serine has been researched along with Acute Disease in 24 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Agents that enhance N-methyl-D-aspartate (NMDA) function through the glycine modulatory site (D-serine, glycine, or D-cycloserine) or through glycine transporter 1 (sarcosine) improve the symptoms of patients with stable chronic schizophrenia." | 9.11 | Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study. ( Chang, YC; Chiu, CC; Lane, HY; Liu, YC; Tsai, GE, 2005) |
| " This study evaluated the potential usefulness of supplementation of total parenteral nutrition with a cysteine, taurine, threonine, and serine mixture (SEAS), with or without glutamine, in an experimental model of turpentine-induced acute inflammation." | 7.72 | Efficiency of a cysteine-taurine-threonine-serine supplemented parenteral nutrition in an experimental model of acute inflammation. ( Bérard, MP; Chaïb, S; Cynober, L; De Bandt, JP; Neveux, N; Osowska, S, 2003) |
| "Hepatocytes isolated from livers of rats with various models of acute uremia (binephrectomy, ureter ligation, uranyl nitrate-induced, or ischemic ARF) were incubated with glucagon, adrenalin, or cyclic AMP using serine as a substrate." | 7.66 | Effect of serine on gluconeogenic ability of hepatocytes in acute uremia. ( Heidland, A; Hörl, WH; Münchmeyer, M; Riegel, W; Stepinski, J, 1983) |
| " Nafamostat mesylate (nafamostat) is a drug licensed in Japan and Korea for indications including acute pancreatitis and disseminated intravascular coagulation." | 5.22 | Nafamostat Mesylate for Treatment of COVID-19 in Hospitalised Patients: A Structured, Narrative Review. ( Bowen, AC; Denholm, JT; Dore, GJ; Hernández-Mitre, MP; Hills, TE; Lewin, SR; McQuilten, Z; Morpeth, SC; Paterson, DL; Roberts, JA; Tong, SYC; Venkatesh, B, 2022) |
| "Agents that enhance N-methyl-D-aspartate (NMDA) function through the glycine modulatory site (D-serine, glycine, or D-cycloserine) or through glycine transporter 1 (sarcosine) improve the symptoms of patients with stable chronic schizophrenia." | 5.11 | Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study. ( Chang, YC; Chiu, CC; Lane, HY; Liu, YC; Tsai, GE, 2005) |
| " This study evaluated the potential usefulness of supplementation of total parenteral nutrition with a cysteine, taurine, threonine, and serine mixture (SEAS), with or without glutamine, in an experimental model of turpentine-induced acute inflammation." | 3.72 | Efficiency of a cysteine-taurine-threonine-serine supplemented parenteral nutrition in an experimental model of acute inflammation. ( Bérard, MP; Chaïb, S; Cynober, L; De Bandt, JP; Neveux, N; Osowska, S, 2003) |
| "Hepatocytes isolated from livers of rats with various models of acute uremia (binephrectomy, ureter ligation, uranyl nitrate-induced, or ischemic ARF) were incubated with glucagon, adrenalin, or cyclic AMP using serine as a substrate." | 3.66 | Effect of serine on gluconeogenic ability of hepatocytes in acute uremia. ( Heidland, A; Hörl, WH; Münchmeyer, M; Riegel, W; Stepinski, J, 1983) |
| "Recently we found that trauma and hemorrhage acutely induced hepatic insulin resistance in the rat." | 1.32 | Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha. ( Chaudry, IH; Holland, LT; Keeton, AB; Ma, Y; Messina, JL; Toth, B, 2004) |
