serine has been researched along with Acute Confusional Senile Dementia in 197 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study investigated the expression of abnormal serine phosphorylation of insulin receptor substrate 1 (IRS1) in 157 human brain autopsy cases that included AD, tauopathies, α-synucleinopathies, TDP-43 proteinopathies, and normal aging." | 7.80 | Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. ( Arnold, SE; Arvanitakis, Z; Han, LY; Kazi, H; Kim, SF; Lee, EB; Lee, VM; Louneva, N; Toledo, JB; Trojanowski, JQ; Yarchoan, M, 2014) |
| "Hyperhomocysteinemia (HHcy) has been recognized as a risk factor for developing Alzheimer's disease (AD)." | 7.76 | Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. ( Gould, TJ; Kruger, WD; Portugal, GS; Pratico, D; Wang, H; Zhuo, JM, 2010) |
| "Repeated amino acid sequences in proteins are widely found, and the glycine-serine-alanine repeat is an element with a general propensity to form β-sheet aggregates as found in key pathological factors, in several neurodegenerative diseases." | 4.31 | A peptide rich in glycine-serine-alanine repeats ameliorates Alzheimer-type neurodegeneration. ( Chen, S; Gao, XD; Meng, Y; Wang, JF; Xu, Z; Xue, Y; Yang, F; Yao, SY; Yao, WB, 2023) |
| " Here, we study the Alzheimer disease-related amyloid-β (Aβ) peptide and investigate how phosphorylation at serine 8 affects the structure of Aβ aggregates." | 3.83 | Phosphorylation Interferes with Maturation of Amyloid-β Fibrillar Structure in the N Terminus. ( Kumar, S; Rezaei-Ghaleh, N; Walter, J; Zweckstetter, M, 2016) |
| " This study investigated the expression of abnormal serine phosphorylation of insulin receptor substrate 1 (IRS1) in 157 human brain autopsy cases that included AD, tauopathies, α-synucleinopathies, TDP-43 proteinopathies, and normal aging." | 3.80 | Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. ( Arnold, SE; Arvanitakis, Z; Han, LY; Kazi, H; Kim, SF; Lee, EB; Lee, VM; Louneva, N; Toledo, JB; Trojanowski, JQ; Yarchoan, M, 2014) |
| "Hyperhomocysteinemia (HHcy) has been recognized as a risk factor for developing Alzheimer's disease (AD)." | 3.76 | Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. ( Gould, TJ; Kruger, WD; Portugal, GS; Pratico, D; Wang, H; Zhuo, JM, 2010) |
| "Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of alpha-synuclein (alpha-syn) in Parkinson disease." | 3.76 | Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. ( Aebischer, P; Chegini, F; Chiappe, D; Eliezer, D; Fernandez, CO; Gai, WP; Kim, HY; Lamberto, GR; Lashuel, HA; Masliah, E; Moniatte, M; Oueslati, A; Paleologou, KE; Rospigliosi, CC; Schmid, A; Schneider, BL; Shakked, G; Zweckstetter, M, 2010) |
| "Although the underlying cause of Alzheimer's disease (AD) is not known, the extracellular deposition of β-amyloid (Aβ) is considered as a hallmark of AD brains." | 1.56 | Complete identification of all 20 relevant epimeric peptides in β-amyloid: a new HPLC-MS based analytical strategy for Alzheimer's research. ( Armstrong, DW; Du, S; Readel, ER; Wey, M, 2020) |
| "Tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes Alzheimer's disease (AD)." | 1.56 | Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies. ( Bell, BM; Chakrabarty, P; Davies, P; Giasson, BI; Gorion, KM; Kim, JD; Manaois, AN; Prokop, S; Sorrentino, ZA; Xia, Y, 2020) |
| "The diagnosis of Alzheimer's disease (AD) relies on the presence of amyloidosis and tauopathy, as reflected in cerebrospinal fluid (CSF), independently from the clinical stage." | 1.56 | Cerebrospinal fluid and serum d-serine concentrations are unaltered across the whole clinical spectrum of Alzheimer's disease. ( Calabresi, P; Casamassa, A; Errico, F; Eusebi, P; Gaetani, L; Homma, H; Katane, M; Mancini, A; Miroballo, M; Nisticò, R; Nuzzo, T; Parnetti, L; Usiello, A, 2020) |
| "Here we demonstrate that in Alzheimer's disease frontal cortex, KLC1 levels are reduced and the relative levels of KLC1 serine-460 phosphorylation are increased; these changes occur relatively early in the disease process." | 1.51 | Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein. ( Bhembre, N; Glennon, EB; Greig, J; Lau, DHW; Mattedi, F; Miller, CCJ; Mórotz, GM; Muschalik, N; Noble, W; Vagnoni, A, 2019) |
| "Alzheimer's disease is characterized by accumulation of amyloid plaques and tau aggregates in several cortical brain regions." | 1.48 | Phosphorylation of different tau sites during progression of Alzheimer's disease. ( Attems, J; Daum, G; Flunkert, S; Hoeller, C; Hutter-Paier, B; Kerschbaumer, B; Loeffler, T; Neddens, J; Niederkofler, V; Temmel, M, 2018) |
| "The progression of Alzheimer's disease (AD) is associated with an increase of phosphorylated tau in the brain." | 1.40 | MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies. ( Berg, M; Gustafsson, E; Lund, H; Nilsson, M; Sunnemark, D; Svensson, A; von Euler, G, 2014) |
| "Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles." | 1.35 | Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease. ( Belarbi, K; Blum, D; Buée, L; Burnouf, S; Caillierez, R; Demeyer, D; Grosjean, ME; Hamdane, M; Schindowski, K; Sergeant, N, 2009) |
