serine has been researched along with Ache in 33 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spinal astrocyte D-serine plays an important role in the development of mirror-image pain." | 7.88 | Differential involvement of ipsilateral and contralateral spinal cord astrocyte D-serine in carrageenan-induced mirror-image pain: role of σ1 receptors and astrocyte gap junctions. ( Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY, 2018) |
| " In this study, we examined the involvement of l-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV)." | 7.77 | Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy. ( Kawamata, T; Kiya, T; Namiki, A; Yamakage, M, 2011) |
| "We propose possible therapeutic approaches for some CNS diseases and chronic pain, targeting the D-serine levels by manipulating its uptake, biosynthesis and metabolism." | 6.45 | D-serine regulation: a possible therapeutic approach for central nervous diseases and chronic pain. ( Lee, TL; Sethuraman, R; Tachibana, S, 2009) |
| "Spinal astrocyte D-serine plays an important role in the development of mirror-image pain." | 3.88 | Differential involvement of ipsilateral and contralateral spinal cord astrocyte D-serine in carrageenan-induced mirror-image pain: role of σ1 receptors and astrocyte gap junctions. ( Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY, 2018) |
| "Spinal hydrogen peroxide is specifically and largely responsible for formalin-induced pain, and DAAO inhibitors produce analgesia by blocking spinal hydrogen peroxide production rather than interacting with spinal D-serine." | 3.78 | D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. ( Gong, N; Lu, JM; Wang, YC; Wang, YX, 2012) |
| " In this study, we examined the involvement of l-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV)." | 3.77 | Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy. ( Kawamata, T; Kiya, T; Namiki, A; Yamakage, M, 2011) |
| " Whether glycinergic mechanisms, which play a pivotal role in pain modulation, are involved in lidocaine-induced antinociception is hitherto unclear." | 3.75 | Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system. ( Bauer, I; Freynhagen, R; Hermanns, H; Kollosche, K; Lipfert, P; Muth-Selbach, U; Stegmann, JU, 2009) |
| "We propose possible therapeutic approaches for some CNS diseases and chronic pain, targeting the D-serine levels by manipulating its uptake, biosynthesis and metabolism." | 2.45 | D-serine regulation: a possible therapeutic approach for central nervous diseases and chronic pain. ( Lee, TL; Sethuraman, R; Tachibana, S, 2009) |
| " Furthermore, the chronic administration of naloxone to mice injected with dsAAV2-MORS196A-EGFP did not induce tolerance, dependence, or reward responses." | 1.34 | dsAAV type 2-mediated gene transfer of MORS196A-EGFP into spinal cord as a pain management paradigm. ( Chen, SL; Han, JM; Law, PY; Loh, HH; Ma, HI; Tao, PL, 2007) |
| "Secondary mechanical allodynia resulting from a thermal stimulus (52." | 1.33 | Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. ( Jones, TL; Sorkin, LS, 2005) |
| "Gabapentin (GBP) is a gamma-aminobutyric acid analog originally synthesized for its anticonvulsant actions." | 1.30 | Gabapentin reverses the allodynia produced by the administration of anti-GD2 ganglioside, an immunotherapeutic drug. ( Gillin, S; Sorkin, LS, 1998) |
| "Gabapentin is an anticonvulsant that may represent a novel class of drugs, which has novel spinal antihyperalgesic activity." | 1.30 | The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. ( Jun, JH; Yaksh, TL, 1998) |
| "Gabapentin (GP) has been shown to have antihyperalgesic properties and the site of drug action is reported to be the central nervous system." | 1.30 | Attenuation of formalin-induced nociceptive behaviors following local peripheral injection of gabapentin. ( Carlton, SM; Zhou, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 14 (42.42) | 29.6817 |