| "Severe hypertriglyceridemia is a major risk for acute pancreatitis." | 1.31 | Severe hypertriglyceridemia with plasma inhibitory factor(s) on lipoprotein lipase activity in a patient with a common Ser(447)-Ter LPL mutation. ( Bujo, H; Kanoh, T; Kobayashi, J; Koshikawa, H; Saito, Y; Sasaki, Y; Taira, K; Takahashi, K; Zhu, Y, 2001) |
| "Glycogen was increased in the presence of serine in the perfusion medium, the value being 1." | 1.27 | Glycogen synthesis from serine in isolated perfused hindquarters of acutely uraemic rats. ( Djovkar, A; Heidland, A; Hörl, WH, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (37.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Hernández-Mitre, MP | 1 |
| Tong, SYC | 1 |
| Denholm, JT | 1 |
| Dore, GJ | 1 |
| Bowen, AC | 1 |
| Lewin, SR | 1 |
| Venkatesh, B | 1 |
| Hills, TE | 1 |
| McQuilten, Z | 1 |
| Paterson, DL | 1 |
| Morpeth, SC | 1 |
| Roberts, JA | 1 |
| Guercio, GD | 1 |
| Bevictori, L | 1 |
| Vargas-Lopes, C | 1 |
| Madeira, C | 1 |
| Oliveira, A | 1 |
| Carvalho, VF | 1 |
| d'Avila, JC | 1 |
| Panizzutti, R | 1 |
| Gu, Y | 1 |
| Zhou, H | 1 |
| Gan, Y | 1 |
| Zhang, J | 1 |
| Chen, J | 1 |
| Gan, X | 1 |
| Li, H | 1 |
| Zheng, W | 1 |
| Meng, Z | 1 |
| Ma, X | 1 |
| Wang, X | 1 |
| Xu, X | 1 |
| Xu, G | 1 |
| Lu, X | 2 |
| Liang, Y | 1 |
| Zhang, X | 1 |
| Huang, W | 1 |
| Xu, R | 1 |
| Nystoriak, MA | 1 |
| Nieves-Cintrón, M | 1 |
| Patriarchi, T | 1 |
| Buonarati, OR | 1 |
| Prada, MP | 1 |
| Morotti, S | 1 |
| Grandi, E | 1 |
| Fernandes, JD | 1 |
| Forbush, K | 1 |
| Hofmann, F | 1 |
| Sasse, KC | 1 |
| Scott, JD | 1 |
| Ward, SM | 1 |
| Hell, JW | 1 |
| Navedo, MF | 1 |
| Shigemi, K | 1 |
| Tsuneyoshi, Y | 1 |
| Hamasu, K | 1 |
| Han, L | 1 |
| Hayamizu, K | 1 |
| Denbow, DM | 1 |
| Furuse, M | 1 |
| Kirschner, DL | 1 |
| Wilson, AL | 1 |
| Drew, KL | 1 |
| Green, TK | 1 |
| Haranishi, Y | 1 |
| Hara, K | 1 |
| Terada, T | 1 |
| Nakamura, S | 1 |
| Sata, T | 1 |
| Osowska, S | 1 |
| De Bandt, JP | 1 |
| Chaïb, S | 1 |
| Neveux, N | 1 |
| Bérard, MP | 1 |
| Cynober, L | 1 |
| Ma, Y | 1 |
| Toth, B | 1 |
| Keeton, AB | 1 |
| Holland, LT | 1 |
| Chaudry, IH | 1 |
| Messina, JL | 1 |
| Tazzari, PL | 1 |
| Cappellini, A | 1 |
| Grafone, T | 1 |
| Mantovani, I | 1 |
| Ricci, F | 1 |
| Billi, AM | 1 |
| Ottaviani, E | 1 |
| Conte, R | 1 |
| Martinelli, G | 1 |
| Martelli, AM | 1 |
| Lane, HY | 1 |
| Chang, YC | 1 |
| Liu, YC | 1 |
| Chiu, CC | 1 |
| Tsai, GE | 1 |
| Morotti, A | 1 |
| Parvis, G | 1 |
| Cilloni, D | 1 |
| Familiari, U | 1 |
| Pautasso, M | 1 |
| Bosa, M | 1 |
| Messa, F | 1 |
| Arruga, F | 1 |
| Defilippi, I | 1 |
| Catalano, R | 1 |
| Rosso, V | 1 |
| Carturan, S | 1 |
| Bracco, E | 1 |
| Guerrasio, A | 1 |
| Saglio, G | 1 |
| Shen, A | 1 |
| Liu, Y | 1 |
| Zhao, J | 1 |
| Qin, J | 1 |
| Shi, S | 1 |
| Chen, M | 1 |
| Gao, S | 1 |
| Xiao, F | 1 |
| Lu, Q | 1 |
| Cheng, C | 1 |
| Riegel, W | 1 |
| Stepinski, J | 2 |
| Münchmeyer, M | 1 |
| Heidland, A | 5 |
| Hörl, WH | 5 |
| Djovkar, A | 1 |
| Bruinvels, J | 1 |
| Pepplinkhuizen, L | 1 |
| Schäfer, RM | 1 |
| Zhu, Y | 1 |
| Bujo, H | 1 |
| Takahashi, K | 1 |
| Taira, K | 1 |
| Kobayashi, J | 1 |
| Koshikawa, H | 1 |
| Sasaki, Y | 1 |
| Kanoh, T | 1 |
| Saito, Y | 1 |
| Behre, G | 1 |
| Singh, SM | 1 |
| Liu, H | 1 |
| Bortolin, LT | 1 |
| Christopeit, M | 1 |
| Radomska, HS | 1 |
| Rangatia, J | 1 |
| Hiddemann, W | 1 |
| Friedman, AD | 1 |
| Tenen, DG | 1 |
| Ushiyama, M | 1 |
| Ikeda, S | 1 |
| Yazawa, M | 1 |
| Yanagisawa, N | 1 |
| Takatsu, M | 1 |
| Groth, DP | 1 |
