sepharose has been researched along with Chemical-and-Drug-Induced-Liver-Injury* in 2 studies
2 other study(ies) available for sepharose and Chemical-and-Drug-Induced-Liver-Injury
| Article | Year |
|---|---|
Development of a high-throughput micropatterned agarose scaffold for consistent and reproducible hPSC-derived liver organoids.
Liver organoids represent emerging human-relevant Topics: Acetaminophen; Cell Differentiation; Chemical and Drug Induced Liver Injury; Humans; Liver; Organoids; Sepharose | 2022 |
[Isoenzyme differentiation of gamma-glutamyltransferase by concanavalin A and Con- A-Sepharose (author's transl)].
In this investigation a new possibility of isoenzyme-differentiation of the gamma-glutamyl-transferase (GGT) (EC Nr.2.3.2.2.) was demonstrated by Concanavalin A and Con A-Sepharose. Because of the different sugar content of the glycoproteins distinction between liver- and kidney-GGT is possible. Furthermore it was possible for the first time to show a different precipitation behaviour of one glycoprotein to Concanavalin A in certain diseases. In cases of alcoholic hepatitis GGT looses its Concanavalin A-affinity because of increased neuraminic acid concentration. The possible reasons of the different behaviour to the binding affinity of Con A and Con A-Sepharose and GGT as well as additional use for enzyme-differentiation by Con A-Sepharose affinity chromatography are discussed. Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Chemical Precipitation; Chromatography, Affinity; Concanavalin A; Ethanol; gamma-Glutamyltransferase; Glycoproteins; Humans; Isoenzymes; Kidney Diseases; Liver Diseases; Neuraminic Acids; Neuraminidase; Polysaccharides; Sepharose | 1976 |