senkyunolide-i and Inflammation

senkyunolide-i has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for senkyunolide-i and Inflammation

ArticleYear
Senkyunolide I Protects against Sepsis-Associated Encephalopathy by Attenuating Sleep Deprivation in a Murine Model of Cecal Ligation and Puncture.
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Sepsis may lead to sleep deprivation, which will promote the development of neuroinflammation and mediate the progression of sepsis-associated encephalopathy (SAE). Senkyunolide I, an active component derived from an herb medicine, has been shown to provide a sedative effect to improve sleep. However, its role in sepsis is unclear. The present study was performed to investigate whether Senkyunolide I protected against SAE in a murine model of cecal ligation and puncture (CLP). Here, we showed that Senkyunolide I treatment improved the 7-day survival rate and reduced the excessive release of cytokines including TNF-

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Benzofurans; Cecum; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Inflammation; Ligation; Male; Memory Disorders; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Punctures; Sepsis-Associated Encephalopathy; Signal Transduction; Sleep Deprivation; Survival Analysis

2021