 1 |
| Tang, H | 1 |
| Xie, Y | 1 |
| Asara, JM | 1 |
| Huffman, KE | 1 |
| Wistuba, II | 1 |
| Minna, JD | 1 |
| DeBerardinis, RJ | 1 |
| Cantley, LC | 1 |
| Gao, X | 1 |
| Feng, J | 1 |
| He, Y | 1 |
| Xu, F | 1 |
| Fan, X | 1 |
| Huang, W | 1 |
| Xiong, H | 1 |
| Liu, Q | 1 |
| Liu, W | 1 |
| Liu, X | 1 |
| Sun, X | 1 |
| He, QY | 1 |
| Zhang, Q | 1 |
| Liu, L | 1 |
| Kang, HJ | 1 |
| Lee, H | 1 |
| Choi, HJ | 1 |
| Youn, JH | 1 |
| Shin, JS | 1 |
| Ahn, YH | 1 |
| Yoo, JS | 1 |
| Paik, YK | 1 |
| Kim, H | 1 |
| Okasaka, T | 1 |
| Matsuo, K | 1 |
| Suzuki, T | 1 |
| Ito, H | 2 |
| Hosono, S | 1 |
| Kawase, T | 1 |
| Watanabe, M | 1 |
| Yatabe, Y | 1 |
| Hida, T | 1 |
| Mitsudomi, T | 1 |
| Tanaka, H | 1 |
| Yokoi, K | 1 |
| Tajima, K | 1 |
| Keller-Pinter, A | 1 |
| Bottka, S | 1 |
| Timar, J | 1 |
| Kulka, J | 1 |
| Katona, R | 1 |
| Dux, L | 1 |
| Deak, F | 1 |
| Szilak, L | 1 |
| Yamada, C | 1 |
| Ozaki, T | 1 |
| Ando, K | 1 |
| Suenaga, Y | 1 |
| Inoue, K | 1 |
| Ito, Y | 1 |
| Okoshi, R | 1 |
| Kageyama, H | 1 |
| Kimura, H | 1 |
| Miyazaki, M | 1 |
| Nakagawara, A | 1 |
| Zheng, HC | 1 |
| Xu, XY | 1 |
| Xia, P | 1 |
| Yu, M | 1 |
| Takahashi, H | 1 |
| Takano, Y | 1 |
| Yang, SX | 1 |
| Costantino, JP | 1 |
| Kim, C | 1 |
| Mamounas, EP | 1 |
| Nguyen, D | 1 |
| Jeong, JH | 1 |
| Wolmark, N | 1 |
| Kidwell, K | 1 |
| Paik, S | 1 |
| Swain, SM | 1 |
| Wang, S | 1 |
| Basson, MD | 1 |
| Bravo-Cordero, JJ | 1 |
| Oser, M | 1 |
| Chen, X | 1 |
| Eddy, R | 1 |
| Hodgson, L | 1 |
| Condeelis, J | 1 |
| Shahaf, G | 1 |
| Rotem-Dai, N | 1 |
| Koifman, G | 1 |
| Raveh-Amit, H | 1 |
| Frost, SA | 1 |
| Livneh, E | 1 |
| Boespflug, A | 1 |
| Couraud, S | 1 |
| Bringuier, PP | 1 |
| Isaac, S | 1 |
| Gérinière, L | 1 |
| Perrot, E | 1 |
| Edery, P | 1 |
| Durieu, I | 1 |
| Souquet, PJ | 1 |
| Ma, L | 1 |
| Tao, Y | 1 |
| Duran, A | 1 |
| Llado, V | 1 |
| Galvez, A | 1 |
| Barger, JF | 1 |
| Castilla, EA | 1 |
| Chen, J | 1 |
| Yajima, T | 1 |
| Porollo, A | 1 |
| Medvedovic, M | 1 |
| Brill, LM | 1 |
| Plas, DR | 1 |
| Riedl, SJ | 1 |
| Leitges, M | 1 |
| Diaz-Meco, MT | 1 |
| Richardson, AD | 1 |
| Moscat, J | 1 |
| Morinaga, Y | 1 |
| Suga, Y | 1 |
| Ehara, S | 1 |
| Harada, K | 1 |
| Nihei, Y | 1 |
| Suzuki, M | 1 |
| Das, KC | 2 |
| Dashnamoorthy, R | 1 |
| Ishii, T | 1 |
| Fujishiro, M | 1 |
| Masuda, M | 1 |
| Goshima, Y | 1 |
| Kitamura, H | 1 |
| Teramoto, S | 1 |
| Matsuse, T | 1 |
| Venkatasubbarao, K | 1 |
| Choudary, A | 1 |
| Freeman, JW | 1 |
| Hung, RJ | 1 |
| Brennan, P | 1 |
| Canzian, F | 1 |
| Szeszenia-Dabrowska, N | 1 |