| "A primary pathologic component of Alzheimer's disease (AD) is the formation of neurofibrillary tangles composed of hyperphosphorylated tau (p-tau)." | 1.34 | The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. ( Ash, P; Bailey, RM; Burrows, F; Dickey, CA; Dickson, DW; Dunmore, J; Eckman, CB; Hutton, M; Kamal, A; Klosak, N; Lundgren, K; Nahman, NS; Patterson, C; Petrucelli, L; Shoraka, S; Zlatkovic, J, 2007) |
| "Propentofylline (PPF) is a synthetic xanthine derivative that inhibits phosphodiesterase and adenosine uptake." | 1.33 | Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576. ( Chauhan, NB; Feinstein, DL; Siegel, GJ, 2005) |
| "In the brains of Alzheimer's disease patients, the tau protein dissociates from the axonal microtubule and abnormally aggregates to form a paired helical filament (PHF)." | 1.33 | Synthesis and conformational properties of phosphopeptides related to the human tau protein. ( Abe, H; Aoyagi, R; Du, JT; Ishizuka, Y; Kanazawa, K; Li, YM; Ma, QF; Nakanishi, H; Nemoto, T; Qiang, W; Qin, XR; Zhao, YF, 2005) |
| "Tau protein pathology in Alzheimer's disease is characterized by the hyperphosphorylation of tau at some specific sites." | 1.33 | Acetylsalicylic acid decreases tau phosphorylation at serine 422. ( Avila, J; Pérez, M; Tortosa, E, 2006) |
| "The tangles of Alzheimer's disease (AD) are comprised of the tau protein displaying numerous alterations, including phosphorylation at serine 422 (S422) and truncation at aspartic acid 421 (D421)." | 1.33 | Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo. ( Berry, RW; Binder, LI; Cahill, ME; Cryns, VL; Guillozet-Bongaarts, AL; Reynolds, MR, 2006) |
| "Tauopathies, including Alzheimer's disease, are neurodegenerative disorders in which tau protein accumulates as a consequence of alterations in its metabolism." | 1.32 | Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease. ( Avila, J; Bhat, R; Hernández, F; Lucas, JJ; Mata, AM; Pérez, M, 2004) |
| "LPL immunostains senile plaques, and is a ligand of the low-density lipoprotein receptor-related protein (LRP), a major apolipoprotein E (apoE) receptor." | 1.31 | Lack of association of two lipoprotein lipase polymorphisms with Alzheimer's disease. ( Cho, HS; Martin-Rehrmann, MD; Rebeck, GW, 2002) |
| "Neurofibrillary tangles associated with Alzheimer's disease are composed mainly of paired helical filaments that are formed by the aggregation of abnormally phosphorylated microtubule-associated protein tau." | 1.31 | 14-3-3zeta is an effector of tau protein phosphorylation. ( Hashiguchi, M; Paudel, HK; Sobue, K, 2000) |
| "The cytoplasmic domain of the Alzheimer's disease amyloid precursor protein (APP) is phosphorylated in vitro at Thr654 and Ser655, and both in vitro and in intact cells at Thr668 (numbering for APP695 isoform)." | 1.30 | The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells. ( Czernik, AJ; Gandy, SE; Greengard, P; Isohara, T; Lim, GS; Nairn, AC; Oishi, M; Suzuki, T, 1997) |
| "PS1 L250S familial Alzheimer's disease is an early onset form of Alzheimer's disease with clinical features similar to other reported familial Alzheimer's disease pedigrees, except that seizures were absent." | 1.30 | Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene. ( Collinge, J; Ellison, D; Fox, NC; Hardy, J; Harvey, RJ; Hutton, M; Roques, PK; Rossor, MN, 1998) |
| "Since S214 is also phosphorylated in Alzheimer's disease tau, our results support the view that reactivation of the cell cycle machinery is involved in tau hyperphosphorylation." | 1.30 | The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. ( Baumann, K; Biernat, J; Godemann, R; Illenberger, S; Mandelkow, E; Mandelkow, EM; Preuss, U; Stamer, K; Trinczek, B; Zheng-Fischhöfer, Q, 1998) |
| "One of the hallmarks of Alzheimer's disease is the abnormal state of the microtubule-associated protein tau in neurons." | 1.30 | Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. ( Biernat, J; Mandelkow, E; Mandelkow, EM; Schneider, A; von Bergen, M, 1999) |
| "The risk of Alzheimer's disease is determined, in part, by inheritance of specific alleles of ApoE." | 1.29 | ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. ( Goedert, M; Huang, DY; Roses, AD; Saunders, AM; Strittmatter, WJ; Weisgraber, KH, 1995) |
| "The paired helical filaments (PHFs) of Alzheimer's disease consist mainly of the microtubule-associated protein tau." | 1.28 | The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region. ( Berling, B; Biernat, J; Goedert, M; Lichtenberg-Kraag, B; Mandelkow, E; Mandelkow, EM; Mercken, M; Meyer, H; Schröter, C; Steiner, B; Vandermeeren, A, 1992) |
| "In contrast, trisomy 21 did not affect the uptake of choline, serine or glucose." | 1.28 | Down's syndrome fibroblasts exhibit enhanced inositol uptake. ( Fruen, BR; Lester, BR, 1990) |
