sennoside a&b has been researched along with Diarrhea in 16 studies
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we sought to identify the toxic metabolite responsible for melanosis coli in rats dosed with rhubarb anthraquinones for up to 90 days." | 1.56 | Identification of rhein as the metabolite responsible for toxicity of rhubarb anthraquinones. ( Cheng, Y; He, Y; Qiao, B; Qu, L; Routledge, MN; Yun Gong, Y; Zhang, H, 2020) |
| " In conclusion, results from the present investigation do not indicate any relationship between long-term administration of purified senna extract and gastrointestinal, liver, kidney or adrenal tumors in the rat." | 1.29 | Two-year carcinogenicity study with sennosides in the rat: emphasis on gastro-intestinal alterations. ( Lydén-Sokolowski, A; Nilsson, A; Sjöberg, P, 1993) |
| " From acute studies, sennosides could be classified as only slightly toxic in rats and mice after a single oral dose." | 1.27 | Toxic effects of sennosides in laboratory animals and in vitro. ( Mengs, U, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Zhong, L | 1 |
| Cao, X | 1 |
| Li, L | 1 |
| He, Y | 3 |
| Liu, Y | 1 |
| Chen, W | 1 |
| Yang, F | 1 |
| Xiao, N | 1 |
| Zhang, J | 1 |
| He, H | 1 |
| Cheng, Y | 2 |
| Zhang, H | 2 |
| Qu, L | 2 |
| Routledge, MN | 1 |
| Yun Gong, Y | 1 |
| Qiao, B | 2 |
| Cao, Y | 1 |
| Wei, C | 1 |
| Li, J | 1 |
| Hay, T | 1 |
| Deane, AM | 1 |
| Rechnitzer, T | 1 |
| Fetterplace, K | 1 |
| Reilly, R | 1 |
| Ankravs, M | 1 |
| Bailey, M | 1 |
| Fazio, T | 1 |
| Anstey, J | 1 |
| D'Costa, R | 1 |
| Presneill, JJ | 1 |
| MacIsaac, CM | 1 |
| Bellomo, R | 1 |
| Kon, R | 1 |
| Ikarashi, N | 1 |
| Nagoya, C | 1 |
| Takayama, T | 1 |
| Kusunoki, Y | 1 |
| Ishii, M | 1 |
| Ueda, H | 1 |
| Ochiai, W | 1 |
| Machida, Y | 1 |
| Sugita, K | 1 |
| Sugiyama, K | 1 |
| Takahashi, M | 1 |
| Miyazawa, M | 1 |
| Sakurai, K | 1 |
| Watabe, K | 1 |
| Kojima, T | 1 |
| Zhang, Y | 1 |
| Wang, X | 1 |
| Sha, S | 1 |
| Liang, S | 1 |
| Zhao, L | 1 |
| Liu, L | 1 |
| Chai, N | 1 |
| Wang, H | 1 |
| Wu, K | 1 |
| Kobayashi, M | 1 |
| Yamaguchi, T | 1 |
| Odaka, T | 1 |
| Nakamura, T | 1 |
| Tsuchiya, S | 1 |
| Yokosuka, O | 1 |
| Yano, S | 1 |
| Leng-Peschlow, E | 1 |
| Odenthal, KP | 1 |
| Voderholzer, W | 1 |
| Müller-Lissner, S | 1 |
| Lydén-Sokolowski, A | 1 |
| Nilsson, A | 1 |
| Sjöberg, P | 1 |
| Yamauchi, K | 3 |
| Yagi, T | 3 |
| Kuwano, S | 3 |
| Beubler, E | 1 |
| Schirgi-Degen, A | 1 |
| Saito, T | 1 |
| Yamada, T | 1 |
| Iwanaga, Y | 1 |
| Morikawa, K | 1 |
| Nagata, O | 1 |
| Kato, H | 1 |
| Mizumoto, A | 1 |
| Itoh, Z | 1 |
| Miyawaki, Y | 2 |
| Nishikawa, A | 1 |
| Nishikawa, T | 1 |
| Mengs, U | 1 |
1 trial available for sennoside a&b and Diarrhea
| Article | Year |
|---|---|
The hospital-based evaluation of laxative prophylaxis in ICU (HELP-ICU): A pilot cluster-crossover randomized clinical trial.
