serine has been researched along with Acoustic Perceptual Disorder in 2 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Schizophrenia is associated with deficits in cortical plasticity that affect sensory brain regions and lead to impaired cognitive performance." | 6.82 | Neurophysiological mechanisms of cortical plasticity impairments in schizophrenia and modulation by the NMDA receptor agonist D-serine. ( Ahissar, M; Beggel, O; Epstein, ML; Javitt, DC; Kantrowitz, JT; Lehrfeld, JM; Lehrfeld, NP; Parker, E; Reep, J; Revheim, N; Rohrig, S; Silipo, G, 2016) |
| "Schizophrenia is associated with deficits in cortical plasticity that affect sensory brain regions and lead to impaired cognitive performance." | 2.82 | Neurophysiological mechanisms of cortical plasticity impairments in schizophrenia and modulation by the NMDA receptor agonist D-serine. ( Ahissar, M; Beggel, O; Epstein, ML; Javitt, DC; Kantrowitz, JT; Lehrfeld, JM; Lehrfeld, NP; Parker, E; Reep, J; Revheim, N; Rohrig, S; Silipo, G, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kantrowitz, JT | 1 |
| Epstein, ML | 1 |
| Beggel, O | 1 |
| Rohrig, S | 1 |
| Lehrfeld, JM | 1 |
| Revheim, N | 1 |
| Lehrfeld, NP | 1 |
| Reep, J | 1 |
| Parker, E | 1 |
| Silipo, G | 1 |
| Ahissar, M | 1 |
| Javitt, DC | 1 |
| Adcock, RA | 1 |
| Dale, C | 1 |
| Fisher, M | 1 |
| Aldebot, S | 1 |
| Genevsky, A | 1 |
| Simpson, GV | 1 |
| Nagarajan, S | 1 |
| Vinogradov, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| D-serine and Cognitive Remediation in Schizophrenia: Open Label Pilot[NCT02156908] | Phase 2 | 8 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Evaluating Two Types of Cognitive Training in Veterans With Schizophrenia[NCT01891721] | 105 participants (Actual) | Interventional | 2013-11-21 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"An MMN event is evoked by a discernible change in the pitch of a repetitive auditory stimulation. The stronger the response to a difference (i.e., the more negative the amplitude of the MMN), the better the outcome.~MMN was obtained to pitch deviant stimuli pre-post auditory plasticity training, utilizing deviants to the same base frequencies as the auditory plasticity sessions, (i.e. 500, 1000, and 2000 Hz), with ~10 minutes of each base frequency. MMN will be conducted at baseline and after the final session. Reported outcome is change in MMN between baseline and final within session." (NCT02156908)
Timeframe: 3 weeks
| Intervention | micro volts (Mean) |
|---|---|
| D-serine | .086 |
| no Intervention | 0.31 |
Change tone matching threshold (the percent difference in pitch of two consecutively played tones that can be distinguished), higher numbers represent better outcomes. D-serine outcomes are for 2 consecutive D-serine sessions (NCT02156908)
Timeframe: three weeks
| Intervention | percentage of difference in pitch (Mean) |
|---|---|
| D-serine | 11 |
| No Intervention | 2.3 |
The University of California San Diego (UCSD) Performance-based Skills Assessment (UPSA) was used to assess functional capacity. The UPSA total score served as a secondary functional outcome measure. Minimum and maximum values are 40 and 100. Higher scores mean a better outcome. (NCT01891721)
Timeframe: Within one week of training completion
| Intervention | score on a scale (Mean) |
|---|---|
| Specific Auditory Training - Brain Fitness Program (BFP) | 76.50 |
| Broad Cognitive Training - Cognitive Package (Cogpack) | 75.96 |
| Control Treatment - Commercial Computer Games (Sporcle) | 76.77 |
The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) was used to assess basic cognition. It includes tests representing 6 separable cognitive domains. The MCCB composite score (average of 6 domain t-scores) served as the primary cognitive outcome measure. Minimum and maximum values are 20 and 68. Higher scores mean a better outcome. (NCT01891721)
Timeframe: Within one week of training completion
| Intervention | score on a scale (Mean) |
|---|---|
| Specific Auditory Training - Brain Fitness Program (BFP) | 42.02 |
| Broad Cognitive Training - Cognitive Package (Cogpack) | 41.92 |
| Control Treatment - Commercial Computer Games (Sporcle) | 41.94 |
A Mismatch Negativity (MMN) Paradigm was used to assess basic auditory processing. MMN amplitude was measured as the mean voltage in the 145-200 ms latency range at pooled frontocentral electodes. Minimum and maximum values are -8 and +2 microvolts. More negative scores mean a better outcome. (NCT01891721)
Timeframe: After 6 weeks of training and within one week of training completion
| Intervention | units on a scale (Mean) | |
|---|---|---|
| MMN at 12 weeks | MMN at 6 weeks | |
| Broad Cognitive Training - Cognitive Package (Cogpack) | -2.17 | -2.16 |
| Control Treatment - Commercial Computer Games (Sporcle) | -2.09 | -2.21 |
| Specific Auditory Training - Brain Fitness Program (BFP) | -2.04 | -1.78 |
1 review available for serine and Acoustic Perceptual Disorder
| Article | Year |
|---|---|
When top-down meets bottom-up: auditory training enhances verbal memory in schizophrenia.
Topics: Acoustic Stimulation; Adult; Attention; Auditory Cortex; Auditory Perceptual Disorders; Brain-Derive | 2009 |
1 trial available for serine and Acoustic Perceptual Disorder
| Article | Year |
|---|---|
Neurophysiological mechanisms of cortical plasticity impairments in schizophrenia and modulation by the NMDA receptor agonist D-serine.
Topics: Adult; Auditory Perceptual Disorders; Brain Waves; Cohort Studies; Evoked Potentials, Auditory; Exci | 2016 |