| "Neuritic plaque core amyloid protein in Alzheimer's disease brain tissue was investigated for the extent of amino acid racemization." | 1.27 | Neuritic plaque amyloid in Alzheimer's disease is highly racemized. ( Austin, GE; Mirra, SS; Shapira, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.51) | 18.7374 |
| 1990's | 26 (13.20) | 18.2507 |
| 2000's | 81 (41.12) | 29.6817 |
| 2010's | 61 (30.96) | 24.3611 |
| 2020's | 28 (14.21) | 2.80 |
| Authors | Studies |
|---|---|
| Heller, L | 1 |
| Schwarz, S | 1 |
| Obernauer, A | 1 |
| Csuk, R | 1 |
| Shen, Q | 1 |
| Wu, X | 1 |
| Zhang, Z | 2 |
| Zhang, D | 1 |
| Yang, S | 1 |
| Xing, D | 1 |
| Shim, KH | 1 |
| Kang, MJ | 1 |
| Bae, H | 1 |
| Kim, D | 1 |
| Park, J | 1 |
| An, SA | 1 |
| Jeong, DE | 1 |
| Ni, X | 1 |
| Mori, H | 1 |
| Chen, X | 2 |
| Calandrelli, R | 1 |
| Girardini, J | 1 |
| Yan, Z | 1 |
| Tan, Z | 1 |
| Xu, X | 1 |
| Hiniker, A | 1 |
| Zhong, S | 1 |
| Bonvento, G | 2 |
| Oliet, SHR | 2 |
| Panatier, A | 2 |
| Baier, MP | 1 |
| Nagaraja, RY | 1 |
| Yarbrough, HP | 1 |
| Owen, DB | 1 |
| Masingale, AM | 1 |
| Ranjit, R | 1 |
| Stiles, MA | 1 |
| Murphy, A | 1 |
| Agbaga, MP | 1 |
| Ahmad, M | 1 |
| Sherry, DM | 1 |
| Kinter, MT | 1 |
| Van Remmen, H | 1 |
| Logan, S | 1 |
| Wu, S | 1 |
| Zhou, J | 1 |
| Zhang, H | 1 |
| Barger, SW | 2 |
| Duarte, JMN | 1 |
| Maffioli, E | 1 |
| Murtas, G | 3 |
| Rabattoni, V | 3 |
| Badone, B | 1 |
| Tripodi, F | 1 |
| Iannuzzi, F | 1 |
| Licastro, D | 1 |
| Nonnis, S | 1 |
| Rinaldi, AM | 1 |
| Motta, Z | 1 |
| Sacchi, S | 3 |
| Canu, N | 1 |
| Tedeschi, G | 1 |
| Coccetti, P | 1 |
| Pollegioni, L | 4 |
| Maitra, S | 1 |
| Vincent, B | 1 |
| Folorunso, OO | 1 |
| Harvey, TL | 1 |
| Brown, SE | 1 |
| Chelini, G | 1 |
| Berretta, S | 1 |
| Balu, DT | 1 |
| Kuzin, AA | 2 |
| Stupnikova, GS | 2 |
| Strelnikova, PA | 2 |
| Danichkina, KV | 2 |
| Indeykina, MI | 2 |
| Pekov, SI | 2 |
| Popov, IA | 2 |
| Jacobsen, AM | 1 |
| van de Merbel, NC | 1 |
| Ditlevsen, DK | 1 |
| Tvermosegaard, K | 1 |
| Schalk, F | 1 |
| Lambert, W | 1 |
| Bundgaard, C | 1 |
| Pedersen, JT | 1 |
| Rosenqvist, N | 1 |
| Yao, SY | 1 |
| Wang, JF | 1 |
| Xu, Z | 1 |
| Meng, Y | 1 |
| Xue, Y | 1 |
| Yang, F | 3 |
| Yao, WB | 1 |
| Gao, XD | 1 |
| Chen, S | 1 |
| Di Maio, A | 1 |
| Nuzzo, T | 2 |
| Gilio, L | 1 |
| Serra, M | 1 |
| Buttari, F | 1 |
| Errico, F | 2 |
| De Rosa, A | 1 |
| Bassi, MS | 1 |
| Morelli, M | 1 |
| Sasabe, J | 1 |
| Sulzer, D | 1 |
| Carta, M | 1 |
| Centonze, D | 1 |
| Usiello, A | 2 |
| Lin, CH | 1 |
| Yang, HT | 1 |
| Lane, HY | 1 |
| Wang, W | 1 |
| Tanokashira, D | 1 |
| Fukui, Y | 1 |
| Maruyama, M | 1 |
| Kuroiwa, C | 1 |
| Saito, T | 2 |
| Saido, TC | 1 |
| Taguchi, A | 1 |
| Chai, JF | 1 |
| Raichur, S | 1 |
| Khor, IW | 1 |
| Torta, F | 1 |
| Chew, WS | 1 |
| Herr, DR | 1 |
| Ching, J | 1 |
| Kovalik, JP | 1 |
| Khoo, CM | 1 |
| Wenk, MR | 1 |
| Tai, ES | 1 |
| Sim, X | 1 |
| Lau, KF | 2 |
| Chow, WN | 2 |
| Ngo, JCK | 1 |
| Chen, YW | 2 |
| Tam, VKM | 1 |
| Chan, EHY | 1 |
| Miller, C | 1 |
| Mórotz, GM | 1 |
| Glennon, EB | 1 |
| Greig, J | 1 |
| Lau, DHW | 1 |
| Bhembre, N | 1 |
| Mattedi, F | 1 |
| Muschalik, N | 1 |
| Noble, W | 1 |
| Vagnoni, A | 1 |
| Miller, CCJ | 1 |
| Du, S | 1 |
| Readel, ER | 1 |
| Wey, M | 1 |
| Armstrong, DW | 1 |
| Hardingham, GE | 1 |
| Le Douce, J | 1 |
| Maugard, M | 1 |
| Veran, J | 1 |
| Matos, M | 1 |
| Jégo, P | 1 |
| Vigneron, PA | 1 |
| Faivre, E | 1 |
| Toussay, X | 1 |
| Vandenberghe, M | 1 |
| Balbastre, Y | 1 |
| Piquet, J | 1 |
| Guiot, E | 1 |
| Tran, NT | 1 |
| Taverna, M | 1 |
| Marinesco, S | 1 |
| Koyanagi, A | 1 |
| Furuya, S | 2 |
| Gaudin-Guérif, M | 1 |
| Goutal, S | 1 |
| Ghettas, A | 1 |
| Pruvost, A | 1 |
| Bemelmans, AP | 1 |
| Gaillard, MC | 1 |
| Cambon, K | 1 |
| Stimmer, L | 1 |
| Sazdovitch, V | 1 |
| Duyckaerts, C | 1 |
| Knott, G | 1 |
| Hérard, AS | 1 |
| Delzescaux, T | 1 |
| Hantraye, P | 1 |
| Brouillet, E | 1 |
| Cauli, B | 1 |
| Lee, JY | 2 |
| Han, SH | 3 |
| Park, MH | 2 |
| Song, IS | 2 |
| Choi, MK | 2 |
| Yu, E | 1 |
| Park, CM | 1 |
| Kim, HJ | 1 |
| Kim, SH | 2 |
| Schuchman, EH | 2 |
| Jin, HK | 2 |
| Bae, JS | 2 |
| Xia, Y | 2 |
| Prokop, S | 1 |
| Gorion, KM | 2 |
| Kim, JD | 1 |
| Sorrentino, ZA | 2 |
| Bell, BM | 1 |
| Manaois, AN | 1 |
| Chakrabarty, P | 1 |
| Davies, P | 3 |
| Giasson, BI | 2 |
| Aquilani, R | 1 |
| Costa, A | 1 |
| Maestri, R | 1 |
| Cotta Ramusino, M | 1 |
| Pierobon, A | 1 |
| Dossena, M | 1 |
| Solerte, SB | 1 |
| Condino, AM | 1 |
| Torlaschi, V | 1 |
| Bini, P | 1 |
| Boselli, M | 1 |
| Ceroni, M | 1 |
| Buonocore, D | 1 |
| Boschi, F | 1 |
| Bruni, M | 1 |
| Verri, M | 1 |
| Marcone, GL | 1 |
| Miroballo, M | 1 |
| Casamassa, A | 1 |
| Mancini, A | 1 |
| Gaetani, L | 1 |
| Nisticò, R | 1 |
| Eusebi, P | 1 |
| Katane, M | 1 |
| Homma, H | 2 |
| Calabresi, P | 1 |
| Parnetti, L | 1 |
| Ploux, E | 1 |
| Freret, T | 1 |
| Billard, JM | 1 |
| Neves, JF | 1 |
| Petrvalská, O | 1 |
| Bosica, F | 1 |
| Cantrelle, FX | 1 |
| Merzougui, H | 1 |
| O'Mahony, G | 1 |
| Hanoulle, X | 1 |
| Obšil, T | 1 |
| Landrieu, I | 2 |
| Piubelli, L | 2 |
| Mauri, M | 1 |
| Princiotta Cariddi, L | 1 |
| Versino, M | 1 |