Topics: Adult; Aged; Catheterization; Constipation; Cross-Over Studies; Diarrhea; Enteral Nutrition; Female; | 2019 |
15 other studies available for sennoside a&b and Diarrhea
| Article | Year |
|---|---|
Renzhu Ointment Regulates L-Type Voltage-Dependent Calcium Channel in Mice Model of Senna-Induced Diarrhea by Transdermal Administration.
Topics: Administration, Cutaneous; Animals; Antidiarrheals; Calcium Channels, L-Type; Calcium Chloride; Diar | 2023 |
Identification of rhein as the metabolite responsible for toxicity of rhubarb anthraquinones.
Topics: Animals; Anthraquinones; Apoptosis; Autophagy; Biotransformation; Cathartics; Chromatography, High P | 2020 |
Aquaporins Alteration Profiles Revealed Different Actions of Senna, Sennosides, and Sennoside A in Diarrhea-Rats.
Topics: Animals; Aquaporins; Colon; Diarrhea; Gene Expression Profiling; Gene Expression Regulation; Hypoxan | 2018 |
Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.
Topics: Animals; Anthracenes; Aquaporin 3; Cell Line; Colon; Colonic Neoplasms; Diarrhea; Dinoprostone; HT29 | 2014 |
[Study on processed senna found in health teas].
Topics: Animals; Anthraquinones; Beverages; Cathartics; Chromatography, High Pressure Liquid; Chromatography | 2009 |
Berberine increases the expression of NHE3 and AQP4 in sennosideA-induced diarrhoea model.
Topics: Animals; Antidiarrheals; Aquaporin 4; Berberine; Cell Line; Coptis; Diarrhea; Drugs, Chinese Herbal; | 2012 |
Regionally differential effects of sennoside A on spontaneous contractions of colon in mice.
Topics: Animals; Anthraquinones; Cathartics; Colon; Diarrhea; Gastrointestinal Motility; Male; Mice; Muscle | 2007 |
Chronic sennoside treatment does not cause habituation and secondary hyperaldosteronism in rats.
Topics: Aldosterone; Animals; Anthraquinones; Cathartics; Diarrhea; Female; Hyperaldosteronism; Intestinal M | 1993 |
Two-year carcinogenicity study with sennosides in the rat: emphasis on gastro-intestinal alterations.
Topics: Animals; Anthraquinones; Carcinogenicity Tests; Cathartics; Diarrhea; Female; Gastrointestinal Neopl | 1993 |
Suppression of the purgative action of rhein anthrone, the active metabolite of sennosides A and B, by calcium channel blockers, calmodulin antagonists and indomethacin.
Topics: Animals; Anthracenes; Anthraquinones; Calcium; Calcium Channel Blockers; Calmodulin; Cathartics; Col | 1993 |
Serotonin antagonists inhibit sennoside-induced fluid secretion and diarrhea.
Topics: Animals; Anthraquinones; Colon; Diarrhea; Dose-Response Relationship, Drug; Female; Intestinal Absor | 1993 |
Calcium polycarbophil, a water absorbing polymer, increases bowel movement and prevents sennoside-induced diarrhea in dogs.
Topics: Acrylic Resins; Animals; Anthraquinones; Antidiarrheals; Defecation; Diarrhea; Dogs; Female; Loperam | 2000 |
Suppression of the purgative action of rhein anthrone, the active metabolite of sennosides A and B, by indomethacin in rats.
Topics: Animals; Anthracenes; Anthraquinones; Cathartics; Colon; Diarrhea; Dinoprostone; Electrolytes; Femal | 1991 |
Involvement of prostaglandin E-like material in the purgative action of rhein anthrone, the intraluminal active metabolite of sennosides A and B in mice.
Topics: Animals; Anthraquinones; Barium Sulfate; Cathartics; Diarrhea; Dibenz(b,f)(1,4)oxazepine-10(11H)-car | 1988 |
Toxic effects of sennosides in laboratory animals and in vitro.
Topics: Animals; Anthraquinones; Cathartics; Colon; Diarrhea; Dogs; Female; Kidney; Lethal Dose 50; Male; Mu | 1988 |