| 2010's | 15 (45.45) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Varga, A | 1 |
| Mészár, Z | 1 |
| Sivadó, M | 1 |
| Bácskai, T | 1 |
| Végh, B | 1 |
| Kókai, É | 1 |
| Nagy, I | 1 |
| Szücs, P | 1 |
| Choi, HS | 1 |
| Roh, DH | 2 |
| Yoon, SY | 2 |
| Choi, SR | 1 |
| Kwon, SG | 1 |
| Kang, SY | 1 |
| Moon, JY | 1 |
| Han, HJ | 2 |
| Beitz, AJ | 2 |
| Lee, JH | 2 |
| Mingorance-Le Meur, A | 1 |
| Ghisdal, P | 1 |
| Mullier, B | 1 |
| De Ron, P | 1 |
| Downey, P | 1 |
| Van Der Perren, C | 1 |
| Declercq, V | 1 |
| Cornelis, S | 1 |
| Famelart, M | 1 |
| Van Asperen, J | 1 |
| Jnoff, E | 1 |
| Courade, JP | 1 |
| Ito, M | 1 |
| Yoshikawa, M | 1 |
| Ito, K | 1 |
| Matsuda, M | 1 |
| Jin, XL | 1 |
| Takahashi, S | 1 |
| Kobayashi, H | 1 |
| Suzuki, T | 1 |
| Takahashi, Y | 1 |
| Hara, K | 2 |
| Haranishi, Y | 2 |
| Terada, T | 2 |
| Obara, G | 1 |
| Sata, T | 2 |
| Muth-Selbach, U | 2 |
| Hermanns, H | 1 |
| Stegmann, JU | 2 |
| Kollosche, K | 2 |
| Freynhagen, R | 1 |
| Bauer, I | 1 |
| Lipfert, P | 2 |
| Sethuraman, R | 1 |
| Lee, TL | 1 |
| Tachibana, S | 1 |
| Nair, A | 1 |
| Simonetti, M | 1 |
| Fabbretti, E | 1 |
| Nistri, A | 1 |
| Nakamura, S | 1 |
| Nishikawa, Y | 1 |
| Sasaki, A | 1 |
| Kuraishi, Y | 1 |
| Polter, A | 1 |
| Beurel, E | 1 |
| Yang, S | 1 |
| Garner, R | 1 |
| Song, L | 1 |
| Miller, CA | 1 |
| Sweatt, JD | 1 |
| McMahon, L | 1 |
| Bartolucci, AA | 1 |
| Li, X | 1 |
| Jope, RS | 1 |
| Kiya, T | 1 |
| Kawamata, T | 1 |
| Namiki, A | 1 |
| Yamakage, M | 1 |
| Nozaki, C | 1 |
| Vergnano, AM | 1 |
| Filliol, D | 1 |
| Ouagazzal, AM | 1 |
| Le Goff, A | 1 |
| Carvalho, S | 1 |
| Reiss, D | 1 |
| Gaveriaux-Ruff, C | 1 |
| Neyton, J | 1 |
| Paoletti, P | 1 |
| Kieffer, BL | 1 |
| Lu, JM | 1 |
| Gong, N | 1 |
| Wang, YC | 1 |
| Wang, YX | 1 |
| Yoshikawa, S | 1 |
| Oguchi, T | 1 |
| Funahashi, Y | 1 |
| de Groat, WC | 1 |
| Yoshimura, N | 1 |
| Laurido, C | 1 |
| Hernández, A | 1 |
| Pelissier, T | 1 |
| Constandil, L | 1 |
| Ben Achour, S | 1 |
| Pascual, O | 1 |
| Tsuzuki, H | 1 |
| Maekawa, M | 1 |
| Konno, R | 1 |
| Hori, Y | 1 |
| Bhave, G | 1 |
| Zhu, W | 1 |
| Wang, H | 2 |
| Brasier, DJ | 1 |
| Oxford, GS | 1 |
| Gereau, RW | 1 |
| Fang, L | 2 |
| Wu, J | 2 |
| Lin, Q | 2 |
| Willis, WD | 2 |
| Zhang, X | 1 |
| Dybek, E | 1 |
| Holthusen, H | 1 |
| Zeilhofer, HU | 1 |
| Maeda, T | 1 |
| Hamabe, W | 1 |
| Gao, Y | 1 |
| Fukazawa, Y | 1 |
| Kumamoto, K | 1 |
| Ozaki, M | 1 |
| Kishioka, S | 1 |
| Jones, TL | 1 |
| Sorkin, LS | 2 |
| Ren, WH | 1 |
| Guo, JD | 1 |
| Cao, H | 1 |
| Wang, PF | 1 |
| Sha, H | 1 |
| Ji, RR | 1 |
| Zhao, ZQ | 1 |
| Zhang, YQ | 1 |
| Ying-Luan, Z | 1 |
| Zhao, YL | 1 |
| Mori, H | 1 |
| Niederberger, E | 1 |
| Ehnert, C | 1 |
| Gao, W | 1 |
| Coste, O | 1 |
| Schmidtko, A | 1 |
| Popp, L | 1 |
| Gall, CV | 1 |
| Korf, HW | 1 |
| Tegeder, I | 1 |
| Geisslinger, G | 1 |
| Rodríguez-Muñoz, M | 1 |
| de la Torre-Madrid, E | 1 |
| Gaitán, G | 1 |
| Sánchez-Blázquez, P | 1 |
| Garzón, J | 1 |
| Chen, SL | 1 |
| Ma, HI | 1 |
| Han, JM | 1 |
| Tao, PL | 1 |
| Law, PY | 1 |
| Loh, HH | 1 |
| Kim, HW | 1 |
| Seo, HS | 1 |
| Kwon, YB | 1 |
| Kim, KW | 1 |
| Gillin, S | 1 |
| Jun, JH | 1 |
| Yaksh, TL | 1 |
| Carlton, SM | 1 |
| Zhou, S | 1 |
3 reviews available for serine and Ache
| Article | Year |
|---|---|
D-serine regulation: a possible therapeutic approach for central nervous diseases and chronic pain.
Topics: Animals; Central Nervous System Diseases; Chronic Disease; Humans; Pain; Serine; Stereoisomerism | 2009 |
Astrocyte-neuron communication: functional consequences.
Topics: Adenosine Triphosphate; Animals; Astrocytes; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Memory; | 2012 |
[Role of D-serine in the mammalian brain].