| Bustos, V | 1 |
| Pulina, MV | 1 |
| Kelahmetoglu, Y | 1 |
| Sinha, SC | 1 |
| Gorelick, FS | 1 |
| Flajolet, M | 1 |
| Greengard, P | 3 |
| Wang, ZH | 1 |
| Liu, P | 1 |
| Liu, X | 3 |
| Manfredsson, FP | 1 |
| Sandoval, IM | 1 |
| Yu, SP | 1 |
| Wang, JZ | 4 |
| Ye, K | 1 |
| Schlepckow, K | 1 |
| Kleinberger, G | 1 |
| Fukumori, A | 1 |
| Feederle, R | 1 |
| Lichtenthaler, SF | 1 |
| Steiner, H | 1 |
| Haass, C | 1 |
| Cabrales Fontela, Y | 1 |
| Kadavath, H | 1 |
| Biernat, J | 8 |
| Riedel, D | 1 |
| Mandelkow, E | 8 |
| Zweckstetter, M | 5 |
| Baek, B | 1 |
| Takuwa, Y | 1 |
| Ryu, H | 1 |
| He, X | 1 |
| Lin, L | 1 |
| Cao, J | 1 |
| Yang, SS | 1 |
| Fu, ZQ | 1 |
| Zeng, P | 1 |
| Chu, J | 1 |
| Ning, LN | 1 |
| Zhang, T | 1 |
| Shi, Y | 1 |
| Tian, Q | 2 |
| Zhou, XW | 2 |
| Ji, M | 1 |
| Xie, XX | 1 |
| Liu, DQ | 1 |
| Yu, XL | 1 |
| Zhang, Y | 1 |
| Zhang, LX | 1 |
| Wang, SW | 1 |
| Huang, YR | 1 |
| Liu, RT | 1 |
| Neddens, J | 1 |
| Temmel, M | 1 |
| Flunkert, S | 1 |
| Kerschbaumer, B | 1 |
| Hoeller, C | 1 |
| Loeffler, T | 1 |
| Niederkofler, V | 1 |
| Daum, G | 1 |
| Attems, J | 1 |
| Hutter-Paier, B | 1 |
| van Ameijde, J | 1 |
| Crespo, R | 1 |
| Janson, R | 1 |
| Juraszek, J | 1 |
| Siregar, B | 1 |
| Verveen, H | 1 |
| Sprengers, I | 1 |
| Nahar, T | 1 |
| Hoozemans, JJ | 1 |
| Steinbacher, S | 1 |
| Willems, R | 1 |
| Delbroek, L | 1 |
| Borgers, M | 1 |
| Dockx, K | 1 |
| Van Kolen, K | 1 |
| Mercken, M | 2 |
| Pascual, G | 1 |
| Koudstaal, W | 1 |
| Apetri, A | 1 |
| Strang, KH | 1 |
| Riffe, CJ | 1 |
| Vijayaraghavan, N | 1 |
| Golde, TE | 1 |
| Cao, LL | 1 |
| Guan, PP | 1 |
| Liang, YY | 1 |
| Huang, XS | 1 |
| Wang, P | 1 |
| Cruchaga, C | 3 |
| Kauwe, JS | 2 |
| Harari, O | 1 |
| Jin, SC | 1 |
| Cai, Y | 1 |
| Karch, CM | 2 |
| Benitez, BA | 1 |
| Jeng, AT | 1 |
| Skorupa, T | 1 |
| Carrell, D | 1 |
| Bertelsen, S | 2 |
| Bailey, M | 1 |
| McKean, D | 1 |
| Shulman, JM | 1 |
| De Jager, PL | 1 |
| Chibnik, L | 1 |
| Bennett, DA | 1 |
| Arnold, SE | 2 |
| Harold, D | 1 |
| Sims, R | 1 |
| Gerrish, A | 1 |
| Williams, J | 1 |
| Van Deerlin, VM | 1 |
| Lee, VM | 7 |
| Shaw, LM | 1 |
| Trojanowski, JQ | 5 |
| Haines, JL | 1 |
| Mayeux, R | 1 |
| Pericak-Vance, MA | 1 |
| Farrer, LA | 1 |
| Schellenberg, GD | 2 |
| Peskind, ER | 1 |
| Galasko, D | 1 |
| Fagan, AM | 2 |
| Holtzman, DM | 2 |
| Morris, JC | 3 |
| Goate, AM | 2 |
| Jia, N | 1 |
| Han, K | 1 |
| Kong, JJ | 1 |
| Zhang, XM | 1 |
| Sha, S | 1 |
| Ren, GR | 1 |
| Cao, YP | 1 |
| Hausner, L | 1 |
| Tschäpe, JA | 1 |
| Schmitt, HP | 1 |
| Hentschel, F | 1 |
| Hartmann, T | 1 |
| Frölich, L | 1 |
| Lund, H | 3 |
| Gustafsson, E | 2 |
| Svensson, A | 2 |
| Nilsson, M | 1 |
| Berg, M | 1 |
| Sunnemark, D | 3 |
| von Euler, G | 1 |
| Bardaweel, SK | 1 |
| Alzweiri, M | 1 |
| Ishaqat, AA | 1 |
| Roychaudhuri, R | 1 |
| Lomakin, A | 1 |
| Bernstein, S | 1 |
| Zheng, X | 1 |
| Condron, MM | 1 |
| Benedek, GB | 1 |
| Bowers, M | 1 |
| Teplow, DB | 1 |
| Tanji, K | 1 |
| Miki, Y | 1 |
| Ozaki, T | 1 |
| Maruyama, A | 1 |
| Yoshida, H | 1 |
| Mimura, J | 1 |
| Matsumiya, T | 1 |
| Mori, F | 1 |
| Imaizumi, T | 1 |
| Itoh, K | 1 |
| Kakita, A | 1 |
| Takahashi, H | 1 |
| Wakabayashi, K | 1 |
| Li, C | 1 |
| Liu, S | 1 |
| Xing, Y | 1 |
| Tao, F | 1 |
| Yarchoan, M | 1 |
| Toledo, JB | 1 |
| Lee, EB | 1 |
| Arvanitakis, Z | 1 |
| Kazi, H | 1 |
| Han, LY | 1 |
| Louneva, N | 1 |
| Kim, SF | 1 |
| Kanno, T | 1 |
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| Cordell, B | 1 |
| McCarthy, JV | 1 |
| Thorpe, JR | 1 |
| Morley, SJ | 1 |
| Rulten, SL | 1 |
| Honda, K | 1 |
| Shimohama, S | 1 |
| Sawada, H | 1 |
| Nakamizo, T | 1 |
| Shibasaki, H | 1 |
| Akaike, A | 1 |
| Morimoto, K | 1 |
| Itoh, N | 1 |
| Hampel, H | 1 |
| Buerger, K | 1 |
| Wiltfang, J | 1 |
| Otto, M | 1 |
| Kretzschmar, H | 1 |
| Moeller, HJ | 1 |
| Imagawa, M | 1 |
| Kohno, H | 1 |
| Kuzuhara, S | 1 |
| Sasaki, H | 1 |
| Imahori, K | 1 |
| Briand, C | 1 |
| Kozlov, SV | 1 |
| Sonderegger, P | 1 |
| Grütter, MG | 1 |
| Milton, NG | 1 |
| Takao, M | 1 |
| Murrell, JR | 1 |
| Unverzagt, FW | 1 |
| Giaccone, G | 1 |
| Tagliavini, F | 1 |
| Bugiani, O | 1 |
| Piccardo, P | 1 |
| Hulette, CM | 1 |
| Crain, BJ | 1 |
| Farlow, MR | 1 |
| Heyman, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Curcumin and Yoga Exercise Effects in Veterans at Risk for Alzheimer's Disease[NCT01811381] | Phase 2 | 80 participants (Anticipated) | Interventional | 2014-01-20 | Active, not recruiting | ||
| Peripheral Gene Expression of Endocannabinoid System Components in Episodic and Chronic Migraine Patients: a Pilot Study[NCT04324710] | 75 participants (Actual) | Observational | 2017-12-12 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for serine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Complex Processes Underlying the Dynamic Changes of D-serine Levels in AD Brains.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Humans; Receptors, N-Methyl-D-Aspartate; Serine | 2022 |
Serine Racemase Expression Differentiates Aging from Alzheimer's Brain.