| Zaridze, D | 1 |
| Lissowska, J | 1 |
| Rudnai, P | 1 |
| Fabianova, E | 1 |
| Mates, D | 1 |
| Foretova, L | 1 |
| Janout, V | 1 |
| Bencko, V | 1 |
| Chabrier, A | 1 |
| Borel, S | 1 |
| Hall, J | 1 |
| Boffetta, P | 1 |
| Duxbury, MS | 1 |
| Benoit, E | 1 |
| Waseem, T | 1 |
| Ashley, SW | 1 |
| Whang, EE | 1 |
| Gross, I | 1 |
| Lhermitte, B | 1 |
| Domon-Dell, C | 1 |
| Duluc, I | 1 |
| Martin, E | 1 |
| Gaiddon, C | 1 |
| Kedinger, M | 1 |
| Freund, JN | 1 |
| Chen, G | 1 |
| Bhojani, MS | 1 |
| Heaford, AC | 1 |
| Chang, DC | 1 |
| Laxman, B | 1 |
| Thomas, DG | 1 |
| Griffin, LB | 1 |
| Yu, J | 1 |
| Coppola, JM | 1 |
| Giordano, TJ | 1 |
| Lin, L | 1 |
| Adams, D | 1 |
| Orringer, MB | 1 |
| Ross, BD | 1 |
| Beer, DG | 1 |
| Rehemtulla, A | 1 |
| Kondo, E | 1 |
| Miyake, T | 1 |
| Shibata, M | 1 |
| Kimura, T | 1 |
| Iwagaki, H | 1 |
| Nakamura, S | 1 |
| Tanaka, T | 2 |
| Ohara, N | 1 |
| Ichimura, K | 1 |
| Oka, T | 1 |
| Yanai, H | 1 |
| Shibasaki, F | 1 |
| Yoshino, T | 1 |
| Turecková, J | 1 |
| Kucerová, D | 1 |
| Vojtechová, M | 1 |
| Sloncová, E | 1 |
| Tuhácková, Z | 1 |
| Matsuzaki, K | 1 |
| Pühringer-Oppermann, F | 1 |
| Stahl, M | 1 |
| Keller, G | 2 |
| Sarbia, M | 1 |
| Asahina, H | 1 |
| Yamazaki, K | 1 |
| Kinoshita, I | 1 |
| Yokouchi, H | 1 |
| Dosaka-Akita, H | 1 |
| Nishimura, M | 3 |
| Popanda, O | 1 |
| Edler, L | 1 |
| Waas, P | 1 |
| Schattenberg, T | 1 |
| Butkiewicz, D | 1 |
| Muley, T | 1 |
| Dienemann, H | 1 |
| Risch, A | 1 |
| Bartsch, H | 1 |
| Schmezer, P | 1 |
| Bianchi, F | 1 |
| Galizia, E | 1 |
| Porfiri, E | 1 |
| Belvederesi, L | 1 |
| Catalani, R | 1 |
| Loretelli, C | 1 |
| Bracci, R | 1 |
| Bearzi, I | 1 |
| Turchi, C | 1 |
| Viel, A | 1 |
| Cellerino, R | 1 |
| Ho, YK | 1 |
| Bargagna-Mohan, P | 1 |
| Wehenkel, M | 1 |
| Mohan, R | 1 |
| Kim, KB | 1 |
| Kulkarni, A | 1 |
| Zoubir, M | 1 |
| Mathieu, MC | 1 |
| Mazouni, C | 1 |
| Liedtke, C | 1 |
| Corley, L | 1 |
| Geha, S | 1 |
| Bouaziz, J | 1 |
| Spielmann, M | 1 |
| Drusche, F | 1 |
| Symmans, WF | 1 |
| Delaloge, S | 1 |
| Andre, F | 1 |
| Tampio, M | 1 |
| Loikkanen, J | 1 |
| Myllynen, P | 1 |
| Mertanen, A | 1 |
| Vähäkangas, KH | 1 |
| Finkelstein, SD | 1 |
| Przygodzki, R | 1 |
| Pricolo, VE | 1 |
| Sayegh, R | 1 |
| Bakker, A | 1 |
| Swalsky, PA | 1 |
| Marceau, M | 1 |
| Forest, K | 1 |
| Béretti, JL | 1 |
| Tainer, J | 1 |
| Nassif, X | 1 |
| Preston, T | 1 |
| Slater, C | 1 |
| McMillan, DC | 1 |
| Falconer, JS | 1 |
| Shenkin, A | 1 |
| Fearon, KC | 1 |
| Oda, K | 1 |
| Arakawa, H | 1 |