Topics: Animals; Astrocytes; Brain; Cell Death; Mice; Neuronal Plasticity; Neurotransmitter Agents; Pain; Ra | 2007 |
30 other studies available for serine and Ache
| Article | Year |
|---|---|
Spinal Excitatory Dynorphinergic Interneurons Contribute to Burn Injury-Induced Nociception Mediated by Phosphorylated Histone 3 at Serine 10 in Rodents.
Topics: Animals; Burns; Epigenesis, Genetic; Female; Histones; Immunohistochemistry; In Situ Hybridization; | 2021 |
Differential involvement of ipsilateral and contralateral spinal cord astrocyte D-serine in carrageenan-induced mirror-image pain: role of σ1 receptors and astrocyte gap junctions.
Topics: Animals; Astrocytes; Carrageenan; Dose-Response Relationship, Drug; Gap Junctions; Injections, Spina | 2018 |
Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain.
Topics: Analgesics; Animals; Benzamides; Blood-Brain Barrier; Brain; Capillary Permeability; Cell Line; Dise | 2013 |
Antinociceptive effect of intracerebroventricular administration of D-serine on formalin-induced pain.
Topics: Analgesics; Animals; Formaldehyde; Infusions, Intraventricular; Male; Pain; Pain Measurement; Quinol | 2014 |
Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine Plasma Membra | 2015 |
Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system.
Topics: Analgesics; Animals; Binding Sites; Glycine; Glycine Agents; Lidocaine; Organophosphonates; Pain; Qu | 2009 |
The Cdk5 kinase downregulates ATP-gated ionotropic P2X3 receptor function via serine phosphorylation.
Topics: Animals; Cell Line; Cyclin-Dependent Kinase 5; Down-Regulation; Humans; Pain; Patch-Clamp Techniques | 2010 |
The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model.
Topics: Acute Disease; Analgesics; Animals; Dose-Response Relationship, Drug; Glycine Plasma Membrane Transp | 2010 |
Blockade of glycine transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain.
Topics: Animals; Dose-Response Relationship, Drug; Female; Glycine Plasma Membrane Transport Proteins; Herpe | 2010 |
Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances.
Topics: Adult; Aged; Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Electro | 2010 |
Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cold Temperature; Ganglia, Spinal; Hyperalgesia; Male; N | 2011 |
Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Disease Models, Animal; DNA Mutational Analysis | 2011 |
D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.
Topics: Analgesics; Animals; Behavior, Animal; D-Amino-Acid Oxidase; Formaldehyde; Hydrogen Peroxide; Hypera | 2012 |
Glycine transporter type 2 (GlyT2) inhibitor ameliorates bladder overactivity and nociceptive behavior in rats.
Topics: Animals; Diterpenes; Female; Freezing Reaction, Cataleptic; Glycine Agents; Glycine Plasma Membrane | 2012 |
Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model.
Topics: Animals; Arthritis; Aspartic Acid; Disease Models, Animal; Enzyme Inhibitors; Pain; Racemases and Ep | 2012 |
Functional roles of endogenous D-serine in pain-induced ultrasonic vocalization.
Topics: Animals; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain; Serine; Ultrasonics; | 2012 |
cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.
Topics: Amino Acid Sequence; Animals; Binding Sites; Capsaicin; Central Nervous System; CHO Cells; COS Cells | 2002 |
Protein kinases regulate the phosphorylation of the GluR1 subunit of AMPA receptors of spinal cord in rats following noxious stimulation.
Topics: Amino Acid Sequence; Animals; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; In | 2003 |
Increased phosphorylation of the GluR1 subunit of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor in rats following intradermal injection of capsaicin.
Topics: Animals; Blotting, Western; Capsaicin; Immunohistochemistry; Injections, Intradermal; Male; Neurons; | 2003 |
The spinal antinociceptive effect of nocistatin in neuropathic rats is blocked by D-serine.
Topics: Analgesics, Opioid; Anesthesia, Spinal; Animals; Dose-Response Relationship, Drug; Glycine; Hyperalg | 2004 |
Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice.
Topics: Animals; Area Under Curve; Blotting, Western; Brain; Dose-Response Relationship, Drug; Drug Administ | 2005 |
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area | 2005 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cing | 2006 |
The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Inflammation; Male; Mice; Mut | 2007 |
RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons.
Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2 | 2007 |
dsAAV type 2-mediated gene transfer of MORS196A-EGFP into spinal cord as a pain management paradigm.
Topics: Animals; Dependovirus; Drug Tolerance; Gene Expression Regulation; Gene Transfer Techniques; Genes, | 2007 |
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.
Topics: Animals; Behavior, Animal; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; D | 2008 |
Gabapentin reverses the allodynia produced by the administration of anti-GD2 ganglioside, an immunotherapeutic drug.
Topics: Acetates; Amines; Analgesics; Animals; Antibodies, Monoclonal; Blood Pressure; Cyclohexanecarboxylic | 1998 |
The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat.
Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relati | 1998 |
Attenuation of formalin-induced nociceptive behaviors following local peripheral injection of gabapentin.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Dose-Response | 1998 |