Topics: Aging; Alzheimer Disease; Brain; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine | 2022 |
Cdk5-p25 as a key element linking amyloid and tau pathologies in Alzheimer's disease: Mechanisms and possible therapeutic interventions.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Calpain; Cyclin-Dependent Kinase 5; | 2022 |
L-serine synthesis via the phosphorylated pathway in humans.
Topics: Alzheimer Disease; Brain; Glycolysis; Humans; Neurons; Phosphoglycerate Dehydrogenase; Phosphorylati | 2020 |
d-serine in physiological and pathological brain aging.
Topics: Aging; Alzheimer Disease; Animals; Astrocytes; Cognition; Gene Expression; Glucose; Glutamic Acid; H | 2021 |
The Role of D-Amino Acids in Alzheimer's Disease.
Topics: Alzheimer Disease; Amino Acids; Animals; Aspartic Acid; Humans; Receptors, N-Methyl-D-Aspartate; Ser | 2021 |
D-Serine in neurobiology: CNS neurotransmission and neuromodulation.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Central Nervous System; Epilepsy; Glutami | 2014 |
An unconventional hypothesis of oxidation in Alzheimer's disease: intersections with excitotoxicity.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cystine; Glutamates; Humans; Inflam | 2004 |
[Role of serine/threonine protein phosphatase in tau phosphorylation].
Topics: Alzheimer Disease; Phosphoprotein Phosphatases; Phosphorylation; Serine; tau Proteins | 2006 |
D-serine: a new word in the glutamatergic neuro-glial language.
Topics: Alzheimer Disease; Animals; Astrocytes; Cell Death; Cell Movement; Glutamic Acid; Humans; Neuroglia; | 2007 |
187 other studies available for serine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Allobetulin derived seco-oleananedicarboxylates act as inhibitors of acetylcholinesterase.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Humans; Kinetics; Mice; | 2015 |
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β-amyloid load in Alzheimer's disease model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2022 |
A Possible Pathogenic PSEN2 Gly56Ser Mutation in a Korean Patient with Early-Onset Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Female; Humans; Middle Age | 2022 |
PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.
Topics: Alzheimer Disease; Animals; Brain; Cell Line, Tumor; Mice; Phosphoglycerate Dehydrogenase; RNA, Mess | 2022 |
Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer's disease.
Topics: Alzheimer Disease; Astrocytes; Glycolysis; Humans; Phosphoglycerate Dehydrogenase; Serine | 2022 |
Selective Ablation of
Topics: Alzheimer Disease; Animals; Antioxidants; Astrocytes; Cognition; Female; Gliosis; Hippocampus; Male; | 2022 |
Serine racemase modulation for improving brain insulin resistance: An Editorial Highlight for "Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers": An Editorial Highlight for "Deletion of serine racemase reve
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Hippocampus; Humans; Insulin; Insulin Resistance; R | 2022 |
Insulin and serine metabolism as sex-specific hallmarks of Alzheimer's disease in the human hippocampus.
Topics: Alzheimer Disease; Female; Hippocampus; Humans; Insulin; Male; Proteomics; Quality of Life; Receptor | 2022 |
The D-serine biosynthetic enzyme serine racemase is expressed by reactive astrocytes in the amygdala of human and a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amygdala; Animals; Astrocytes; Disease Models, Animal; Humans; Mice; Plaque, Amyl | 2023 |
Quantitative Assessment of Serine-8 Phosphorylated β-Amyloid Using MALDI-TOF Mass Spectrometry.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Serine; Spectrometry, Mass, Matrix-Assisted Laser | 2022 |
Quantitative Assessment of Serine-8 Phosphorylated β-Amyloid Using MALDI-TOF Mass Spectrometry.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Serine; Spectrometry, Mass, Matrix-Assisted Laser | 2022 |
Quantitative Assessment of Serine-8 Phosphorylated β-Amyloid Using MALDI-TOF Mass Spectrometry.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Serine; Spectrometry, Mass, Matrix-Assisted Laser | 2022 |
Quantitative Assessment of Serine-8 Phosphorylated β-Amyloid Using MALDI-TOF Mass Spectrometry.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Serine; Spectrometry, Mass, Matrix-Assisted Laser | 2022 |
A Quantitative LC-MS/MS Method for Distinguishing the Tau Protein Forms Phosphorylated and Nonphosphorylated at Serine-396.
Topics: Alzheimer Disease; Animals; Biomarkers; Chromatography, Liquid; Humans; Mice; Phosphorylation; Serin | 2023 |
A peptide rich in glycine-serine-alanine repeats ameliorates Alzheimer-type neurodegeneration.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caenorhabditis elegans; Humans; Mice; Mice, Trans | 2023 |
Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson's disease patients.
Topics: Alzheimer Disease; Amino Acids; Amyotrophic Lateral Sclerosis; Homeostasis; Humans; N-Methylaspartat | 2023 |
D-glutamate, D-serine, and D-alanine differ in their roles in cognitive decline in patients with Alzheimer's disease or mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Behavioral Symptoms; Chromatography, Liquid; Co | 2019 |
Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Dia | 2019 |
Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer's and Parkinson's diseases.
Topics: Alzheimer Disease; Asian People; ATP-Binding Cassette Transporters; Carnitine; China; DNA-Binding Pr | 2020 |
FE65 serine-610 phosphorylation and its functional implications in Alzheimer disease amyloid precursor protein processing.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Humans; Immediate-Early Pr | 2019 |
Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Ani | 2019 |
Complete identification of all 20 relevant epimeric peptides in β-amyloid: a new HPLC-MS based analytical strategy for Alzheimer's research.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Chromatography, High P | 2020 |
Targeting Synaptic NMDA Receptor Co-agonism as a Therapy for Alzheimer's Disease?
Topics: Alzheimer Disease; Astrocytes; Cognition; Glycolysis; Humans; Receptors, N-Methyl-D-Aspartate; Serin | 2020 |
Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Astrocytes; Binding Sites | 2020 |
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Topics: Acetyl Coenzyme A; Acetylation; Alzheimer Disease; Animals; Anti-Inflammatory Agents; Brain; Cell Li | 2020 |
Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies.
Topics: Alzheimer Disease; Animals; Cells, Cultured; Disease Models, Animal; HEK293 Cells; Humans; Mice, Inb | 2020 |
Mini Nutritional Assessment May Identify a Dual Pattern of Perturbed Plasma Amino Acids in Patients with Alzheimer's Disease: A Window to Metabolic and Physical Rehabilitation?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids; Attention; Female; Histidine; Humans; Male; | 2020 |
Cerebrospinal fluid and serum d-serine concentrations are unaltered across the whole clinical spectrum of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Brain; | 2020 |
Phosphorylated full-length Tau interacts with 14-3-3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14-3-3 dimer.
