serine has been researched along with Acute Lymphoid Leukemia in 12 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The survival rate of childhood acute lymphoblastic leukemia (ALL) is approaching 90%, while the prognosis of adults remains poor due to the limited therapeutic approaches." | 1.46 | Identification of a novel functional JAK1 S646P mutation in acute lymphoblastic leukemia. ( Chen, H; Hu, L; Jiang, M; Li, B; Li, Q; Liu, T; Ning, H; Wang, D; Zhang, B, 2017) |
| "We propose that patients whose tumors show this phenotype will be sensitive to folate antagonists targeting thymidylate or purine biosynthesis." | 1.39 | Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors. ( Bertino, JR; Tedeschi, PM; Vazquez, A, 2013) |
| "We studied 170 patients with acute lymphoblastic leukemia (ALL), treated from 1988 to 1994 according to a protocol derived from BFM-83 studies, in order to evaluate the incidence and prognostic significance of mutations in this gene in childhood ALL." | 1.31 | Lack of association between N-ras gene mutations and clinical prognosis in Brazilian children with acute lymphoblastic leukemia. ( Clementino, NC; Costa, FF; Figueiredo, MS; Kerbauy, J; Saad, ST; Viana, MB; Yamamoto, M, 2001) |
| "The t(4;11) chromosomal translocation marks a subset of acute lymphoblastic and secondary myeloid leukemias." | 1.30 | The FEL (AF-4) protein donates transcriptional activation sequences to Hrx-Fel fusion proteins in leukemias containing T(4;11)(Q21;Q23) chromosomal translocations. ( Cleary, ML; Morrissey, JJ; Raney, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fioretti, T | 1 |
| Cevenini, A | 1 |
| Zanobio, M | 1 |
| Raia, M | 1 |
| Sarnataro, D | 1 |
| Salvatore, F | 1 |
| Esposito, G | 1 |
| Li, Q | 1 |
| Li, B | 1 |
| Hu, L | 1 |
| Ning, H | 1 |
| Jiang, M | 1 |
| Wang, D | 1 |
| Liu, T | 1 |
| Zhang, B | 1 |
| Chen, H | 1 |
| Habib, T | 1 |
| Sadoun, A | 1 |
| Nader, N | 1 |
| Suzuki, S | 1 |
| Liu, W | 1 |
| Jithesh, PV | 1 |
| Kino, T | 1 |
| Uckun, FM | 1 |
| Ma, H | 1 |
| Zhang, J | 1 |
| Ozer, Z | 1 |
| Dovat, S | 1 |
| Mao, C | 1 |
| Ishkhanian, R | 1 |
| Goodman, P | 1 |
| Qazi, S | 1 |
| Jensen, RH | 1 |
| Johansen, HK | 1 |
| Arendrup, MC | 1 |
| Vazquez, A | 1 |
| Tedeschi, PM | 1 |
| Bertino, JR | 1 |
| Miller, AL | 1 |
| Webb, MS | 1 |
| Copik, AJ | 1 |
| Wang, Y | 1 |
| Johnson, BH | 1 |
| Kumar, R | 1 |
| Thompson, EB | 1 |
| Malempati, S | 1 |
| Tibbitts, D | 1 |
| Cunningham, M | 1 |
| Akkari, Y | 1 |
| Olson, S | 1 |
| Fan, G | 1 |
| Sears, RC | 1 |
| Morrissey, J | 1 |
| Tkachuk, DC | 1 |
| Milatovich, A | 1 |
| Francke, U | 1 |
| Link, M | 1 |
| Cleary, ML | 2 |
| Morrissey, JJ | 1 |
| Raney, S | 1 |
| Clementino, NC | 1 |
| Yamamoto, M | 1 |
| Viana, MB | 1 |
| Figueiredo, MS | 1 |
| Kerbauy, J | 1 |
| Saad, ST | 1 |
| Costa, FF | 1 |
| Sukemori, S | 1 |
| Sugimura, K | 1 |
12 other studies available for serine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation.
Topics: 14-3-3 Proteins; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; DNA-B | 2019 |
Identification of a novel functional JAK1 S646P mutation in acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Animals; Cell Line, Tumor; Cell Proliferation; Exome Sequencing; Female; Genetic | 2017 |
AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.
Topics: 14-3-3 Proteins; Biomarkers, Tumor; Cell Nucleus; Chromatin; E1A-Associated p300 Protein; Exoribonuc | 2017 |
Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros.
Topics: Cell Nucleus; Humans; Ikaros Transcription Factor; Intracellular Signaling Peptides and Proteins; Mu | 2012 |
Stepwise development of a homozygous S80P substitution in Fks1p, conferring echinocandin resistance in Candida tropicalis.
Topics: Amino Acid Substitution; Antifungal Agents; Candida tropicalis; Candidiasis; Clone Cells; Drug Resis | 2013 |
Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors.
Topics: Biological Transport; Folic Acid; Folic Acid Antagonists; Glycine; Humans; Methotrexate; Mitochondri | 2013 |
p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211.
Topics: Alanine; Animals; Apoptosis; Cell Line; Cell Line, Tumor; Cell Survival; Dexamethasone; DNA; Enzyme | 2005 |
Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias.
Topics: Amino Acid Sequence; Blotting, Western; Cell Line; Child; Enzyme Activation; Gene Amplification; Gly | 2006 |
A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.
Topics: Amino Acid Sequence; Base Sequence; Child; Chromosome Mapping; Chromosomes, Human, Pair 11; Chromoso | 1993 |
The FEL (AF-4) protein donates transcriptional activation sequences to Hrx-Fel fusion proteins in leukemias containing T(4;11)(Q21;Q23) chromosomal translocations.
Topics: Adenoviridae; Adenovirus E1B Proteins; Amino Acid Sequence; Animals; Binding Sites; Chromosomes, Hum | 1997 |
Lack of association between N-ras gene mutations and clinical prognosis in Brazilian children with acute lymphoblastic leukemia.
Topics: Amino Acid Substitution; Base Sequence; Bone Marrow Cells; Brazil; Child; Child, Preschool; Cloning, | 2001 |
Stimulation of amino acid efflux from cells by extracellular serine.
Topics: Amino Acids; Animals; Biological Transport, Active; Cell Division; Culture Media; Extracellular Spac | 1992 |