senkyunolide-i has been researched along with Inflammation* in 1 studies
1 other study(ies) available for senkyunolide-i and Inflammation
| Article | Year |
|---|---|
Senkyunolide I Protects against Sepsis-Associated Encephalopathy by Attenuating Sleep Deprivation in a Murine Model of Cecal Ligation and Puncture.
Sepsis may lead to sleep deprivation, which will promote the development of neuroinflammation and mediate the progression of sepsis-associated encephalopathy (SAE). Senkyunolide I, an active component derived from an herb medicine, has been shown to provide a sedative effect to improve sleep. However, its role in sepsis is unclear. The present study was performed to investigate whether Senkyunolide I protected against SAE in a murine model of cecal ligation and puncture (CLP). Here, we showed that Senkyunolide I treatment improved the 7-day survival rate and reduced the excessive release of cytokines including TNF- Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Benzofurans; Cecum; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Inflammation; Ligation; Male; Memory Disorders; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Punctures; Sepsis-Associated Encephalopathy; Signal Transduction; Sleep Deprivation; Survival Analysis | 2021 |