Topics: 14-3-3 Proteins; Alzheimer Disease; Binding Sites; Cyclic AMP-Dependent Protein Kinases; Exoribonucl | 2021 |
Serum D-serine levels are altered in early phases of Alzheimer's disease: towards a precocious biomarker.
Topics: Alzheimer Disease; Amino Acids; Aspartic Acid; Biomarkers; Humans; Receptors, N-Methyl-D-Aspartate; | 2021 |
Bidirectional regulation of Aβ levels by Presenilin 1.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2017 |
Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Behavior, Animal; Brain; Cognition | 2017 |
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
Topics: ADAM10 Protein; ADAM17 Protein; Alzheimer Disease; Amyloid Precursor Protein Secretases; Cell Membra | 2017 |
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau.
Topics: Actin Cytoskeleton; Actin Depolymerizing Factors; Alzheimer Disease; Humans; Hydrophobic and Hydroph | 2017 |
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Topics: Acetyl Coenzyme A; Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Protein Pre | 2018 |
Endoplasmic reticulum stress induces spatial memory deficits by activating GSK-3.
Topics: Activating Transcription Factor 6; Alzheimer Disease; Animals; Brain; Cyclic AMP Response Element-Bi | 2018 |
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia.
Topics: Alzheimer Disease; Animals; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, | 2018 |
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Disease Progression; Female; Humans; Male; Middle | 2018 |
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies; Antibody Affinity; Autopsy; Brain; | 2018 |
Phosphorylation of serine 305 in tau inhibits aggregation.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Brain; Cells, Cultured; HEK293 Cells; Humans; Mi | 2019 |
Cyclooxygenase-2 is Essential for Mediating the Effects of Calcium Ions on Stimulating Phosphorylation of Tau at the Sites of Ser 396 and Ser 404.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Blotting, Western; Calcium; Cyclooxygenase 2; C | 2019 |
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Case-Control S | 2013 |
(-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Blotting, Western | 2013 |
Clinical characterization of a presenilin 1 mutation (F177S) in a family with very early-onset Alzheimer's disease in the third decade of life.
Topics: Adult; Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Brain; Brain Waves; Cognition D | 2014 |
MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Casein Kinase Idelta; Cytoplasmic Granules; Female; HEK2 | 2014 |
Gly25-Ser26 amyloid β-protein structural isomorphs produce distinct Aβ42 conformational dynamics and assembly characteristics.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biophysical Phenomena; Click Chemistry; Glycine; Humans; M | 2014 |
Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.
Topics: Adaptor Proteins, Signal Transducing; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Pepti | 2014 |
The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cognition; Cognition D | 2014 |
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies.
Topics: Age Factors; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Analysis of Variance; Anim | 2014 |
Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Gene Expression | 2014 |
Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.
Topics: alpha-Synuclein; Alzheimer Disease; Brain; Calpain; Case-Control Studies; Cell Line, Tumor; Child; C | 2014 |
Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Dementia; Deme | 2015 |
d-serine levels in Alzheimer's disease: implications for novel biomarker development.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A | 2015 |
Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; As | 2015 |
Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brai | 2016 |
Semi-synthesis of a tag-free O-GlcNAcylated tau protein by sequential chemoselective ligation.
Topics: Acetylglucosamine; Alzheimer Disease; Chemistry Techniques, Synthetic; Humans; Molecular Structure; | 2016 |
CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; | 2016 |
Phosphorylation Interferes with Maturation of Amyloid-β Fibrillar Structure in the N Terminus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Deuterium Exchange Measurement; Humans; Nuclear Magnetic R | 2016 |
Disruption of neuronal nitric oxide synthase dimerization contributes to the development of Alzheimer's disease: Involvement of cyclin-dependent kinase 5-mediated phosphorylation of neuronal nitric oxide synthase at Ser(293).
Topics: Alzheimer Disease; Animals; Cattle; Cells, Cultured; Cerebral Cortex; Cyclin-Dependent Kinase 5; Fem | 2016 |
Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Axonal Transport; Enzyme-Linked Immunosorbent Assay; Fem | 2016 |
HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Disease Models, Animal; H | 2016 |
Phosphorylation at Ser
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Circular Dichroism; Humans; | 2017 |
Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Atrophy; Brain; Exosomes; Female; | 2017 |
GSK3β 5'-flanking DNA Methylation and Expression in Alzheimer's Disease Patients.
Topics: 14-3-3 Proteins; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cell Line, Tumor; | 2017 |
C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.
Topics: Active Transport, Cell Nucleus; Aged, 80 and over; Alzheimer Disease; Animals; Autopsy; Blotting, We | 2017 |
O-GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau.
Topics: Acetylglucosamine; Acylation; Alzheimer Disease; Amino Acid Sequence; Humans; Microtubules; Molecula | 2008 |
Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer's disease patients.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Apoptosis; Brain Stem; Caspase 3; Ca | 2009 |
Age-related decrease in constructive activation of Akt/PKB in SAMP10 hippocampus.
Topics: Age Factors; Aging; Aging, Premature; Alzheimer Disease; Animals; Hippocampus; Male; Maze Learning; | 2009 |
Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Brain Mapping; Disease Models, Animal; Glycine; Hippocampus | 2009 |
S655 phosphorylation enhances APP secretory traffic.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Endocytosis; Golgi Apparatus; Humans; Phosphoryla | 2009 |
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A | 2009 |
Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules.
Topics: Alzheimer Disease; Binding Sites; Circular Dichroism; Glutamic Acid; Humans; Magnetic Resonance Spec | 2009 |
Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.
Topics: Actin Depolymerizing Factors; Actins; Adenosine Triphosphate; Alzheimer Disease; Amino Acid Motifs; | 2009 |
Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Brain; CHO Cells; Cricetinae | 2010 |
A novel mutation in the predicted TMIII domain of the PSEN2 gene in an Italian pedigree with atypical Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cognition Disorders; Cysteine; DNA Mutational Analysis; Female; Humans; Ita | 2010 |
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cell Membrane; Creatine Kin | 2010 |
Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model.
Topics: Alzheimer Disease; Animals; Cells, Cultured; Disease Models, Animal; Glycogen Synthase Kinase 3; Gly | 2010 |
Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Blood Platelets; Cognition Disorde | 2011 |
Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.
Topics: Age of Onset; Aged; Alzheimer Disease; Amino Acid Substitution; Female; Frontotemporal Lobar Degener | 2011 |
Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; CHO Ce | 2011 |
Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
Topics: Adaptor Proteins, Signal Transducing; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Pepti | 2011 |
Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.
Topics: Alzheimer Disease; Cell Line, Tumor; Drug Evaluation, Preclinical; High-Throughput Screening Assays; | 2011 |
Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.
Topics: Alzheimer Disease; Antineoplastic Agents, Phytogenic; Apoptosis; Brain; Cell Death; Cell Line, Tumor | 2011 |
Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Chrom | 2011 |
Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356.