| D'Angelo, JM | 1 |
| Vogler, WR | 1 |
| Mingioli, ES | 1 |
| Betz, B | 1 |
| Björnesjö, KB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NMDA Enhancers in the Treatment of Schizophrenia[NCT00328276] | Phase 2 | 20 participants | Interventional | 2004-12-31 | Completed | ||
| NMDA Enhancers in the Treatment of Schizophrenia: Sarcosine vs. D-Serine[NCT00491569] | Phase 2 | 60 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| The Effects of Glycine Transport Inhibition on Brain Glycine Concentration[NCT00538070] | 68 participants (Actual) | Interventional | 2007-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for serine and Acute Disease
| Article | Year |
|---|---|
Nafamostat Mesylate for Treatment of COVID-19 in Hospitalised Patients: A Structured, Narrative Review.
Topics: Acute Disease; Antiviral Agents; Benzamidines; COVID-19 Drug Treatment; Fibrinolytic Agents; Guanidi | 2022 |
1 trial available for serine and Acute Disease
| Article | Year |
|---|---|
Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.
Topics: Acute Disease; Adult; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combination; Female; | 2005 |
Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.
Topics: Acute Disease; Adult; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combination; Female; | 2005 |
Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.
Topics: Acute Disease; Adult; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combination; Female; | 2005 |
Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.
Topics: Acute Disease; Adult; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combination; Female; | 2005 |
Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.
Topics: Acute Disease; Adult; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combination; Female; | 2005 |
Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.
Topics: Acute Disease; Adult; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combination; Female; | 2005 |
Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.
Topics: Acute Disease; Adult; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combination; Female; | 2005 |
Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.
Topics: Acute Disease; Adult; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combination; Female; | 2005 |
Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.
Topics: Acute Disease; Adult; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combination; Female; | 2005 |
22 other studies available for serine and Acute Disease
| Article | Year |
|---|---|
D-serine prevents cognitive deficits induced by acute stress.
Topics: Acute Disease; Animals; Cognition Disorders; Corticosterone; Disease Models, Animal; Glycine; Hippoc | 2014 |
Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue.
Topics: Acute Disease; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Line, Tumor; Dose | 2015 |
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.
Topics: Acute Disease; Adult; Aged; Animals; Calcium Channels, L-Type; Cyclic AMP-Dependent Protein Kinases; | 2017 |
l-Serine induces sedative and hypnotic effects acting at GABA(A) receptors in neonatal chicks.
Topics: Acute Disease; Animals; Animals, Newborn; Chickens; Disease Models, Animal; Glycine; Hypnotics and S | 2008 |
Simultaneous efflux of endogenous D-ser and L-glu from single acute hippocampus slices during oxygen glucose deprivation.