| Matsuda, K | 1 |
| Tanikawa, C | 1 |
| Mori, T | 1 |
| Nishimori, H | 1 |
| Tamai, K | 1 |
| Tokino, T | 1 |
| Nakamura, Y | 1 |
| Taya, Y | 1 |
| Matsuo, Y | 1 |
| Akiyama, N | 1 |
| Nakamura, H | 1 |
| Yodoi, J | 1 |
| Noda, M | 1 |
| Kizaka-Kondoh, S | 1 |
| Schuman, J | 1 |
| Qiu, D | 1 |
| Koganty, RR | 1 |
| Longenecker, BM | 1 |
| Campbell, AP | 1 |
| Herzfeld, A | 2 |
| Legg, MA | 1 |
| Greengard, O | 1 |
| Longnecker, DS | 1 |
| Curphey, TJ | 1 |
| Perán, S | 1 |
| Muñoz, M | 1 |
| Saiz, MT | 1 |
| Nakada, H | 2 |
| Nakajima, H | 1 |
| Hori, Y | 1 |
| Ezaki, M | 1 |
| Goto, T | 2 |
| Okuhara, M | 2 |
| Watanabe, J | 1 |
| Holinka, CF | 1 |
| Anzai, Y | 1 |
| Kuramoto, H | 1 |
| Gurpide, E | 1 |
| Kawamura, I | 1 |
| Mizota, T | 1 |
| Shimomura, K | 1 |
| Nakahara, K | 1 |
| Yamaguchi, I | 1 |
| Fujita, M | 1 |
| Taniguchi, N | 1 |
| Makita, A | 1 |
| Ono, M | 1 |
| Oikawa, K | 1 |
| Knox, WE | 1 |
| Hudson, J | 1 |
| Korytnyk, W | 1 |
| Ahrens, H | 1 |
| Codington, JF | 1 |
| Sanford, BH | 1 |
| Jeanloz, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Levels of Phosphorylated AKT in Patients With Node-Positive Breast Cancer: Correlation With Disease-Free and Overall Survival[NCT00965276] | 2,500 participants (Actual) | Observational | 2004-01-13 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for serine and Adenocarcinoma
| Article | Year |
|---|---|
Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Colorec | 2006 |
1 trial available for serine and Adenocarcinoma
| Article | Year |
|---|---|
Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adju | 2010 |
56 other studies available for serine and Adenocarcinoma
| Article | Year |
|---|---|
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Carbon; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2022 |
Requirement for Serine-384 in Caspase-2 processing and activity.
Topics: Adenocarcinoma; Apoptosis; Binding Sites; Caspase 2; Caspase 9; Cysteine Endopeptidases; Humans; Mut | 2020 |
Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer.
Topics: Adenocarcinoma; Aged; Animals; Axons; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Prolifera | 2020 |
PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Proliferation; DNA, Neoplasm | 2017 |
The association between p53 protein phosphorylation at serine 15, serine 20 and sensitivity of cells isolated from patients with ovarian cancer and cell lines to chemotherapy in in vitro study.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell | 2018 |
Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs.