Topics: Adenine; Adenosine Triphosphatases; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Autophagy; | 2011 |
Pin1 contribution to Alzheimer's disease: transcriptional and epigenetic mechanisms in patients with late-onset Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Apolipoprotein E4; Case-Control St | 2012 |
Phosphorylation of amyloid-β peptide at serine 8 attenuates its clearance via insulin-degrading and angiotensin-converting enzymes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cyclic AMP-Dependent Protein Kinases; Fibrinoly | 2012 |
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Topics: Age Factors; Alzheimer Disease; Animals; Antibodies; Cognition Disorders; Disease Models, Animal; En | 2012 |
Propagation of tau pathology in a model of early Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Disease Progression; Entorhinal Cor | 2012 |
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Biomarkers; Brain; Cell Lin | 2013 |
Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain; Cell Line, Transformed; Enzyme Inhibitor | 2013 |
Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Dendrites; Female; Gene Expression Regulation; HE | 2013 |
Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease.
Topics: Alzheimer Disease; Animals; Cytoplasm; DNA-Binding Proteins; Female; HEK293 Cells; Histone Chaperone | 2013 |
Lack of association of two lipoprotein lipase polymorphisms with Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Apolipoproteins E; Asparagine; Brain; Brain Chemistry; DNA M | 2002 |
In vivo conversion of racemized beta-amyloid ([D-Ser 26]A beta 1-40) to truncated and toxic fragments ([D-Ser 26]A beta 25-35/40) and fragment presence in the brains of Alzheimer's patients.
Topics: Aged; Aging; Alzheimer Disease; Amino Acid Isomerases; Amyloid beta-Peptides; Animals; Astrocytes; B | 2002 |
Phosphorylated serine 199 of microtubule-associated protein tau is a neuronal epitope abundantly expressed in youth and an early marker of tau pathology.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain; Child | 2003 |
Beta-amyloid racemized at the Ser26 residue in the brains of patients with Alzheimer disease: implications in the pathogenesis of Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Brain; Enzym | 2003 |
Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A | 2003 |
[The measurement of phosphorylated tau in human cerebrospinal fluid as a diagnostic marker for Alzheimer's disease].
Topics: Adult; Aged; Alzheimer Disease; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; | 2003 |
Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Blotting, Western; Brain; | 2003 |
Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tangles.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebral Cortex; Epitopes; Humans; Immunohistochemistry; | 2003 |
Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating tau protein Ser phosphorylation.
Topics: Adult; Alzheimer Disease; Bradykinin; Cell Line; Down Syndrome; Fibroblasts; Humans; Membrane Protei | 2003 |
MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.
Topics: Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Animals; Blotting, Northern; Brain; Catal | 2004 |
Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.
Topics: Alternative Splicing; Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; | 2004 |
Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry.
Topics: Alzheimer Disease; Brain; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calci | 2003 |
Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoproteins E; Aryldialkylphosphatase; Asia | 2004 |
Possible role of D-serine in the pathophysiology of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Case-Control Studies; Chi-Square D | 2004 |
A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; C | 2004 |
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anisomycin; Anthracenes; Brain; Cell Line; Cell Line, Tumor; COS Cells; | 2004 |
The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation.
Topics: Alzheimer Disease; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Line, Tumor; Cell S | 2004 |
Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis.
Topics: Aged; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Astrocytes; Cell Line, T | 2005 |
Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Blotting, | 2005 |
Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Female; Hippocampus; Histones; Hum | 2005 |
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antibodies, Monoclonal; Blotting, Western; Cerebral Cort | 2005 |
Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Pepti | 2005 |
Synthesis and conformational properties of phosphopeptides related to the human tau protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Circular Dichroism; Humans; Ions; Magnetic Resonance Spectro | 2005 |
PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau.
Topics: Alzheimer Disease; Animals; Antibodies; Brain; Calcineurin; Enzyme Activation; Humans; In Vitro Tech | 2006 |
Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2.
Topics: Alanine; Alzheimer Disease; Arginine; Binding Sites; Carrier Proteins; Catalytic Domain; Crystallogr | 2005 |
Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amy | 2006 |
Functional plasticity in the substrate binding site of beta-secretase.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Se | 2005 |
GSK-3beta directly phosphorylates and activates MARK2/PAR-1.
Topics: Alzheimer Disease; Binding Sites; Blotting, Western; Brain; Cell Line; Down-Regulation; Enzyme Activ | 2005 |
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.
Topics: Aged, 80 and over; Alzheimer Disease; Catalytic Domain; Dose-Response Relationship, Drug; Enzyme Act | 2005 |
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Br | 2005 |
P70 S6 kinase mediates tau phosphorylation and synthesis.
Topics: Alzheimer Disease; Cell Line, Tumor; Cell-Free System; Enzyme Activation; Humans; Membrane Proteins; | 2006 |
Acetylsalicylic acid decreases tau phosphorylation at serine 422.
Topics: Alzheimer Disease; Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Cel | 2006 |
Anomalously phosphorylated tau and Abeta fragments in the CSF correlates with cognitive impairment in MCI subjects.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Blotting, Western; Case-Contro | 2006 |
Analysis of the LRRK2 G2019S mutation in Alzheimer Disease.
Topics: Aged; Alzheimer Disease; DNA Mutational Analysis; Female; Glycine; Humans; Leucine-Rich Repeat Serin | 2006 |
Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.
Topics: Algorithms; Alzheimer Disease; Amino Acid Sequence; Chromatography, Liquid; Humans; Immunoblotting; | 2006 |
Activated c-Jun is present in neurofibrillary tangles in Alzheimer's disease brains.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Enzyme Activation; Female; Humans; Immunohistoche | 2006 |
Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism.
Topics: Alanine; Alzheimer Disease; Animals; Brain; Cattle; Cells, Cultured; Glycogen Synthase Kinase 3; Gly | 2006 |
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Antibodies; Apoptosis; Aspar | 2006 |
Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Case-Control Studies; Chi-Square Distrib | 2006 |
Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules.
Topics: Alzheimer Disease; Animals; Brain; Chlorocebus aethiops; COS Cells; Humans; Inositol 1,4,5-Trisphosp | 2006 |
Simultaneous detection of tau phospho-epitopes with haptenylated antibodies.
Topics: Alzheimer Disease; Antibodies, Monoclonal; Antibody Specificity; Epitopes; Humans; Immunohistochemis | 2006 |
The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism.
Topics: Alzheimer Disease; Circular Dichroism; Glycine; Humans; Hydrophobic and Hydrophilic Interactions; In | 2006 |
Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Apoptosis; Base Sequence; Circular Dichroism; Glycine; Human | 2006 |
Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Biomarkers; Brain; Cytoplasmic Gran | 2006 |
The DeltaK280 mutation in MAP tau favors exon 10 skipping in vivo.
Topics: Alzheimer Disease; Blotting, Western; Brain; Dementia; Exons; Female; Humans; Immunohistochemistry; | 2007 |
The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimer's disease patients.
Topics: Alleles; Alzheimer Disease; Apolipoprotein E4; Cognition Disorders; Disease Progression; Follow-Up S | 2007 |
A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Brain; Cystine; DNA Damage; DNA | 2007 |
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Blood-Brain Barrier; Disease Models, Animal; DN | 2007 |
14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9.