Topics: Acute Disease; Animals; Diffusion Chambers, Culture; Glucose; Glutamic Acid; Glutamine; Hippocampus; | 2009 |
The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model.
Topics: Acute Disease; Analgesics; Animals; Dose-Response Relationship, Drug; Glycine Plasma Membrane Transp | 2010 |
Efficiency of a cysteine-taurine-threonine-serine supplemented parenteral nutrition in an experimental model of acute inflammation.
Topics: Acute Disease; Animals; Cysteine; Dietary Supplements; Inflammation; Male; Parenteral Nutrition; Pro | 2003 |
Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha.
Topics: Abdomen; Acute Disease; Animals; Hemorrhage; Insulin Receptor Substrate Proteins; Insulin Resistance | 2004 |
Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry.
Topics: Acute Disease; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blotting, Western; Flow Cyto | 2004 |
CD7/CD56-positive acute myeloid leukemias are characterized by constitutive phosphorylation of the NF-kB subunit p65 at Ser536.
Topics: Acute Disease; Antigens, CD7; CD56 Antigen; Humans; Leukemia, Myeloid; Phosphorylation; Serine; Tran | 2007 |
Temporal-spatial expressions of p27kip1 and its phosphorylation on Serine-10 after acute spinal cord injury in adult rat: Implications for post-traumatic glial proliferation.
Topics: Active Transport, Cell Nucleus; Acute Disease; Amino Acid Sequence; Animals; Astrocytes; Cell Prolif | 2008 |
Effect of serine on gluconeogenic ability of hepatocytes in acute uremia.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Bucladesine; Dihydroxyacetone; Epinephrine; Female; | 1983 |
Glycogen synthesis from serine in isolated perfused hindquarters of acutely uraemic rats.
Topics: Acute Disease; Animals; Female; Glycogen; Hindlimb; Muscles; Perfusion; Rats; Rats, Inbred Strains; | 1983 |
Impaired glycine-serine conversion and increased plasma taurine levels in episodic psychotic patients with psychedelic symptoms.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Acute Disease; Adult; Female; Glycine; Ha | 1984 |
Glycogen metabolism in muscle in uremia.
Topics: Acute Disease; Animals; Dietary Proteins; Enzyme Activation; Fasting; Glycogen; Glycogen Synthase; I | 1980 |
Isolation of protein-glycogen complexes from rat skeletal muscle in acute uremia: role of serine.
Topics: Acute Disease; Animals; Diet; Female; Glycogen; Glycogen Synthase; Phosphorylases; Protein Binding; | 1982 |
The gluconeogenetic ability of hepatocytes in various types of acute uraemia.
Topics: Acute Disease; Acute Kidney Injury; Animals; Dihydroxyacetone; Female; Fructose; Gluconeogenesis; Gl | 1982 |
Severe hypertriglyceridemia with plasma inhibitory factor(s) on lipoprotein lipase activity in a patient with a common Ser(447)-Ter LPL mutation.
Topics: Acute Disease; Adult; Enzyme Inhibitors; Heparin; Humans; Hypertriglyceridemia; Lipoprotein Lipase; | 2001 |
Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248.
Topics: Acute Disease; Alanine; Amino Acid Substitution; CCAAT-Enhancer-Binding Protein-alpha; Cell Differen | 2002 |
[A case with acute pandysautonomia with aseptic meningitis--Pathophysiological and therapeutic study].
Topics: Acute Disease; Adult; Autonomic Nervous System Diseases; Droxidopa; Humans; Hypotension, Orthostatic | 1987 |
Selective metabolic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea upon de novo purine biosynthesis.
Topics: Acute Disease; Amino Acids; Animals; Antineoplastic Agents; Ascitic Fluid; Carbon Isotopes; Carcinom | 1971 |
The erythrocyte plasma distribution of amino acids in health and disease.
Topics: Acute Disease; Adolescent; Adult; Alanine; Amino Acids; Anemia, Hemolytic; Anemia, Pernicious; Bronc | 1968 |