Topics: 14-3-3 Proteins; Adenocarcinoma; Amino Acid Motifs; Animals; Apoptosis; Blotting, Western; Cell Line | 2014 |
Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chem | 2014 |
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
Topics: Adenocarcinoma; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Gene Expression Regulation, Neo | 2014 |
Increased phosphorylation on residue S795 of the retinoblastoma protein in esophageal adenocarcinoma.
Topics: Adenocarcinoma; Aged; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Esophageal Neoplasms; | 2015 |
Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biom | 2015 |
NRF2 regulates serine biosynthesis in non-small cell lung cancer.
Topics: Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Carcinoma, Non-Small-Cell | 2015 |
hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells.
Topics: Adenocarcinoma; Apoptosis; Blotting, Western; CASP8 and FADD-Like Apoptosis Regulating Protein; Casp | 2016 |
Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers.
Topics: Adenocarcinoma; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Nucleus; Colonic Neoplasms; | 2009 |
hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Case-Control Studies; | 2009 |
Syndecan-4 promotes cytokinesis in a phosphorylation-dependent manner.
Topics: Adenocarcinoma; Amino Acid Substitution; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cytokinesis | 2010 |
RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53.
Topics: Adenocarcinoma; Apoptosis; Cell Line, Tumor; Core Binding Factor Alpha 3 Subunit; DNA Damage; Gene E | 2010 |
Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cell Line, Tumor; Disease Progres | 2010 |
Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis.
Topics: Adenocarcinoma; Amino Acid Sequence; Caco-2 Cells; Catalytic Domain; Colonic Neoplasms; Focal Adhesi | 2011 |
A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia.
Topics: Actin Depolymerizing Factors; Actins; Adenocarcinoma; Animals; Biosensing Techniques; Cell Movement; | 2011 |
PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; F | 2012 |
Primary lung adenocarcinoma occurring in a PTEN related syndrome (Cowden's disease): routine EGFR sequencing also highlights two rare somatic mutations S768I and V769L.
Topics: Adenocarcinoma; Adult; Chromosome Disorders; Diagnosis, Differential; DNA Mutational Analysis; ErbB | 2013 |
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.
Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Biosynthetic Pathways; Cell Tr | 2013 |
Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Col | 2003 |
Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.
Topics: Adenocarcinoma; Androstadienes; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Protein | 2004 |
Effects of p27Kip1 on cell cycle status and viability in A549 lung adenocarcinoma cells.
Topics: Adenocarcinoma; Amino Acid Substitution; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell | 2004 |
Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases.
Topics: Adenocarcinoma; Alkyl and Aryl Transferases; Cell Cycle Proteins; Cell Growth Processes; Cyclin-Depe | 2005 |
Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study.
Topics: Adenocarcinoma; Adult; Aged; Arginine; Case-Control Studies; Confounding Factors, Epidemiologic; Cys | 2005 |
RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Caspases; Cell Line, | 2005 |
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.
Topics: Adenocarcinoma; Alanine; Alkaline Phosphatase; Amino Acid Sequence; Amino Acid Substitution; Animals | 2005 |
Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Apoptosis; Cell Cycle; Cell Nucleus; Cell Prol | 2005 |
Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms.
Topics: Adenocarcinoma; Adenoma; Antibody Specificity; Apoptosis; Cell Cycle; Cell Line, Tumor; Colorectal N | 2005 |
Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells.
Topics: Adenocarcinoma; Alkaline Phosphatase; Androstadienes; beta Catenin; Butyrates; Cell Line, Tumor; Col | 2006 |
Lack of prognostic impact of p53 gene mutation and p53 phosphorylation at serine 15 in multimodally treated adenocarcinomas of the gastroesophageal junction.
Topics: Adenocarcinoma; Base Sequence; Chromatography, High Pressure Liquid; Clinical Trials, Phase III as T | 2006 |
Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.
Topics: Adenocarcinoma; DNA, Neoplasm; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Isoleuc | 2006 |
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Carcinoma, Squamo | 2007 |
A missense germline mutation in exon 7 of the MSH2 gene in a HNPCC family from center-Italy.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Colorectal Neopla | 2007 |
LMP2-specific inhibitors: chemical genetic tools for proteasome biology.