Topics: 14-3-3 Proteins; Alzheimer Disease; Catalytic Domain; Cell Line; Enzyme Activation; Epithelial Cells | 2007 |
Presenilin 2 Ser130Leu mutation in a case of late-onset "sporadic" Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Humans; Leucine; Male; Mutation; Pedigree; Presenilin-2; Serin | 2007 |
Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.
Topics: 3T3 Cells; Alzheimer Disease; Animals; Antineoplastic Agents; Brain; Cytosol; Dose-Response Relation | 2007 |
Association of a presenilin 1 S170F mutation with a novel Alzheimer disease molecular phenotype.
Topics: Adult; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Brain; DNA Mutation | 2007 |
DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.
Topics: Alzheimer Disease; Animals; Brain; Cell Line; DNA, Complementary; Down Syndrome; Dyrk Kinases; Human | 2007 |
Early-onset Alzheimer's disease with a de novo mutation in the presenilin 1 gene.
Topics: Adult; Alzheimer Disease; Brain; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Mo | 2007 |
Homocysteine induces tau hyperphosphorylation in rats.
Topics: Alzheimer Disease; Animals; Binding Sites; Brain; Brain Chemistry; Homocysteine; Hyperhomocysteinemi | 2007 |
Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Biopsy; Case-Control Studies; Cyclin-De | 2008 |
Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blotting, Western; CHO Cell | 1994 |
ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation.
Topics: Alzheimer Disease; Amino Acid Sequence; Apolipoprotein E3; Apolipoproteins E; Humans; Molecular Sequ | 1995 |
Free D-serine concentration in normal and Alzheimer human brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Frontal Lobe; Humans; Middle Aged; Reference Values; Ser | 1995 |
Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.
Topics: Adult; Alzheimer Disease; Amino Acid Sequence; Animals; Biopsy; Female; Fetus; Humans; Mice; Microtu | 1995 |
Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Chromatography, Ion Exchange; Cloning, Molec | 1995 |
Tau protein kinase I/GSK-3 beta/kinase FA in heparin phosphorylates tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cattle; Glycogen Synthase Kinase 3; Heparin; | 1995 |
Time-related cortical amino acid changes after basal forebrain lesion: a microdialysis study.
Topics: Alzheimer Disease; Amino Acids; Animals; Brain Diseases; Cerebral Cortex; Chromatography, High Press | 1995 |
Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Animals; Cattle; Cyclic AMP-Dependent Protein Kinases; Humans; Male; Middle | 1994 |
Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattl | 1993 |
Developmental changes in tau phosphorylation: fetal tau is transiently phosphorylated in a manner similar to paired helical filament-tau characteristic of Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Amino Acid Sequence; Animals; Blotting, Western; Brain; Electrophoresis, P | 1993 |
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.
Topics: Adult; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cerebral Cortex; CHO Cells; Cricetina | 1993 |
Presence of the N-methyl-D-aspartate-associated glycine receptor agonist, D-serine, in human temporal cortex: comparison of normal, Parkinson, and Alzheimer tissues.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Gas Chromatography-Mass Spectrometry; Humans; M | 1993 |
The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.
Topics: Adult; Aging; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cerebral Cortex; Fetus; Humans | 1993 |
Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A.
Topics: Alzheimer Disease; Amino Acid Sequence; Antibodies; Autoradiography; Blotting, Western; Cells, Cultu | 1996 |
Monoclonal antibody PHF-9 recognizes phosphorylated serine 404 of tau protein and labels paired helical filaments.
Topics: Alzheimer Disease; Amino Acid Sequence; Antibodies, Monoclonal; Blotting, Western; Enzyme-Linked Imm | 1996 |
The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Antibodies; Brain; | 1997 |
Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.
Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Carci | 1997 |
Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene.
Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Chromosome Aberrations; Chromosome Disorde | 1998 |
Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Antibodies, Monoclonal; Brain; Calciu | 1998 |
The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 | 1998 |
Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.
Topics: Alzheimer Disease; Cyclic AMP-Dependent Protein Kinases; Humans; Microtubules; Neurofibrillary Tangl | 1999 |
Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Chromatography, Ion Exchange; Cyt | 1999 |
Chemical modifications of deposited amyloid-beta peptides.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Humans; Molecular Sequ | 1999 |
Conformation of paired helical filaments blocks dephosphorylation of epitopes shared with fetal tau except Ser199/202 and Ser202/Thr205.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Alzheimer Disease; Amino Acid Sequence; Brain; Epitop | 2000 |
14-3-3zeta is an effector of tau protein phosphorylation.
Topics: 14-3-3 Proteins; Alzheimer Disease; Antibodies, Monoclonal; Binding Sites; Brain; Cyclic AMP-Depende | 2000 |
PKA phosphorylations on tau: developmental studies in the mouse.
Topics: Age Factors; Alzheimer Disease; Animals; Antibody Specificity; Brain; Cyclic AMP-Dependent Protein K | 2000 |
Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling.
Topics: Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amyloid beta-Peptides; Apoptosis; beta Ca | 2001 |
Utilizing the peptidyl-prolyl cis-trans isomerase pin1 as a probe of its phosphorylated target proteins. Examples of binding to nuclear proteins in a human kidney cell line and to tau in Alzheimer's diseased brain.
Topics: Alzheimer Disease; Brain; Cell Line; Cell Nucleus; Humans; Hydrogen-Ion Concentration; Immunohistoch | 2001 |
Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons.
Topics: Alzheimer Disease; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element | 2001 |
Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments.
Topics: Alzheimer Disease; Amino Acid Isomerases; Amino Acid Sequence; Aminopeptidases; Amyloid beta-Peptide | 2001 |
Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Biomarkers; Enzyme | 2001 |
Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease.
Topics: Alzheimer Disease; Crystallography, X-Ray; Humans; Models, Molecular; Mutation; Neuropeptides; Neuro | 2001 |
Paradoxical phosphorylation of the serine 199 on tau proteins from young individuals.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Child; Fe | 2001 |
Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Antisense Elements (Genetics | 2001 |
Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Brain; Choristoma | 2001 |
Progressive reduction of synaptophysin message in single neurons in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antibodies; Female; Gene Expression; Humans; Immunohisto | 2002 |
F175S change and a novel polymorphism in presenilin-1 gene in late-onset familial Alzheimer's disease.
Topics: Aged; Alleles; Alzheimer Disease; Apolipoproteins E; Female; Humans; Male; Membrane Proteins; Middle | 2002 |
The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Binding Sites; Brain; Cattle; Cloning, Molecular; H | 1992 |
The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs.
Topics: Alzheimer Disease; Amino Acid Sequence; Brain; Chromatography, High Pressure Liquid; Electrophoresis | 1992 |
Down's syndrome fibroblasts exhibit enhanced inositol uptake.
Topics: Alzheimer Disease; Biological Transport; Cell Line; Choline; Chromosome Mapping; Chromosomes, Human, | 1990 |
Neuritic plaque amyloid in Alzheimer's disease is highly racemized.
Topics: Aged; Alzheimer Disease; Amino Acids; Amyloid; Amyloid beta-Peptides; Aspartic Acid; Brain Chemistry | 1988 |