Topics: Adenocarcinoma; Animals; Catalytic Domain; Cell Line, Tumor; Chymotrypsin; Cysteine Endopeptidases; | 2007 |
Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Apoptosis; Ataxia Telangiectasia Mutated Prote | 2008 |
Modulation of ER phosphorylation on serine 118 by endocrine therapy: a new surrogate marker for efficacy.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Brea | 2008 |
Benzo(a)pyrene increases phosphorylation of p53 at serine 392 in relation to p53 induction and cell death in MCF-7 cells.
Topics: Adenocarcinoma; Apoptosis; Benzo(a)pyrene; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cell Pro | 2008 |
K-ras-2 topographic genotyping of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Alanine; Arginine; Aspartic Acid; Codon; Cysteine; DNA, Neoplasm; Exons; Forecasting | 1994 |
Consequences of the loss of O-linked glycosylation of meningococcal type IV pilin on piliation and pilus-mediated adhesion.
Topics: Adenocarcinoma; Alanine; Amino Acid Sequence; Bacterial Adhesion; Bacterial Outer Membrane Proteins; | 1998 |
Fibrinogen synthesis is elevated in fasting cancer patients with an acute phase response.
Topics: Acute-Phase Reaction; Adenocarcinoma; Adult; Aged; Amino Acids; C-Reactive Protein; Cachexia; Fastin | 1998 |
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.
Topics: Adenocarcinoma; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoma, Non- | 2000 |
Identification of a novel thioredoxin-related transmembrane protein.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Apoptosis; Base Sequence; Binding Sites; Blotting, Nor | 2001 |
Glycosylations versus conformational preferences of cancer associated mucin core.
Topics: Adenocarcinoma; Cancer Vaccines; Epitopes; Glycosylation; Hydrogen Bonding; Magnetic Resonance Spect | 2000 |
Human colon tumors: enzymic and histological characteristics.
Topics: Adenocarcinoma; Cell Differentiation; Colonic Neoplasms; Glucosephosphate Dehydrogenase; Humans; Org | 1978 |
Adenocarcinoma of the pancreas in azaserine-treated rats.
Topics: Adenocarcinoma; Adenoma; Animals; Azaserine; Dipeptides; Disease Models, Animal; Hyperplasia; Inject | 1975 |
Rapid and steady-state amino acid transport in perfused human fibroblasts and colon adenocarcinoma cells: effects of methotrexate.
Topics: Adenocarcinoma; Amino Acids; Biological Transport; Colonic Neoplasms; Fibroblasts; Humans; Methotrex | 1990 |
A new antitumor antibiotic, FR900840. I. Discovery, identification, isolation and characterization.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Female; Fermentation; Humans | 1989 |
Effects of serine and glycine on proliferation of an Ishikawa cell variant.
Topics: Adenocarcinoma; Adult; Breast Neoplasms; Cell Division; Cell Line; DNA Replication; DNA, Neoplasm; F | 1989 |
A new antitumor antibiotic, FR900840. III. Antitumor activity against experimental tumors.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Carcinoma, Small Cell; Carcinoma, Squamous Cel | 1989 |
Protein phosphorylation of beta-glucuronidase in human lung cancer--identification of serine- and threonine-phosphates.
Topics: Adenocarcinoma; Chemical Phenomena; Chemistry; Electrophoresis, Polyacrylamide Gel; Glucuronidase; H | 1985 |
Phosphoserine phosphatase distribution in normal and neoplastic rat tissues.
Topics: Adenocarcinoma; Animals; Brain; Carcinoma, Hepatocellular; Female; Fetus; Fibrosarcoma; Kidney; Kine | 1969 |
5-homopyridoxals, 5-thiopyridoxal, and related compounds. Synthesis, tautomerism, and biological properties.
Topics: Adenocarcinoma; Animals; Deuterium; Female; Hydro-Lyases; Infrared Rays; Liver; Lymphoid Tissue; Mag | 1971 |
Glycoprotein coat of the TA3 cell. Isolation and partial characterization of a sialic acid containing glycoprotein fraction.
Topics: Acetates; Adenocarcinoma; Amino Acids; Animals; Cell Membrane; Chromatography, Gel; Galactosamine; G | 1972 |